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| 1 | Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma 显示文摘 | Reichert TE Day R Wagner EM | 1998 | Cancer Res1998，58，23： | 1 |
| 2 | Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species显示文摘 | Redout EM Wagner MJ Zuidwijk MJ | 2007 | Cardiovasc Res2007，75，： | 1 |
| 3 | Role of the bronchial circulation in ischemia-reperfusion lung injury显示文摘 | Pearse DB Wagner EM | 1994 | J Appl Physiol1994，76，1： | 1 |
| 4 | Reduced dopamine D4 receptor mRNA expression in lymphocytes of long-term abstinent alcohol and heroin addicts显示文摘 | Czermak C Lehofer M Wagner EM | 2004 | Addiction2004，99，2： | 1 |
| 5 | Direct assessment of small airways reactivity in human subjects显示文摘 | Wagner EM Bleecker ER Permutt S Liu MC | | 0，，： | 1 |
| 6 | A comparative study of homeless, previously homeless, and never homeless school aged children's heslth显示文摘 | Menke EM Wagner JD | 1998 | Issues Compr Pediatr Nurs1998，20，3： | 1 |
| 7 | Peripheral lung resistance in normal and asthmatic subjects 显示文摘 | Wagner EM Liu MC Weinmann GG | 1990 | Am Rev Respir Dis1990，141，3： | 1 |
| 8 | Reduced dopamine D4 receptor mRNA expression in lymphocytes of long-term abstinent alcohol and heroin addicts显示文摘 | Czermak C Lehofer M Wagner EM Prietl B Lemonis L Rohrhofer A Schauenstein K Liebmann PM | | 0，，02： | 1 |
| 9 | Mutagenicity of the mycotoxin alternariol in cultured mammalian cells显示文摘 | Brugger EM Wagner J Schumacher DM | 2006 | Toxicot Lett2006，164，3： | 1 |
| 10 | Mutagenicity of the mycotoxin ahernariol in cultured mammalian cells 显示文摘 | Brugger EM Wagner J Schumacher DM | 2006 | Toxicol Lett2006，164，3： | 1 |
| 11 | Is serum fructosamine assay specific for determination of glycated serum protein 显示文摘 | Schleicher ED Mayerr R Wagner EM | 1988 | Clin Chem1988，34，： | 1 |
| 12 | Mechanisms of bronchoprotection by anesthetic induction agents:propofol versus ketamine显示文摘 | Brown RH Wagner EM | 1999 | Anesthesiology1999，90，3： | 1 |
| 13 | Peripheral airways responsiveness to cool,dry air in normal and asthmatic individuals显示文摘 | Kaminsky DA Irvin CG Gurka DA Feldsien DC Wagner EM Liu MC | | 0，，6： | 1 |
| 14 | Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload显示文摘BACKGROUND Patients with hepatitis C virus(HCV) and hepatocellular carcinoma(HCC) may or not develop iron overload(IO),which is associated with worst prognosis,because can cause serious damage to organs.HFE gene controls the iron uptake from gut,particularly in patients with hereditary hemochromatosis(HH).AIM To identify associations between HFE coding region in patients exhibiting hereditary hemochromatosis and in diseases associated with acquired IO.METHODS We sequenced exons 2 to 5 and boundary introns of HFE gene,evaluating all polymorphic sites in patients presenting hereditary(hemochromatosis) or acquired iron overload HCV and HCC) and in healthy controls,using Sanger sequencing.We also determined the ensemble of extended haplotype in healthy control individuals,including several major histocompatibility complex loci,using sequence specific probes.Haplotype reconstruction was performed using the Arlequin and Phase softwares,and linkage disequilibrium(LD) between histocompatibility loci and HFE gene was performed using the Haploview software.RESULTS The HFE*003 allele was overrepresented(f = 71%) and HFE*001 allele was underrepresented(f = 14%) in HH patients compared to all groups.A strong linkage disequilibrium was observed among the H63 D-G,IVS2(+4)-C and C282 YG gene variants,particularly in HH;however,the mutation IVS2(+4)T>C was not directly associated with HH susceptibility.The HFE*001/HFE*002 genotype conferred susceptibility to HCC in HCV patients exhibiting IO(P = 0.02,OR =14.14).Although HFE is telomeric to other histocompatibility genes,the H63 DG/IVS2(+4)-C(P ≤ 0.00001/P ≤ 0.0057) combination was in LD with HLA-B*44 allele group in healthy controls.No LD was observed between HFE alleles and other major histocompatibility loci.CONCLUSION A differential HFE association was observed for HH and for diseases associated with acquired IO(HCV,HCC).Since HFE is very distant from other histocompatibility loci,only weak associations were observed with these alleles. | Wagner Narciso de Campos Juliana Doblas Massaro Eduardo Luiz Rachid Can?ado Cláudia Emília Vieira Wiezel Aguinaldo Luiz Sim?es Andreza Correa Teixeira Fernanda Fernandes de Souza Celso Teixeira Mendes-Junior Ana de Lourdes Candolo Martinelli Eduardo Ant?nio Donadi | 2019 | World Journal of Hepatology2019，11，2： | 1 |
| 15 | Computer-tomotraphically guided fierbronchoscopic transbronchial biopsy of small pulmonary lesions:a feasibility study显示文摘 | Wagner U Walthers EM Gelmetti W | 1996 | Respiration1996，63，3： | 1 |
| 16 | Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase deficient mouse adipose tissue显示文摘 | Kratky D Zimmermannn R Wagner EM | 2005 | Clin Invest2005，115，1： | 1 |
| 17 | Reproducibility and accuracy of measurements with a hand held autorefractor in children显示文摘 | Harvey EM Miller JM Wagner LK | 1997 | Br J Ophthalmol1997，81，11： | 1 |
| 18 | High cumulative risk of intussusception in patients with Peutz-Jeghers syndrome:time to update surveillance guidelines显示文摘 | van Lier MG Mathus-Vliegen EM Wagner A | | 0，，05： | 1 |
| 19 | Importance of airway blood flow on particle clearance from the lung显示文摘 | Foster WM | 1996 | J Appl Physiol1996，81，5： | 1 |
| 20 | Peripheral lung resistance in normal and asthmatic subjects 显示文摘 | Wagner EM Liu MC Weinmann GG | 1990 | Am Rev Respir Dis1990，141，3： | 1 |
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