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| 1 | Regional Tectonic Transformation in East Kunlun Orogenic Belt in Early Paleozoic: Constraints from the Geochronology and Geochemistry of Helegangnaren Alkali-feldspar Granite显示文摘The Helegangnaren feldspar granite exposed in the eastern part of East Kunlun, is characterized by high concentrations of SiO2 and alkaline, low abundances of Fe, Mg and Ca, metaluminous-weak peraluminous. Trace elements analysis shows that the granite is depleted extremely in Ba, Sr and Eu, and rich in some large-ion lithophile elements and high field strength elements. Besides, the granite has high Ga contents, the values of 104 (Ga/Al) vary from 2.50 to 2.77, which is mainly greater than the lower limit of A-type granites (2.6), and is higher than the I-and S-type granites' average (2.1 and 2.28, respectively). Rare earth element (REE) is characterized by relatively high fractionations of light REE (LREE) and heavy REE (HREE) (LREE/HREE=9.3-13.60, (La/Yb)N =10.92-18.02), pronounced negative Eu anomalies (δEu=0.08-0.13), and exhibits right-dipping gull pattern. Major elements, rare elements and trace elements features show the granite is ascribed to A-type granite and A2 subtype in tectonic genetic type. They are plotted into post-collision or within-plate area in a variety of tectonic discriminations. Geological and geochemical data comprehensively suggest that the granite is formed in a post-collision extensive tectonic setting. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) zircon U-Pb dating yields a weighted mean age of 425 Ma, belonging to Middle Silurian, which is similar to the age of the post-collision geological events in the region. The differences of magmatic rocks in formation age, rocks assemblage and rocks series systematically indicate that the regional tectonic stress regime in the East Kunlun orogenic belt experienced a major transformation from compress to extension in Middle Silurianin, and the Helegangnaren feldspar granite intruded in the early stage of tectonic transformation. | LI Ruibao PEI Xianzhi LI Zhuochen SUN Yu PEI Lei CHEN Guochao CHEN Youxin LIU Chengjun WEI Fanghui | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 35 |
| 2 | Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China:insights from ERS-COVID-19 study显示文摘Dear Editor,A series of novel coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)since the end of 2019 is ongoing and triggering a global public health crisis.The estimated case fatality rate is approximately 3.4%in China.However,some patients experience dyspnea within 1 week and develop rapidly to organ injury and even death within 2 weeks after dyspnea.1 In addition,early organ injury could lead to higher risks of mortality.Thus,early identification of patients at risk of organ injury and death is crucial,which saves the patients from classified and invasive treatment,improving clinical outcome and prognosis.The human immune system plays significant roles in the resistance of foreign pathogens and the progress of pneumonia.Recent studies have mentioned that T cells were decreased in COVID-19 patients,excessive activated immune response was caused by pathogenic Th1 cells,and inflammatory CD14+CD16+monocytes may connect to pulmonary immunopathology,leading to deleterious clinical manifestations and even acute mortality after SARS-CoV-2 infections.2 SARS-CoV-2 might damage lymphocytes,especially T lymphocytes,and the immune system was impaired during the period of disease to cause tissue injury. | Dongze Li You Chen Hong Liu Yu Jia Fanghui Li Wei Wang Jiang Wu Zhi Wan Yu Cao Rui Zeng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 3 | Cuprous Oxide/Nitrogen-doped Graphene Nanocomposites as Electrochemical Sensors for Ofloxacin Determination显示文摘 | WU Fanghui XU Fan CHEN Le JIANG Binbin SUN Wenbin WEI Xianwen | 2016 | Chemical Research in Chinese Universities2016，32，3： | 3 |
| 4 | Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells显示文摘Regulatory B cells(Bregs)are a functionally defined B cell subset,and IL-10 is crucial for the suppressive functions of Bregs.However,little is known regarding how IL-10 production is regulated in B cells.To explore the mechanisms by which IL-10 is regulated in B cells,we used mRNA microarrays to screen for molecules that are upregulated in IL-10-producing B cells and identified RNA-binding motif protein 47(Rbm47)as a post-transcriptional regulator.Rbm47 was found to promote IL-10 production in B cells.We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′untranslated region of Il10 mRNA.In addition,we demonstrated that the overexpression of Rbm47 enabled B cells to facilitate Foxp3+regulator T-cell induction and reduce the severity of DSS-induced ulcerative colitis.Taken together,these results suggest that Rbm47 plays an important role in regulating IL-10 at the post-transcriptional level,thus promoting the regulatory functions of B cells.The findings presented in this study not only increase our understanding of the post-translational regulation of IL-10 in B cells but also identify a novel strategy for the potential application of Bregs. | Yinxiang Wei Fanghui Zhang Yu Zhang Xiaoqian Wang Chen Xing Jing Guo Hui Zhang Zhimin Suo Yan Li Jianli Wang Renxi Wang Zhijian Cai | 2019 | Cellular & Molecular Immunology2019，16，6： | 2 |
| 5 | Electrocatalytic oxidation of nitric oxide at multi-walled carbon nanotubes modified electrode显示文摘 | WU Fanghui ZHAO Guangchao WEI Xianwen | 2002 | Electrochemistry Communications2002，4，： | 1 |
| 6 | Electrocatalysis of tryptophan at multi-walled carbon nanotube modified electrode 显示文摘 | Wu Fanghui Zhao Guangchao Wei Xianwen | 2004 | Microchim Acta2004，144，4： | 1 |
| 7 | PI-3K mediated modulation of red light and resveratrol on high glucose induced dysfunctional myoblasts显示文摘 | LI Fanghui WEI Enxiu LIU Yanying | 2011 | Lasers Surg Med2011，43，23： | 1 |
| 8 | Electrocatalytic oxidation of nitric oxide at multi-walled carbon nanotubes modified electrode显示文摘 | WU Fanghui ZHAO Guangchao WEI Xianwen | 2002 | Electrochem Commun2002，4，： | 1 |
| 9 | Numerical study of underwater fate of oil spilled from deepwater blowout显示文摘 | Haibo Chen Wei An Yunxiang You Fanghui Lei Yupeng Zhao Jianwei Li | 2015 | Ocean Engineering2015，，： | 1 |
| 10 | Guidelines for cervical cancer screening in China显示文摘In response to the incidence of cervical intraepithelial neoplasia and cervical cancer in China and global screening strategies,a collaborative effort was undertaken by seven Chinese medical associations to develop this guideline for cervical cancer screening.The guideline recommends high-risk human papillomavirus(hr-HPV)testing as the preferred method for primary screening,which should have been approved by authoritative institutions and clinically validated for primary screening.In areas without access to HPV testing,cytology can be used as an alternative.However,it is recommended to replace cytology with HPV-based screening as conditions permit.Cotesting(HPV testing in combination with cytology)is recommended for areas with sufficient medical resources,opportunistic screening populations,and partial special populations.The guideline recommends that individuals with a cervix initiate cervical cancer screening at the age 25 years and undergo HPV testing alone or cotesting every five years,or cytology alone every three years.Women over the age of 65 who have had documented adequate negative prior screening in the past may terminate screening.Corresponding screening programs are proposed for different special populations.The development of these guidelines is an important step in the effort to eliminate cervical cancer in China. | Mingzhu Li Lihui Wei Long Sui Ding Ma Beihua Kong Xiaohua Wu Peng Wu Youlin Qiao Fanghui Zhao Linhong Wang | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，4： | 0 |
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