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| 1 | Physical activity as a treatment of non-alcoholic fatty liver disease:A systematic review显示文摘AIM: To review the effectiveness of exercise as a therapy for nonalcoholic fatty liver disease(NAFLD) and potential benefits in treating insulin resistance and atherosclerosis.METHODS: Medline(EBSCOhost) and Pub Med were searched for English-language randomized controlled trials and prospective cohort studies in human adults aged ≥ 18 which investigated the various effects of exercise alone, a combination of exercise and diet, or exercise and diet coupled with behavioral modification on NAFLD from 2010 to Feburary 2015.RESULTS: Eighteen of 2298 available studies were chosen for critical review, which included 6925 patients. Nine(50%) studies were randomized controlled trials. Five(27.8%) studies utilized biopsy to examine the effects of physical activity on hepatic histology. The most commonly employed imaging modality to determine change in hepatic steatosis was hydrogen-magnetic resonance spectroscopy. Only two studies examined the effects of low impact physical activity for patients with significant mobility limitations and one compared the efficacy of aerobic and resistance exercise. No studies examined the exact duration of exercise required for hepatic and metabolic improvement in NAFLD.CONCLUSION: While exercise improved hepatic steatosis and underlying metabolic abnormalities in NAFLD, more studies are needed to define the most beneficial form and duration of exercise treatment. | Maureen Whitsett Lisa B VanWagner | 2015 | World Journal of Hepatology2015，7，16： | 281 |
| 2 | 实验性单纯疱疹性角膜炎的免疫组织化学研究显示文摘目的 研究单纯疱疹Ⅰ型病毒 (HSV 1)感染后疾病的严重性与宿主遗传因素的关系 ;分析HSV 1感染后小鼠角膜中炎症细胞的亚群分布 ;检测角膜三层细胞中病毒抗原的表达及其临床意义。方法 以单克隆抗体和常规组织学技术作免疫组织化学研究。结果 HSV 1感染后疾病取决于宿主的遗传因素 ,在角膜基质炎中 ,T细胞对引发疾病起主导作用 ,炎症细胞的数量与抗原量相关 ,病毒抗原沉积于角膜三层细胞 ,而BLAB/c中的频率 ( 71%~ 10 0 % )高于C5 7BL/ 6( 11%~ 5 6% )。结论 实验性单纯疱疹性角膜基质炎的严重性取决于宿主的遗传因素 :在引发角膜基质炎过程中 ,T细胞起主导作用 ;基质层为HSV 1最主要沉积场所 。 | 朱志忠 Abghari Shahla Z Stulting R.Doyle Whitsett Carolyn F | 1999 | 眼科研究1999，17，5： | 3 |
| 3 | Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide svnthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution 显示文摘 | Whitsett J Martasek P Zhao H | 2006 | Free Radio Biol Med2006，40，11： | 1 |
| 4 | Sensitivity and specificity of helical computed tomtgraphy in the diagnosis of pulmonary embolism: a systematic review 显示文摘 | Rathbun SW Raskob GE Whitsett TL | 2000 | Ann Intern Med2000，132，： | 1 |
| 5 | Regulation of surfactant protein gene transcription显示文摘 | Whitsett JA Glasser SW | 1998 | Biochim Biophys Acta1998，1408，23： | 1 |
| 6 | LPS - induced lung inflammation显示文摘 | Harrod KS Mounday AD Whitsett JA | 2000 | Am J Physiol Lung Cell Mol Physiol2000，278，7： | 1 |
| 7 | Hydrophobic surfactant proteinsin lung function and diseade显示文摘 | Whitsett JA Weaver TE | 2002 | N Engl J Med2002，347，： | 1 |
| 8 | Elevated expression ofFn14 in nonsmall cell lung cancer correlates with activatedEGFR and promotes tumor cell migration and invasion显示文摘 | Whitsett TG Cheng E Inge L | 2012 | Am JPathol2012，181，1： | 1 |
| 9 | Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung显示文摘 | LeVine AM Whitsett JA Gwozdz JA | 2000 | J Immunol2000，165，7： | 1 |
| 10 | The ratio be tween tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study显示文摘 | Vasquez Vivar J Martasek P Whitsett J | 2002 | Biochem J2002，，： | 1 |
| 11 | In defense of the lung:surfactant protein A and surfactant protein D显示文摘 | KINGMA P S WHITSETT J A | | 0，，03： | 1 |
| 12 | Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo显示文摘 | Hayashida S Harrod KS Whitsett JA | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，3： | 1 |
| 13 | Regulation and function of CCSP during pulmonary pseudomonas aeruginosa infection in vivo 显示文摘 | Hayashida S Harrod KS Whitsett JA | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，3： | 1 |
| 14 | Surfactant protein D enhances clearance of influenza A virus from the lung in vivo显示文摘 | LeVine AM Whitsett JA Hartshorn KL | 2001 | J Immunol2001，167，10： | 1 |
| 15 | Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus 显示文摘 | LeVine AM Elliott J Whitsett JA | 2004 | Am J Respir Cell Mol Biol2004，31，2： | 1 |
| 16 | Function and regulation of expression of pulmonary surfactant-associated proteins显示文摘 | Weaver TE Whitsett JA | 1991 | Biochem J1991，273，2： | 1 |
| 17 | Uterine deletion of Gpl30 or Stat3 shows implantation failure with increased estrogenic responses显示文摘 | Sun X Bartos A Whitsett JA | 2013 | Mol Endocrinol2013，27，9： | 1 |
| 18 | Purification of a cell surface receptor for surfactant protein A显示文摘 | Chroneos ZC Abdolrasulnia R Whitsett JA | 1996 | J Biol Chem1996，271，16： | 1 |
| 19 | Sensitivity and specificity of helical computed tomography in the diagnosis of pulmonary embolism: A systematic review显示文摘 | Raskob GE Whitsett TL | 2000 | Ann Intern Med2000，132，3： | 1 |
| 20 | Sensitivity and specificity of helical computed tomography in the diagnosis of pulmonaryembolism:A systematic review显示文摘 | Rathbun SW Raskob GE Whitsett TI | 2000 | Ann Intern Med2000，132，6： | 1 |
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