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| 1 | Corticosteroids and pentoxifylline for the treatment of alcoholic hepatitis:Current status显示文摘The treatment of choice for patients with severe alcoholic hepatitis (AH) is use of corticosteroids.Many randomized well designed studies have been reported from all over the world on the use of corticosteroids in the treatment of AH.However,the data on the efficacy of corticosteroids in these patients have been conflicting.Initial meta-analyses also failed to show beneficial effects of corticosteroids.Based on individual data meta-analysis showing clear benefit of corticosteroids amongst patients with severe AH (modified discriminant function of 32 or more),led American College of Gastroenterology to recommend use of corticosteroids as the first line treatment option amongst patients with severe AH.However,corticosteroids are relatively contraindicated amongst patients with severe AH and coexistent sepsis,gastrointestinal bleeding,and acute pancreatitis.These patients may be candidates for second line treatment with pentoxifylline.Further,specific treatment of AH with corticosteroids far from satisfactory with as many as 40%-50% of patients failing to respond to steroids,thus classified as nonresponsive to steroids.The management of these patients is a continuing challenge for physicians.Better treatment modalities need to be developed for this group of patients in order to improve the outcome of patients with severe AH.This article describes at length the available trials on use of corticosteroids and pentoxifylline with their current status.Route of administration,dosage,adverse effects,and mechanisms of action of these two drugs are also discussed.Finally,an algorithm with clinical approach to management of patients who present with clinical syndrome of AH is described. | Ashwani K Singal Ishmeet Walia Anjna Singal Roger D Soloway | 2011 | World Journal of Hepatology2011，3，8： | 7 |
| 2 | IL-6 induces NF-kappa B activation in the intestinal epithelia 显示文摘 | Wang L Walia B Evans J Gewirtz AT Merlin D Sitaraman SV | 2003 | J Immunol2003，171，6： | 1 |
| 3 | Effect of rotation and thermal relaxation on Rayleigh waves in piezothermoelastic half space显示文摘 | Shanna d N Walia V Gupta S K | 2008 | Int J Mech Sci2008，50，3： | 1 |
| 4 | SurveiUance of communicable dis- eases in tertiary health care system in Chandigarh, UT显示文摘 | Sharma MK Kalia M Walia D | 2007 | Indian J MedSei2007，61，： | 1 |
| 5 | Side effects of antiepilepties-a review显示文摘 | WALIA K S KHAN E A KO D H | 2004 | Pain Practice : the Official Journal of World Institute of Pain2004，4，3： | 1 |
| 6 | Contrast enhancement via texture region based his- togram equalization显示文摘 | SINGH K V1SHWAKARMA D K WALIA G S | 2016 | Journal of Modern Optics2016，63，15： | 1 |
| 7 | Water stress induced proline accumulation in contrasting wheat genotypes as affected by calcium and abscisic acid 显示文摘 | Nayyar H Walia D P | 2003 | Biol Plant2003，46，2： | 1 |
| 8 | Water stress induced proline accumulation in contrasting wheat genotypes as affected by calcium and abscisic acid显示文摘 | Nayyar H Walia D P | 2003 | Biologia Plantarum2003，46，2： | 1 |
| 9 | Water stress induced praline accumulation in contrasting wheat genotypes as affected by calcium and abscisic acid 显示文摘 | Nayyar H Walia D P | 2003 | Biologia Plautarum2003，46，2： | 1 |
| 10 | Growth failure in children with chronic myeloid leukemia receiving imatinib is due to disruption of GH/IGF-1 axis显示文摘 | Narayanan KR Bansal D Walia R et a1 | 2013 | Pediatr Blood Cancer2013，60，7： | 1 |
| 11 | Water stress induced proline accumulation in contrasting wheat genotypes as affected by calcium and abscisic acid显示文摘 | NAYYAR H WALIA D P | 2003 | BiologiaPlantarum2003，46，27： | 1 |
| 12 | Beneficial effects of Rhizopus oligo- sorus fermentation on reduction of glucosinolates, fibre and phytic acid in rapeseed ( Brassica napus ) meal 显示文摘 | Vig A P d A Walia | 2001 | Bioresour Techno12001，78，： | 1 |
| 13 | Ex-ome sequencing identifies GRIN2A as frequently muta-ted in melanoma显示文摘 | Wei X Walia V Lin J C Teer J K Prickett T D Gartner J Davis S NISC Comparative Sequencing Program Stemke-Hale K Davies M A Gershenwald J E Rob-inson W Robinson S Rosenberg S A Samuels Y | | 0，，： | 1 |
| 14 | TGF-beta down-regulates IL-2 signaling in intestinal epithelia] cells: critical role of SMAD-2 显示文摘 | Walia B Wang L Merlin D | 2003 | FASEB J2003，17，14： | 1 |
| 15 | Metronidazole-induced fixed drug eruption显示文摘 | Kumar N Sundriyal D Walia M | 2013 | BMJ Case Rep2013，11，： | 1 |
| 16 | Water stress induced proline accumulation in contrasting wheat genotypes as affected by calcium and abscisic acid显示文摘 | Nayyar H Walia D P | 2003 | Biologia Plantarum2003，46，： | 1 |
| 17 | High-resolution, deeptowed,multichannel seismic survey of deep-sea gas hydrates off western Canada 显示文摘 | Chapman N R Gettrust J F Walia R David Hannay Spence G D Wood W T Hyndman R D | 2002 | Geophysics2002，67，4： | 1 |
| 18 | Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression ( SAGE ) 显示文摘 | Walia A Morinb P J Houghb C D | 2005 | Lung Cancer2005，48，1： | 1 |
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