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| 1 | Sleep,immunity and inflammation in gastrointestinal disorders显示文摘Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research endeavors.An estimated 70 million Americans suffer from some form of sleep disorder.Certain sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance detriments.Recent research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause mortality.Several research studies support the associations among sleep,immune function and inflammation.Here,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal disorders.Different physiologic processes including immune system and inflammatory cytokines help regulate the sleep.The inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep disturbances.On the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory cytokines.Alterations in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal cancer.In turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal diseases.Knowledge of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients. | Tauseef Ali James Choe Ahmed Awab Theodore L Wagener William C Orr | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | An approach to incorporate linkage disequilibrium structure into genomic association analysis显示文摘In this study,we propose to use the principal component analysis (PCA) and regression model to incorporate linkage disequilibrium (LD) in genomic association data analysis. To accommodate LD in genomic data and reduce multiple testing,we suggest performing PCA and extracting the PCA score to capture the variation of genomic data,after which regression analysis is used to assess the association of the disease with the principal component score. An empirical analysis result shows that both genotype-based correlation matrix and hap-lotype-based LD matrix can produce similar results for PCA. Principal component score seems to be more powerful in detecting genetic association because the principal component score is quantitatively measured and may be able to capture the effect of multiple loci. | Diane Wagener | 2008 | Journal of Genetics and Genomics2008，35，6： | 2 |
| 3 | Impact of rifaximin use for hepatic encephalopathy on the risk of early post‐transplant infections in liver transplant recipients显示文摘 | Hsin‐Yun Sun Marilyn Wagener Thomas V. Cacciarelli Nina Singh | 2012 | Clin Transplant2012，，6： | 2 |
| 4 | A Different Light in Predicting Ungauged Basins: Regionalization Approach Based on Eastern USA Catchments显示文摘 | Syed Abu Shoaib Andras Bardossy Thorsten Wagener Yingchun Huang Nahid Sultana | 2013 | Journal of Civil Engineering and Architecture2013，7，3： | 2 |
| 5 | Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase显示文摘 | Eggert A | 2001 | Blood2001，98，： | 1 |
| 6 | Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney显示文摘 | Wagener N Crnkovic-Mertens I Vetter C | 2007 | Br J Cancer2007，97，9： | 1 |
| 7 | Vulnerability to psychological distress and depression in patients with end-stage liver disease due to hepatitis C virus 显示文摘 | Singh N Gayowski T Wagener MM | 1997 | Clin Transplant1997，11，5： | 1 |
| 8 | Geometric division with a fixed point: Not half the cake, but at least 4/9显示文摘 | Wagener A | 2006 | Group Decision Negotiation2006，15，1： | 1 |
| 9 | Surgical correction of tracheo-oesophageal fistula and oesophageal atresia in infants with VACTERL association: a retrospective ease-control study显示文摘 | Morgan RD O'Callaghan JM Wagener S | 2012 | Pediatr Surg Int2012，28，10： | 1 |
| 10 | Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis显示文摘 | I. Crnkovi?-Mertens N. Wagener J. Semzow E. F. Gr?ne A. Haferkamp M. Hohenfellner K. Butz F. Hoppe-Seyler | 2007 | Cellular and Molecular Life Sciences2007，，9： | 1 |
| 11 | Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery 显示文摘 | HAN W K WAGENER G ZHU Y | 2009 | Clin J Am Soe Nephrol2009，4，： | 1 |
| 12 | Sputtering on liquids - a versatile process for the production of magnetic suspensions显示文摘 | Wagener M Guünther B | 1999 | Journal of Magnetism and Magnetic Materials1999，201，1： | 1 |
| 13 | Urinary biomarkersin the early detection of acute kidney injury after cardiacsurgery 显示文摘 | HAN W K WAGENER G ZHU Y | 2009 | Clin J Am Soc Nephrol2009，4，5： | 1 |
| 14 | Effects of cross-channel synergies and complementarity in a multichannel e-commerce system-an investigation of the interrelation of e-commerce,m-commerce and IETV-commerce显示文摘 | Wagener G Klein H S Steinmann S | 2013 | The International Review of Retail Distribution and Consumer Research2013，23，5： | 1 |
| 15 | Effect of long-acting nifedilpine on mortality and cardiovascular mortality in patients with symptomatic stable angina and hypertension:the ACTION trial显示文摘 | Lubsen J Wagener G Kirwan BA | 2005 | J Hypertens2005，23，： | 1 |
| 16 | Starch granule initiation and growth are altered in barly mutant that lack isoamylase activity显示文摘 | Jenner H Carrangis L Fahy B Fincher G B Hylton C Laurie D A Parker M Waite D Wagen S V Verhoeven T Denyer K | 2002 | The Plant Journal2002，31，1： | 1 |
| 17 | The importance of human exposure information: a need for exposure-related data bases to protect and promote public health显示文摘 | WAGENER D K SELEVAN S G SEXTON K | 1995 | Annual Review of Public Health1995，16，： | 1 |
| 18 | Effect of long-acting nifedipine On mortality and cardiovascular morbidity in patients with symptomatic stable angina and hypertension:the ACTION trial显示文摘 | Lubsen J Wagener G Kirwan BA et a1 | 2005 | J Hypertens2005，23，3： | 1 |
| 19 | Targeted inhibi- tion of Livin resensitizes renal cancer cells towards apoptosis显示文摘 | Crnkovic-Mertens I Wagener N SemzowJ | 2007 | Cell Mol Life Sci2007，64，9： | 1 |
| 20 | A prospective, double-blind, randomized, placebo- controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery显示文摘 | WAHLANDER S FRUMENTO R J WAGENER G | 2005 | J Cardiothorac Vasc Anesth2005，19，5： | 1 |
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