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| 1 | Microstructure evolution and hot deformation behavior of carbon nanotube reinforced 2009Al composite with bimodal grain structure显示文摘The hot deformation behaviors of the bimodal carbon nanotube reinforced 2009Al(CNT/2009Al)composite were studied by establishing processing map and characterizing the microstructure evolution.The results indicate that the grain size in the ultra-fine grained zones was stable during hot deformation,while the coarse grained zones were elongated with their long axis directions tending to be perpendicular to the compression direction.Low temperature with high strain rate(LTHR),as well as high temperature with low strain rate(HTLR)could increase the length/width ratio of the coarse grained zones.However,LTHR and HTLR could cause the instable deformation.The instable deformation at LTHR was induced by severe intragranular plastic deformation and the localized shear crack,while the instable deformation at HTLR resulted from the more deformation component at the coarse grained zones,and the micro-pore initiation due to CNT re-agglomeration at the boundaries between the coarse and the ultra-fine grained zones. | K.Ma Z.Y.Liu S.Bi X.X.Zhang B.L.Xiao Z.Y.Ma | 2021 | Journal of Materials Science & Technology2021，，11： | 3 |
| 2 | 血压和血氧感受的分子调节机制及临床意义显示文摘机体的正常运作需要血压和血氧浓度维持在一定范围。短暂性异常水平的血压和血氧通过特异的感受器形成负反馈,从而使得机体维持正常的血压和血氧浓度。调节血压的神经元细胞感受器主要位于主动脉弓(aortic arch)和颈动脉窦(carotid sinus),通过延髓的运动中枢来调节血管收缩。肾脏的球旁细胞(juxtaglomerular cell)也能感受血压变化,通过释放肾素颗粒(renin)进入血液循环来调节血压。血氧的感受主要发生在颈动脉体(carotid body),通过延髓的运动中枢来快速调节呼吸和心率,而相对长期的血氧浓度维持和对低氧的适应是由EGLN氧气受体介导的。理解血压和血氧感受在正常和疾病条件下(比如高血压和脑卒中)的分子机制,对诸多心脑血管疾病的药物开发和临床应用具有重大的意义。本文介绍此领域的历史和研究进展,提出亟待解决的主要科学问题,并阐述这些进展和问题对与血压和血氧感受相关心脑血管疾病的临床意义。 | Dengke K.Ma | 2015 | 中华高血压杂志2015，23，5： | 2 |
| 3 | Concurrent hypermethylation of multiple tumor‐related genes in gastric carcinoma and adjacent normal tissues显示文摘 | Wai K.Leung JunYu Enders K. W.Ng Ka FaiTo Po K.Ma Tin LapLee Minnie Y.Y.Go S. C. SydneyChung Joseph J. Y.Sung | 2001 | Cancer2001，，12： | 1 |
| 4 | Prevalence and specificity of clinically significant red cell alloantibodies in Chinese women during pregnancy – a review of cases from 1997 to 2001显示文摘 | C. K.Lee E. S. K.Ma M.Tang C. C. K.Lam C. K.Lin L. C.Chan | 2003 | Transfusion Medicine2003，，： | 1 |
| 5 | 极端嗜热菌Thermotoga hypogea细胞抽提液中醇脱氢酶和氢化酶的活性检测显示文摘 极端嗜热菌Thermotogahypogea(T.h.)是一株来自中非油田井下的,能够生长在90℃高温下的短杆状厌氧嗜热菌,经研究发现,在T.h.菌体细胞抽提液中存在一种特殊的NADP依赖性醇脱氢酶(ADH)。该酶在T.h.菌的醇醛代谢途径中起着关键性的催化作用,可催化多种醇醛底物的脱氢反应。同时,当以二氯联卞吡啶为作用底物时,T.h.菌的细胞抽提物显示很高的氢化活性(Km=0.29mmol·L-1,Vmax=41.69)。 | 王颖 吕巡贤 K.Ma | 2003 | 新疆农业大学学报2003，26，3： | 1 |
| 6 | Approaches to fast gas chromatography/tandem mass spectrometry显示文摘 | K.Ma(s)tovskà S.J.Lehotay | | 0，，： | 1 |
| 7 | 极端嗜热菌Thermotoga hypogea生长条件的研究显示文摘以DSMZ(DeutscheSammlungvonMikroorganismenundZellkulturenGmbH ,Germany)提供的原始培养基配方为基础 ,对来源于中非油田井下的极端嗜热菌Thermotogahypogeasp .nov .(T .h .)的生长及扩菌条件进行了研究。结果表明 ,葡萄糖和木糖可作为T .h .菌生长的碳水化合物来源 ;胰蛋白胨和胰蛋白酶均可被T .h .菌利用作为其生长氮源 ;在T .h .菌的生长过程中 ,Na2 S2 O3 可被还原为H2 S而作为电子受体刺激T .h .菌生长 ,因此 ,培养基中若不含硫代硫酸钠时T .h .菌生长非常缓慢 ;但培养基内若不含原始配方中的氯化钠和醋酸钠时 ,T .h .菌仍然生长良好。扩菌培养基的最佳pH值为 7.0 ,最佳厌氧培养温度为 70℃。 | 王颖 L.Nie K.Ma | 2003 | 新疆农业大学学报2003，26，1： | 1 |
| 8 | An ultra-compact hairpin band pass filter with additional zero poimts显示文摘 | K.Ma K.S.Yeo J.Ma | | 0，，04： | 1 |
| 9 | Extra‐medullary relapse of leukemia following allogeneic bone marrow transplantation显示文摘 | W. Y.Au Y. L.Kwong A. K. W.Lie S. K.Ma R.Liang | 1999 | Hematol. Oncol1999，，： | 1 |
| 10 | Original article: Upregulation of caspase‐3 expression in esophageal cancer correlates with favorable prognosis: an immunohistochemical study from a high incidence area in northern China显示文摘 | H.Jiang M.Gong Y.Cui K.Ma D.Chang T. Y.Wang | 2010 | Diseases of the Esophagus2010，，6： | 1 |
| 11 | Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells显示文摘Nicotine, a major component of tobacco, is highly addictive and acts on nicotinic acetylcholine receptors (nAChRs) to stimulate reward-associated circuits in the brain. It is well known that nAChRs play critical roles in mediating nicotine reward and addiction. Current FDA-approved medications for smoking cessation are the antidepressant bupropion and the nicotinic partial agonist varenicline, yet both are limited by adverse side effects and moderate efficacy. Thus, development of more efficacious medications with fewer side effects for nicotine addiction and smoking cessation is urgently needed. l-Tetrahydropalmatine (l-THP) is an active ingredient of the Chinese medicinal herb Corydalis ambigua that possesses rich neuropharmacological actions on dopamine (DA) receptors in the mesocorticolimbic dopaminergic reward pathway. L-THP has been explored as anti-addiction treatments for drug abuse including nicotine. However, the targets and mechanisms of l-THP-caused anti-nicotine effects are largely unknown. In this study we address this question by elucidating the effects of l-THP on human neuronal nAChRs using patch-clamp recordings. Human neuronal α4β2-nAChRs were heterologously expressed in SH-EP1 human epithelial cells. Bath application of nicotine (0.1–100 μM) induced inward currents, co-application of l-THP (3 μM) inhibited nicotine-induced currents in the transfected cells. L-THP-caused inhibition was concentration-dependent (the EC50 values for inhibiting the peak and steady-state current were 18 and 2.1 μM, respectively) and non-competitive. Kinetic analysis of the whole-cell currents showed that l-THP slowed rising time and accelerated decay time constants. L-THP specifically modulated α4β2-nAChRs, as it did not affect α7-nAChRs or α1*-nAChRs (muscle type). Interestingly, two putative α4β2-nAChR isoforms, namely sazetidine A-activated, high-sensitive one (α42β23-nAChR) and cytisine-activated, low-sensitive one (α43β22-nAChR) were pharmacologically separated, and the low-sensitive one was more susceptible to l-THP inhibition than the high-sensitive one. In conclusion, we demonstrate that l-THP blocks neuronal α4β2-nAChR function, which may underlie its inhibition on nicotine addiction. | Yuan-bing Huang Ze-gang Ma Chao Zheng Xiao-kuang K.Ma Devin HTaylor Ming Gao Ronald J.Lukas Jie Wu | 2022 | Acta Pharmacologica Sinica2022，43，4： | 0 |
| 12 | Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells显示文摘The CRISPR/Cas9 system,originally derived from the prokaryotic adaptive immune system,has been developed as efficient genome editing tools.It enables precise gene manipulation on chromosomal DNA through the specific binding of programmable sgRNA to target DNA,and the Cas9 protein,which has endonuclease activity,will cut a double strand break at specific locus.However,Cas9 is a foreign protein in mammalian cells,and the potential risks associated with its introduction into mammalian cells are not fully understood.In this study,we performed pull-down and mass spectrometry(MS)analysis of Streptococcus pyogenes Cas9(SpyCas9)interacting proteins in HEK293T cells and showed that the majority of Cas9-associated proteins identified by MS were localized in the nucleolus.Interestingly,we further discovered that the Cas9 protein contains a sequence encoding a nucleolus detention signal(NoDS).Compared with wild-type(WT)Cas9,NoDS-mutated variants of Cas9(mCas9)are less stable,although their gene editing activity is minimally affected.Overexpression of WT Cas9,but not mCas9,causes general effects on transcription and protein translation in the host cell.Overall,identification of NoDS in Cas9 will improve the understanding of Cas9's biological function in vivo,and the removal of NoDS in Cas9 may enhance its safety for future clinical use. | Renke Tan Wenhao Du Yiyang Liu Xiaoji Cong Meirong Bai Chenxiao Jiang Zengxia Li Minjia Tan Dengke K.Ma Qiang Huang Wei Jiang Yongjun Dang | 2022 | Genes & Diseases2022，9，3： | 0 |
| 13 | Anisotropy of the Wear Behavior for Carbon Nanotube-Reinforced 6061Al Composites显示文摘Carbon nanotube(CNT)-reinforced 6061Al(CNT/6061Al)composites with directionally aligned CNT were fabricated,and their wear behavior was investigated.The results indicate that the wear properties of CNT/6061Al composites exhibited a significant anisotropy.A certain CNT concentrations(1 wt%and 2 wt%)could effectively improve the wear resistance of CNT/6061Al composites along the CNT circumferential and CNT radial directions for the load transfer,grain refinement and self-lubrication effect of CNT.The Brass{011}<211>and{112}<110>textures inhibited the load transfer effect of CNT along the CNT radial direction,resulting in a better wear resistance along CNT circumferential direction than CNT radial direction.Along the CNT axial direction,the weak deformability of composites caused by the intensifying<111>fiber texture was the main reasons for the poor wear resistance of CNT/6061Al composites with increasing CNT concentration. | X.N.Li J.F.Zhang W.H.Xue K.Ma P.Y.Li Z.Y.Liu B.L.Xiao D.R.Ni Q.Z.Wang D.Wang Z.Y.Ma | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，5： | 0 |
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