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| 1 | GDNF-Enhanced Axonal Regeneration and Myelination Following Spinal Cord Injury is Mediated by Primary Effects on Neurons显示文摘我们先前研究表明胶质细胞源性神经营养因子(GDNF)联合施万细胞移植能促进脊髓损伤后轴突再生和髓鞘形成。然而,GDNF介导这一过程的细胞靶点尚不清楚。在此,我们报道了GDNF可增加在体再生轴突的数目和直径,并促进体外背根神经节神经元的轴突向外生长,提示GDNF对神经元有直接作用。在施万细胞-背根神经节神经元共培养下,GDNF显著增加施万细胞生成的髓鞘数目;GDNF处理对孤立培养的施万细胞增殖无作用,但可促进已与神经轴突有突触联系的施万细胞增殖;GDNF可增加孤立施万细胞中分子量为140kDa的神经细胞黏附分子(NCAM)的表达,但对黏附分子L1表达或神经营养因子NGF、NT3及BDNF分泌没有影响。总之,这些结果支持假设:GDNF提高轴突再生和施万细胞髓鞘形成主要是通过GDNF对神经元的直接作用介导的,并且提示GDNF联合施万细胞移植可能是促进脊髓损伤后轴突再生和髓鞘形成的有效策略之一。 | LIQUN ZHANG ZHENGWEN MA GEORGE M. SMITH XUEJUN WEN YELENA PRESSMAN PATRICK M. WOOD AND XIAO-MING XU | 2009 | 神经损伤与功能重建2009，4，4： | 25 |
| 2 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 3 | Physical design of target station and neutron instruments for China Spallation Neutron Source显示文摘The China Spallation Neutron Source(CSNS)is the first accelerator-based multidiscipline user facility to produce pulsed neutrons by tungsten target under collision of a pulsed proton beam with a beam power of 100 kW at a repetition rate of 25 Hz.In this paper,we focus on the physical design of CSNS target station and neutron instruments.Under optimized design,the flat tungsten target and the compact target-moderator-reflector coupling enhance effective cold and thermal neutron output from moderators.Three wing-type moderators supply four different characteristics of neutrons to 19 beamlines primarily for neutron scattering applications.Layout of neutron instruments are conceptually planned for total 20 beamlines,the configuration and specification have been determined for three day-one neutron instruments.All designs are optimized for the Phase I of 100 kW with a upgradable capacity to 500 kW. | WANG FangWei LIANG TianJiao YIN Wen YU QuanZhi HE LunHua TAO JuZhou ZHU Tao JIA XueJun ZHANG ShaoYing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 7 |
| 4 | 氮沉降模拟实验亟待研究大气氨浓度增加的影响显示文摘大气活性氮污染及其过量沉降是全球变化重要议题。为研究氮沉降对自然生态系统结构和功能的影响,基于喷淋加氮的控制实验在草地或林下广泛开展。该实验体系假定氮沉降是通过增加土壤氮的有效性从而影响整个生态系统,没有考虑植被与大气活性氮的相互作用,也未能反映氮沉降以干沉降为主的自然过程。考虑到大气氨是氮沉降的主要前体物,且全球氨气浓度呈现上升趋势,未来的氮沉降模拟实验亟待研究氨气干沉降的重要影响,以期更加完整的刻画大气氮沉降过程及其生态环境效应。 | PAN Yuepeng TIAN Shili WU Dianming XU Wen ZHU Xiaying LIU Chunyan LI Dejun FANG Yunting DUAN Lei LIU Xuejun WANG Yuesi | 2020 | Atmospheric and Oceanic Science Letters2020，13，3： | 5 |
| 5 | Atmospheric deposition of inorganic nitrogen in a semi-arid grassland of Inner Mongolia, China显示文摘Due to increasing global demand for crop production and energy use, more and more reactive nitrogen(Nr) has been generated and emitted to the environment. As a result, global atmospheric nitrogen(N) deposition has tripled since the industrial revolution and the ecological environment and human health have been harmed. In this study, we measured dry and wet/bulk N deposition from July 2013 to December 2015 in a semi-arid grassland of Duolun County, Inner Mongolia, China. The samples of dry and wet/bulk N deposition were collected monthly with a DELTA(DEnuder for Long Term Atmospheric sampling) system and with Gradko passive samplers and a precipitation gauge. The measured results show that the annual mean concentrations of NH_3, NO_2, HNO_3, particulate NH_4^+(pNH_4^+) and particulate NO_3^-(pNO_3^-) in atmosphere were 2.33, 1.90, 0.18, 1.42 and 0.42 μg N/m3, respectively, and that the annual mean volume-weighted concentrations of NH_4^+-N and NO_3^--N in precipitation were 2.71 and 1.99 mg N/L, respectively. The concentrations of Nr components(including NH_3, NO_2, HNO_3, p NH_4^+, pNO_3^-, NH_4^+-N and NO_3^--N) exhibited different seasonal variations. Specifically, NO_2 and HNO_3 exhibited higher concentrations in autumn than in summer, while the other Nr components(NH_3, pNH_4^+, pNO_3^-, NH_4^+-N and NO_3^--N) showed the highest values in summer. Based on measured concentrations of Nr components and their deposition velocities estimated using the GEOS-Chem global atmospheric chemical transport model, the calculated annual mean dry deposition fluxes were 3.17, 1.13, 0.63, 0.91 and 0.36 kg N/(hm^2·a) for NH_3, NO_2, HNO_3, p NH_4^+ and pNO_3^-, respectively, and the calculated annual mean wet/bulk deposition fluxes were 5.37 and 3.15 kg N/(hm^2·a) for NH_4^+-N and NO_3^--N, respectively. The estimated annual N deposition(including dry N deposition and wet/bulk N deposition) reached 14.7 kg N/(hm^2·a) in grassland of Duolun County, approaching to the upper limit of the N critical load(10–15 kg N/(hm^2·a)). Dry and wet/bulk deposition fluxes of all Nr components(with an exception of HNO_3) showed similar seasonal variations with the maximum deposition flux in summer and the minimum in winter. Reduced Nr components(e.g., gaseous NH_3 and p NH_4^+ in atmosphere and NH_4^+-N in precipitation) dominated the total N deposition at the sampling site(accounted for 64% of the total N deposition), suggesting that the deposited atmospheric Nr mainly originated from agricultural activities. Considering the projected future increases in crop and livestock production in Inner Mongolia, the ecological and human risks to the negative effects of increased N deposition could be increased if no mitigation measures are taken. | ZHANG Yibo XU Wen WEN Zhang WANG Dandan HAO Tianxiang TANG Aohan LIU Xuejun | 2017 | Journal of Arid Land2017，9，6： | 5 |
| 6 | Laminin-coated multifilament entubulation, combined with Schwann cells and glial cell line-derived neurotrophic factor, promotes unidirectional axonal regeneration in a rat model of thoracic spinal cord hemisection显示文摘Biomaterial bridging provides physical substrates to guide axonal growth across the lesion.To achieve efficient directional guidance,combinatory strategies using permissive matrix,cells and trophic factors are necessary.In the present study,we evaluated permissive effect of poly(acrylonitrile-co-vinyl chloride)guidance channels filled by different densities of laminin-precoated unidirectional polypropylene filaments combined with Schwann cells,and glial cell line-derived neurotrophic factor for axonal regeneration through a T10 hemisected spinal cord gap in adult rats.We found that channels with filaments significantly reduced the lesion cavity,astrocytic gliosis,and inflammatory responses at the graft-host boundaries.The laminin coated low density filament provided the most favorable directional guidance for axonal regeneration which was enhanced by co-grafting of Schwann cells and glial cell line-derived neurotrophic factor.These results demonstrate that the combinatorial strategy of filament-filled guiding scaffold,adhesive molecular laminin,Schwann cells,and glial cell line-derived neurotrophic factor,provides optimal topographical cues in stimulating directional axonal regeneration following spinal cord injury.This study was approved by Indiana University Institutional Animal Care and Use Committees(IACUC#:11011)on October 29,2015. | Ling-Xiao Deng Nai-Kui Liu Ryan Ning Wen Shuang-Ni Yang Xuejun Wen Xiao-Ming Xu | 2021 | Neural Regeneration Research2021，16，1： | 4 |
| 7 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 8 | A green eco-environment for sustainable development:framework and action显示文摘Following its 40-year reform and‘Open Door’policy,China has recently proposed a new approach to green development and rural revitalization—the idea of Agriculture Green Development(AGD),with the key feature of creating a green eco-environment.In this minireview we introduce the definition,theory,framework and major components of a green eco-environment as a key part of the AGD.We define a green eco-environment as including four key elements or measures:(1)a green ecoenvironmental indicator system;(2)environmental monitoring and warning networks;(3)emission standards and environmental thresholds for key pollutants;(4)emission controls and pollution remediation technologies.We have used Quzhou County(a typical county in the center of the North China Plain)as an example to show how detailed air,water and soil monitoring networks,as well as improved farmer practices and pollution control measures(especially ammonia emission mitigation and PM2.5 pollution reduction),can begin to create a green eco-environment in China and that AGD is possible.We conclude by stressing the need to improve the framework and practice for a green eco-environment,especially the importance of linking proposals and practices for a green eco-environment with the United Nations high priority Sustainable Development Goals. | Xuejun LIU Wen XU Zhipeng SHA Yangyang ZHANG Zhang WEN Jingxia WANG Fusuo ZHANG Keith GOULDING | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 3 |
| 9 | Relationship Between Perisylvian Essential Language Sites and Arcuate Fasciculus in the Left Hemisphere of Healthy Adults显示文摘Essential language sites and the arcuate fasciculus(AF) have been extensively researched. However, the relationship between them remains insufficiently studied,especially in healthy people. Navigated transcranial magnetic stimulation(n TMS) is increasingly used in language mapping. While enjoying the advantage of non-invasiveness, it is also capable of inducing a virtual lesion in the brain. Thus, it offers the possibility of using the virtuallesion method to study the healthy brain. This study combined n TMS and diffusion tensor imaging(DTI)tractography to investigate the relationship between essential language sites and the AF in 30 healthy right-handedvolunteers. A total of 143 essential language sites were identified using n TMS, and a total of 175 AF terminations were identified using DTI tractography. Sixty-six sites had a direct correlation with the AF, accounting for 46% of the total essential language sites. Forty-seven AF terminations harbored essential language sites, accounting for 27% of the total AF terminations. Upon data rendering to the cortical parcellation system, a region-related heterogeneity of the correlation rate was found. This study provides the first data on the relationship between essential language sites and the AF in healthy adults. | Yu Lin Kai Zhang Shuai Li Song Li Jingna Jin Fang Jin Wen Qin Long Hai Meng Zhu Chunshui Yu Zhipeng Liu Tao Yin Xuejun Yang | 2017 | Neuroscience Bulletin2017，33，6： | 3 |
| 10 | Plant growth,antioxidative enzyme,and cadmium tolerance responses to cadmium stress in Canna orchioides显示文摘The cadmium tolerance capacity of Canna orchioides was evaluated using glasshouse experiment to lay a theoretical foundation to broad applications of this species in cadmium(Cd)polluted areas.The plant growth,Cd absorption,and antioxidative enzyme activities of canna plants treated with different Cd concentrations(0,100,and 200mg·kg^(-1)per dry soil)for 30 days were investigated.The results indicated that the growth of roots,leaves and stems was restricted following Cd addition.The bio-concentration factor was the highest in the roots,followed by the leaves,rhizomes,and stems.Compared with the control,the translocation factor decreased sharply after 100mg·kg^(-1)or 200mg·kg^(-1)Cd treatment,whereas the tolerance index decreased significantly under 200mg·kg^(-1)Cd exposure.The Cd accumulation rate and total Cd accumulation significantly increased under 200mg·kg^(-1)Cd treatment than the control.Themalondialdehyde content remained unchanged at different Cd concentrations,while the relative electrical conductivity of the root increased significantly following 200mg·kg^(-1)Cd treatment.Cd stress increased significantly the activity of superoxide dismutase(SOD),peroxidase(POD),and ascorbate peroxidase(APX)in the leaves,whereas only SOD was raised in the roots.The catalase(CAT)and POD activity in the roots did not differ significantly at different Cd concentrations.Conversely,APX in the roots decreased significantly under Cd stress,which suggests that the protective mechanisms in the leaves differ from those in the roots.These results indicated that C.orchioides has a high tolerance for Cd.Furthermore,the reactive oxygen species caused by Cd stress could be effectively scavenged by the antioxidative system.The present study proved that C.orchioides constitutes a promising ornamental plant for use in the restoration of areas contaminated with Cd. | Wen’e Zhang Xuejun Pan Qian Zhao Ting Zhao | 2021 | Horticultural Plant Journal2021，7，3： | 3 |
| 11 | Enhancement of cooperation between file systems and applications — VFS extensions for optimized performance显示文摘Modern operating systems incorporate an abstract layer called Virtual File System(VFS), which is positioned between user applications and real file systems to hide the differences of various file systems and to expose generic application interfaces for requesting file system services. However, VFS sometimes does not give applications an opportunity to pass information to file systems to help them make correct optimization decisions. In this paper, we review the Linux VFS, discuss its deficiencies and propose several extensions to allow applications to cooperate with the file systems more efficiently. We introduce simple prefetching interfaces and advisory flags to allow applications to communicate application-related semantics to VFS and/or the underlying file systems. These suggestions, which neither affect the semantics of applications nor modify their programming models, not only lead to simple VFS/file systems but also guide them to make correct performance-related decisions, if required. We demonstrate that these interfaces and flags are also easy to implement and can boost application performance by up to 4.29 X. | WANG Li LIAO XiangKe XUE JingLing WEIL Sage WEN YunChuan YANG XueJun | 2015 | Science China(Information Sciences)2015，58，9： | 2 |
| 12 | PM_(2.5)and water-soluble inorganic ion concentrations decreased faster in urban than rural areas in China显示文摘We investigated variations of PM_(2.5)and water-soluble inorganic ions chemical characteristics at nine urban and rural sites in China using ground-based observations.From 2015 to 2019,mean PM_(2.5)concentration across all sites decreased by 41.9μg/m~3with a decline of 46%at urban sites and 28%at rural sites,where secondary inorganic aerosol(SIAs)contributed to 21%(urban sites)and 17%(rural sites)of the decreased PM_(2.5).SIAs concentrations underwent a decline at urban locations,while sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),and ammonium(NH_(4)^(+))decreased by 49.5%,31.3%and 31.6%,respectively.However,only SO_(4)^(2–)decreased at rural sites,NO_(3)^(–)increased by 21%and NH_(4)^(+)decreased slightly.Those changes contributed to an overall SIAs increase in 2019.Higher molar ratios of NO_(3)^(–)to SO_(4)^(2–)and NH_(4)^(+)to SO_(4)^(2–)were observed at urban sites than rural sites,being highest in the heavily polluted days.Mean molar ratios of NH_(3)/NH_xwere higher in 2019 than 2015 at both urban and rural sites,implying increasing NH_xremained as free NH_(3).Our observations indicated a slower transition from sulfate-driven to nitrate-driven aerosol pollution and less efficient control of NO_(x)than SO_(2)related aerosol formation in rural regions than urban regions.Moreover,the common factor at urban and rural sites appears to be a combination of lower SO_(4)^(2–)levels and an increasing fraction of NO_(3)^(–)to PM_(2.5)under NH_(4)^(+)-rich conditions.Our findings imply that synchronous reduction in NO_(x)and NH_(3)emissions especially rural areas would be effective to mitigate NO_(3)^(–)-driven aerosol pollution. | Yangyang Zhang Aohan Tang Chen Wang Xin Ma Yunzhe Li Wen Xu Xiaoping Xia Aihua Zheng Wenqing Li Zengguo Fang Xiufen Zhao Xianlong Peng Yuping Zhang Jian Han Lijuan Zhang Jeffrey L.Collett Jr Xuejun Liu | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 13 | 有序PCL支架的制备与对细胞的定向生长作用显示文摘利用静电纺丝技术制备了有序和无序聚己内酯(PCL)纤维支架。通过扫描电镜(SEM)、X射线衍射(XRD)和万能试验机对支架结构与形态、结晶性能及力学性能进行了表征;将体外培养的细胞接种至支架表面,用激光共聚焦显微镜(LSCM)和SEM观察了细胞在支架表面的生长情况。研究结果表明,电纺丝得到的纤维直径均一,有序化纤维支架中86.14%的纤维沿着确定方向有序排列;有序纤维拉伸强度为(27.63±0.75)MPa,比无序纤维的拉伸强度增大了232%。弹性模量基本不变,断裂伸长率明显降低;有序纤维对细胞的定向生长具有良好的引导作用。 | 李红 郭振招 Li Xiaowei Liu Xiaoyan Wen Xuejun 薛博 | 2012 | 高分子材料科学与工程2012，28，10： | 2 |
| 14 | Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes显示文摘Vulnerable atherosclerotic plaques are responsible for most cardiovascular diseases(CVDs).Folate receptor(FR)positive activated macrophages were thought to be a prominent component in the development of vulnerable plaque.The objective of this study is to develop folate conjugated two-dimensional(2D)Pd@Au nanomaterials(Pd@Au-PEG-FA)for targeted multimodal imaging of the FRs in advanced atherosclerotic plaques.Pharmacokinetic and imaging studies(single photon emission computed tomography(SPECT),computed tomography(CT)and photoacoustic(PA)imaging)were performed to confirm the prolonged blood half-life and enrichment of radioactivity in atherosclerotic plaques.Strong signals were detected in vivo with SPECT,CT and PA imaging in heavy atherosclerotic plaques,which were significantly higher than those of the normal aortas after injection of Pd@Au-PEG-FA.Blocking studies with preinjection of excess FA could effectively reduce the targeting ability of Pd@Au-PEG-FA in atherosclerotic plaques,further demonstrating the specific binding of Pd@Au-PEG-FA for plaque lesions.Histopathological characterization revealed that the signal of probe was in accordance with the high-risk plaques.In summary,the Pd@Au-PEG-FA has favorable pharmacokinetic properties and provides a valuable approach for detecting high-risk plaques in the presence of FRs in atherosclerotic plaques. | Zhide Guo Liu Yang Mei Chen Xuejun Wen Huanhuan Liu Jingchao Li Duo Xu Yuanyuan An Changrong Shi Jindian Li Xinhui Su Zijing Li Ting Liu Rongqiang Zhuang Nanfeng Zheng Haibo Zhu Xianzhong Zhang | 2020 | Nano Research2020，13，1： | 2 |
| 15 | A NEW APPROACH TO HOLISTIC NITROGEN MANAGEMENT IN CHINA显示文摘Since the 1980s,the widespread use of N fertilizer has not only resulted in a strong increase in agricultural productivity but also caused a number of environmental problems,induced by excess reactive N emissions.A range of approaches to improve N management for increased agricultural production together with reduced environmental impacts has been proposed.The 4R principles(right product,right amount,right time and right place)for N fertilizer application have been essential for improving crop productivity and N use efficiency while reducing N losses.For example,site-specific N management(as part of 4R practice)reduced N fertilizer use by 32%and increased yield by 5%in China.However,it has not been enough to overcome the challenge of producing more food with reduced impact on the environment and health.This paper proposes a new framework of food-chainnitrogen-management(FCNM).This involves good N management including the recycling of organic manures,optimized crop and animal production and improved human diets,with the aim of maximizing resource use efficiency and minimizing environmental emissions.FCNM could meet future challenges for food demand,resource sustainability and environmental safety,key issues for green agricultural transformation in China and other countries. | Xuejun LIU Zhenling CUI Tianxiang HAO Lixing YUAN Ying ZHANG Baojing GU Wen XU Hao YING Weifeng ZHANG Tingyu LI Xiaoyuan YAN Keith GOULDING David KANTER Robert HOWARTH Carly STEVENS Jagdish LADHA Qianqian LI Lei LIU Wim DE VRIES Fusuo ZHANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 2 |
| 16 | Polymer nanofibrous structures :Fabrication, biofunctionalization, and cell interactions显示文摘 | Beachley Vince Wen Xuejun | 2010 | Progress inPolymer Science2010，35，7： | 1 |
| 17 | Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model显示文摘 | Jianmei Cai Zhimin Kang Wen Wu Liu Xu Luo Sun Qiang John H. Zhang Shigeo Ohta Xuejun Sun Weigang Xu Hengyi Tao Runping Li | 2008 | Neuroscience Letters2008，，2： | 1 |
| 18 | Effect of power density on the properties of μc-Si:H deposited by VHF-PECVD 显示文摘 | Guo Xuejun Lu Jingxiao Wen shutang | 2008 | Chinese journal of semiconductors2008，29，6： | 1 |
| 19 | Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro显示文摘 | Lauren Shor Sel?uk Gü?eri Xuejun Wen Milind Gandhi Wei Sun | 2007 | Biomaterials2007，，35： | 1 |
| 20 | Tissue-engineering approaches for axonal guidance显示文摘 | Ning Zhang Honghai Yan Xuejun Wen | 2004 | Brain Research Reviews2004，，1： | 1 |
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