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| 1 | Combining targeted therapy and immune checkpoint inhibitors in the treatment of metastatic melanoma显示文摘Melanoma is the deadliest form of skin cancer and has an incidence that is rising faster than any other solid tumor. Metastatic melanoma treatment has considerably progressed in the past five years with the introduction of targeted therapy(BRAF and MEK inhibitors) and immune checkpoint blockade(anti-CTLA4, anti-PD-1, and anti-PD-L1). However, each treatment modality has limitations. Treatment with targeted therapy has been associated with a high response rate, but with short-term responses. Conversely, treatment with immune checkpoint blockade has a lower response rate, but with longterm responses. Targeted therapy affects antitumor immunity, and synergy may exist when targeted therapy is combined with immunotherapy. This article presents a brief review of the rationale and evidence for the potential synergy between targeted therapy and immune checkpoint blockade. Challenges and directions for future studies are also proposed. | Teresa Kim Rodabe N.Amaria Christine Spencer Alexandre Reuben Zachary A.Cooper Jennifer A.Wargo | 2014 | Cancer Biology & Medicine2014，11，4： | 9 |
| 2 | Innovative approaches to genome editing in avian species显示文摘The tools available for genome engineering have significantly improved over the last 5 years, allowing scientist to make precise edits to the genome. Along with the development of these new genome editing tools has come advancements in technologies used to deliver them. In mammals genome engineering tools are typically delivered into in vitro fertilized single cell embryos which are subsequently cultured and then implanted into a recipient animal.In avian species this is not possible, so other methods have been developed for genome engineering in birds. The most common involves in vitro culturing of primordial germ cells(PGCs), which are cells that migrate through the embryonic circulatory system to the developing gonad and colonize the gonad, eventually differentiating into the gonadocytes which produce either sperm or ova. While in culture the PGCs can be modified to carry novel transgenes or gene edits, the population can be screened and enriched, and then transferred into a recipient embryo. The largest drawback of PGC culture is that culture methods do not transfer well across avian species, thus there are reliable culture methods for only a few species including the chicken. Two newer technologies that appear to be more easily adapted in a wider range of avian species are direct injection and sperm transfection assisted gene editing(STAGE).The direct injection method involves injecting genome engineering tools into the circulatory system of the developing embryo just prior to the developmental time point when the PGCs are migrating to the gonads. The genome engineering tools are complexed with transfection reagents, allowing for in vivo transfection of the PGCs. STAGE utilizes sperm transfection to deliver genome engineering tools directly to the newly fertilized embryo. Preliminary evidence indicates that both methodologies have the potential to be adapted for use in birds species other than the chicken, however further work is needed in this area. | Caitlin A.Cooper Timothy J.Doran Arjun Challagulla Mark L.V.Tizard Kristie A.Jenkins | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 2 |
| 3 | Surface Acoustic Wave Interactions with Cracks and Slots:ANoncontacting Study Using Laser显示文摘 | Jeremy A.Cooper Ross A.Crosbie Richard J.Dewhust | | 0，，： | 1 |
| 4 | 初次修复后巩膜缝线侵入12年显示文摘1例33岁男性右眼突然视力下降.可见红色斑点。眼部病史为12年前在进行重金属冲压时右眼穿通伤。受伤后.患者接受了巩膜裂伤缝合术.经扁平部玻璃体切除术,眼内异物取出术和巩脱环扎术.应用4-0和5-0的Dacron缝线(Alcon Surgical Inc, Fort Worth, Tex)缝合6mm长的巩膜裂伤,并用5mm放射状巩膜海绵外垫压和240带环扎。 | Blake A.Cooper Kevin J.Blinder Gaurav K.Shah Isaac Boniuk 刘敬(译) 赵光喜(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，2： | 1 |
| 5 | 酪氨酸激酶受体EphA5及其配体ephrin-A5在小鼠脊髓发育过程中的表达显示文摘目的研究两个Eph家族分子,EphA5受体及其配体e phrin-A5,在脊髓发育过程中的表达方式。方法β-半乳糖苷酶基因敲入小鼠和配体亲和探针分析受体的表达,两种不同的亲利探针分析配体的表达,基因敲除小鼠作为对照。结果在发育过程中,EphA5表达于脊髓腹侧,而ephrin—A5表达于脊髓背侧。结论EphA5和ephrin-A5在多个脊髓发育阶段都有表达,他们可能在脊髓背腹侧组织结构的建立过程中发挥重要作用。 | Christopher P.WASHBURN Margaret A.COOPER 周仁平 | 2007 | Neuroscience Bulletin2007，23，5： | 1 |
| 6 | Effects of wood species and retention levels on removal of copper,chromium,and arsenic from CCA-treated wood using sodium hypochlorite显示文摘Chemical extraction, bioremediation, and electrodialytic processes have been extensively studied for removal of copper, chromium, and arsenic from wood treated with chromated copper arsenate(CCA). However,one problem has not been addressed: the effects of wood species and retention levels on remediation efficiency. The objectives of this study were to investigate the effects of wood species and retention levels on removal of copper,chromium, and arsenic from CCA-treated wood samples using sodium hypochlorite. Our results showed that sodium hypochlorite(Na OCl) was very effective for removal of copper, chromium, and arsenic from CCA-C treated milled wood samples for all three species used in this study. The Cu, Cr, and As extraction efficiencies for red pine were95 % Cu, 97 % Cr and 94 % As, for maple were 95 % Cu,97 % Cr, and 98 % As at 4.0 kg m-3retention levels, and for aspen were 95 % Cu, 92 % Cr, and 91 % As at9.6 kg m-3retention level, respectively. However, the results showed that wood species and initial retention levels of CCA-treated wood products played very important roles in terms of removal of Cu, Cr, and As. | Engin Derya Gezer Paul A.Cooper | 2016 | Journal of Forestry Research2016，27，2： | 1 |
| 7 | Clinical Implications of Thrombocytopenia Among Patients Undergoing Intra‐aortic Balloon Pump Counterpulsation in the Coronary Care Unit显示文摘 | Sion K.Roy Edward W.Howard Julio A.Panza Howard A.Cooper | 2010 | Clin Cardiol2010，，1： | 1 |
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