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| 1 | Phylogenetically Distinct Cellulose Synthase Genes Support Secondary Wall Thickening in Arabidopsis Shoot Trichomes and Cotton Fiber显示文摘Through exploring potential analogies between cotton seed trichomes (or cotton fiber) and arabidopsis shoot trichomes we discovered that CesAs from either the primary or secondary wall phylogenetic clades can support secondary wall thickening. CesA genes that typically support primary wall synthesis, AtCesA1,2,3,5, and 6, underpin expansion and secondary wall thickening of arabidopsis shoot trichomes. In contrast, apparent orthologs of CesA genes that support secondary wall synthesis in arabidopsis xylem, AtCesA4,7, and 8, are up-regulated for cotton fiber secondary wall deposition. These conclusions arose from: (a) analyzing the expression of CesA genes in arabidopsis shoot trichomes; (b) observing birefringent secondary walls in arabidopsis shoot trichomes with mutations in AtCesA4, 7, or 8; (c) assaying up-regulated genes during different stages of cotton fiber development; and (d) comparing genes that were co-expressed with primary or secondary wall CesAs in arabidopsis with genes upregulated in arabidopsis trichomes, arabidopsis secondary xylem, or cotton fiber during primary or secondary wall deposition. Cumulatively, the data show that: (a) the xylem of arabidopsis provides the best model for secondary wall cellulose synthesis in cotton fiber; and (b) CesA genes within a 'cell wall toolbox' are used in diverse ways for the construction of particular specialized cell walls. | Lissete Betancur Bir Singh Ryan A.Rapp Jonathan F.Wendel M. David Marks Alison W.Roberts Candace H.Haigler | 2010 | Journal of Integrative Plant Biology2010，52，2： | 4 |
| 2 | Review of mass-flow hopper design with respect to stress fields and surcharge loads显示文摘Current procedures for mass-flow hopper design are based on the radial stress theory developed by Jenike and involve the determination of the critical outlet dimensions for flow to be initiated.These procedures ignore the surcharge loads on the hopper and involve a study of the passive or arched stress field that exists under flow conditions.An alternative approach as applied to hopper wall load analysis is to employ the horizontal slice method.The arched stress field and horizontal slice methods of analysis are compared.The influence of surcharge loads in the determination of hopper geometry is investigated. | Alan W.Roberts | 2010 | Particuology2010，8，6： | 2 |
| 3 | 超临界二氧化碳溶胀聚甲基丙烯酸甲酯的在线可视测量及热力学模拟计算显示文摘采用高压视窗釜配合高清晰相机研究了聚甲基丙烯酸甲酯(PMMA)在超临界二氧化碳(scCO2)中溶胀行为,得到了PMMA在scCO2中的平衡溶胀率。Sanchez-Lacombe(S-L)状态方程对于高压气体和聚合物系统的热力学性质有着很强的预测能力。将PMMA的PVT数据使用S-L状态方程进行拟合,得到压力、温度和密度的特征参数分别为:212.38MPa、898.04K以及1206.7kg·m-3(8~25MPa,305~350K),类似地可以得到二氧化碳(CO2)的特征参数541.56MPa、313.38K以及1502.1kg·m-3(8~25MPa,305~325K)。将实验得到的PMMA平衡溶胀率使用S-L状态方程拟合,可得二元相互作用参数为1.0671,结果表明在超临界区域,S-L状态方程模拟溶胀率与实验值吻合较好。 | 陈力骅 曹贵平 张人瀚 何峰 刘涛 赵玲 袁渭康 George W.Roberts | 2009 | 化工学报2009，60，9： | 2 |
| 4 | Product innovation, product–market competition and persistent profitability in the U.S. pharmaceutical industry显示文摘 | Peter W.Roberts | 1999 | Strat. Mgmt. J1999，，7： | 1 |
| 5 | Sociogenomic Personality Psychology显示文摘 | Brent W.Roberts Joshua J.Jackson | 2008 | Journal of Personality2008，，6： | 1 |
| 6 | IL‐33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii显示文摘 | Leigh A.Jones FionaRoberts Mohammad B.Nickdel FrankBrombacher Andrew N. J.McKenzie Fiona L.Henriquez JamesAlexander Craig W.Roberts | 2010 | Eur. J. Immunol2010，，2： | 1 |
| 7 | Corporate reputation and sustained superior financial performance显示文摘 | Peter W.Roberts Grahame R.Dowling | 2002 | Strat Mgmt J2002，，12： | 1 |
| 8 | THE STRUCTURE OF CONSCIENTIOUSNESS: AN EMPIRICAL INVESTIGATION BASED ON SEVEN MAJOR PERSONALITY QUESTIONNAIRES显示文摘 | BRENT W.ROBERTS OLEKSANDR S.CHERNYSHENKO STEPHENSTARK LEWIS R.GOLDBERG | 2005 | Personnel Psychology2005，，1： | 1 |
| 9 | Technological and product‐market experience and the success of new product introductions in the pharmaceutical industry显示文摘 | AtulNerkar Peter W.Roberts | 2004 | Strat Mgmt J (鈥?)2004，，8： | 1 |
| 10 | Cellulose synthase ‘class specific regions’ are intrinsically disordered and functionally undifferentiated显示文摘Cellulose synthases(CESAs) are glycosyltransferases that catalyze formation of cellulose microfibrils in plant cell walls.Seed plant CESA isoforms cluster in six phylogenetic clades, whose non-interchangeable members play distinct roles within cellulose synthesis complexes(CSCs).A ‘class specific region’(CSR), with higher sequence similarity within versus between functional CESA classes, has been suggested to contribute to specific activities or interactions of different isoforms.We investigated CESA isoform specificity in the moss,Physcomitrella patens(Hedw.) B.S.G.to gain evolutionary insights into CESA structure/function relationships.Like seed plants, P.patens has oligomeric rosette-type CSCs, but the Pp CESAs diverged independently and form a separate CESA clade.We showed that P.patens has two functionally distinct CESAs classes, based on the ability to complement the gametophore-negative phenotype of a ppcesa5 knockout line.Thus, non-interchangeable CESA classes evolved separately in mosses and seed plants.However, testing of chimeric moss CESA genes for complementation demonstrated that functional classspecificity is not determined by the CSR.Sequence analysis and computational modeling showed that the CSR is intrinsically disordered and contains predicted molecular recognition features, consistent with a possible role in CESA oligomerization and explaining the evolution of class-specific sequences without selection for class-specific function. | Tess R.Scavuzzo-Duggan Arielle M.Chaves Abhishek Singh Latsavongsakda Sethaphong Erin Slabaugh Yaroslava G.Yingling Candace H.Haigler Alison W.Roberts | 2018 | Journal of Integrative Plant Biology2018，60，6： | 0 |
| 11 | Critical Considerations in the Immunochemical Detection and Quantitation of Antigenic Biomarkers显示文摘The formation of covalent adducts as a result of the interaction of metabolically activated chemicals with host macromolecules is a common critical event in mutagenic,carcinogenic ,and immunologic phenomena.Because of their antigenicity and their immunogenicity,covalent adducts may be detected using sensitive immunochemical techniques.The immunochemical approaches to biomonitoring and molecular dosimetry of DNA damage are particularly attractive because they allow sensitive quantitation of specific DNA adducts present in small samples and do not rely on the use of radiolabeled adducts.Two examples of biomarker immunoassay development are presented:an avidin/biotin-amplified ELISA for the major DNA adduct of the human bladder carcinogen 4-aminobipheny1(ABP) ,and a particle concentration fluorescent immunoassay(PCFIA) for the major protein adduct associated with toxicity by the prototype hepatotoxin acetaminophen.The examples illustrate critical steps in the development of biomarker immunoassays which include selection of the relevant adduct, preparation of an appropriate immunogen,immunization,characterization of antisera,and development of application-specific sample processing techniques for biomarker quantitation.Immunochemical procedures may be combined with other analytical techniques to form hybrid systems which take advantage of both the antigenicity and the physical or chemical properties of a biomarker to achieve greater specificity and /or sensitivity.The future usefulness of these new tools of molecular epidemiology will depent on a compound-by-compound validation of methods and critical evaluation of the biologic importance of the particular antigenic biomarker as an indicator of exposure and as an indicator of risk. | DEAN W.ROBERTS R.WAYNEBENSON JACK A.HINSON FRED F.KADLUBAR | 1991 | Biomedical and Environmental Sciences1991，4，1： | 0 |
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