|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 自发性脑出血管理指南 美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索,检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见,采用美国心脏协会/美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南,重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。 | J. Claude Hemphill Ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok Mary Cushman Gordon L. Fung Joshua N. Goldstein R. LochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, Daniel Woo 高圆圆 徐欣 | 2015 | 国际脑血管病杂志2015，23，10： | 444 |
| 2 | Effect of trapping vascular endothelial growth factor-A in a murine model of dry eye with inflammatory neovascularization显示文摘·AIM: To evaluate whether trapping vascular endothelial growth factor-A(VEGF-A) would suppress angiogenesis and inflammation in dry eye corneas in a murine corneal suture model.·METHODS: We established two groups of animals, one with non-dry eyes and the other with induced dry eyes.In both groups, a corneal suture model was used to induce inflammation and neovascularization. Each of two groups was again divided into three subgroups according to the treatment; subgroup I(aflibercept),subgroup II(dexamethasone) and subgroup III(phosphate buffered saline, PBS). Corneas were harvested and immunohistochemical staining was performed to compare the extents of neovascularization and CD11b+ cell infiltration. Real-time polymerase chain reaction was performed to quantify the expression of inflammatory cytokines and VEGF-A in the corneas.·RESULTS: Trapping VEGF-A with aflibercept resulted in significantly decreased angiogenesis and inflammation compared with the dexamethasone and PBS treatments in the dry eye corneas(all P <0.05), but with no such effects in non-dry eyes. The anti-inflammatory and antiangiogenic effects of VEGF-A trapping were stronger than those of dexamethasone in both dry eye and non-dry eye corneas(all P <0.05). The levels of RNA expression of VEGF-A, TNF-alpha, and IL-6 in the aflibercept subgroup were significantly decreasedcompared with those in the PBS subgroup in the dry eye group.·CONCLUSION: Compared with non-dry eye corneas,dry eye corneas have greater amounts of inflammation and neovascularization and also have a more robust response to anti-inflammatory and anti-angiogenic agents after ocular surface surgery. Trapping VEGF-A is effective in decreasing both angiogenesis and inflammation in dry eye corneas after ocular surface surgery. | Jin Woo Kwon Jin A Choi Eun Young Shin Tae Yoon La Dong Hyun Jee Yeon Woong Chung Yang Kyung Cho | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 5 |
| 3 | Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer显示文摘AIM: To determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer.METHODS: Hematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and 5 cases indefinite for lymph node metastases. Lymph node metastases were divided into ITC s, micrometastases, or macrometastases, according to the sizes of tumor deposits in largest dimension. ITCs were further classified into four groups according to metastasis pattern.RESULTS: Lymph node metastases were identified by immunostaining in 58 of 280 node-negative cases (20.7%)and were not significantly associated with patient survival (P = 0.3460). After cytokeratin immunostaining, 196 cases were classified as pN1, which consisted of 20 cases with micrometastases detected by immunostaining (pN1mi(i+)),34 cases with only micrometastases (pN1mi), and 142 cases with pN1 with one or more macrometastases (pN1).Cases with pN1mi and pN1mi(i+) had a significantly better prognosis than the cases with pN1 (P = 0.0037). ITCs were found in 38 of these 58 cases, and could be divided into four groups: 12 cases with only a single cell pattern,7 cases with multiple individual cells, 5 cases with single small cluster, and 14 cases with multiple small clusters.Among these four groups, cases with ITCs of multiple individual cell pattern showed the worst survival (median survival: 28 mo, P<0.0001).CONCLUSION: Both size and pattern of lymph node metastases can give prognostic information on the survival of gastric cancer patients. | Hye Seung Lee Min A Kim Han-Kwang Yang Byung Lan Lee Woo Ho Kim | 2005 | World Journal of Gastroenterology2005，11，38： | 5 |
| 4 | Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model显示文摘AIM: To compare the effects of the surgical insult of cataract surgery on corneal inflammatory infiltration,neovascularization(NV) and lymphangiogenesis(LY)between the dry eye and non-dry eye in murine cataract surgery models.·METHODS: We established two groups of animals, one with normal eyes(non-dry eye) and the second with induced dry eyes. In both groups, we used surgical insults to mimic human cataract surgery, which consisted of lens extraction, corneal incision and suture.After harvesting of corneas on the 9th postoperative day and immunohistochemical staining, we compared NV, LY and CD11b+ cell infiltration in the corneas.· RESULTS: Dry eye group had significantly more inflammatory infiltration(21.75%±7.17% vs 3.65%±1.49%;P =0.049). The dry eye group showed significantly more NV(48.21% ±4.02% vs 26.24% ±6.01%; P =0.016) and greater levels of LY(9.27%±0.48% vs 4.84%±1.15%; P =0.007). In corneas on which no surgery was performed,there was no induction of NV in both the dry and non-dry group, but dry eye group demonstrated more CD11b+cells infiltration than the non-dry eye group(0.360% ±0.160% vs 0.023% ±0.006%; P =0.068). Dry eye group showed more NV than non-dry eye group in both topical PBS application and subconjunctival PBS injection(P =0.020 and 0.000, respectively).·CONCLUSION: In a murine cataract surgery model,preexisting dry eye can induce more postoperative NV,LY, and inflammation in corneal tissue. | Jin Woo Kwon Yeon Woong Chung Jin A Choi Tae Yoon La Dong Hyun Jee Yang Kyung Cho | 2016 | International Journal of Ophthalmology(English edition)2016，9，2： | 5 |
| 5 | Fibroblast growth factor receptor 2 gene amplification status and its clinicopathologic significance in gastric carcinoma显示文摘 | Eun-Jung Jung Eun-Ji Jung Sun Young Min Min A Kim Woo Ho Kim | 2012 | Human Pathology2012，，10： | 3 |
| 6 | Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer显示文摘 | Nam Kyung Han Lee Byung Lan Park Joo Hyun Kim Jin Han Nayoung Lee Hee Eun Kim Min A Lee Hye Seung Kim Woo Ho | 2012 | Pathobiology2012，，2： | 2 |
| 7 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 8 | 对急性心肌梗塞病人的临床处理显示文摘在过去十年中,医护人员目睹了急性心梗病人临床处理的一场革命。急性心梗病人的治疗与护理已从单一的缓解措施,如控制疼痛及症状,发展到在急性病程中采取积极的干预,消除或减少心肌损伤。 | Woo M A 张慧红 陈虹 刘美良 | 1993 | 国外医学(护理学分册)1993，12，3： | 2 |
| 9 | Reconstruction for renal artery aneurysm: Operative techniques and long-term results显示文摘 | Jong A H Young K W | 2003 | J Vas Surg2003，37，2： | 1 |
| 10 | Treatment re- suits of sinonasal inverted papilloma: an 18-year study 显示文摘 | Sham C L Woo J K van Hasselt C A | 2009 | Am J Rhinol Allergy2009，23，2： | 1 |
| 11 | System architecture di- rections for networked sensors显示文摘 | Hill J Szewczyk R Woo A | 2000 | ACM SIGPLAN Notices2000，，11： | 1 |
| 12 | Entrepreneurs' perceived chance of success 显示文摘 | Cooper A C Woo C Y Dunkelberg W C | 1988 | Journal of Bus- iness Venturing1988，3，3： | 1 |
| 13 | Public health significance of the frailty index 显示文摘 | Woo J Goggins W Sham A | 2006 | Disabil Rehabil2006，28，8： | 1 |
| 14 | Development of a new measurement unit (MilkSpec-Ⅰ) for rapid determination of fat, lactose, and protein in raw milk using near-infrared transmittance spectroscopy显示文摘 | WOO Y A TERAZAWA YOKO CHEN J Y | 2002 | Applied Spectroscopy2002，56，5： | 1 |
| 15 | Effect of chromi- um on the corrosion behavior of low-alloy steels con- taining copper in FGD environment显示文摘 | PARK S A WOO S J JUNG G K | 2013 | Int J Electro- chem Sci2013，8，： | 1 |
| 16 | Diastolic myocardial me-chanics in hypertrophic cardiomyopathy显示文摘 | Carasso S Yang H Woo A | 2010 | J Am Soc Echo-cardiogr2010，23，2： | 1 |
| 17 | Response of the Ca- nadian permafrost environment to climatic change显示文摘 | Woo M K Lewkowicz A G Rouse W R | 1992 | Physical Geography1992，13，4： | 1 |
| 18 | Biflavonoids are superior to monoflavonoids in inhibiting amyloid-P toxicity andfibrillogenesis via accumulation of nontoxic oligomer-like structures显示文摘 | Thapa A Woo ER Chi EY | 2011 | Biochemistry2011，50，13： | 1 |
| 19 | Fries Re- arrangement of Acetanilide Over Zeolite Catalysts显示文摘 | Balkus Jr K J Khanmamedova A K Woo R | 1998 | Journal of Molecular Catalysis A: Chemical1998，134，1： | 1 |
| 20 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员