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| 1 | Relationship between age at diagnosis and outcome of premenopausal breast cancer: age less than 35?years is a reasonable cut-off for defining young age-onset breast cancer显示文摘 | Wonshik Han So Young Kang | 2010 | Breast Cancer Research and Treatment2010，，1： | 1 |
| 2 | Endoscopic Thyroidectomy for Thyroid Malignancies: Comparison with Conventional Open Thyroidectomy显示文摘 | Yoo Seung Chung Jun-Ho Choe Kyung-Ho Kang Seok Won Kim Ki-Wook Chung Kyoung Sik Park Wonshik Han Dong-Young Noh Seung Keun Oh Yeo-Kyu Youn | 2007 | World Journal of Surgery2007，，12： | 1 |
| 3 | Endoscopic Thyroidectomy Using a New Bilateral Axillo-Breast Approach显示文摘 | Jun-Ho Choe MD Seok Won Kim MD Ki-Wook Chung MD Kyoung Sik Park MD Wonshik Han MD Dong-Young Noh MD Seung Keun Oh MD Yeo-Kyu Youn MD | 2007 | World Journal of Surgery2007，，3： | 1 |
| 4 | Fibrin glue reduces the duration of lymphatic drainage after lumpectomy and level Ⅱ or Ⅲ maxillary lymph node dissection for breast cancer:a prospective randomized trial 显示文摘 | Eunyoung Ko Wonshik Han Jihyoung Cho | 2009 | J Korean Med Sci2009，2，： | 1 |
| 5 | Relationship between age at diagnosis and outcome of premenopausal breast cancer: age less than 35 years is a reasonable cut-off for defining young age-onset breast cancer显示文摘 | Wonshik Han So Young Kang | 2010 | Breast Cancer Research and Treatment2010，，1： | 1 |
| 6 | Medical and psychosocial considerations in the treatment of young breast cancer patients显示文摘Although advances in early detection and treatment have made breast cancer more a chronic illness rather than a death sentence,breast cancer remains a dreaded experience for women.A diagnosis of breast cancer can lead to serious psychosocial problems since this disease can have a devastating impact on women’s sexual function | Min Kyoon Kim Wonshik Han | 2015 | 中华乳腺病杂志(电子版)2015，9，5： | 1 |
| 7 | Clinical signif- icance of Annexin A1 expression in breast cancer显示文摘 | Cha Kyong Yom Wonshik Han Sung-Won Kim | 2011 | J Breast Canc- er2011，14，4： | 1 |
| 8 | Preoperative serum tissue polypeptide‐specific antigen is a valuable prognostic marker in breast cancer显示文摘 | Soo Kyung Ahn Hyeong‐Gon Moon Eunyoung Ko Han Suk Kim Hee‐Chul Shin Jisun Kim Jee Man You Wonshik Han Dong‐Young Noh | 2012 | Int J Cancer2012，，4： | 1 |
| 9 | Young age: an independent risk factor for disease - free survival in women with operable breast cancer显示文摘 | Wonshik Han Seok Won Kim In Ae Park | 2004 | BMC cancer2004，4，： | 1 |
| 10 | Endoscopic Thyroidectomy for Thyroid Malignancies: Comparison with Conventional Open Thyroidectomy显示文摘 | Yoo Seung Chung Jun-Ho Choe Kyung-Ho Kang Seok Won Kim Ki-Wook Chung Kyoung Sik Park Wonshik Han Dong-Young Noh Seung Keun Oh Yeo-Kyu Youn | 2007 | World Journal of Surgery2007，，12： | 1 |
| 11 | Endoscopic Thyroidectomy for Thyroid Malignancies: Comparison with Conventional Open Thyroidectomy显示文摘 | Yoo Seung Chung Jun-Ho Choe Kyung-Ho Kang Seok Won Kim Ki-Wook Chung Kyoung Sik Park Wonshik Han Dong-Young Noh Seung Keun Oh Yeo-Kyu Youn | 2007 | World Journal of Surgery2007，，12： | 1 |
| 12 | Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement显示文摘 | Kyoung-Mu Lee Ji-Yeob Choi Jong Eun Lee Dong-Young Noh Sei-Hyun Ahn Wonshik Han Keun-Young Yoo Richard B. Hayes Daehee Kang | | Breast Cancer Research and Treatment0，，： | 1 |
| 13 | Young age:an independent risk factor for disease-free survival in women with operable breast cancer显示文摘 | Wonshik Han Seok Won Kim In Ae Park | 2004 | Br Med Cancer2004，4，： | 1 |
| 14 | Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity显示文摘Genetic information is transcribed from genomic DNA to mRNA,which is then translated into threedimensional proteins.mRNAs can undergo various post-transcriptional modifications,including RNA editing that alters mRNA sequences,ultimately affecting protein function.In this study,RNA editing was identified at the 499th base(c.499)of human vaccinia-related kinase 2(VRK2).This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine(with adenine base)to valine(with guanine base).Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2,which leads to an increase in tumor cell proliferation.Earlier we reported that VRK2 directly interacts with dystrobrevin-binding protein(dysbindin)and results in reducing its stability.Herein,we demonstrate that isoleucine-containing VRK2 decreases the level of dysbindin than valinecontaining VRK2.Dysbindin interacts with cyclin D and thereby regulates its expression and function.The reduction in the level of dysbindin by isoleucine-containing VRK2 further enhances the cyclin D expression,resulting in increased tumor growth and reduction in survival rates.It has also been observed that in patient samples,VRK2 level was elevated in breast cancer tissue compared to normal breast tissue.Additionally,the isoleucine form of VRK2 exhibited a greater increase in breast cancer tissue.Therefore,it is concluded that VRK2,especially dependent on the 167th variant amino acid,can be one of the indexes of tumor progression and proliferation. | SEUNG-HEE GWAK JUHYUN LEE EUNJI OH DOHYUN LEE WONSHIK HAN JONGMIN KIM KYONG-TAI KIM | 2024 | Oncology Research2024，32，2： | 0 |
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