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| 1 | Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers. | Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 2 | Expression of lung vascular and airway ICAM-1 after exposure to bacterial lipopolysaccharide显示文摘 | Beck-schimmer B Schimmer RC Warner RL | 1997 | Am J Respir Cell Mol Biol1997，17，2： | 1 |
| 3 | 显示文摘 | Khambatta F B Warner E Russel T | 1976 | Journal of Polymer Science Polymer Physics Edition1976，14，8： | 1 |
| 4 | Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappa B and CXC chemokines 显示文摘 | Karl E Warner K Zeitlin B | 2005 | Cancer Res2005，65，： | 1 |
| 5 | On Financial Contracting : An Analysis of Bond Covenants 显示文摘 | Smith C W Warner J B | 1979 | Journal of Financial Economics1979，，7： | 1 |
| 6 | Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis显示文摘 | WARNER B W WARNER B B | 2005 | Seminars in Pediatric Surgery2005，14，3： | 1 |
| 7 | To breathe,perchance to sleep:sleep-disordered breathing and chronic insomnia among trauma survivors显示文摘 | Krakow B Melendrez D Warner TD | 2002 | Sleep Breathing2002，6，： | 1 |
| 8 | Using Daily Stock Returns: The Case of Event Studies显示文摘 | Warner J B | 1985 | Journal of Financial Economics1985，14，： | 1 |
| 9 | Maternal Serum Dioxin Levels and Birth Outcomes in Women of Seveso,Italy显示文摘 | Eskenazi B Mocarelli P Warner M | 2003 | Enviromental Health Perspectives2003，111，： | 1 |
| 10 | Hemodynamics and emergence profile of remifentanil versus fentanyl prospectively compared in a large population of surgical patients显示文摘 | TWERSKY RS JAMESON B WARNER DS | 2001 | J Clin Anesth2001，13，6： | 1 |
| 11 | Ecology of testate amoebae (Protozoa: Rhizopoda) in Sphagnum peatlands in the Jura mountains, Switzerland and France显示文摘 | Mitchell E A D Buttler A J Warner B G | 1999 | Ecoscicnce1999，6，： | 1 |
| 12 | Olmesartan medoxomil显示文摘 | Warner GT Jarvis B | 2002 | Drugs2002，62，9： | 1 |
| 13 | Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis 显示文摘 | NAIR R R WARNER B B WARNER B W | 2008 | Semi- nars in Perinatology2008，32，2： | 1 |
| 14 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 15 | Stock prices and top management changes显示文摘 | Warner J B Watts R L Wruck K H | 1988 | Journal of Financial Eco-nomics1988，20，12： | 1 |
| 16 | The atrial fibrillation follow- up investigation of rhythm management investigators显示文摘 | Olshansky B RosenfeldLE Warner AL | 2002 | N Engl J Meal2002，347，23： | 1 |
| 17 | The atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study Approaches to Control Rate in Atrial Fibrillation显示文摘 | Olshansky B Rosenfeld LE Warner AL | 2004 | Am Coll Cardiol2004，43，： | 1 |
| 18 | Hemodynamies and emergence profile of remifentanil versus fentanyl prospectively compared in a large population of surgical patients显示文摘 | Twersky RS Jamerson B Warner DS | 2001 | J Clin Anesth2001，13，6： | 1 |
| 19 | Serum dioxin concent rations and endometriosis:a cohort study in Seveso, Italy 显示文摘 | Eskenazi B OcareUi P Warner M | 2002 | Environ Health Perspect2002，110，7： | 1 |
| 20 | Relationship between testate amoebae(Protozoa:Rhisopoda)and microenvironmental parameters on a forested peatland in northeastern Ontario显示文摘 | Charman D J Warner B G | 1992 | Canadian Journal of Zoology1992，70，： | 1 |
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