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| 1 | Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics显示文摘This article describes cell signaling network of metastatic prostate cancer(PCa)to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics.The article focuses on our recent progress in the understanding of:1)The plasticity and dynamics of tumorestroma interaction;2)The significance of epigenetic reprogramming in conferring cancer growth,invasion and metastasis;3)New insights on altered junctional communication affecting PCa bone and brain metastases;4)Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy;5)Geneticbased therapy to co-target tumor and bone stroma;6)PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis;7)The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis;and 8)Characterization of imprinting cluster of microRNA,in tumorestroma interaction.This article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical translation.This article referenced the details of the various approaches and discoveries described herein in peer-reviewed publications.We dedicate this article in our fond memory of Dr.Donald S.Coffey who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine. | Gina Chia-Yi Chu Leland W.K.Chung Murali Gururajan Chia-Ling Hsieh Sajni Josson Srinivas Nandana Shian-Ying Sung Ruoxiang Wang Jason Boyang Wu Haiyen E.Zhau | 2019 | Asian Journal of Urology2019，6，1： | 5 |
| 2 | 前列腺基底细胞增生显示文摘尽管目前在中国前列腺癌的发病率明显低于美国[1~3],但对容易误诊的病变不应忽视。前列腺基底细胞增生(basalcelhyperplasia,BCH)是少见的良性增生性疾病,而其重要性在于可能与腺癌混淆[4,5],无论是普查穿刺的小标本,还是根治性手... | 杨华 HAIYEN E.ZHAU HENRY FRISON LELAND W.K.CHUNG | 1998 | 中华病理学杂志1998，27，6： | 4 |
| 3 | Cultured circulating tumor cells and their derived xenografts for personalized oncology显示文摘Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s blood.Once identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and treatment.In this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested cells.Because of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis.By analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells. | Ruoxiang Wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson Michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas Michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 4 | Applications of circulating tumor cells for prostate cancer显示文摘One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression.Prostate cancer is among these diseases and greatly affects the health of men globally.Circulating tumor cells(CTCs)are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral circulation.Not until recently,clinical applications of CTCs have been limited to using enumeration as a prognostic tool in Oncology.However,advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate cancer.It is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes,biochemical analyses,and genomic profiling.These advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic resistance.These recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men. | Shirley Cheng Jie-Fu Chen Yi-Tsung Lu Leland W.K.Chung Hsian-Rong Tseng Edwin M.Posadas | 2016 | Asian Journal of Urology2016，3，4： | 1 |
| 5 | Adaptive robust precision motion control of systems with unknown input dead zones a case study with comparative experiments显示文摘 | B.K.Kim W.K.Chung K.Ohba | | 0，，06： | 1 |
| 6 | 干扰素α诱导PML蛋白表达抑制前列腺癌细胞生长显示文摘PML是一个生长和转录抑制因子,研究表明PML表达变化可能和一些实体癌的发生有关。PML是干扰素的靶基因,可以被干扰素诱导,认为PML可能部分介导了干扰素的抗肿瘤细胞生长作用。我们的研究结果提示,干扰素对前列腺癌细胞生长的抑制作用可能直接和干扰素诱导PML生长抑制因子表达相关,我们的结果支持干扰素抑制肿瘤细胞生长的作用部分是通过其诱导PML生长抑制因子表达来实现的构想。 | 贺大林 南勋义 Leland W.K.Chung | 1998 | 现代泌尿外科杂志1998，3，1： | 0 |
| 7 | Introducing the Asian Journal of Urology显示文摘We are delighted to publish the inaugural issue through which announces the launch of the Asian Journal of Urology(AJU).AJU is an international peer-reviewed journal jointly founded by the Chinese Urological Association(CUA)and the Second Military Medical University(SMMU)in Shanghai,China.The journal will publish articles in urologic specialties both scientifically and clinically. | Yinghao Sun Leland W.K.Chung Michael J.Droller | 2014 | Asian Journal of Urology2014，1，1： | 0 |
| 8 | Biology and therapy of urological cancer metastasis显示文摘From the early roots of modern urology to today,genitourinary(GU)cancers have been an important part of the fields of urology and cancer biology.As medical science has advanced,newer clinical and basic viewpoints have impacted the thinking and practice in this important field.As such,GU oncology has been consistently seen as an area of rapid evolution both in biological understanding and clinical care.GU cancers continue to rise in incidence worldwide.Moreover,they represent a significant portion of cancer mortality in Asia and the western world.These facts have been met with some of the boldest and most important advances in cancer biology and therapy that have reshaped this field. | Edwin M.Posadas David J.McConkey Leland W.K.Chung | 2016 | Asian Journal of Urology2016，3，4： | 0 |
| 9 | Obituary for Donald S.Coffey:Remembering a pioneer in the field of prostate cancer research.(1932-2017)显示文摘It is with the deepest sadness that we publish the following obituary for Donald S.Coffey,an Asian Journal of Urology(AJU)respected author.Dr.Coffey was invited to write a paper for the inaugural issue of AJU in 2014.Despite he was 82 years old,he accepted our invitation and contributed a thoughtful perspective article. | Shawn E.Lupold Ken J.Pienta Hari K.Koul Leland W.K.Chung Yinghao Sun | 2018 | Asian Journal of Urology2018，5，1： | 0 |
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