|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The influence of nitroglycerin on the proliferation of endothelial progenitor cells from peripheral blood of patients with coronary artery disease显示文摘Endothelial 祖先房间(EPC ) 与脉管的修理和动脉粥样硬化患者损害的前进被联系。如果传播 EPC 失去他们的函数,它可以导致冠的动脉疾病(CAD ) 。连续硝化甘油(NTG ) 治疗原因增加了脉管的氧化应力和 endothelial 机能障碍。这研究的目的是在人的外部导出血的 EPC 的增长上调查 NTG 的效果。EPC 文化,从 60 个 CAD 病人镇定、为 712 天有教养,分别地为 72 h 与 NTG (0.0, 0.3, 1.0, 2.0, 7.5, 15.0,和 20.0 mg/l ) 的不同集中被对待。房间计数和 EPC 的 proliferative 活动;脉管的 endothelial 生长因素的层次 -- 一(VEGF -- 一) ,氮的氧化物(没有) 并且 peroxynitrite (在文化媒介的 ONOO ) ;并且在支持者房间的反应的氧种类(ROS ) 的水平被测量。与控制(0.0 mg/l NTG ) 相比,当与 1.0 mg/l NTG 对待并且当 NTG 集中是 7.5 mg/l 时,到达了最大的水平时, EPC 的房间数字和 proliferative 活动被增加。然而,当与 NTG (15.0 mg/l ) 的更高的剂量对待时,有重要减小。同时, VEGF -- 表情与 7.5 mg/l NTG 到达了它的最大的表示,但是逐渐地与 NTG 的更高的剂量由孵化衰退了。在没有水平和 NTG 集中之间有一种线性关系,但是当 EPC 与 0.37.5 mg/l NTG 被孵化时, ONOO 的变化和 ROS 层次都没被发现。然而,当与 15 和 20 mg/l NTG 孵化了时, ONOO 和 ROS 层次显著地被增加。我们的数据证明 NTG 的那中等剂量可以刺激从 CAD 病人孤立的 EPC 的 proliferative 活动。 | Xin Wang Caiyu Zeng Huiping Gong Hong He Mengxin Wang Qin Hu Falin Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 4 |
| 2 | Regulation of the cellular uptake of nanopartides by the orientation of helical polypeptides显示文摘Controlling the cellular interactio n and internal izatio n of polymer-modified nan oparticles (NPs) is of central importa nee to the developme nt of promisi ng nano medici nes. Here, we describe the use of synthetic polypeptides for NP surface coati ng and regulati on of their cellular uptake behaviors by simply switching the conformation and anchoring orientation. Our results show that gold NPs (AuNPs) coated with a helical poly(Y-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)esteryl「glutamate)(L-P(EG3Glu)5o) from the C-terminus ((L-C)-AuNPs) exhibit greater zeta potential and more cellular uptake (2.0-5.5 fold higher) than those coated with the same polypeptide but anchored from the N-terminus ((L-N)-AuNPs), or from both the C- and N-terminus at a 1/1 molar ratio ((L-C/L-N)-AuNPs). A similar orientation-regulated cellular internalization pattern is observed in D-P(EG3Glu)50 but not the unstructured DL-P(EG3Glu)5o-rnodified AuNPs, suggesting an important and universal role of the helix-derived macrodipole in cellular uptake. Moreover, this orientation-governed internalization is successfully reproduced in P(EG3Glu)50-coated gold nano rods (AuNRs), and applied to the desig n of doxorubici reloaded polypeptide micelles. Simulation study offers time-resolved in sights regarding the NP-membrane in teracti ons and membrane remodeling. Thus, our study provides a delicate way of regulating the surface chemistry of NPs and the subsequent NP-cell interactions. Moreover, the results highlight the uniqueness of polypeptides in NP surface engineering, and urge a more careful consideration on the polymer orientation effect. | Chong Zhang Jianhua Lu Falin Tian Lindong Li Yingqin Hou Yaoyi Wang Lingdong Sun Xinghua Shi Hua Lu | 2019 | Nano Research2019，12，4： | 4 |
| 3 | The responses of photosynthetic capacity, chlorophyll fluorescence and chlorophyll content of nectarine ( Prunus persica var. Nectarina Maxim) to greenhouse and field grown conditions显示文摘 | Hong Wang Falin Wang Gang Wang Khalid Majourhat | 2007 | Scientia Horticulturae2007，，1： | 1 |
| 4 | Complete estrogen receptor blocker ICI182,780 promotes the proliferation of vascular smooth muscle cells显示文摘ICI182,780 在乳癌的辅助治疗被使用。作为完全的雌激素受体(嗯) blocker, ICI182,780 可以在心血管的系统上反对雌激素的效果。雌激素禁止脉管的光滑的肌肉房间(VSMC ) 的增长,它是雌激素能施加的机制之一 cardioprotective 效果。在现在的学习,在 VSMC 的增长上估计 ICI182,780 的效果,我们从老鼠主动脉孤立与或没有 ER 对手 ICI182,780 的有教养的 VSMC。3-(4,5-dimethylthiazol-2-yl ) 的结果 -2,5-diphenyltetrazolium 溴化物试金, bromodeoxyuridine 加入试金,可行房间计数,为增殖的房间的免疫化学的染色原子抗原(PCNA ) ,和流动 cytometry 决定的 S 阶段比率在 ICI182,780 治疗以后揭示了 VSMC 的显著增长。ICI182,780 显著地以一种剂量依赖者方式提高了房间生长(10 ? 810 ? 5 M ) 。而且, PCNA 积极的房间的数字和 VSMC 的 S 阶段前进与 ICI182,780 在治疗以后增加了。反向的 transcriptase 聚合酶链反应(RTPCR ) 和西方的污点分析证明在 VSMC 的 cyclin D1 的 mRNA 和蛋白质水平在 ICI182,780 的处理下面增加了。这些数据建议 ICI182,780 能支持 VSMC 的生长,它可能在心血管的系统上生产一些不利效果。 | Hong He Falin Yang Xin Wang Xianwei Zeng Qin Hu Jinghuan Huang Jinbo Feng | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 1 |
| 5 | Molecular simulation of diffusion of rigidity-tuned nanoparticles in biological hydrogels显示文摘The penetration capability of the drug nano-carriers (NCs) in biological hydrogels, such as mucus and tumor interstitial matrix, would typically influence the efficiency of drug delivery. Understanding the effect of the physicochemical property of the drug carriers on their diffusion capability in biological hydrogel becomes important for designing and optimizing the nano-carriers. Here, using a coarse-grained molecular dynamics model, we studied how the rigidity of NCs affected their diffusivity in biological hydrogel. The results showed that semi-elastic NCs have higher diffusivity than the hard and the soft NCs. Furthermore, the affinity between the NCs and biological hydrogels and the size ratio between the hydrogel meshes and NCs have also affected the diffusivity of the NCs. Further analysis revealed the mechanism that the deformation of the NCs dominates their diffusivity. These findings demonstrated that the rigidity of NCs is a key parameter in designing efficient NCs for deep penetration into the biological hydrogels. | Falin Tian Hui Wang Huawei Li Ping Cheng Xinghua Shi | 2019 | Acta Mechanica Sinica2019，35，2： | 1 |
| 6 | Impacts of reforestation approaches on runoff control in the hilly red soil region of Southern China显示文摘 | Hua Zheng Falin Chen Zhiyun Ouyang Naimei Tu Weihua Xu Xiaoke Wang Hong Miao Xiquan Li Yuxin Tian | 2008 | Journal of Hydrology2008，，1： | 1 |
| 7 | A bull-heading water control technique of thermo-sensitive temporary plugging agent显示文摘Aimed at the disadvantages of secondary damage to oil layers caused by the conventional bull-heading water control technique, a thermo-sensitive temporary plugging agent for water control was synthesized by water solution polymerization and applied in the field with a new secondary temporary plugging technique. The optimization and performance evaluation of thermo-sensitive temporary plugging agent were carried out through laboratory experiments. The optimized formula is as follows:(6%-8%) acrylamide +(0.08%-0.12%) ammonium persulfate +(1.5%-2.0%) sepiolite +(0.5%-0.8%) polyethylene glycol diacrylate. The thermo-sensitive temporary plugging agent is suitable for formation temperatures of 70-90 ?C, it has high temporary plugging strength(5-40 k Pa), controllable degradation time(1-15 d), the apparent viscosity after degradation of less than 100 m Pa?S and the permeability recovery value of simulated cores of more than 95%. Based on the research results, secondary temporary plugging technique was used in a horizontal well in the Jidong Oilfield. After treatment, the well saw a drop of water cut to 27%, and now it has a water cut of 67%, its daily increased oil production was 4.8 t, and the cumulative oil increment was 750 t, demonstrating that the technique worked well in controlling water production and increasing oil production. | LIU Pingde WEI Falin ZHANG Song ZHU Xiuyu WANG Longfei XIONG Chunming | 2018 | Petroleum Exploration and Development2018，45，3： | 0 |
| 8 | Development of Digital Multi-function Dendrometer显示文摘Multi-functional dendrometer is a kind of forestry tool that can measure multiple factors of forest.By combining sensor technology and computer technology,a digital multi-function dendrometer has been developed,which integrated the functions of measuring height,distance,azimuth, slope,elevation,form quotient of any parts of the stem into one body at the same test.The dendrometer can fit the complex forest environment,solve the difficult problems in aspects of plant height,measure distance,central diameter and form quotient of breast height.The accuracy can meet the requirements of general forest survey. | Liu Falin Zeng Siqi Yan Qianfei Wang Long Hong Lingfei | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 9 | Raloxifene hydrochloride treatment leads to better outcomes than medroxyprogesterone acetate when paired with estrogen in ovariectomized cholesterol-fed rabbits显示文摘 | Caiyu Zeng Falin Yang Hong He Keqing Hu Xin Wang Qin Hu Jifu Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 0 |
| 10 | Modeling and Decoupling of Coupling Tasks in Collaborative Development Process of Complicated Electronic Products显示文摘It is important to improve the development efficiency of decoupling a coupling task package according to the information relevancy relation between development tasks in the collaborative development process of complicated electronic products.In order to define the task coupling model in the development process,the weighted directed graph based on the information relevancy is established,and the correspondence between weighted directed graph model and numerical design structure matrix model of coupling tasks is introduced.The task coupling model is quantized,thereby the interactivity matrix of task package is built.A multi-goal task decoupling method based on improved genetic algorithm is proposed to decouple the task coupling model,which transforms the decoupling of task package into a multi-goal optimization issue.Then the improved genetic algorithm is used to solve the interactivity matrix of coupling tasks.Finally,the effectiveness of this decomposition method is proved by using the example of task package decoupling of collaborative development of a radar’s phased array antenna. | WANG Xiaofei LIAO Wenhe GUO Yu WANG Falin PAN Zhihao LIU Daoyuan | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，5： | 0 |
| 11 | Challenges and improvement in management of neonates born to mothers with COVID-19 in China显示文摘Objective:China was the first country suffering from the SARS-CoV-2 pandemic and one of the countries with stringent mother-neonate isolation measure implemented.Now increasing evidence suggests that coronavirus disease 2019(COVID-19)should not be taken as an indication for formula feeding or isolation of the infant from the mother.Methods:We conducted a retrospective cohort study in 44 hospitals from 14 provinces in China to investigate the management of neonates whose mothers have confirmed or suspected COVID-19.In addition,65 members of Chinese Neonatologist Association(CNA)were invited to give their comments and suggestions on the clinical management guidelines for high-risk neonates.Results:There were 121 neonates born to 118 mothers suspected with COVID-19 including 42 mothers with SARS-CoV-2 positive results and 76 mothers with SARS-CoV-2 negative results.All neonates were born by caesarean section,isolated from their mothers immediately after birth and were formula-fed.Five neonates were positive for SARSCoV-2 at initial testing between 36 and 46 h after birth.Regarding the confusion on the clinical management guidelines,58.78%of the newborns were put into isolation,32.22%were subject to PCR tests,and 5.16%and 2.75%received breastfeeding and vaccination,respectively.Conclusion:The clinical symptoms of neonates born to mothers with confirmed SARS-CoV-2 were mild,though five neonates might have been infected in utero or during delivery.Given the favorable outcomes of neonates born to COVID-confirmed mothers,full isolation may not be warranted.Rather,separation of the mother and her newborn should be assessed on a case-by-case basis,considering local facilities and risk factors for adverse outcomes,such as prematurity and fetal distress. | Jie Yang Zhuxiao Ren Lingkong Zeng Shiwen Xia Lin Wang Jiayu Miao Zhe Zhao Chuanzhong Yang Xiuyong Cheng Huayan Zhang Yuanfang Zhu Li Liu Xirong Gao Bin Yi Zhenlang Lin Wei Liu Xiaoyu Zhou Benqing Wu Ling Chen Zhankui Li Xuefeng Zhang Wei Lu Lianhong Zhang Xiao Chen Xiaoyun Zhong Falin Xu Jinhui Wu Yong Ji Jiahua Pan Yanxiang Chen Carine Ronsmans Zhichun Feng | 2022 | Frigid Zone Medicine2022，2，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员