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| 1 | Status monitoring and health assessment of Luhuitou fringing reef of Sanya, Hainan, China显示文摘The monitoring survey and health assessment for benthic community were carried out in Luhuitou fringing reef of Sanya, Hainan, China in 2002. Monitoring survey included manta tow, line intercept transect, video transect and digital photograph. The mean live coral cover was 23.40%. Comparison of used monitoring methods showed that video transect can replace line intercept transect, and 50 m transect is better than 20 m transect in uneven coral region. Survey data and comparison with previous research work showed that Luhuitou fringing reef has been damaged severely and has a general declining trend with live coral cover from about 85% in the 1960s down to 20% in 2004, but it still has quite high biodiversity and therefore has special protection value. Main factors of Luhuitou fringing reef declining were human activities including reef rock digging and curios collecting, destructive fishing, sediment and pollutant from coastal land, and recent marine aquaculture. Only strengthening integrated management can reach improvement and restoration of Luhuitou declining coral reef ecosystem. | ZHANG Qiaomin SHI Qi CHEN Gang FONG T C W WONG D C C HUANG Hui WANG Hankui ZHAO Meixia | 2006 | Chinese Science Bulletin2006，51，B12： | 15 |
| 2 | 残余应力导致三层聚烯烃管道防腐层剥离与开裂显示文摘这是美国运输部发起的研究项目,一个管道防腐层专家团队参与了本研究项目,评价了三层聚烯烃管道外防腐涂层(3LPO)的完整性。研究表明,三层聚烯烃管道外防腐涂层(3LPO)存在剥离和面层开裂两大完整性问题。过去几年里,据文献报道,三层聚烯烃管道外防腐涂层(3LPO)的熔结环氧粉末(FBE)底漆与钢管界面上发生多起防腐层剥离事故,以及聚丙烯(PP)面层发生开裂事故。这些防腐层事故引起人们对使用三层聚烯烃管道外防腐涂层(3LPO)的关注。一般来讲,三层聚烯烃管道外防腐涂层(3LPO)采用比较厚的聚烯烃面层增强防腐层抗机械损伤和防止水渗透的能力。但是,聚烯烃的热膨胀系数比钢材高得多,结果在防腐层系统里产生比较高的残余热应力。因为残余应力高,造成防腐层剥离,尤其在管端截短防腐层和任何防腐层的边上,因为这些是高应力集中部位。特别是假如钢管表面预处理不当,就无法保证防腐层持久达到很强的粘合强度。如果熔结环氧粉末(FBE)底漆配方选择不当,发生热氧化降解,也导致防腐层过早失效。如果使用温度很高,聚丙烯也会因为热氧化降解而变脆。在残余应力下,这样脆性的聚丙烯面层就会开裂。本文分析了三层聚烯烃管道外防腐涂层(3LPO)中的残余应力,并且探讨了残余应力对三层聚烯烃管道外防腐涂层(3LPO)剥离和聚丙烯(PP)面层开裂机理的影响。 | B.T.A.Cheng S Hung-jue J Han D Wong A Kehr M Mallozzi F Aguirre H Pham W Snider 王向农(译) | 2011 | 防腐保温技术2011，19，3： | 3 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 5 | Focus: Rainfall prediction model using soft computing technique显示文摘 | Wong K W Wong P M C_ edeon T D | 2003 | Soft Computing2003，7，6： | 1 |
| 6 | TGF-beta regates the blood testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway : an in vivo study显示文摘 | Lui W Y Wong C H Mruk D D | 2003 | Endocrinology2003，14，41： | 1 |
| 7 | An Intemet-enabled integrated system for co-design and concurrent engineering显示文摘 | LI W D FUH J Y H WONG Y S | 2004 | Computer in Industry2004，55，1： | 1 |
| 8 | Enhanced Multi-Line Code for Minutiae-Based Fingerprint Template Protection 显示文摘 | Wong W J Teoh A B J Wong M L D | 2013 | Pattern Recognition Letters2013，34，11： | 1 |
| 9 | PhaseⅡstudy of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma显示文摘 | CHUA D T WEI W I WONG M P | 2008 | Head Neck2008，30，： | 1 |
| 10 | Inhibition of heterocyclic amine formation by water-soluble vitamins in Maillard reaction model systems and beef patties显示文摘 | Wong D Cheng K W Wang M | | 0，，03： | 1 |
| 11 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 12 | An efficient chaotic image encryption algorithm based on a generalized Arnold map显示文摘 | Ye G D Wong K W | 2012 | Nonlinear Dynamics2012，69，4： | 1 |
| 13 | Assessment of the air quality in indoor car parks显示文摘 | Wong Y C Sin D W M Yeung L L | 2002 | Indoor and Built Enviment2002，11，3： | 1 |
| 14 | Creep properties of aged duplex stainless steels containing σ phase 显示文摘 | Shek C H Li D J Wong K W | 1999 | Mater Sci Eng A1999，266，12： | 1 |
| 15 | A review of the techniques for the preparation of biological samples for mass spectrometric measurements of H^2/H^1 and O^18/O^16 isotope ratios 显示文摘 | Wong W W Klein P D | 1986 | Mass Spectrometry Reviews1986，5，： | 1 |
| 16 | Cone-beam-CT guided radiation therapy: technical implementation 显示文摘 | Letourneau D Wong J W Oldham M | 2005 | Radiother Oncol2005，75，3： | 1 |
| 17 | A decision support system for environmental effects monitoring显示文摘 | Booty W G Wong I Lam D | | Environment Model- ling Software0，24，： | 1 |
| 18 | Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex 显示文摘 | Zhang W Perry K W Wong D T | 2000 | Neuropsychopharmacology2000，23，3： | 1 |
| 19 | Quantitative analysis of lincomycin in animal tissues and bovine milk by liquid chromatography electrospray ionization tandem mass spectrometry显示文摘 | SIN D W M WONG Y C IPB A C | | 0，，03： | 1 |
| 20 | Trends of ambient carbonyl compounds in the urban environment of Hong Kong显示文摘 | Sin D W M Wong Y C Louie P K K | 2001 | Atmospheric Environment2001，35，34： | 1 |
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