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| 1 | 功能的限制的积极选择而非松驰在鸡驯服期间驾驶视觉的进化显示文摘是由达尔文,注意了鸡有所有鸟,而是国内鸡和他们的野祖先之间的有趣的进化差别的最大的 phenotypic 差异,红 Junglefowl,是他们的比较地更弱的视觉。存在理论建议在国内鸡之中的减少的视觉英勇反映功能的限制的松驰在识别负责的内在的基因机制的视觉,而是证据上驾驶的变化因为这个变化决定性地没被描绘。这里,国内鸡的染色体宽的分析和红 Junglefowl 染色体为涉及视觉的发展的断然选择的基因显示出重要丰富。关于为在视网膜的这些基因的 mRNA 表示的水平国内鸡和他们的野祖先之间有重要差别。涉及视觉的发展的众多的另外的基因也在在国内鸡和他们的野祖先之间的 mRNA 表示显示出重要差别,特别地为与 phototransduction 和光敏电阻器开发联系的基因,例如 RHO (视紫红质) , GUCA1A, PDE6B 和 NR2E3。最后,我们在视觉描绘了 VIT 基因的潜在的角色,它在村庄鸡的视网膜经历了积极选择和 downregulated 表示。总的来说,我们的结果建议净化选择的那种积极选择,而非松驰,在国内鸡贡献了视觉的进化。怀有更弱的视觉的国内鸡的祖先可能显示出减少的害怕回答和警戒,使他们更安逸无意识地被选择或驯养。 | Ming-Shan Wang Rong-wei Zhang Ling-Yan Su Yah Li Min-Sheng Peng He-Qun Liu Lin Zeng David M Irwin Jiu-Lin Du Yong-Gang Yao Dong-Dong Wu Ya-Ping Zhang | 2016 | Cell Research2016，26，5： | 15 |
| 2 | Hydrogen peroxide primes heart regeneration with a derepression mechanism显示文摘当成年的人的心很限制了再生潜力时,成年 zebrafish 心能充分在 20% 室的切除术以后再生。尽管以前的报告建议象 FGF 和 PDGF 那样的发展发信号小径在成年的心新生被再使用,内在的细胞内部的机制仍然保持大部分未知。这里,我们显示出那 H 2 O 2 充当新奇 epicardial 和心肌的信号在成年 zebrafish 为新生告知心。未经触动的心的实时成像揭示了高度局部性的 H 2 O 2(~ 30 μ M ) 在在切除术地点的心外膜和邻近的紧缩的心肌层的生产。减少的 H 2有 Duox 禁止者 diphenyleneiodonium (点每英寸)或 apocynin 的 O 2形成,或清除 H 2当时,由过氧化氢酶 overexpression 的 O 2显著地损害了心脏的新生外长的 H 2 O 2在心脏的新生上救了点每英寸的禁止的效果,显示那 H 2 O 2是在这个过程的一个必要、足够的信号。机械学地,提高了 H 2 O 2 使动摇氧化还原作用敏感的磷酸酶 Dusp6 并且因此增加了 Erk1/2 的 phosphorylation。当 dusp6 的转基因的 overexpression 损害了心脏的新生时, Dusp6 禁止者 BCI 完成了类似的支持 regenerative 效果。H 2 O 2 在招募起一个双作用通过二条相对独立的小径的有免疫力的房间和支持的心新生。我们结束那 H 2 潜在地从 Duox/Nox2 产生的 O 2 由解开通过包含 Dusp6 的 derepression 机制发信号的地图 kinase 在 zebrafish 支持心新生。 | Peidong Han Xiao-Hai Zhou Nannan Chang Cheng-Lu Xiao Shouyu Yah He Ren Xin-Zhuang Yang Mei-Ling Zhang Qing Wu Boyang Tang Ju-Peng Diao Xiaojun Zhu Chuanmao Zhang Chuan-Yun Li Heping Cheng Jing-Wei Xiong | 2014 | Cell Research2014，24，9： | 10 |
| 3 | Expert Consensus on Clinical Diagnostic Criteria for Fatal Familial Insomnia显示文摘 | Li-Yong Wu Shu-Qin Zhan Zhao-Yang Huang Bin Zhang Tao Wang Chun-Feng Liu Hui Lu Xiao-Ping Dong Zhi-Ying Wu Jie-Wen Zhang Ji-Hui Zhang Zhong-Xin Zhao Fang Han Yah Huang Jun Lu Serge Gauthier Jian-Ping Jia Yu-Ping Wang | 2018 | Chinese Medical Journal2018，，13： | 10 |
| 4 | The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells显示文摘AIM:Toinvestigate the effects of vitamin E succinate(VES)on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.METHODS:After SGC-7901cells were treated with VESat different doses(5,10,20mg·L^-1)at different time,reverse transcription-PCR technique was used to detect the level of c-jun mRNA;Western Blot was applied to measure the expression of c-jun protein.RESULTS:After the cells were theated with VESat 20mg·L^-1for 3h,the expression rapidly reached its maximun that was3.5times of UT control(P<0.01).The level of c-jun mRNA was also increased following treatment of VESfor 6h.However the expression after treatment of VES at 5mg·L^-1for24h was 1.6tmes compared with UTcontrol(P<0.01),Western blot analysis showed that the level of c-jun protein was obviusly elevated in VES-treated SGC-7901cells at 20mg·L^-1for3h,The expression of c-jun protein was gradually increased after treatment of VES at 20mg·L^-1for3,6,12and24h,respectively,with an evident time-effect relationship.CONCONCLUSION:The levels of c-jun mRNA and protein in VES-treated SGC-7901cells were increased in a dose-and time-dependent manner;the expression of c-jun was prolonged by VES,indicating that c-jun is involvedin VES-induced apoptosis in SGC-7901 cells. | Yah Zhao Kun Wu Wei Xia Yu-Juan Shan Li-Jie Wu Department of Nutrition and Food Hygiene,Public Health School,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Wei-Ping Yu Genetics Institute,Texas University of USA,Austin,USA | 2002 | World Journal of Gastroenterology2002，8，5： | 8 |
| 5 | Constructions of optimal variable-weight OOCs via quadratic residues显示文摘可变重量的光直角的代码(OOC ) 被 G.C. 杨介绍[IEEE Trans。Commun, 1996, 44:4755 ] 为多媒体有服务(QoS ) 的多重质量的光 CDMA 系统要求。在这份报纸,七个新无限的班最佳(v, { 3, 4, 6 } , 1, Q )-OOCs 被构造。 | Yah LIU Dianhua WU | 2013 | Frontiers of Mathematics in China2013，8，4： | 3 |
| 6 | Effect of haemorrheological changes in the transition of edematous pancreatitis to necrosis显示文摘 | Yah LN Liu XB Wu JX | 1995 | Asian J Surg1995，18，1： | 1 |
| 7 | Enhancement of the plasma chemistry process in a three-phase discharge reactor显示文摘 | Zhang Ruobing Wu Yah Li Guofeng | 2005 | Plasma Sources Science and Technology2005，，14： | 1 |
| 8 | Effects of Merogel coverage on wound healing and ostial patency in endonasal endoscopic dacryoeystorhinostomy for primary chronic dacryoeystitis显示文摘 | Wu W Cannon PS Yah W | 2011 | Eye (Lond)2011，25，6： | 1 |
| 9 | Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1 显示文摘 | Tu CF Yah YT Wu SY | 2008 | J Biol Chem2008，283，12： | 1 |
| 10 | Ventricular hypertrophy amplifies transmural repolarization dispersion and induces ear- ly afterdepolarization显示文摘 | Yah GX Rials SJ Wu Y | 2001 | Am J Physiol Heart Circ Physiol2001，281，5： | 1 |
| 11 | Expression of IL-23/Thl 7 pathway in a murine model of Coxsackie virus B3-induced viral myocarditis 显示文摘 | Yang F Wu WF Yah YL | 2011 | Virol J2011，8，： | 1 |
| 12 | Cohl Sensitivity Differences among Body Sections under Clothing 显示文摘 | LI Jun WU Hai- yah WANG Yun -yi | 2005 | Textile Research Journal2005，75，3： | 1 |
| 13 | The structural basis for activation of plant immunity by bacterial effector protein AvrPto显示文摘 | Xing Wei-rnan Zou Yah Liu Qun Liu Jia-ning Luo Xi Huang Qing-qiu Chen She Zhu Li-huang Bi Ru-chang Hao Quan Wu Jia-wei Zhou Jian-min and Chai Ji-jie | 2007 | Nature2007，449，7159： | 1 |
| 14 | Comparisons of Technological Innova- tion Capabilities in the Solar Photovoltaic Industries of Taiwan, China, and Korea 显示文摘 | Wu Citing- Yah | 2014 | Scientometrics2014，98，1： | 1 |
| 15 | Color image ntation using fuzzy clustering and suriSed learning显示文摘 | Wu J Chalmers A N Yah H | 1994 | Journal of Electronic Imaging1994，3，4： | 1 |
| 16 | Magnesium hydroxide nanoparticles synthesized in water-in-oil microemulsions 显示文摘 | Wu J Yah H Zhang X Wei L Liu X Xu B | 2008 | Journal of Colloid andlnterface Science2008，324，1： | 1 |
| 17 | Hydrothermal Synthesis of Three No- vel Multidimensional Metal-0rganic Frameworks with Unusual U- nits and Mixed Ligands 显示文摘 | He X Yah Y wu C D | 2006 | Crys Growth Des2006，，6： | 1 |
| 18 | Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis显示文摘 | Wu K M Li L H Yah J J | 2009 | J Bacteriol2009，191，14： | 1 |
| 19 | Human Dynamic Model Co-driven by In- terest and Social Identity in the Microblog Community 显示文摘 | Yah Q Yi L Wu L | 2012 | Physica A: Statistical Mechanics and its Applications2012，391，4： | 1 |
| 20 | Multivariate statistical study of organic pollutants in Nanjing reach of Yangtze River显示文摘 | WU Bing ZHAO Dayong ZHANG Yah | 2009 | J Hazard Mater2009，169，123： | 1 |
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