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| 1 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 2 | Petrology, Geochemistry and Geochronology of Gabbros from the Zhongcang Ophiolitic Mélange, Central Tibet: Implications for an Intra-Oceanic Subduction Zone within the Neo-Tethys Ocean显示文摘In order to investigate the evolution of Shiquanhe-Yongzhu-Jiali ophiolitic mélange belt, the gabbros from new discovered Zhongcang ophiolitic mélange are studied through petrology, whole-rock geochemistry, zircon U-Pb dating and Lu-Hf isotope. The gabbros investigated in this paper contain cumulate gabbro and gabbro dike, and they have undergone greenschist-amphibolite facies metamorphism. The chondrite normalized rare earth element(REE) patterns of most of these rocks show flat types with slightly light REE(LREE) depletion and the N-MORB normalized incompatible elements diagrams indicate depletion in high field strength elements(HFSE)(Nb, Ta) and enrichment in large ion lithophile elements(LILE). These gabbros have island arc and mid-ocean ridge basalt affinities, suggesting that they were originated in an oceanic back arc basin. Whole rock geochemistry and high positive εNd(t) values show that these gabbros were derived from ~30% partial melting of a spinel lherzolite mantle, which was enriched by interaction with slab-derived fluids and melts from sediment. U-Pb analyses of zircons from cumulate gabbro yield a weighted mean age of 114.3±1.4 Ma. Based on our data and previous studies, we propose that an intra-oceanic subduction system and back arc basin operated in the Neo-Tethy Ocean of central Tibet during Middle Jurassic and Early Cretaceous, resembling modern active intra-oceanic subduction systems in the western Pacific. | Mengjing Xu Cai Li Wei Xu Chaoming Xie Peiyuan Hu Ming Wang | 2014 | Journal of Earth Science2014，25，2： | 11 |
| 3 | MLKL forms cation channels显示文摘 | Bingqing Xia Sui Fang Xueqin Chen Hong Hu Peiyuan Chen Huayi Wang Zhaobing Gao | 2016 | Cell Research2016，26，5： | 10 |
| 4 | Opening of the Longmu Co–Shuanghu–Lancangjiang ocean:constraints from plagiogranites显示文摘This paper reports new zircon U-Pb ages,and Hf isotope and whole-rock major and trace element data for Cambrian plagiogranites from the Tuobeiling ophiolite in central Qiangtang,Tibetan Plateau.Zircon SIMS and LAICP-MS U-Pb dating of the plagiogranites yield weighted mean ages of 504.8±4.2 and 491.6±1.5 Ma,respectively.The zircons from plagiogranites exhibit positive eHf(t)values(ranging from 11.46 to 15.16),indicating that the plagiogranites are derived from depleted mantle.These plagiogranites are characterized by high SiO2and Na2O,low K2O,low REE contents,and flat REE distribution patterns.These rocks have geochemical compositions typical of oceanic plagiogranite and,considered along with their petrography and field relationships,are interpreted to have derived from anatexis of hydrated amphibolites by ductile shearing during transports of the oceanic crust.The formation age of such type of plagiogranite is slightly younger than that of the associated section of oceanic crust.Thus the new results from these plagiogranites suggest that the Longmu Co–Shuanghu–Lancangjiang ocean had probably opened before the Middle Cambrian. | Peiyuan Hu Cai Li Yanwang Wu Chaoming Xie Ming Wang Jiao Li | 2014 | Chinese Science Bulletin2014，59，25： | 9 |
| 5 | The Oldest Paleo-Tethyan Ophiolitic Mélange in the Xizang(Tibetan) Plateau显示文摘An Early Paleozoic ophiolitic mélange has recently been documented in the W.Gangma Co area,north-central Tibetan Plateau.It is composed of serpentinite,isotropic and cumulate gabbros,basalt and plagiogranite.Whole- | ZHAI Qingguo JAHN Bor-ming WANG Jun HU Peiyuan TANG Yue | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 9 |
| 6 | Petrology, geochemistry and geochronology of the Zhongcang ophiolite, northern Tibet: implications for the evolution of the Bangong-Nujiang Ocean显示文摘Ophiolites are widespread along the Bangong-Nujiang suture zone, northern Tibet. However, it is still debated on the formation ages and tectonic evolution process of these ophiolites. The Zhongcang ophiolite is a typical ophiolite in the western part of the Bangong-Nujiang suture zone. It is composed of serpentinized peridotite, cumulate and isotropic gabbros, massive and pillow basalts, basaltic volcanic breccia, and minor red chert. Zircon SHRIMP Ue Pb dating for the isotropic gabbro yielded weighted mean age of 163.4 ± 1.8 Ma. Positive zircon ε Hf(t) values(+15.0 to +20.2) and mantle-like σ^(18)O values(5.29 ±0.21)% indicate that the isotropic gabbros were derived from a long-term depleted mantle source. The isotropic gabbros have normal mid-ocean ridge basalt(N-MORB) like immobile element patterns with high Mg O, low TiO_2 and moderate rare earth element(REE) abundances, and negative Nb,Ti, Zr and Hf anomalies. Basalts show typical oceanic island basalt(OIB) geochemical features, and they are similar to those of OIB-type rocks of the Early Cretaceous Zhongcang oceanic plateau within the Bangong-Nujiang Ocean. Together with these data, we suggest that the Zhongcang ophiolite was probably formed by the subduction of the Bangong-Nujiang Ocean during the Middle Jurassic. The subduction of the Bangong-Nujiang Tethyan Ocean could begin in the Earlye Middle Jurassic and continue to the Early Cretaceous, and finally continental collision between the Lhasa and Qiangtang terranes at the west Bangong-Nujiang suture zone probably has taken place later than the Early Cretaceous(ca. 110 Ma). | Yue Tang Qingguo Zhai Peiyuan Hu Xuchang Xiao Haitao Wang | 2018 | Geoscience Frontiers2018，9，5： | 9 |
| 7 | Petrology, Geochemistry and Tectonic Significance of the Metamorphic Peridotites from Longmuco-Shuanghu Ophiolitic Melange belt, Tibet显示文摘Taoxinghu metamorphic peridotite is a firstly reported mantle sequence of ophiolite since Longmuco-Shuanghu-Lancangjiang suture zone (LSLSZ) was proposed, and it is also an important discovered for ophiolite studying in central Qiangtang. Based on detailed analyses of whole-rock geochemistry of Taoxinghu metamorphic peridotites and contrast to metamorphic peridotites in typical ophiolites worldwide, the paper investigates their petrogenesis and geological implication. The petrologic results show that the protolith of Taoxinghu metamorphic perdotites have the mineral assemblage and texture characteristic of mantle peridotite. Most metamorphic peridotites hav near global abyssal peridotites major elements contents, while the few is similar to SSZ-type peridotites. They exhibit typically U-shaped REE patterns, characterized by slight enrichment of LREE and HREE relative to MREE and a low fractionated LREE to HREE segment. Trace elements contents are low and all samples are strong enrichment in Cs, U, Pb, weak enrichment in Ba and depletion in Th, but negative Nb anomalies are only observed in few samples. That suggests Taoxinghu metamorphic peridotites have depletion mantle and suprasubduction affinities. A two-stage evolution history is considered: Taoxinghu metamorphic peridotites originated as the residue from melting at a ridge with 7%-20% degree of fraction melting and were subsequently modified by interaction with mafic melt and aqueous fluid within mantle wedge on subducted zone. Combined with previous studies, we preliminarily propose Taoxinghu metamorphic peridotites may be the Products of initial rifting of palo-Tethys, forming at middle Ordivician-upper Cambrian, and they may be the direct evidences for spreading of palo-Tethys. | WU Yanwang LI Cai XIE Chaoming WANG Ming HU Peiyuan | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 9 |
| 8 | Dynamic tubulation of mitochondria drives mitochondrial network formation显示文摘 | Chong Wang Wanqing Du Qian Peter Su Mingli Zhu Peiyuan Feng Ying Li Yichen Zhou Na Mi Yueyao Zhu Dong Jiang Senyan Zhang Zerui Zhang Yujie Sun Li Yu | 2015 | Cell Research2015，25，10： | 8 |
| 9 | Progress of the satellite laser ranging system TROS1000显示文摘The mobile satellite laser ranging system TROS1000, successfully developed in 2010, achieves a high repetition rate and enables daytime laser ranging. Its measurement range has reached up to 36000 km with an accuracy as precise as 1 cm. Using recent observations in Wuhan, Jiufeng, Xianning, and Rongcheng, Shandong, we introduce the progress made using this mobile observation system. | Guo Tangyong Wang Peiyuan Li Xin Zhu Wei Zou Tong Li Shipeng Luo Qingshan | 2015 | Geodesy and Geodynamics2015，6，1： | 7 |
| 10 | Key technologies implementation of high-repetition-rate satellite laser ranging显示文摘Satellite laser ranging (SLR) is one of the major space geodetic instruments, which has various applications in earth science. In this paper, we introduce several issues regarding the key technology implementation of high-repetition-rate SLR system. Compared with traditional technology, using kHz and 8ps pulse width laser component, the data quantity and quality of high-repetition-rate satellite laser ranging (SLR) can be significantly improved. The characteristics of high-repetition-rate laser ranging and the key technologies are presented, including the event timer with the precision of picosecond, the generation of range gate signal, and so on. All of them are based on the Field Programmable Gate Arrays (FPGA) and tested on China mobile SLR system-TROS1000. Finally, the observations of satellite Beacon-C are given. | Wang Peiyuan Guo Tangyong Gao Hao Li Xin Zhu Wei Zou Tong Li Shipeng | 2013 | Geodesy and Geodynamics2013，4，1： | 4 |
| 11 | Oxide-based cathode materials for rechargeable zinc ion batteries:Progresses and challenges显示文摘With the increasing demands for electrical energy storage technologies,rechargeable zinc ion batteries(ZIBs)have been rapidly developed in recent years owing to their high safety,low cost and high energy storage capability.The cathode is an essential part of ZIBs,which hosts zinc ions and determines the capacity,rate and cycling performance of the battery.The mainstream cathodes for ZIBs are oxidebased materials with tunnel,layer or 3 D crystal structures.In this review,we mainly focus on the latest advanced oxide-based cathode materials in ZIBs,including manganese oxides,vanadium oxides,spinel compounds,and other metal oxide based cathodes.In addition,the mechanisms of zinc storage and recent development in cathode design have been discussed in detail.Finally,current challenges and perspectives for the future research directions of oxide-based cathodes in ZIBs are presented. | Yingze Zhou Fandi Chen Hamidreza Arandiyan Peiyuan Guan Yunjian Liu Yuan Wang Chuan Zhao Danyang Wang Dewei Chu | 2021 | Journal of Energy Chemistry2021，30，6： | 4 |
| 12 | A correction method of encoder bias in satellite laser ranging system显示文摘In a satellite laser ranging telescope system,well-aligned encoders of the elevation and azimuth axes are essential for tracking objects.However,it is very difficult and time-consuming to correct the bias between the absolute-position indices of the encoders and the astronomical coordinates,especially in the absence of a finder scope for our system.To solve this problem,a method is presented based on the phenomenon that all stars move anti-clockwise around Polaris in the northern hemisphere.Tests of the proposed adjustment procedure in a satellite laser ranging(SLR)system demonstrated the effectiveness and the time saved by using the approach,which greatly facilitates the optimization of a tracking system. | Wang Peiyuan Zhu Wei Zou Tong Guo Tangyong | 2013 | Geodesy and Geodynamics2013，4，3： | 3 |
| 13 | Imine-Linked Covalent Organic Framework on Surface for Biosensor显示文摘Imine-linked covalent organic framework on amino functionalized silicon substrate was constructed via a step-wise reaction between 1,3,5-benzenetricarboxaldehyde and 1,4-diaminobenzene.The obtained material was used as biosensor for bovine serum albumin(BSA)adsorption and probe DNA immobilization,which extended the application of covalent organic frameworks(COFs)to a new field. | Peiyuan Wang Mengmeng Kang Shumin Sun Qiang Liu Zhihong Zhang Shaoming Fang | 2014 | Chinese Journal of Chemistry2014，32，9： | 3 |
| 14 | Effect of Facet Displacement on Radiation Field and Its Application for Panel Adjustment of Large Reflector Antenna显示文摘Large reflector antennas are widely used in radars, satellite communication, radio astronomy, and so on. The rapid developments in these fields have created demands for development of better performance and higher surface accuracy. However, low accuracy and low efficiency are the common disadvantages for traditional panel alignment and adjustment. In order to improve the surface accuracy of large reflector antenna, a new method is presented to determinate panel adjustment values from far field pattern. Based on the method of Physical Optics(PO),the effect of panel facet displacement on radiation field value is derived. Then the linear system is constructed between panel adjustment vector and far field pattern.Using the method of Singular Value Decomposition(SVD), the adjustment value for all panel adjustors are obtained by solving the linear equations. An experiment is conducted on a 3.7 m reflector antenna with 12 segmented panels. The results of simulation and test are similar, which shows that the presented method is feasible. Moreover, the discussion about validation shows that the method can be used for many cases of reflector shape. The proposed research provides the instruction to adjust surface panels efficiently and accurately. | Wei WANG Peiyuan LIAN Shuxin ZHANG Binbin XIANG Qian XU | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 3 |
| 15 | Genome-wide association study and transcriptome analysis reveal new QTL and candidate genes for nitrogen-deficiency tolerance in rice显示文摘The development of rice cultivars with improved nitrogen use efficiency(NUE)is desirable for sustainable agriculture.Achieving this goal depends in part on understanding how rice responds to low soil nitrogen(N)and identifying causative genes underlying this trait.To identify quantitative trait loci(QTL)or genes associated with low N response,we conducted a genome-wide association study(GWAS)using a diverse panel of 230 rice accessions and performed a transcriptomic investigation of rice accessions with differential responses to low N stress at two N levels.We detected 411 GWAS-associated genes in 5 QTL and 2722 differentially expressed genes in response to low N,of which 24 were identified by both methods and ranked according to gene annotations,literature queries,gene expression,and genetic diversity analysis.The large-scale datasets obtained from this study reveal low N-responsive characteristics and provide insights towards understanding the regulatory mechanisms of N-deficiency tolerance in rice,and the candidate genes or QTL would be valuable resources for increasing rice NUE via molecular biotechnology. | Qing Li Xueli Lu Changjian Wang Lan Shen Liping Dai Jinli He Long Yang Peiyuan Li Yifeng Hong Qiang Zhang Guojun Dong Jiang Hu Guangheng Zhang Deyong Ren Zhenyu Gao Longbiao Guo Qian Qian Li Zhu Dali Zeng | 2022 | The Crop Journal2022，10，4： | 3 |
| 16 | Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics显示文摘 | Qiang Huang Yexiong Tan Peiyuan Yin Guozhu Ye Peng Gao Xin Lu Hongyang Wang Guowang Xu | 2013 | Cancer Research2013，，16： | 2 |
| 17 | The Beila Ophiolite from the Bangong-Nujiang Suture Zone, Northern Tibetan Plateau显示文摘The Beila ophiolite is located in the middle part of the Bangong-Nujiang suture zone,northern Tibetan plateau.It is a complete ophiolite suite,and plays a key role in understanding the evolution of the Bangong-Nujiang suture zone,as well as the Meso-Tethys Ocean.The Beila ophiolite was composed of peridotite,serpentinite,gabbro,pillow basalt,and minor rodingite.Peridotites comprisemainlymedium–tocoarse–grained serpentinized harzburgites and minor plagioclase-bearing lherzolites and dunites.There are some felsic-ultramafic dykes within the peridotite and they are mainlypegmatoidal pyroxenites,coarse to fine-grained gabbros,and diabases.Gabbros included isotropic and cumulate gabbros,and they commonly contain minor pegmatoidal gabbros veins.Pillow basalts and basaltic andesites overlaid on the margin of the serpentinized peridotites.Rodingite occurs as lenses and/or dykes within the host serpentinized peridotites.Zircon SHRIMP U–Pb dating for two rodingite samples yielded the ages ranging from172 to 164 Ma.Whole-rock geochemical and zircon Hf isotopic data show that the Beila ophiolite shows SSZ-type ophiolite affinity.Finally,we suggest that the Beila ophiolite was generated in an initial subduction process at the middle Jurassic(164–172 Ma). | ZHAI Qingguo TANG Yue HU Peiyuan XIAO Xuchang WANG Haitao | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 2 |
| 18 | ^(40)Ar/^(39)Ar Thermochronology Constraints on Jurassic Tectonothermal Event of Nyainrong Microcontinent显示文摘To reveal the Jurassic tectonothermal event occurring to the Nyainrong microcontinent which is gripped among the Bangong-Nujiang suture zone,40Ar/39Ar dating was carried out on the basement orthogneiss and Jurassic granitc gneiss in the microcontinent.In the heating stage,four samples exhibited a flat plateau age,with the value Tp concentrated in the range of 166–176 Ma;isochron age Ti was concentrated in the range of 165–175 Ma,and their corresponding ages were the consistent within allowable range.The ages should be representative of the era of the final deformation of the Amdo gneiss and cooling emplacement of the magmatic rock in the Jurassic.The geochronological studies have shown that the final deformation of microcontinent crystalline basement and the cooling of the Mesozoic large-scale tectonothermal events occurred in late Middle Jurassic.In Middle Jurassic,Nyainrong microcontinent experienced strong tectonic movement.Combining with the geochronological with isotope geochemistry for the microcontinent,the cause of the tectonothermal event should be attributed to the collision between the Nyainrong microcontinent and South Qiangtang Block following the northward subduction of Bangong-Nujiang oceanic crust. | Chaoming Xie Cai Li Yanwang Wu Ming Wang Peiyuan Hu | 2014 | Journal of Earth Science2014，25，1： | 2 |
| 19 | Tumor Microenvironment Cascade‑Responsive Nanodrug with Self‑Targeting Activation and ROS Regeneration for Synergistic Oxidation‑Chemotherapy显示文摘Carrier-free nanodrug with exceptionally high drug payload has attracted increasing attentions.Herein,we construct a pH/ROS cascade-responsive nanodrug which could achieve tumor acidity-triggered targeting activation followed by circularly amplified ROS-triggered drug release via positive-feedback loop.The di-selenide-bridged prodrug synthesized from vitamin E succinate and methotrexate(MTX)self-assembles into nanoparticles(VSeM);decorating acidity-cleavable PEG onto VSeM surface temporarily shields the targeting ability of MTX to evade immune clearance and consequently elongate circulation time.Upon reaching tumor sites,acidity-triggered detachment of PEG results in targeting recovery to enhance tumor cell uptake.Afterward,the VSeM could be dissociated in response to intracellular ROS to trigger VES/MTX release;then the released VES could produce extra ROS to accelerate the collapse of VSeM.Finally,the excessive ROS produced from VES could synergize with the released MTX to efficiently suppress tumor growth via orchestrated oxidation-chemotherapy.Our study provides a novel strategy to engineer cascade-responsive nanodrug for synergistic cancer treatment. | Yang Li Jinyan Lin Peiyuan Wang Qiang Luo Fukai Zhu Yun Zhang Zhenqing Hou Xiaolong Liu Jingfeng Liu | 2020 | Nano-Micro Letters2020，12，12： | 2 |
| 20 | Future Research Trend for Improving Large Reflector Antenna Service Performance显示文摘A large reflector antenna is one of the key components of a deep space telemetry track and command(TT&C)network,which is of great importance for human space activities,such as satellite communication,spaceflight,and deep space exploration[1].The main feature of this antenna type is its large aperture and often it requires strict surface accuracy to ensure high gain and high pointing performance[2,3].There are two kinds of reflector antennas:non-fully movable antenna and fully steerable antenna.The Fivehundred-meter Aperture Spherical Radio Telescope in China is one representative non-fully movable antenna with a super large aperture and low operation frequency.The fully steerable reflector antennas worldwide can be further divided into four categories according to their aperture diameters and highest operation frequencies,as shown in Fig.1.Most of the antennas in Fig.1 can be found in Ref.[4]and the details are not presented here.Category 1 includes the traditional reflectors with large apertures and low operation frequencies. | Peiyuan Lian Congsi Wang Song Xue Yan Wang Yuefei Yan Qian Xu Baoyan Duan Na Wang Yuhu Duan Yang Wu | 2021 | Engineering2021，7，8： | 2 |
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