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| 1 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 2 | Fluidization of non-spherical particles:Sphericity,Zingg factor and other fluidization parameters显示文摘A comparison of sphericity and Zingg factor for particle morphology and description of fluidized-bed dynamics are presented.It is found that Zingg factor Fz = LH/B2(where L,H and B are,respectively,the length,breadth and height of a particle) well describes the effect of particle morphology.Experimental results show that non-spherical particles give poor fluidizing quality as compared to spherical particles in terms of pressure drop,Umf,etc.With the same volume-equivalent diameter,non-spherical particles have lower Umf and fluidizing coefficient δ.Some smooth curves have been obtained between the parameters δ,Umf and Fz.The quality of fluidization could be evaluated by fluidizing coefficient,which has been correlated to the Zingg factor and minimum fluidizing velocity in this paper. | Baiqian Liu Xiaohui Zhang Ligang Wang Hui Hong | 2008 | Particuology2008，6，2： | 14 |
| 3 | Itinerant-electron metamagnetic transition and giant magnetic entropy change in La_(0.8)Ce_(0.2)Fe_(11.4)Si_(1.6) compound显示文摘The crystal structure, itinerant-electron metamagnetic transition (IEMT) and magnetocaloric effect (MCE) in the iron-based rare-earth intermetallic compound La0.8Ce0.2Fe11.4Si1.6 have been investi- gated. The powder X-ray diffraction revealed that the ingot of La0.8Ce0.2Fe11.4Si1.6 annealed at 1373 K in vacuum for only 5 days could be crystallized in the cubic NaZn13-type structure. The La0.8Ce0.2Fe11.4Si1.6 compound exhibited giant values of the isothermal entropy change ?SM around the Curie temperature TC (about 186 K). And the maximum value ΔS M max is about 78.29 J/(kg·K) under a field change of 0—3 T, which can be calculated by the magnetization iso- therms around TC. Such a large MCE is attributed to the sharp change of magnetization and susceptibility around TC and the first-order magnetic transition of field-induced IEMT above TC. | XU Chao LI Guodong LI Xiaowei WANG Ligang | 2006 | Chinese Science Bulletin2006，51，17： | 11 |
| 4 | Switched adaptive active disturbance rejection control of variable structure near space vehicles based on adaptive dynamic programming显示文摘Based on the switched nonlinear system, a switched adaptive Active Disturbance Rejection Control(ADRC) law is proposed for the Variable Structure Near Space Vehicle(VSNSV) with unknown uncertainties and external disturbances. The reduced-order Extended State Observers(ESOs) are constructed for the attitude angle system and the angular rate system to estimate the total disturbance in real time. With the extended state introduced to counteract the effects of uncertainties and disturbances, a systematic procedure is presented for the synthesis of the switched adaptive ADRC strategy. Rigorous proof shows that the estimation errors of the reduced-order ESOs would converge to a small neighborhood of zero in finite time, and that the output of the closedloop system can track a given signal stably for a class of switching signals with average dwell time via the proposed approach. The variable gain control strategy based on Adaptive Dynamic Programming(ADP) with the actor-critic structure is also designed to improve the dynamic performance of the system. Simulation results verify the effectiveness and advantage of the proposed control scheme. | Chaoyang DONG Chen LIU Qing WANG Ligang GONG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 10 |
| 5 | Effect of the column height on the performance of liquid-solid fluidized bed for the separation of coarse slime显示文摘A liquid-solid fluidized bed separator,used for the separation of coarse slime,was developed.Test particles sized in the range from 0.25 to 0.5,0.5 to 1.0,and 0.25 to 1.0 mm were separated in the liquid-solid fluidized bed.Beds with column heights of 1200,1500,and 1800 mm were tried.The clean coal and the tailings were subsequently analyzed by float-sink testing.The results showed that the ash and yield of clean coal both decreased with increasing column height,for all three size fractions,and that the ash of the clean coal obtained from tests on the broader size fraction was less than that from the narrower sized fractions.The separation density decreased with increasing column height.The lowest E value was seen for a column height of 1500 mm,for which conditions the separation density was 1.45 g/cm 3.The E value was 0.084 for the 0.25-0.5 mm fraction but the corresponding separation density was 1.48 g/cm 3,and the E value 0.089,for the broader 0.25-1.0 mm fraction. | Sha Jie Xie Guangyuan Wang Hong Liu Junzhang Tang Ligang | 2012 | International Journal of Mining Science and Technology2012，22，4： | 10 |
| 6 | Estimation of inbreeding and identification of regions under heavy selection based on runs of homozygosity in a Large White pig population显示文摘Background: Runs of homozygosity(ROHs) are homozygous segments of the genome where the two haplotypes inherited from the parents are identical. The current availability of genotypes for a very large number of single nucleotide polymorphisms(SNPs) is leading to more accurate characterization of ROHs in the whole genome. Here,we investigated the occurrence and distribution of ROHs in 3,692 Large White pigs and compared estimates of inbreeding coefficients calculated based on ROHs(FROH), homozygosity(FHOM), genomic relationship matrix(FGRM)and pedigree(FPED). Furthermore, we identified genomic regions with high ROH frequencies and annotated their candidate genes.Results: In total, 176,182 ROHs were identified from 3,569 animals, and all individuals displayed at least one ROH longer than 1 Mb. The ROHs identified were unevenly distributed on the autosomes. The highest and lowest coverages of Sus scrofa chromosomes(SSC) by ROH were on SSC14 and SSC13, respectively. The highest pairwise correlation among the different inbreeding coefficient estimates was 0.95 between FROH_totaland FHOM, while the lowest was-0.083 between FGRMand FPED. The correlations between FPEDand FROHusing four classes of ROH lengths ranged from 0.18 to 0.37 and increased with increasing ROH length, except for ROH > 10 Mb. Twelve ROH islands were located on four chromosomes(SSC1, 4, 6 and 14). These ROH islands harboured genes associated with reproduction, muscular development, fat deposition and adaptation, such as SIRT1, MYPN, SETDB1 and PSMD4.Conclusion: FROHcan be used to accurately assess individual inbreeding levels compared to other inbreeding coefficient estimators. In the absence of pedigree records, FROHcan provide an alternative to inbreeding estimates.Our findings can be used not only to effectively increase the response to selection by appropriately managing the rate of inbreeding and minimizing the negative effects of inbreeding depression but also to help detect genomic regions with an effect on traits under selection. | Liangyu Shi Ligang Wang Jiaxin Liu Tianyu Deng Hua Yan Longchao Zhang Xin Liu Hongmei Gao Xinhua Hou Lixian Wang Fuping Zhao | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 10 |
| 7 | Association of renal function with cardiac reverse remodeling and long-term outcome in heart failure patients following cardiac resynchronization therapy显示文摘 | Cai Chi Hua Wei Ding Ligang Wang Jing Chen Keping Yang Xinwei Liu Zhimin Zhang Shu | 2014 | Chinese Medical Journal2014，，23： | 8 |
| 8 | Precipitation trends and variability from 1950 to 2000 in arid lands of Central Asia显示文摘Climate warming will cause differences in precipitation distribution and changes in hydrological cycle both at regional and global scales. Arid lands of Central Asia(ALCA), one of the largest arid regions at the middle latitudes in the world, is likely to be strongly influenced by climate warming. Understanding the precipitation variations in the past is an important prerequisite for predicting future precipitation trends and thus managing regional water resources in such an arid region. In this study, we used run theory, displacement, extreme deviation theory, precipitation concentration index(PCI), Mann-Kendall rank correlation and climatic trend coefficient methods to analyze the precipitation in wet and dry years, changes in precipitation over multiple-time scales, variability of precipitation and its rate of change based on the monthly precipitation data during 1950–2000 from 344 meteorological stations in the ALCA. The occurrence probability of a single year with abundant precipitation was higher than that of a single year with less precipitation. The average duration of extreme drought in the entire area was 5 years, with an average annual water deficit of 34.6 mm(accounting for 11.2% of the average annual precipitation over the duration). The occurrence probability of a single wet year was slightly higher than that of a single dry year. The occurrence probability of more than 5 consecutive wet years was 5.8%, while the occurrence probability of more than 5 consecutive dry years was 6.2%. In the center of the study area, the distribution of precipitation was stable at an intra-annual timescale, with small changes at an inter-annual timescale. In the western part of the study area, the monthly variation of precipitation was high at an inter-annual timescale. There were clear seasonal changes in precipitation(PCI=12–36) in the ALCA. Precipitation in spring and winter accounted for 37.7% and 24.4% of the annual precipitation, respectively. There was a significant inter-annual change in precipitation in the arid Northwest China(PCI=24–34). Annual precipitation increased significantly(P=0.05) in 17.4% of all the meteorological stations over the study period. The probability of an increase in annual precipitation was 75.6%, with this increase being significant(P=0.05) at 34.0% of all the meteorological stations. The average increasing rate in annual precipitation was 3.9 mm/10a(P=0.01) in the ALCA. There were significant increasing trends(P=0.01) in precipitation in Kazakhstan, Kyrgyzstan and Tajikistan, with rates of 2.6, 3.1 and 3.7 mm/10 a, respectively. | XU Ligang ZHOU Hongfei DU Li YAO Haijiao WANG Huaibo | 2015 | Journal of Arid Land2015，7，4： | 8 |
| 9 | An overview of energy and metabolic regulation显示文摘The physiology and behaviors related to energy balance are monitored by the nervous and humoral systems. Because of the difficulty in treating diabetes and obesity, elucidating the energy balance mechanism and identifying critical targets for treatment are important research goals. Therefore, the purpose of this article is to describe energy regulation by the central nervous system(CNS) and peripheral humoral pathway. Homeostasis and rewarding are the basis of CNS regulation. Anorexigenic or orexigenic effects reflect the activities of the POMC/CART or NPY/AgRP neurons within the hypothalamus. Neurotransmitters have roles in food intake, and responsive brain nuclei have different functions related to food intake, glucose monitoring, reward processing. Peripheral gut-or adipose-derived hormones are the major source of peripheral humoral regulation systems. Nutrients or metabolites and gut microbiota affect metabolism via a discrete pathway. We also review the role of peripheral organs, the liver,adipose tissue, and skeletal muscle in peripheral regulation. We discuss these topics and how the body regulates metabolism. | Song Wen Chaoxun Wang Min Gong Ligang Zhou | 2019 | Science China(Life Sciences)2019，62，6： | 8 |
| 10 | A study of miRNAs targets prediction and experimental validation显示文摘microRNAs(miRNAs)are 20–24 nucleotide(nt)RNAs that regulate eukaryotic gene expression post-transcriptionally by the degradation or translational inhibition of their target messenger RNAs(mRNAs).To identify miRNA target genes will help a lot by understanding their biological functions.Sophisticated computational approaches for miRNA target prediction,and effective biological techniques for validating these targets now play a central role in elucidating their functions.Owing to the imperfect complementarity of animal miRNAs with their targets,it is difficult to judge the accuracy of the prediction.Complexity of regulation by miRNA-mediated targets at protein and mRNAs levels has made it more challenging to identify the targets.To date,only a few miRNAs targets are confirmed.In this article,we review the methods of miRNA target prediction and the experimental validation for their corresponding mRNA targets in animals. | Yong Huang Quan Zou Haitai Song Fei Song Ligang Wang Guozheng Zhang Xingjia Shen | 2010 | Protein & Cell2010，1，11： | 7 |
| 11 | Single-atom catalysis for carbon neutrality显示文摘Currently,more than 86%of global energy consumption is still mainly dependent on traditional fossil fuels,which causes resource scarcity and even emission of high amounts of carbon dioxide(CO_(2)),resulting in a severe“Greenhouse effect.”Considering this situation,the concept of“carbon neutrality”has been put forward by 125 countries one after another.To achieve the goals of“carbon neutrality,”two main strategies to reduce CO_(2) emissions and develop sustainable clean energy can be adopted.Notably,these are crucial for the synthesis of advanced single-atom catalysts(SACs)for energyrelated applications.In this review,we highlight unique SACs for conversion of CO_(2) into high-efficiency carbon energy,for example,through photocatalytic,electrocatalytic,and thermal catalytic hydrogenation technologies,to convert CO_(2) into hydrocarbon fuels(CO,CH_(4),HCOOH,CH_(3)OH,and multicarbon[C_(2+)]products).In addition,we introduce advanced energy conversion technologies and devices to replace traditional polluting fossil fuels,such as photocatalytic and electrocatalytic water splitting to produce hydrogen energy and a high-efficiency oxygen reduction reaction(ORR)for fuel cells.Impressively,several representative examples of SACs(including d-,ds-,p-,and f-blocks)for CO_(2) conversion,water splitting to H2,and ORR are discussed to describe synthesis methods,characterization,and corresponding catalytic activity.Finally,this review concludes with a description of the challenges and outlooks for future applications of SACs in contributing toward carbon neutrality. | Ligang Wang Dingsheng Wang Yadong Li | 2022 | Carbon Energy2022，4，6： | 7 |
| 12 | Microstructure, Mechanical Properties and Oxidation Resistance of Nb-22Ti-14Si-2Hf-2Al-xCr Alloys显示文摘Nb-22Ti-14Si-2Hf-2Al-xCr (x=2, 6, 10, 14, 17 at%) alloys are prepared by arc-melting under argon atmosphere. Microstructural characteristics, mechanical properties and oxidation resistance of the arc-melted alloys are investigated. At 2 at% Cr content, the microstructure is composed of Nbss, Nb3Si and a small quantity of Nb5Si3, when the Cr contents increase, Nb3Si disappears. For the high Cr content (x ≥ 10 at%) alloys, besides the Nbss and Nb5Si3, Cr2Nb is also detected. With the increase of Cr content, the volume fractions of Cr2Nb and Nb5Si3 increase, while that of Nbss increases firstly and then begins to degrade when the Cr content is higher than 6 at%. For the alloy with 2 at% Cr, the room temperature fracture toughness is about 14.5 MPa·m1/2, but badly decreases to about 8.5 MPa·m1/2, when the Cr contents increase. Vickers hardness of Nbss tends to increase linearly from about 400 to 500, while that of silicides is not sensitive to Cr contents, about 950. The appearance of Cr2Nb phase significantly improves the high temperature oxidation resistance of the alloys with high Cr contents. The isothermal oxidation tests show that the oxidation kinetics of the alloys with various Cr contents follows parabolic oxidation kinetics. | WANG Ligang JIA Lina CUI Renjie ZHENG Lijing ZHANG Hu | 2012 | Chinese Journal of Aeronautics2012，25，2： | 7 |
| 13 | Object-based classification approach for greenhouse mapping using Landsat-8 imagery显示文摘Suburban greenhouses with intensive agricultural productivity have increasingly influenced the daily diet and vegetable supply in Chinese cities.With their enormous input of fertilizers and pesticides,greenhouses have considerably changed the local soil quality and environmental risk factors.The ability to obtain timely and accurate information regarding the spatial distribution of greenhouses could make an important contribution to local agricultural management and soil protection.This paper attempts to present a practical framework for extracting suburban greenhouses,integrating remote sensing data from Landsat-8 and object-oriented classification.Inheritance classification was implemented,and various properties,including texture and neighborhood features in addition to spectral information,were investigated through the popular random forest technique for feature selection prior to SVM classification to improve the mapping accuracy.The results demonstrated that object-based classification incorporating non-spectral features yielded a significant improvement compared with the classification results obtained using only the spectral information in traditional per-pixel classification.Both the producer’s and user’s accuracy were higher than 85%for greenhouse identification.Although it remained a challenge to completely distinguish greenhouses from sparse plants,the final greenhouse map indicated that the proposed object-based classification scheme,providing multiple feature selections and multi-scale analysis,yielded worthwhile information when applied to a continuous series of the freely available Landsat-8 imagery data. | Wu Chaofan Deng Jinsong Wang Ke Ma Ligang Amir Reza Shah Tahmassebi | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 7 |
| 14 | Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer显示文摘Clusterin/apolipoprotein J (Clu ) 是在几个生理的过程被含有的无所不在地表示的分泌 heterodimeric glycoprotein。这被报导了分泌 clusterin (sClu ) 的提高的水平蛋白质在乳癌病人与差的幸存被联系并且能在啮齿类动物模型导致转移。在这研究,我们在 vitro 并且在 vivo 在细胞活动性,侵略,和生长上与小介入 RNA (siRNAs ) 调查了 sClu 抑制的效果。MDA-MB-231 房间是有 pSuper-siRNA/sClu 的 transfected。房间幸存和增长被 3-(4,5-dimethyl-thiazol-2yl ) 检验 -5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 和 clonogenic 幸存试金。结果证明 sClu silencing 显著地禁止了 MDA-MB-231 房间的增长。侵略和迁居能力戏剧性地也被减少,它被 matrigel 试金检测。染色的 TUNEL 和 caspase-3 活动试金证明 sClu silencing 能也增加房间的 apoptosis 率,导致房间生长的抑制。我们也在一个 orthotopic 乳癌模型在肿瘤生长和变形前进上决定了 sClu silencing 的效果。结果比肿瘤源于父母 MDA-MB-231 或 MDA-MB-231/pSuper 的证明主要肿瘤从 MDA-MB-231/pSuper sClu siRNA 房间导出的 orthotopic 变得显著地慢爬 siRNA 房间,并且少些转移到肺。这些数据建议能分泌的 clusterin 在肿瘤生长和变形前进起一个重要作用。敲门下面 sClu 基因表示可以为乳癌治疗提供一个珍贵方法。 | Zhaohe Niu Xinhui Li Bin Hu Rong Li Ligang Wang Lilin Wu Xingang Wang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，12： | 6 |
| 15 | Bifurcation and chaos of the bladed overhang rotor system with squeeze film dampers显示文摘To study the nonlinear dynamic behavior of the bladed overhang rotor system with squeeze film damper (SFD), a blade-overhang rotor-SFD model is formulated using the lumped mass method and the Lagrange approach. The cavitated short bearing model is employed to describe the nonlinear oil force of the SFD. To reduce the scale of the nonlinear coupling system, a set of orthogonal transformations is employed to decouple the one nodal diameter equations of blades, which are coupled with the dy- namical equations of the rotor, with other equations of blades. In this way, the original system with 16+4n (n≥3) degrees of freedom (DoF) is reduced to a system with 24 DoF only. Then the parametric excitation terms in the blade-overhang rotor-SFD model are simplified in terms of periodic transforma- tions. The coupling equations are numerically solved and the solutions are used to analyze the dy- namic behavior of the system in terms of the bifurcation diagram, whirl orbit, Poincaré map and spec- trum plot. A variety of motion types are found such as multi-periodic, quasi-periodic, and chaotic mo- tions. Moreover, the typical nonlinear dynamic evolutions including the periodic-doubling bifurcation and reverse bifurcation are noted. It is noticed that there exist apparent differences in the dynamic behavior between the blade-overhang rotor-SFD models without and with considering the effect of blades. | CAO DengQing WANG LiGang CHEN YuShu HUANG WenHu | 2009 | Science China(Technological Sciences)2009，52，3： | 5 |
| 16 | Publication trends in studies examining radix notoginseng as a treatment for ischemic brain injury显示文摘Acute ischemic stroke has become a major disease burden with high mortality and morbidity rates. There is a lack of evidence-based medicine confirming the efficacy of common treatments. Panax notoginseng saponins, the main active ingredient of radix notoginseng, have a neuroprotective role in ischemic brain injury, and have been popularized as a maintenance treatment for acute cerebral infarction and its sequelae. We conducted literature searches on the Web of Science, ClinicalTrials.gov, Cochrane Collaboration, CNKI, Wanfang and the China Scientific & Technological Achievements Database and analyzed the experimental and clinical outcomes of studies investigating the use of radix notoginseng in the treatment of ischemic brain injury to improve the understanding of relevant research trends and existing problems. We found that over the past 10 years, China has maintained its interest in Panax notoginseng research, while such studies are scarce on the Web of Science. However, Chinese researchers often focus on the neuroprotective role of radix notoginseng in ischemic brain injury, but there are no large-scale clinical data to confirm its efficacy and safety. There remains a need for more rigorous large-sample randomized controlled clinical trials with long-term follow-up, to determine whether radix notoginseng lowers stroke recurrence and improves patient's quality of life. | Haiping Li Luo Qiang Chunyang Zhang Chaohui Wang Zhenxing Mu Ligang Jiang | 2014 | Neural Regeneration Research2014，9，17： | 5 |
| 17 | Total phenols, flavonoids, and procyanidins levels and total antioxidant activity of different Korean pine(Pinus koraiensis) varieties显示文摘Total phenols,flavonoids,procyanidins,and total antioxidant capacity,measured with ferric reducing antioxidant power,radical scavenging capacity,and oxygen radical absorption capacity assays were first evaluated in the extracts of the shells,skins and kernels of 10 varieties of Pinus koraiensis.Results indicate that these varieties had strong radical scavenging capacities,ferric reducing antioxidant power and oxygen radical absorption capacities.Phenolic,flavonoid and procyanidin values ranged from 138.6(#3 kernel)to 518.6(#10 shell)mg GAE/g,from 23.3(#2 kernel)to 70.8(#5 skin)mg RE/g,from 2.5(#2 kernel)to 142.1(#7 skin)mg CE/g,respectively.Radical scavenging capacity and ferric reducing antioxidant power values were positively correlated to the polyphenol contents which play a major role in antioxidant properties.The varieties may be divided into two groups by cluster analysis and the variables being measured.These results will be useful for breeding varieties and guiding their production. | Sitong Zhang Ligang Zhang Lu Wang Yuhong Zhao | 2019 | Journal of Forestry Research2019，30，5： | 5 |
| 18 | Genome-wide identification of RNA editing in seven porcine tissues by matched DNA and RNA high-throughput sequencing显示文摘Background: RNA editing is a co/posttranscriptional modification mechanism that increases the diversity of transcripts, with potential functional consequences. The advent of next-generation sequencing technologies has enabled the identification of RNA edits at unprecedented throughput and resolution. However, our knowledge of RNA editing in swine is still limited.Results: Here, we utilized RES-Scanner to identify RNA editing sites in the brain, subcutaneous fat, heart, liver,muscle, lung and ovary in three 180-day-old Large White gilts based on matched strand-specific RNA sequencing and whole-genome resequencing datasets. In total, we identified 74863 editing sites, and 92.1% of these sites caused adenosine-to-guanosine(A-to-G) conversion. Most A-to-G sites were located in noncoding regions and generally had low editing levels. In total, 151 A-to-G sites were detected in coding regions(CDS), including 94 sites that could lead to nonsynonymous amino acid changes. We provide further evidence supporting a previous observation that pig transcriptomes are highly editable at PRE-1 elements. The number of A-to-G editing sites ranged from 4155(muscle) to 25001(brain) across the seven tissues. The expression levels of the ADAR enzymes could explain some but not all of this variation across tissues. The functional analysis of the genes with tissuespecific editing sites in each tissue revealed that RNA editing might play important roles in tissue function.Specifically, more pathways showed significant enrichment in the fat and liver than in other tissues, while no pathway was enriched in the muscle.Conclusions: This study identified a total of 74863 nonredundant RNA editing sites in seven tissues and revealed the potential importance of RNA editing in tissue function. Our findings largely extend the porcine editome and enhance our understanding of RNA editing in swine. | Yuebo Zhang Longchao Zhang Jingwei Yue Xia Wei Ligang Wang Xin Liu Hongmei Gao Xinhua Hou Fuping Zhao Hua Yan Lixian Wang | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 19 | Sliding mode H_∞ control for a class of uncertain nonlinear state-delayed systems显示文摘A new proportional-integral (PI) sliding surface is designed for a class of uncertain nonlinear state-delayed systems. Based on this, an adaptive sliding mode controller (ASMC) is synthesized, which guarantees the occurrence of sliding mode even when the system is undergoing parameter uncertainties and external disturbance. The resulting sliding mode has the same order as the original system, so that it becomes easy to solve the H_∞ control problem by designing a memoryless H_∞ state feedback controller. A delay-dependent sufficient condition is proposed in terms of linear matrix inequalities (LMIs), which guarantees the sliding mode robust asymptotically stable and has a noise attenuation level γ in an H_∞ sense. The admissible state feedback controller can be found by solving a sequential minimization problem subject to LMI constraints by applying the cone complementary linearization method. This design scheme combines the strong robustness of the sliding mode control with the H_∞ norm performance. A numerical example is given to illustrate the effectiveness of the proposed scheme. | Wu Ligang Wang Changhong Gao Huijun Zhang Lixian | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 4 |
| 20 | Effects of Tensor Interaction on Pseudospin Energy Splitting and Shell Correction显示文摘 | Dong Jianmin Zuo Wei Gu Jianzhong Y. Z. Wang Cao Ligang X. Z. Zhang | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
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