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| 1 | Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations显示文摘AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD.METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing highperformance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP.RESULTS: NOD2/CARD15 mutations were found in 185patients (35.1%) and in 33 controls (16.5%, P<0.0001).SNP8/R702W (10.8% vs 6%, P = 0.02), SNP13/3020insC (19.4% vs 5%, P<0.0001) and exon4 R703C (2.1% vs 0%, P = 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vscontrols: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet = 1.71,95%CI = 1.12-2.6, P= 0.0001, ORtwo-riskalleles = 25.2,95%CI = 4.37- , P<0.0001), early disease onset (carrier:26.4 years vs non-carrier: 29.8 years, P = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08,P = 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55,P = 0.026) and increased need for resection (OR=1.71,95%CI: 1.13-2.62, P= 0.01), but not with duration, extraintestinal manifestations, familial disease or smoking. TLR4exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P= 0.06), in NOD2mut/wt: 26.7 years.CONCLUSION: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease,stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4mutation carriers tended to present at earlier age. | Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch Janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 2 | Parenting preschoolers with autism: Socioeconomic influences on wellbeing and sense of competence显示文摘BACKGROUND Previous research suggests that parents raising a child with autism experience higher levels of psychological distress than parents of typically developing children and parents of children with other developmental disorders. Little is known, however, about the intersection between the effects of socioeconomic status(SES) on the wellbeing and sense of parental competency of parents of preschoolers with autism and how it relates to child symptom severity.AIM To examine the relationship between their child's symptom severity, SES, as measured by neighbourhood advantage and occupational status, on the psychological wellbeing and perceived parenting competence among parents of preschoolers with autism.METHODS Parents of 117 preschool-aged children with a diagnosis of autism spectrum disorder(ASD), 107 mothers and 54 fathers, completed questionnaires about their child's symptoms of ASD and functioning, their own perceptions of their wellbeing and parental competence on entry to an early intervention program in Sydney, Australia. Parents also provided demographic information pertaining to their occupation, level of education attained and address(postcode). All children were also assessed for their severity of symptoms using the Autism Diagnostic Observation Schedule. The Australian Socioeconomic Index of occupationalstatus as a measure of familial SES and the Index of Relative Socio-economic Advantage and Disadvantage as a measure of neighbourhood advantage were used to examine the impact of SES on parental sense of competence and wellbeing.RESULTS Compared to normative populations, both mothers and fathers in our sample reported significantly higher levels of parenting sense of efficacy but lower levels of interest in the parenting role. Mothers also displayed higher levels of satisfaction. Both mothers and fathers displayed higher levels of depression than normative populations with mothers also reporting greater levels of stress and anxiety. Child symptom severity was associated with maternal parenting competency with these relationships amplified among mothers with higher familial SES and who lived in areas of greater neighbourhood advantage.Increased adaptive functioning was associated with better maternal wellbeing,particularly among mothers who lived in areas of greater neighbourhood advantage. Contrastingly, paternal parenting competence was generally not influenced by child adaptive functioning or symptom severity, although for those in higher familial SES brackets, children's symptom severity and maladaptive symptoms were negatively related to paternal sense of parenting efficacy. There was a trend towards moderate relationships between lower familial SES and greater depression, stress and anxiety among fathers, but no relationship with their child's ASD symptom severity or functioning.CONCLUSION SES differentially impacts wellbeing and sense of parenting competence and its relationship to the impact of child symptoms for mothers and fathers of preschoolers with autism. | Nisha E Mathew Karen L O Burton Anne Schierbeek Rudi ?rn?ec Amelia Walter Valsamma Eapen | 2019 | World Journal of Psychiatry2019，9，2： | 6 |
| 3 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 4 | Solar cells based on CuIn(Se,S)2显示文摘 | WALTER T CONTENT A VELTHAUS K O | 1992 | Solar Energy Materials and Solar Cells1992，26，： | 1 |
| 5 | Matured-endritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicitEBV-specific CD4+ and CD8T lymphocyte responses 显示文摘 | WOLFGANG H ELENA R WALTER O | 2000 | Blood2000，7，96： | 1 |
| 6 | Resveratrol inhibits the proliferation of normal human keratinocytes in vitro 显示文摘 | HOLIAN O WALTER R J | 2001 | Cell Biochem2001，81，36： | 1 |
| 7 | DNA methylation at promoter regions regulates the timing of gene activation in Xenopus laevis embryos 显示文摘 | STANCHEVA I MAARRI O WALTER J | 2002 | Dev Bid2002，243，： | 1 |
| 8 | Frequency of Allogeneic Hematopoietic Cell Transplantation Among Patients With High- or Intermediate-Risk Acute Myeloid Leukemia in First Complete Remission显示文摘 | Raya Mawad Ted A. Gooley Vicky Sandhu Jack Lionberger Bart Scott Brenda M. Sandmaier Paul O’Donnell Pamela S. Becker Stephen Petersdorf Kathleen Shannon Dorcy Paul Hendrie Mohamed L. Sorror Roland B. Walter H. Joachim Deeg Frederick R. Appelbaum Elihu H. | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 9 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication显示文摘 | Kessler R C Berglund P Demler O Jin R Merikangas K R Walters E E | | 0，，62： | 1 |
| 10 | Genotoxicity of cyanobacterial extracts containing microcystins from Polish water reservoirs as determined by SOS chromotest and comet assay显示文摘 | Mankiewicz J Walter Z Tarczynska M Palyvoda O Wojtysiak-Staniaszczyk M Zalewski M | 2002 | Environ Toxicol2002，17，4： | 1 |
| 11 | Discovery of a mu- tant-selective covalent inhibitor of EGFR that overcomes T790M- mediated resistance in NSCLC显示文摘 | Walter A O Sjin R T Haringsma H J | 2013 | Cancer Discov2013，3，12： | 1 |
| 12 | Extracellular Matrix-Associated Serine Protease Inhibitors ( M r 33,000, 31,000, and 27,000) Are Single-Gene Products with Differential Glycosylation: cDNA Cloning of the 33-kDa Inhibitor Reveals Its Identity to Tissue Factor Pathway Inhibitor-2显示文摘 | C.N. Rao Prasad Reddy Yueying Liu Edel O’toole Dennis Reeder Donald C. Foster Walter Kisiel David T. Woodley | 1996 | Archives of Biochemistry and Biophysics1996，，1： | 1 |
| 13 | The pumping of fluid in cementless cups with holes 显示文摘 | Walter WL Walter WK O'Sullivan M | 2004 | J Arthroplasty2004，19，2： | 1 |
| 14 | Squeaking in ceram- ic - on - ceramic hips; the importance of acetabular componentorientation 显示文摘 | Waiter WL O Toole GC walter WK | 2007 | J Arthroplasty2007，22，： | 1 |
| 15 | A technique for establishing reference nutrient concentrations across watersheds affected by humans 显示文摘 | WALTER K D ROBERT M O | 2004 | Limnology and Oceanography : Methods2004，2，： | 1 |
| 16 | Torque Ripple Minimization in a Switched Reluctance Drive by Neuro-fuzzy Compensation 显示文摘 | Luis O A P Henriques Luis G B Rolim Walter I Suemitsu etal | 2000 | IEEE Transactions on magnetics2000，36，5： | 1 |
| 17 | IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype显示文摘 | Walter O Prasad M Lu S | 2009 | Hum Pathol2009，40，11： | 1 |
| 18 | The pumping of fluid in cementless cups with holes 显示文摘 | Walter W L Walter W K O' Sullivan M | 2004 | J Arthroplasty2004，19，： | 1 |
| 19 | Ion exchange of cation-terminated poly(ethylene oxide) chains on mics surfaces显示文摘 | Michael O G Ronald A S Walter R C | 1997 | J Colloid Interface Sci1997，，189： | 1 |
| 20 | Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression:a voxel-based morphometry study显示文摘 | Vasic N Walter H H(o)se A | | 0，，1： | 1 |
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