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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 3 | Species Richness, Diversity and Density of Understory Vegetation along Disturbance Gradients in the Himalayan Conifer Forest显示文摘We investigated whether species richness, diversity and density of understory herbaceous plants differed along logging(gap) and grazing(primarily by cattle) disturbance gradients, and sought to identify drivers of richness, diversity and density of understory vegetation of logged sites. A factorial experiment was conducted in the mixed conifer forest of Gidakom in Western Bhutan. Levels of the logging treatment included small(0.15 – 0.24 ha), medium(0.25 – 0.35 ha) and large(0.36 – 1.31 ha) gaps. The grazing treatment included grazed(primarily by cattle) and ungrazed(where herbivores were excluded by a fence) plots nested within each gap. Data were collected from 12 gaps(4 replicates at each level of logging) using the point intercept method. Shannon Weaver Diversity and Margalef's indices were used to estimate species diversity and describe species richness, respectively. Soil samples were analyzed for pH and nutrients. The interaction effect of logging and grazing was significant(p≤0.001) only on species diversity. Relative to ungrazed areas, species diversity was significantly higher(0.01≤p≤0.05) in medium grazed gaps. Under grazed conditions, soil P was negatively correlated with gap size and species diversity. While species diversity was positivelycorrelated(0.01≤p≤0.05) with soil N in grazed plots species richness was positively correlated(0.001≤p≤0.01) with soil N in ungrazed plots. Relative density of Yushania microphylla and Carex nubigena were higher under ungrazed conditions. Our study suggests that the combined effect of cattle grazing and logging results in higher species diversity of understory vegetation in medium and grazed gaps in mixed conifer forests of Bhutan,whereas increase or decrease in relative density of major species is determined primarily by the independent effects of grazing and logging. From management perspective, forest managers must refrain from creating large gaps to avoid loss of nutrients(mainly P and N), which may eventually affect tree regeneration. Managers intending to maintain understory vegetation diversity must consider the combined effects of grazing and logging, ensuring low to moderate grazing pressure. | Kesang WANGCHUK András DARABANT Prem Bahadur RAI Maria WURZINGER Werner ZOLLITSCH Georg GRATZER | 2014 | Journal of Mountain Science2014，11，5： | 2 |
| 4 | Intravenous transfusion of endothelial progeni- tor cells reduces neointima formation after vaseular injury显示文摘 | Werner N Junk S Lads U | 2003 | Cite Res2003，93，2： | 1 |
| 5 | Keratinocyte growth factor:a unique player in epithelial repair processes显示文摘 | Werner S | 1998 | Cytokine Growth Factor Rev1998，9，2： | 1 |
| 6 | Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease显示文摘 | WERNER N WASSMANN S AHLERS P | 2007 | Basic Res Cardiol2007，102，6： | 1 |
| 7 | Large induction keratinocyte growth of factor expression in the dermis during woun healing显示文摘 | Werner S Peters KG Longaker MT | 1992 | Proc Natl Acad U S A1992，89，15： | 1 |
| 8 | An auto polyploidy-based genetic algorithm for enhanced evolution of linear polyfractal arrays 显示文摘 | PETKO J S WERNER D H | 2007 | IEEE Trans on Antenas and Propagation2007，55，3： | 1 |
| 9 | Impact of age onthe relationships of brown adipose tissue with sex and adiposity inhumans显示文摘 | Pfannenberg C Werner MK Ripkens S | 2010 | Diabetes2010，59，7： | 1 |
| 10 | A novel hybrid seed sys- tem for plants显示文摘 | GILS M MARILLONNET S WERNER S | 2008 | Plant Biotechnol2008，6，3： | 1 |
| 11 | Ciculating endothelial progenitor cells and cardiovascular outcomes显示文摘 | Werner N Kosiol S Schiegl T | | 0，，： | 1 |
| 12 | Regulation of wound healing by growth factors and cytokines显示文摘 | Werner S Grose R | 2003 | Physiol Rev2003，83，3： | 1 |
| 13 | Treadmill training with partial body weight support after stroke显示文摘 | Hesse S Werner C von Frankenberg S et a/ | 2003 | Phy Med Rehabil Clin N Am2003，，1： | 1 |
| 14 | A positive geno-type-phenotype correlation in a large cohort of patientswith Pseudohypoparathyroidism Type Ia and Pseudo-pseudohypoparathyroidism and 33 newly identified muta-tions in the GNAS gene显示文摘 | Thiele S Werner R Grotzinger J | 2015 | Mol Genet Genomic Med2015，3，2： | 1 |
| 15 | Synthesis and haemolytic activity of oleanolic acid trisaccharides显示文摘 | Robert W Johann J | 1999 | Monatshefte fur Chemie Chemical Monthly1999，130，： | 1 |
| 16 | Functionalcharacterization of GNAS mutations found in patientswith pseudohypoparathyroidism type Ic defines a newsubgroup of pseudohypoparathyroidism affecting Gsα-receptor interaction显示文摘 | Thiele S de Sanctis L Werner R | 2011 | Hum Mutat2011，32，6： | 1 |
| 17 | Toxicity of methyl-tert-butyl ether to freshwater organism 显示文摘 | Werner I Koger C S Deanovic L A | 2001 | Environmental Pollution2001，111，： | 1 |
| 18 | The Textile and Clothing Industry in the EU-A Survey 显示文摘 | Werner S | 2001 | Enterprise Papers2001，，2： | 1 |
| 19 | Intravenous transfusion of endothelial progenitor cells reduced neointima formation after vascular injury显示文摘 | Werner N Junk S Laufs U | 2003 | Circ Res2003，93，2： | 1 |
| 20 | Influences on Strategic Decision-making in the Dutch Financial Services Industry显示文摘 | Brouthers K.D Brouthers L.E Werner S | | 0，，： | 1 |
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