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| 1 | Causal relationship between hypoalbuminemia and acute kidney injury显示文摘Our meta-analysis published in 2010 provided evidence that low levels of serum albumin(hypoalbuminemia) are a significant independent predictor of acute kidney injury(AKI) and death following AKI.Since then,a large volume of additional data from observational clinical studies has been published further evaluating the relationship between serum albumin and AKI occurrence.This is an updated review of the literature to re-evaluate the hypothesis that hypoalbuminemia is independently associated with increased AKI risk.Eligible studies published from September 2009 to December 2016 were sought in PubM ed(MEDLINE) and forty-three were retained,the great majority being retrospective observational cohort studies.These included a total of about 68000 subjects across a diverse range of settings,predominantly cardiac surgery and acute coronary interventions,infectious diseases,transplant surgery,and cancer.Appraisal of this latest data set served to conclusively corroborate and confirm our earlier hypothesis that lower serum albumin is an independent predictor both of AKI and death after AKI,across a range of clinical scenarios.The body of evidence indicates that hypoalbuminemia may causally contribute to development of AKI.Furthermore,administration of human albumin solution has the potential to prevent AKI;a randomized,controlled study provides evidence that correcting hypoalbuminemia may be renal-protective.Therefore,measurement of serum albumin to diagnose hypoalbuminemia may help identify high-risk patients who may benefit from treatment with exogenous human albumin.Multi-center,prospective,randomized,interventional studies are warranted,along with basic research to define the mechanisms through which albumin affords nephroprotection. | Christian J Wiedermann Wolfgang Wiedermann Michael Joannidis | 2017 | World Journal of Nephrology2017，6，4： | 15 |
| 2 | Management of borderline and locally advanced pancreatic cancer:Where do we stand?显示文摘Many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic laparoscopy.The definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of LAPC.For the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal vein.When feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 resection.For initially unresectable LAPC,neoadjuvant should be strongly considered.Specifically,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual resection.The efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with radiation.This review focuses on patients with LAPC and addresses recent advances and controversies in the field. | Jin He Andrew J Page Matthew Weiss Christopher L Wolfgang Joseph M Herman Timothy M Pawlik | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 3 | Design,delivery and efficacy testing of therapeutic nucleic acids used to inhibit hepatitis C virus gene expression in vitro and in vivo显示文摘Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are | Wolfgang H.Caselmann Matthias Serwe Thomas Lehmann János Ludwig Brian S.Sproat Joachim W.Engels | 2000 | World Journal of Gastroenterology2000，6，5： | 9 |
| 4 | Agenesis of the dorsal pancreas显示文摘During the last 100 years in medical literature,there are only 54 reports,including the report of Pasaoglu et al(World J Gastroenterol 2008;14:2915-2916),with clinical descriptions of agenesis of the dorsal pancreas in humans.Agenesis of the dorsal pancreas,a rare congenital pancreatic malformation,is associated with some other medical conditions such as hyperglycemia,abdominal pain,pancreatitis and a few other diseases.In approximately 50% of reported patients with this congenital malformation,hyperglycemia was demonstrated.Evaluation of hyperglycemia and diabetes mellitus in all patients with agenesis of the dorsal pancreas including description of fasting blood glucose,oral glucose tolerance test,glycated hemoglobin and medical treatment would be a future goal.Since autosomal dominant transmission has been suggested in single families,more family studies including imaging technologies with demonstration of the pancreatic duct system are needed for evaluation of this disease.With this letter to the editor,we aim to increase available information for the better understanding of this rare disease. | Wolfgang J Schnedl Claudia Piswanger-Soelkner Sandra J Wallner Robert Krause Rainer W Lipp | 2009 | World Journal of Gastroenterology2009，15，3： | 7 |
| 5 | 睾丸主要血管或睾丸网旁取精点与取精成功率不具显著相关性:以220例非梗阻性无精子症患者行传统或显微睾丸取精术为例显示文摘采用传统与显微睾丸取精术相结合方式对220例梗阻性无精症患者行精子提取术,如果传统手术方式未见精子即为阴性取精位点,然后选取2—3个阴性取精位点行显微睾丸取精术。术中通过手术显微镜评价睾丸血管系统,同时记录阳性取精位点与睾丸血供的关系。总的精子获取率为58-2%,早期应用传统手术方式精子获取率为46.8%,而后行显微睾丸取精术则精子获取率增加11.7%。故显微睾丸取精术的应用可显著增加精子获取率(P=0.017),且在睾丸网或睾丸主要血管处并不能显著增加阳性取精位点。 | J Ullrich Schwarzer Heiko Steinfatt Heiko Steinfatt Manfred Schleyer Frank M Kōhn Klaus Fiedler2, Irene von Hertwig Gottfried Krüsmann Wolfgang Würfel | 2013 | Asian Journal of Andrology2013，15，6： | 5 |
| 6 | Transepithelial transport of putrescine across monolayers of the human intestinal epithelial cell line, Caco-2显示文摘AIM To study the transepithelial transport characteristics of the polyamine putrescine in human intestinal Caco-2 cell monolayers to elucidate the mechanisms of the putrescine intestinal absorption.METHODS The transepithelial transport and the cellular accumulation of putrescine was measured using Caco 2 cell monolayers grown on permeable filters.RESULTS Transepithelial transport of putrescine in physiological concentrations (>0.5 mM)from the apical to basolateral side was linear. Intracellular accumulation of putrescine was higher in confluent than in fully differentiated Caco-2 cells, but still negligible (less than 0.5%) of the overall transport across the monolayers in apical-to-basolateral direction. EGF enhanced putrescine accumulation in Caco-2 cells by four-fold, as well as putrescine conversion to spermidine and spermine by enhancing the activity of Sadenosylmethionine decarboxylase. However,EGF did not have any significant influence on putrescine flux across the Caco-2 cell monolayers. Excretion of putrescine from Caco-2cells into the basolateral medium did not exceed 50 picomoles, while putrescine passive flux from the apical to the basolateral chamber,contributed hundreds of micromoles polyamines to the basolateral chamber.CONCLUSION Transepithelial transport of putrescine across Caco-2 cell monolayers occurs in passive diffusion, and is not influenced when epithelial cells are stimulated to proliferate by a potent mitogen such as EGF. | Vladan Milovic Lyudmila Turchanowa Jürgen Stein Wolfgang F.Caspary | 2001 | World Journal of Gastroenterology2001，7，2： | 5 |
| 7 | Analysis of the human Atox 1 homologue in Wilson patients显示文摘AIM: To analyze the metallochaperone antioxidant-1 (Atox1) gene sequence in Wilson disease patients. METHODS: Mutation analysis of the four exons of the Atox1 gene including the intron- exon boundaries was performed in 63 Wilson disease patients by direct sequencing. RESULTS: From 63 selected patients no mutations were identified after the entire coding region including the intron- exon boundaries of Atox1 were sequenced. One known polymorphism within the Atox1 gene (5’UTR -99 T>C) in 31 (49%) of the Wilson patients as well as one previously undescribed variation (5’UTR -68 C>T) in 2 of the Wilson patients could be detected. Statistical analyses revealed that the existence of a variation within the Atox1- gene showed a tendency towards an earlier onset of the disease. CONCLUSION: Based on the data of this study, no major role can be attributed to Atox1 in the pathophysiology or clinical variation of Wilson disease. | Isabel Simon Mark Schaefer Jürgen Reichert Wolfgang Stremmel | 2008 | World Journal of Gastroenterology2008，14，15： | 4 |
| 8 | Effects of sleep bruxism on functional and occlusal parameters:a prospective controlled investigation显示文摘This study was conducted to verify the results of a preceding retrospective pilot study by means of a prospective controlled investigation including a larger sample size.Therefore,the aim of this clinical investigation was to analyze the relationship between sleep bruxism and several functional and occlusal parameters.The null hypothesis of this study was that there would be no differences among sleep bruxism subjects and non-sleep bruxism controls regarding several functional and occlusal parameters.Fifty-eight sleep bruxism subjects and 31 controls participated in this study.The diagnosis sleep bruxism was based on clinical criteria of the American Academy of Sleep Medicine.Sixteen functional and occlusal parameters were recorded clinically or from dental study casts.Similar to the recently published retrospective pilot study,with a mean slide of 0.77 mm(s.d.,0.69 mm) in the sleep bruxism group and a mean slide of 0.4 mm(s.d.,0.57 mm) in the control group,the evaluation of the mean comparison between the two groups demonstrated a larger slide from centric occlusion to maximum intercuspation in sleep bruxism subjects(Mann-Whitney U-test;P50.008).However,following Bonferroni adjustment,none of the 16 occlusal and functional variables differed significantly between the sleep bruxism subjects and the non-sleep bruxism controls.The present study shows that the occlusal and functional parameters evaluated do not differ between sleep bruxism subjects and non-sleep bruxism subjects.However,as the literature reveals a possible association between bruxism and certain subgroups of temporomandibular disorders,it appears advisable to incorporate the individual adaptive capacity of the stomatognathic system into future investigations. | Michelle Alicia Ommerborn Maria Giraki Christine Schneider Lars Michael Fuck Jrg Handschel Matthias Franz Wolfgang Hans-Michael Raab Ralf Schfer | 2012 | International Journal of Oral Science2012，4，3： | 4 |
| 9 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 10 | The proximal femoral nail (PFN) - a minimal invasive treatment of unstable proximal femoral fractures: A prospective study of 55 patients with a follow-up of 15 months显示文摘 | Christian Boldin Franz J Seibert Florian Fankhauser Gerolf Peicha Wolfgang Grechenig Rudolf Szyszkowitz | 2003 | Acta Orthopaedica2003，，1： | 2 |
| 11 | Differential Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by S-Ketamine and Clonidine in Humans显示文摘 | Wolfgang Koppert Reinhard Sittl Karin Scheuber Monika Alsheimer Martin Schmelz Jürgen Schüttler | 2003 | Anesthesiology2003，，1： | 2 |
| 12 | Perceptual watermarks for digital images and video显示文摘 | Wolfgang R B PODICHUK C I DELP E J | | 0，，： | 2 |
| 13 | A new direction in effective accounting for the atmospheric CO2 budget: Considering the combined action of carbonate dissolution, the global water cycle and photosynthetic uptake of DIC by aquatic organisms显示文摘 | Liu Z H Wolfgang D Wang H J | 2010 | Earth-Science Reviews2010，99，： | 1 |
| 14 | Selenium redox biochemistry of zinc - sulfur co- ordination sites in proteins and enzymes显示文摘 | Claus J wolfgang M Bert V | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 15 | Prognostic significance of an increased number of micrometastatic tumor cells in the bone marrow of patients with first recurrence of breast carcinoma显示文摘 | Wolfgang J Stephan G Christina K | 2000 | Cancer2000，88，10： | 1 |
| 16 | Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells显示文摘 | Matthias L Wolfgang J Michael F | 2001 | Circ Res2001，89，： | 1 |
| 17 | Neurotopographic considerations in microsurgical treatment of small acoustic neurimomas显示文摘 | Wolfgang TK J diaz D Christian M | 1998 | Neurosurg1998，88，4： | 1 |
| 18 | Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis显示文摘 | Hideyuki Kojima Anne T Nies J?rg K?nig Wolfgang Hagmann Herbert Spring Masahito Uemura Hiroshi Fukui Dietrich Keppler | 2003 | Journal of Hepatology2003，，5： | 1 |
| 19 | Three dimensional flow structures and vorticity control in fish-like swimming显示文摘 | ZHU Q WOLFGANG M J YUE D K P | 2002 | Journal of flu- id mechanics2002，488，： | 1 |
| 20 | Safety,pharmacokinetics and pharmacodynamics of GS-9620,an oral Toll-like receptor 7 agonist显示文摘 | Lopatin U Wolfgang G Tumas D Frey CR Ohmstede C Hesselgesser J Kearney B Moorehead L Subramanian G M McHutchison J G | 2013 | Antivir Ther2013，18，3： | 1 |
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