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| 1 | A new tripodal rhodamine B derivative as a highly selective and sensitive fluorescence chemosensor for copper(Ⅱ)显示文摘A new tripodal rhodamine B derivative 2 was designed and synthesized by tripodal trialdehyde and rhodamine B hydrazide for the first time. This derivative could be used as a fluorescent chemosensor for the selective and sensitive determination of copper(II) in Tris-HCl buffer and ethanol aqueous mixed media. Under the optimum conditions described herein,fluorescence enhancement at 557/577 nm was linearly related to the concentration of copper(II) in the range of 0.10 to 10.00×10-5 mol·L-1,with a corre-lation coefficient of R2=0.9964 (n=15) and a detection limit of 1.129×10-7 mol·L-1 (the relative standard deviation for five repeated measurements at 4.00×10-5 mol·L-1 Cu(II) was 2.2%). The absorbance meas-urements at 557 nm were linearly related to the concentration of Cu(II) in the range of 0.50 to 25.00×10-5 mol·L-1,with a correlation coefficient of R2=0.9948 (n=13) and a detection limit of 3.338×10-7mol·L-1. | ZENG Xi,WU Chong,DONG Lei,MU Lan,XUE SaiFeng & TAO Zhu College of Chemistry and Chemical Engineering ,Guizhou University,Guiyang 550003,China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province,Guizhou University,Guiyang 550025,China | 2009 | Science China Chemistry2009，52，4： | 7 |
| 2 | Bioinformatics analysis for structure and function of CPR of Plasmodium falciparum显示文摘Objective:To analyse the structure and function of NADPH-cytochrome p450 reductase(CYPOR or CPR) from Plasmodium falciparum(Pf),and to predict its’ drug target and vaccine target. Methods:The structure,function,drug target and vaccine target of CPR from Plasmodium falciparum were analyzed and predicted by bioinformatics methods.Results:PfCPR,which was older CPR,had close relationship with the CPR from other Plasmodium species,but it was distant from its hosts,such as Homo sapiens and Anopheles.PfCPR was located in the cellular nucleus of Plasmodium falciparum.335aa-352aa and 591aa - 608aa were inserted the interior side of the nuclear membrane,while 151aa-265aa was located in the nucleolus organizer regions.PfCPR had 40 function sites and 44 protein-protein binding sites in amino acid sequence.The teriary structure of laa-700aa was forcep-shaped with wings.15 segments of PfCPR had no homology with Homo sapien CPR and most were exposed on the surface of the protein.These segments had 25 protein-protein binding sites.While 13 other segments all possessed function sites. Conclusions:The evolution or genesis of Plasmodium falciparum is earlier than those of Homo sapiens.PfCPR is a possible resistance site of antimalarial drug and may involve immune evasion, which is associated with parasite of sporozoite in hepatocytes.PfCPR is unsuitable as vaccine target,but it has at least 13 ideal drug targets. | Zhigang Fan Lingmin Zhang Guogang Yan Qiang Wu Xiufeng Gan Saifeng Zhong Guifen Lin | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 3 |
| 3 | 为从变形体 berghei 的氮的氧化物 synthase 和类似的蛋白质的结构和功能的生物信息学分析和预言显示文摘 <正>Objective:To search and analyze nitric oxide synthase(NOS) and similar proteins from Plasmodium berghei(Pb).Methods:The structure and function of nitric oxide synthase and similar proteins from Plasmodium berghei were analyzed and predicted by bioinformatics. Results:P6NOS were not available,but nicotinamide adenine dinucleotide 2’-phosphate reduced tetrasodium(NADPH)-cytochrome p450 reductase(CPR) were gained.PiCPR was in the nucleus of Plasmodium berghei,while 134aa-229aa domain was localize in nucleolar organizer. The amino acids sequence of P6CPR had the closest genetic relationship with Plasmodium vivax showing a 73%homology.The tertiary structure of PbCPR displayed the forcep-shape with wings,but no wings existed in the tertiary structure of its’ host,Mus musculus(Mm).137aa-200aa, 201aa-218aa,220aa-230aa,232aa-248,269aa-323aa,478aa-501aa and 592aa-606aa domains of P6CPR showed no homology with MmCPRs’,and all domains were exposed on the surface of the protein.Conclusions:NOS can’t be found in Plasmodium berghei and other Plasmodium species.PbCPR may be a possible resistance site of antimalarial drug,and the targets of antimalarial drug and vaccine.It may be also one of the mechanisms of immune evasion.This study on Plasmodium berghei may be more suitable to Plasmodium vivax.And137aa-200aa, 201aa-218aa,220aa-230aa,232aa-248,269aa-323aa,478aa-501aa and 592aa-606aa domains of PbCPR are more ideal targets of antimalarial drug and vaccine. | Zhigang Fan Gang Lv Lingmin Zhang Xiufeng Gan Qiang Wu Saifeng Zhong Guogang Yan Guifen Lin | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 2 |
| 4 | Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1‐modulated P53 activity显示文摘 | Saifeng Wang Lipeng Qiu Xiaoli Yan Wensong Jin Yanzhong Wang Lizhao Chen Erjie Wu Xin Ye George F. Gao Fusheng Wang Yu Chen Zhongping Duan Songdong Meng | 2012 | Hepatology2012，，3： | 1 |
| 5 | Quantitative susceptibility mapping: current status and future directions显示文摘 | E. Mark Haacke Saifeng Liu Sagar Buch Weili Zheng Dongmei Wu Yongquan Ye | 2014 | Magnetic Resonance Imaging2014，，： | 1 |
| 6 | Fujian Tulou Seat of World-class Tourism Ambitions显示文摘NANJING County under Fujian’s Zhangzhou City is a major site of Fujian Tulou–indigenous earthen residential buildings inscribed into the World Cultural Heritage List in 2008. It is | WU SAIFENG | 2010 | China Today2010，59，2： | 0 |
| 7 | Shenzhen:Lodestar of China’s Reform and Opening-up显示文摘THE Third Plenary Session of the 11th Central Commit-tee of the CPC in 1978 has always been regarded as the starting point of China’s reform and opening-up drive. Since there was no previous development model to follow and most Chinese people were | WU SAIFENG, SONG XIAOGU ZENG BO | 2008 | China Today2008，57，12： | 0 |
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