| 1 | A review of Leishmaniasis in Eastern Africa显示文摘The review presents the epidemiology of leishmaniasis in the Eastern Africa region. We searched PUB MED and MEDLINE with several key words-namely,'leishmaniasis';'cutaneous','diffuse cutaneous','mucosal', and'visceral leishmaniasis'; 'kala azar'and 'post kala azar dermal leishmaniasis'-for recent clinical and basic science articles related to leishmaniasis in countries in the Eastern Africa region. Poverty, wars, conflicts and migration have significantly aggravated leishmaniases in Eastern Africa. Of particular concern is the increasing incidence of Leishmania-HIV co-infection in Ethiopia where 20~40% of the persons affected by visceral leishmaniasis are HIV-co-infected. Sudan has the highest prevalence rate of post kala-azar dermal leishmaniasis(PKDL) in the world, a skin complication of visceral leishmaniasis(VL) that mainly afflicts children below age ten. In view of its spread to previously non-endemic areas and an increase in imported cases, leishmaniasis in Eastern Africa should be considered a health emergency. | Peter K.Ngure Albert Kimutai Zipporah W.Ng'ang'a Geoffrey Rukunga Willy K.Tonui | 2009 | Journal of Nanjing Medical University2009，23，2： | 2 |
| 3 | Perspective on the relationship between microbiota dysbiosis and neuroinflammation:probiotics as a treatment option显示文摘Introduction:In the 1680s,Antonie van Leewenhoek was the first to observe the differences in the human gut microbiome versus the oral cavity diversity,and it led to the birth of a new term,“microbiota”.Later,the link between the brain and the gut was observed to be facilitated by the vagus nerve,allowing for neurotransmitters secreted in the gastrointestinal tract to travel to the brain,directing signals that influence brain function.The gut microbiome is linked to various diseases ranging from autism spectrum disorder to Parkinson’s disease(PD)and is projected to be the new“disease-causing mechanism,”calling for interventions that can modulate gut microbiota and mitigate brain disorders.Gut dysbiosis is observed before and after the onset of various neurodegenerative diseases and often manifests itself into gut-related diseases such as. | Chiao W.Ng Zahoor A.Shah | 2022 | Neural Regeneration Research2022，17，9： | 0 |
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