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| 1 | Vascular endothelial growth factor receptor 2(VEGFR-2) plays a key role in vasculogenic mimicry formation,neovascularization and tumor initiation by Glioma stem-like cells显示文摘Human glioblastomas(GBM)are thought to be initiated by glioma stem-like cells(GSLCs).GSLCs also participate in tumor neovascularization by transdifferentiating into vascular endothelial cells.Here,we report a critical role of GSLCs in the formation of vasculogenic mimicry(VM),which defines channels lined by tumor cells to supply nutrients to early growing tumors and | Yao X Ping Y Liu Y Chen K Yoshimura T Liu M Gong W Chen C Niu Q Guo D Zhang X Wang JM Bian X | 2013 | 中国神经肿瘤杂志2013，11，3： | 23 |
| 2 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 3 | Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression显示文摘 | Chen T Guo J Yang M Han C Zhang M Chen W Liu Q Wang J Cao X | 2005 | 第二军医大学学报2005，26，11： | 11 |
| 4 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 5 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 6 | Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis显示文摘To assess the utility of longitudinal ultrasound(US) to quantify volumetric changes in joint soft tissues during the progression of posttraumatic osteoarthritis(PTOA) in mice, and validate the US results with histological findings. A longitudinal cohort of 3-month-old wild-type C57 BL/6 male mice received the Hulth-Telhag surgical procedure on right knee to induce PTOA, and sham surgery on their left knee as control. US scans were performed on both knees before, 2, 4, 6, and 8 weeks post-surgery. Joint space volume and Power-Doppler(PD) volume were obtained from US images via Amira software. A parallel cross-sectional cohort of mice was killed at each US time point, and knee joints were subjected to histological analysis to obtain synovial soft-tissue area and OARSI scores. The correlation between US joint space volume and histological synovial soft-tissue area or OARSI score was assessed via linear regression analysis. US images indicated increased joint space volume in PTOA joints over time, which was associated with synovial inflammation and cartilage damage by histology. These changes started from 2 weeks post-surgery and gradually became more severe. No change was detected in sham joints. Increased joint space volume was significantly correlated with increased synovial soft-tissue area and the OARSI score(P o 0.001). PD signal was detected in the joint space of PTOA joints at 6 weeks post-surgery, which was consistent with the location of blood vessels that stained positively for CD31 and alpha-smooth muscle actin in the synovium.This study indicates that US is a cost-effective longitudinal outcome measure of volumetric and vascular changes in joint soft tissues during PTOA progression in mice, which positively correlates with synovial inflammation and cartilage damage. | Hao Xu Echoe M Bouta Ronald W Wood Edward M Schwarz Yongjun Wang Lianping Xing | 2017 | Bone Research2017，5，3： | 7 |
| 7 | High-dose methylprednisolone can induce remissions in patients with fludarabine- refractory chronic lymphocytic leukaemia显示文摘 | Xu, W Miao, KR Hong, M Zhu, DX Fang, C Dong, HJ Wang, DM Cao, X Li, JY | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 5 |
| 8 | Antenna-assisted picosecond control of nanoscale phase transition in vanadium dioxide显示文摘Nanoscale devices in which the interaction with light can be configured using external control signals hold great interest for next-generation optoelectronic circuits.Materials exhibiting a structural or electronic phase transition offer a large modulation contrast with multi-level optical switching and memory functionalities.In addition,plasmonic nanoantennas can provide an efficient enhancement mechanism for both the optically induced excitation and the readout of materials strategically positioned in their local environment.Here,we demonstrate picosecond all-optical switching of the local phase transition in plasmonic antenna-vanadium dioxide(VO_(2))hybrids,exploiting strong resonant field enhancement and selective optical pumping in plasmonic hotspots.Polarization-and wavelength-dependent pump–probe spectroscopy of multifrequency crossed antenna arrays shows that nanoscale optical switching in plasmonic hotspots does not affect neighboring antennas placed within 100 nm of the excited antennas.The antenna-assisted pumping mechanism is confirmed by numerical model calculations of the resonant,antenna-mediated local heating on a picosecond time scale.The hybrid,nanoscale excitation mechanism results in 20 times reduced switching energies and 5 times faster recovery times than a VO_(2) film without antennas,enabling fully reversible switching at over two million cycles per second and at local switching energies in the picojoule range.The hybrid solution of antennas and VO_(2) provides a conceptual framework to merge the field localization and phase-transition response,enabling precise,nanoscale optical memory functionalities. | Otto L Muskens Luca Bergamini Yudong Wang Jeffrey M Gaskell Nerea Zabala CH de Groot David W Sheel Javier Aizpurua | 2016 | Light(Science & Applications)2016，5，1： | 5 |
| 9 | Establishment and Applications of Epstein-Barr Virus-based Episomal Vectors in Human Embryonic Stem Cells显示文摘 | Ren C Zhao M Yang X Li D Jiang X Wang L Shan W Yang H Zhou L Zhou W Zhang H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 10 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 11 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 12 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 13 | Isozyme inheritance and variation in Actinidia显示文摘 | Huang H W Fenny D Wang Z R Jiang Z W Huang R H Wang S M | 1997 | Heredity1997，78，： | 2 |
| 14 | Ferroelectric, Piezoelectric and Pyroelectric Properties of Sr1+ xBi4- x- Ti4- xTaxO Ceramics (x=0- 1) 显示文摘 | Zhao M L Wang C L Zhong W L | 2002 | Jpn J Appl Phys2002，41，： | 2 |
| 15 | 2019年中国湖北省外新型冠状病毒肺炎的流行病学与传播动力学研究显示文摘新型冠状病毒是由新型冠状病毒(2019-nCoV)感染后引起的一种急性呼吸道传染病。了解疾病在湖北省以外省份的流行过程和动态变化有助于及时的提供疾病干预措施,利于全国疾病防控。该研究的目的是描述湖北省外的其他省份新型冠状病毒肺炎暴发后50 d的流行病学特征,估计关键的时间-事件间隔变化,并运用估计的基本再生数(R0)评价中国所实施的严格控制措施是否有效的减缓了疾病的传播。该研究纳入了中国除湖北省外30个省(市)的确诊病例信息,根据病例定义的第四次修订日期(1月27日)将流行病分为两个时间段(12月24日至1月27日以及1月28日至2月17日)。文章统计了病例的人口特征以及关键事件的间隔时间,利用贝叶斯方法估算各省有效再生数(Rt)的动态变化。调查结果显示,病例的中位年龄为44岁,随着流行病的发展,年龄较小的人群和老年人的病例比例在增加。从发生症状到入院的平均时间从4.4 d(12月24日至1月27日)降低到2.6 d(1月28日至2月17日)。 | 彭志行(编译) Zhang J Litvinova M Wang W | 2020 | 中华预防医学杂志2020，54，8： | 2 |
| 16 | Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat显示文摘 | Shyu K G Wang M T Wang B W | 2002 | Cardiovasc Res2002，54，3： | 2 |
| 17 | Preparation and characterization of Bi2Ti2O7 thin films by chemical solution deposition technique 显示文摘 | WU X M WANG S W WANG H | 2000 | Thin Solid Films2000，370，： | 2 |
| 18 | A novel Ru-B/SiO_2 amorphous catalyst used in benzene-selective hydrogenation显示文摘 | Xie S H Qiao M H Li H X Wang W J Deng J-F | | 0，，： | 2 |
| 19 | Mutagenicity and acute toxicity of waters from different treatment processess in Beijing waterworks 显示文摘 | Ma M Wang Z J Shang W | 2000 | J Environmental Science and Health (A)2000，35，10： | 2 |
| 20 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
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