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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Gas desorption characteristics of the high-rank intact coal and fractured coal显示文摘The objective of this work is to study the gas desorption characteristics of the high-rank intact coal and fractured coal.The gas adsorption,mercury porosimetry and gas desorption experiments were carried out in this study.Then,the theories of thermodynamics,diffusion mechanism and desorption kinetics were used to estimate the gas desorption characteristics.The results of gas adsorption experiments show that the initial isosteric adsorption heat of the intact coal is greater than that of the fractured coal,indicating that the gas molecules desorb more easily from fractured coal than intact coal.Using the mercury porosimetry,we find that the diffusion channels of fractured coal are more developed than those of intact coal.The difficult diffusion form dominates in the intact coal during the gas diffusing,while the easy diffusion form dominates in the fractured coal.The results of gas desorption experiments show that the initial gas desorption volume and velocity of the fractured coal are both greater than those of the intact coal.Using the Fick diffusion law,the study calculates the gas diffusion coefficients of the intact coal and fractured coal.The diffusion coefficients of the fractured coal are 2 times and 10 times greater than those of the intact coal at the time of 0-120 and 0-10 min,respectively. | Lu Shouqing Cheng Yuanping Qin Liming Li Wei Zhou Hongxing Guo Haijun | 2015 | International Journal of Mining Science and Technology2015，25，5： | 15 |
| 3 | Algorithm for Smooth S-curve Feedrate Profiling Generation显示文摘The algorithms for feedrate profile generation,such as linear and S-curve profiles,have been widely used in machinery controllers,and these algorithms can greatly improve the smoothness of motion.However,most of the algorithms lead to the discontinuous acceleration/deceleration and jerk,or high jerk levels,which is very harmful to machine tool or robot in most occasions. This paper presents a smooth S-curve feedrate profiling generation algorithm that produces continuous feedrate,acceleration,and jerk profiles.Smooth jerk is obtained by imposing limits on the first and second time derivatives of acceleration,resulting in trapezoidal jerk profiles along the tool path.The discretization of smooth S-curve feedrate is realized with a novel approach that improves the efficiency without calculating the deceleration point in each sampled time.To ensure that the interpolation time is a multiple of the value of sampled time,the feedrate,acceleration,jerk,and jerk derivative are recalculated.Meantime,to improve the efficiency,the interpolation steps of all regions are computed before interpolation.According to the distance of trajectory,the smooth S-curve acceleration and decelerations are divided into three blocks:normal block,short block type-Ⅰ,and short block type-Ⅱ.Finally feedrate discretization of short block type-Ⅰand type-Ⅱis obtained with considering the efficiency.The proposed generation algorithm is tested in machining a part on a five axis milling machine,which is controlled with the CNC system for newly developed high-speed machine tools.The test result shows that the smooth S-curve approach has the smoother feedrate,acceleration,deceleration,and jerk profiles than S-curve.The proposed algorithm ensures the automated machinery motion smoothness,and improves the quality and efficiency of the automated machinery motion planning. | CHEN Youdong WEI Hongxing SUN Kai LIU Miao WANG Tianmiao | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 13 |
| 4 | Rice Male Development under Drought Stress: Phenotypic Changes and Stage-Dependent Transcriptomic Reprogramming显示文摘干旱影响米饭复制并且导致严重收益损失。在在干旱应力下面的繁殖纸巾的基因规定网络的发展缺点和变化大部分是未知的。在这研究,受到繁殖阶段干旱应力的米饭植物为花的开发和 transcriptomic 变化被检验。结果证明男富饶戏剧性地被影响,与在由于在水应力下面的异常花药开发的一样的圆锥花序的花的不同花粉生存能力。本地淀粉分发的检查表明那淀粉在强调水的植物的花药以位置和丰富反常地积累了。用不同尺寸的小花的 Microarray 分析识别了 > 1000 干旱应答的基因,其大多数明确地在仅仅或小花的二种特别尺寸被调整,建议发展阶段依赖者回答到干旱。知道涉及 tapetum 或小孢子开发,房间墙形成或扩大的基因,和淀粉合成在干旱比染色体一般水准影响的基因之中更经常被发现,当成熟分裂和疯盒子的基因不太经常被影响时。另外,与赤霉素酸发信号有关的小径和 abscisic 酸分解代谢是由干旱的 reprogrammed。我们的结果强烈在强调水的植物建议在繁殖开发,发信号的植物激素,和糖类新陈代谢之间的相互作用。 | Yue Jin Hongxing Yang Zheng Wei Hong Ma Xiaochun Ge | 2013 | Molecular Plant2013，6，5： | 11 |
| 5 | Applications of gold nanorods in biomedical imaging and related fields显示文摘Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered. | MA ZhiYa XIA HongXing LIU YuPing LIU Bo CHEN Wei ZHAO YuanDi | 2013 | Chinese Science Bulletin2013，58，21： | 6 |
| 6 | Siting of Dark Sky Reserves in China Based on Multi-source Spatial Data and Multiple Criteria Evaluation Method显示文摘With the rapid development of population and urbanization and the progress of lighting technology, the influence of artificial light sources has increased.In this context, the problem of light pollution has attracted wide attention.Previous studies have revealed that light pollution can affect biological living environments, human physical and mental health, astronomical observations and many other aspects.Therefore, organizations internationally have begun to advocate for measures to prevent light pollution, many of which are recognized by the International Dark-Sky Association(IDA).In addition to improving public awareness, legal protections, technical treatments and other means, the construction of Dark Sky Reserves(DSR) has proven to be an effective preventive measure.So far, as a pioneer practice in this field, the IDA has identified 11 DSRs worldwide.Based on the DA requirements for DSRs, this paper utilizes NPP-VIIRS nighttime light data and other multi-source spatial data to analyze possible DSR sites in China.The land of China was divided into more than ten thousand 30 km × 30 km fishnets, and constraint and suitable conditions were designated, respectively, as light and cloud conditions, and scale, traffic and attractiveness conditions.Using a multiple criteria evaluation, 1443 fishnets were finally selected as most suitable sites for the construction of DSRs.Results found that less than 25% of China is not subject to light pollution, and less than 13% is suitable for DSR construction, primarily in western and northern areas, including Tibet, Xinjiang, Qinghai, Gansu and Inner Mongolia. | WEI Ye CHEN Zuoqi XIU Chunliang YU Bailang LIU Hongxing | 2019 | Chinese Geographical Science2019，29，6： | 5 |
| 7 | Genetic Bottlenecks of the Wild Chinese Giant Salamander in Karst Caves显示文摘The rarity of limestone cave species due to habitat degradation makes them of special interest in conservation biology.The wild Chinese Giant Salamander Andrias davidianus,an evolutionarily distinct and globally endangered species,are nearly all obligate into living in inaccessible mountain caves now.We detected that only 14–29 breeders,with the effective population size of 9–25(5–44 of 95% confidence interval),were in each of three caves,through genotyping 20 microsatellite loci on larvae that were flushed out of caves.Both heterzygosity excess and M(ratios of allele number to allele size range) tests indicated severe genetic bottlenecks among populations.Both mitochondrial,with only one or two haplotypes of D-loop region(770–771bp) in each population,and nuclear genetic structure showed clear divergence between populations.Considering the long life history,small population size,and genetic differentiationof the Chinese Giant Salamander,putting an end to poaching and recovering the karst ecosystem instead of releasing may be the sole measures to save this severely threated species. | Jie WANG Hongxing ZHANG Feng XIE Gang WEI Jianping JIANG | 2017 | Asian Herpetological Research2017，18，3： | 3 |
| 8 | Surface-enhanced Raman scattering on dual-layer metallic gratingstructures显示文摘Dual-layer Metallic grating(DMG)structures as surface-enhanced Raman scattering(SERS)substrates are studied using benzenethiol as the probe analyte.The DMG structure consists of a SiO2 grating and 100-nm-thick gold coating layers.An enhancement factor of 105 is achieved by optimizing the SiO 2 grating height within the range from 165 to 550 nm.The enhancement factor dependence on the SiO2 grating height is due to the surface plasmon excitation,which is dependent on the polarization of the incident light,and confirmed by finite difference time domain simulations.This study demonstrates the advantages of high uniformity,reproducibility and sensitivity in the DMG structures for SERS applications. | GUAN ZhiQiang HAKANSON Ulf ANTTU Nicklas WEI Hong XU HongQi MONTELIUS Lars XU HongXing | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 9 | Optimal sizing method for stand-alone hybrid solar–wind system with LPSP technology by using genetic algorithm显示文摘 | Hongxing Yang Wei Zhou Lin Lu Zhaohong Fang | 2007 | Solar Energy2007，，4： | 3 |
| 10 | PARALLEL IMPLEMENTATION AND OPTIMIZATION OF THE SEBVHOS ALGORITHM显示文摘In this paper, a parallel Surface Extraction from Binary Volumes with Higher-Order Smoothness (SEBVHOS) algorithm is proposed to accelerate the SEBVHOS execution. The original SEBVHOS algorithm is parallelized first, and then several performance optimization techniques which are loop optimization, cache optimization, false sharing optimization, synchronization overhead op-timization, and thread affinity optimization, are used to improve the implementation's performance on multi-core systems. The performance of the parallel SEBVHOS algorithm is analyzed on a dual-core system. The experimental results show that the parallel SEBVHOS algorithm achieves an average of 1.86x speedup. More importantly, our method does not come with additional aliasing artifacts, com-paring to the original SEBVHOS algorithm. | Li Wen Guo Li Yuan Hongxing Wei Yifang Guan Hua | 2011 | Journal of Electronics(China)2011，28，3： | 2 |
| 11 | Self-assembly control and experiments in swarm modular robots显示文摘This paper presents a self-assembly control strategy for the swarm modular robots. Simulated and physical experiments are conducted based on the Sambot platform, which is a novel self-assembly modular robot having the characteristics of both the chain-type and the mobile self-reconfigurable robots. Multiple Sambots can autonomously move and connect with one another through self-assembly to form robotic organisms. The configuration connection state table is used to describe the configuration of the robotic structure. A directional self-assembly control model is proposed to perform the self-assembly experiments. The self-assembly process begins with one Sambot as the seed, and then the Docking Sambots use a behavior-based controller to achieve connection with the seed Sambot. The controller is independent of the target configuration. The seed and connected Sambots execute a configuration comparison algorithm to control the growth of the robotic structure. Furthermore, the simul- taneous self-assembly of multiple Sambots is discussed. For multiple configurations, self-assembly experiments are conducted in simulation platform and physical platform of Sambot. The experimental results verify the effectiveness and scalability of the self-assembly algorithms. | WEI HongXing LI HaiYuan TAN JinDong WANG TianMiao | 2012 | Science China(Technological Sciences)2012，55，4： | 2 |
| 12 | Preparation and characterization of highly active nanosized strontium-doped lanthanum cobaltate catalysts with high surface areas显示文摘La1?xSrxCoO3?δ (x=0, 0.4) nanoparticles have been prepared using the citric acid complex-ing-hydrothermal synthesis coupled method and citric acid complexing method. The physico-chemical properties of these materials were characterized by means of X-ray diffraction (XRD), high resolution scanning electron microscopy (HRSEM), element analysis (EDX), X-ray photoelectron spectroscopic (XPS), oxygen temperature-programmed desorption (O2-TPD), hydrogen temperature-programmed re-duction (H2-TPR) as well as surface area measure-ments and oxidation state titration. Their catalytic performance was examined for the total oxidation of ethylacetate (EA). It is found that the La1?xSrxCoO3?δ (x=0, 0.4) catalysts were single-phase and rhombo-hedrally-structured perovskites and their surface ar-eas ranged from 16 to 26 m2/g. The Sr-doped sample derived from the coupled procedure was uniformly distributed nanoparticles with a short rod-shaped morphology. The doping of Sr (i) enhanced the con-centrations of Co3+ and oxygen vacancies, (ii) in-creased the amount of oxygen adsorbed on the sur-face at low temperatures, (iii) promoted the mobility of lattice oxygen, and (iv) improved the properties of redox. The La0.6Sr0.4CoO2.78 catalyst prepared by the citric acid complexing-hydrothermal synthesis cou-pled strategy performed the best in the oxidation of EA, furthermore no partially oxidized products were formed. Based on the above results, we conclude that in addition to the surface area, the catalytic ac-tivity of the perovskite-type oxide nanoparticles was associated with the structural defect (oxygen vacancy) concentration and redox ability. | NIU Jianrong LIU Wei DAI Hongxing HE Hong Zl Xuehong LI Peiheng | 2006 | Chinese Science Bulletin2006，51，14： | 2 |
| 13 | Monitoring p21 mRNA expression in living cell based on molecular beacon fluorescence increasing rate显示文摘Studying the expression level of mRNA in living cells will offer tremendous opportunities for ad-vancement in cell biology research,disease diagnostics,and drug discovery.In this paper,a molecular beacon(MB)specific for the important tumor suppressor gene p21 has been designed and synthesized.The fluorescence signal was detected in real-time after the MB entered the cytoplasm of nasopharyn-geal carcinoma cells.After injecting the p21MB into nasopharyngeal carcinoma cell and p33-trans-fected nasopharyngeal carcinoma cell,the consistent increase of fluorescent signal intensity was de-tected in both cell lines,and maximum fluorescence intensity achieved in about 15 min.In about 4 min following microinjection,the fluorescence increasing rate was significantly different between these two cell lines,which indicate the different p21 mRNA expression levels.The results obtained in the real-time detection were also validated by RT-PCR.Analysis of the initial fluorescence increasing rate can effi-ciently reduce the side effect of enzyme and improve the accuracy in living cell mRNA detection. | TANG HongXing YANG XiaoHai WANG KeMin TAN WeiHong LIU Bin HE LiFang WANG Wei | 2008 | Chinese Science Bulletin2008，53，3： | 2 |
| 14 | Detection of Asymptomatic Carotid Artery Stenosis in High-Risk Individuals of Stroke Using a Machine-Learning Algorithm显示文摘Objective Asymptomatic carotid stenosis(ACS)is closely associated to the incidence of severe cerebrovascular diseases.Early identifying the individuals with ACS and its associated risk factors could be beneficial for primary prevention of stroke.This study aimed to investigate a machine-learning algorithm for the detection of ACS among high-risk population of stroke based on the associated risk factors.Methods A novel model of machine learning was utilized to screen the associated predictors of ACS based on 30 potential risk factors.The algorithm of this model adopted a random forest pattern based on the training data and then was verified using the testing data.All of the original data were retrieved from the China National Stroke Screening and Prevention Project(CNSSPP),including demographic,clinical and laboratory characteristics.The individuals with high risk of stroke were enrolled and randomly divided into a training group and a testing group at a ratio of 4:1.The identification of carotid stenosis by carotid artery duplex scans was set as the golden standard.The receiver operating characteristic(ROC)curve and the area under the curve(AUC)was used to evaluate the efficacy of the model in detecting ACS.Results Of 2841 high risk individual of stroke enrolled,326(11.6%)were diagnosed as ACS by ultrasonography.The top five risk fectors contributing to ACS in this model were identified as family history of dyslipidemia,high level of lowdensity lipoprotein cholesterol(LDL-c),low level of high-density lipoprotein cholesterol(HDL-c),aging,and low body. | Junxiong Yin Cheng Yu Lixia Wei Chuanyong Yu Hongxing Liu Mingyang Du Feng Sun Chongjun Wang Xiaoshan Wang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 2 |
| 15 | Battery behavior prediction and battery working states analysis of a hybrid solar-wind power generation system 显示文摘 | Zhou Wei Yang Hongxing Fang Zhaohong | 2008 | Renewable Energy2008，33，6： | 1 |
| 16 | A novel optimization sizing model for hybrid solar-wind power Generation system显示文摘 | Yang Hongxing Lu Lin Zhou Wei | 2007 | Solar Energy2007，81，1： | 1 |
| 17 | Optimal sizing method for stand-alone hybrid solar–wind system with LPSP technology by using genetic algorithm显示文摘 | Hongxing Yang Wei Zhou Lin Lu Zhaohong Fang | 2007 | Solar Energy2007，，4： | 1 |
| 18 | Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies显示文摘Whether Fanconi anemia(FA)heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting.We retrospectively analyzed rare possibly significant variations(PSVs)in the five most obligated FA genes,BRCA2,FANCA,FANCC,FANCD2,and FANCG,in 788 patients with aplastic anemia(AA)and hematologic malignancy.Sixty-eight variants were identified in 66 patients(8.38%).FANCA was the most frequently mutated gene(n=29),followed by BRCA2(n=20).Compared with that of the ExAC East Asian dataset,the overall frequency of rare PSVs was higher in our cohort(P=0.016).BRCA2 PSVs showed higher frequency in acute lymphocytic leukemia(P=0.038),and FANCA PSVs were significantly enriched in AA and AML subgroups(P=0.020;P=0.008).FA-PSV-positive MDS/AML patients had a higher tumor mutation burden,higher rate of cytogenetic abnormalities,less epigenetic regulation,and fewer spliceosome gene mutations than those of FA-PSV-negative MDS/AML patients(P=0.024,P=0.029,P=0.024,and P=0.013).The overall PSV enrichment in our cohort suggests that heterozygous mutations of FA genes contribute to hematopoietic failure and leukemogenesis. | Daijing Nie Jing Zhang Fang Wang Xvxin Li Lili Liu Wei Zhang Panxiang Cao Xue Chen Yang Zhang Jiaqi Chen Xiaoli Ma Xiaosu Zhou Qisheng Wu Ming Liu Mingyue Liu Wenjun Tian Hongxing Liu | 2022 | Frontiers of Medicine2022，16，3： | 1 |
| 19 | Adaptive filte-ring in phase space for fetal electrocardiogram estimationfrom an abdominal electrocardiogram signal and a thorac-ic electrocardiogram signal 显示文摘 | WEI Z HONGXING L JIANCHUN C | 2012 | IET Signal Processing2012，6，3： | 1 |
| 20 | Optimal siz- ing method for stand - alone hybrid solar - wind system with LPSP technology by using genetic algorithm显示文摘 | YANG Hongxing ZHOU Wei LU Lin | 2008 | So- lar Energy2008，82，4： | 1 |
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