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| 1 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 2 | Determination of organic acids in Vaccinium berry standard reference materials显示文摘 | Phillips M M Case R J Rimmer C A Sander L C Sharpless K E Wise S A Yen J H | 2010 | Analytical and Bioanalytical Chemistry2010，398，1： | 1 |
| 3 | Effects of Positive end-expiratory pressure on the canine venous return curve 显示文摘 | FESSLER H E BROWER R G WISE R A | 2003 | Am Rev Respir Dis2003，146，1： | 1 |
| 4 | Choosing between Professionalism and Amateurism显示文摘 | WISE A E | 1994 | The Education Forum1994，58，： | 1 |
| 5 | The ehemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor显示文摘 | MEISER A MUELLER A WISE E L | 2008 | J Immunol2008，180，67： | 1 |
| 6 | Interaction of ventral and orbital prefrontal cortex with inferotemporal cortex in conditional visuomotor learning显示文摘 | Bussey T J Wise S P Murray E A | 2002 | Behav Neurosci2002，116，4： | 1 |
| 7 | A wetlandaquifer interaction test显示文摘 | Wise W R Annable M D Walser J A E | 2000 | Journal of Hydrology2000，227，： | 1 |
| 8 | Mobile sources of atmospheric polycyclic aromatic hydrocarbons:a road-way tunnel study显示文摘 | Benner B A Gordon G E Wise S A | 1989 | Environmental Science & Technology1989，23，： | 1 |
| 9 | IL-12 enhances CTL synapse formation and induces self-reactivity 显示文摘 | Markiewicz M A Wise E L Buchwald Z S | 2009 | J Immunol2009，182，3： | 1 |
| 10 | Stability of passively modelocked lasers with fast saturable absorbers显示文摘 | SERGEEV A M VANIN E V WISE F W | 1997 | Opt Commun1997，140，： | 1 |
| 11 | Mobile sources of atmospheric polycyclic aromatic hydrocarbons: A roadway tunnel study 显示文摘 | Jr Benner B A Gordon G E Wise S A | 1989 | Environmental Science & Technology1989，23，10： | 1 |
| 12 | T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival显示文摘 | Theodoropoulos G Wise W E Padmanabhan A | 2002 | Dis Colon Rectum2002，45，7： | 1 |
| 13 | Establishing Teaching as a Profession:The Essential Role of Professional Accreditation Journal显示文摘 | | 2005 | Journal of Teacher Education2005，，4： | 1 |
| 14 | Teacher Evaluation in the Organizational Context: A Review of the Literature 显示文摘 | Darling-Hammond L Wise A E Pease S R | 1983 | Review of Educational Research1983，53，3： | 1 |
| 15 | Hair loss after routineimmunizations 显示文摘 | Wise RP Katonga PK Salive E/\A | 1997 | JAMA1997，278，14： | 1 |
| 16 | Identification and comparison of low-molecular-weight neutral constituents in two different coal extracts显示文摘 | CHANG H-C K NISHIOKA M BARTLE K D WISE S A BAYONAJ M MARKlDES K E LEE M L | 1988 | Fuel1988，67，1： | 1 |
| 17 | The role of ventral and orbital prefrontal cortex in conditional visuomotor learning and strategy use in rhesus monkeys ( Macaca mulatta) 显示文摘 | Bussey T J Wise S P Murray E A | 2001 | Behav Neurosci2001，115，5： | 1 |
| 18 | Long QT syndrome and anaesthesia显示文摘 | WISELY N A SHIPTON E A | 2002 | Eur J Anaesthesiol2002，19，12： | 1 |
| 19 | Pre-existing psychiatric disorders,psychological reactions to stress and the recovery of burn survivors显示文摘 | WISELY J A WILSON E DUNCAN R T | 2010 | Burns2010，36，2： | 1 |
| 20 | Synthesis and character- ization of PbSe quantum dots in phosphate glass 显示文摘 | LIPOVSKII A KOLOBKOVA E PETRIKOV V KANG I OLKHOVETS A KRAUSS T THOMAS M SILCOX J WISE F SHEN Q KYCIA S | 1997 | Applied Physics Letters1997，71，34： | 1 |
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