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| 1 | Risky business? Asking tourists what hazards they actually encountered in Thailand显示文摘 | Robert W.Howard | | 0，，30： | 1 |
| 2 | “Tower, Am I Cleared to Land?”: Problematic Communication in Aviation Discourse显示文摘 | John W.Howard | 2008 | Human Communication Research2008，，3： | 1 |
| 3 | Clinical Implications of Thrombocytopenia Among Patients Undergoing Intra‐aortic Balloon Pump Counterpulsation in the Coronary Care Unit显示文摘 | Sion K.Roy Edward W.Howard Julio A.Panza Howard A.Cooper | 2010 | Clin Cardiol2010，，1： | 1 |
| 4 | Climate change and invasive species:double jeopardy显示文摘Two of the key drivers of biodiversity loss today are climate change and invasive species.Climate change is already having a measurable impact on species distributions,reproduction and behavior,and all evidence suggests that things will get worse even if we act tomorrow to mitigate any future increases in greenhouse gas emissions:temperature will increase,precipitation will change,sea level will rise and ocean chemistry will change.At the same time,biological invasions remain an important threat to biodiversity,causing species loss,changes in distribution and habitat degradation.Acting together,the impacts of each of these drivers of change are compounded and interactions between these two threats present even greater challenges to field conservationists as well as policymakers.Similarly,the social and economic impacts of climate change and invasive species,already substantial,will be magnified.Awareness of the links between the two should underpin all biodiversity management planning and policy. | Susan A.MAINKA Geoffrey W.HOWARD | 2010 | Integrative Zoology2010，5，2： | 0 |
| 5 | ANTI-TUMOR RESPONSES INDUCED BY LASER IRRADIATION AND IMMUNOLOGICAL STIMULATION USING A MOUSE MAMMARY TUMOR MODEL显示文摘Anti-tunor immunological response induced by local intervention is ideal for treatment of metastatic tumors.Laser immunot herapy was developed to synergize photot hermal interaction with immunological stimulation for cancer treatment.Using an infrared laser,indocyanine green(ICG,as a light abeorbing agent),and glycated chitosan(GC,as an immunostimulant),.laser imm unot herapy has resulted in tumor suppression and anti-tumor responses in pre-clinical as well as clinical studies.To further understand the mechanism of laser immunotherapy,the efects of laser and GC treatment without specifc enhancement of laser absorption were studied.Passive adoptive immunity transfer was perfomed using splenocytes as immune cells.Spleen cells harvested from tumor-bearing mice treated by laser+GC provided 60%immunity in naive recipients.Furthermore,cytotoxicity and TNF-ar secretion by splenocytes from treated mice also indicated that laser+GC induced immunity was tumor-specific.The high level of infiltrating T cells in tumors after laser+GC treatment furt her confirned a specific anti-tumor immune response.Therefore,laser+GC could prove to be a promisi ng selective local trea tment modality that induces a systemic anti-tumor response,with appropriate laser parameters and GC doses. | FEIFAN ZHOU XIAOSONG LI SHENG SONG JOSEPH T.ACQUAVIVA III ROMAN F.WOLF ERIC W.HOWARD WEI R.CHEN | 2013 | Journal of Innovative Optical Health Sciences2013，6，4： | 0 |
| 6 | Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model显示文摘The ideal treatment modality for metastatic cancer would be a local treatment that can destroy primary tumors while inducing an effective systemic anti-tumor response.To this end,we de-veloped laser immunotherapy,combining photothermal laser application with an immunoadju-vant for the treatment of metastatic cancer.Additionally,to enhance the selective photothermal effect,we integrated light-absorbing nanomaterials into this innovative treatment.Specifically,we developed an immunologically modified carbon nanotube combining single-walled carbon nanotubes(SWNTs)with the immunoadjuvant glycated chitosan(GC).To determine the ef-fectiveness of laser iradiation,a series of experiments were performed using two different irra-diation durations-5 and 10 min.Rats were inoculated with DMBA-4 cancer cells,a metastatic cancer cell line.The treatment group of rats receiving laser irradiation for 10 min had a 50%long-term survival rate without residual primary or metastatic tumnors.The treatment group of rats receiving laser irradiation for 5 min had no long-term survivors;all rats died with multiple metastases at several distant sites.Therefore,Laser+SWNT-GC treatment with 10 min of laser irradiation proved to be efective at reducing tumor size and inducing long-term anti-tumor immunity. | Joseph T.Acquaviva III Cody F.Bahavar Feifan Zhou Xiaosong Li Eric W.Howard Liz C.Bullen Ricardo P.Silvy Wei R.Chen | 2015 | Journal of Innovative Optical Health Sciences2015，8，4： | 0 |
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