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| 1 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 2 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 3 | Role of penehyclidine in acute organophosphorus pesticide poisoning显示文摘BACKGROUND:Penehyclidine is a newly developed anticholinergic agent.We aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)patients.METHODS:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang databases.Randomized controlled trials(RCTs)recruiting acute OP patients were identifi ed for meta-analysis.Main outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi ed.Compared with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine vs.atropine,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine vs.penehyclidine,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine vs.atropine,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine vs.penehyclidine,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of ADR.Compared with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of IMS.CONCLUSION:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of hospitalization.Penehyclidine combined with atropine is likely a better initial therapy for OP patients than atropine alone. | Shi-yuan Yu Yan-xia Gao Joseph Walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li | 2020 | World Journal of Emergency Medicine2020，11，1： | 18 |
| 4 | DOAS方法在连续排放污染源及过程气体在线监测中的实现显示文摘分析DOAS原理和DOAS系统设计表明,DOAS系统可以监测从紫外(UV)波段到红外(IR)波段的多种气体浓度。经TV认证机构测试,DOAS系统性能符合监测标准,适用于普通固定污染源和垃圾焚烧厂烟气排放连续监测,尤其在监测Hg,HCl,NH3和HF等气体时有明显优势。采用多通道技术可以只使用一台主机同时监测多个测点。DOAS系统可以在高温、腐蚀性强和含尘量高的环境中正常工作,使过程工艺气体在线监测得以实现。DOAS系统还可以监测不同位置不同浓度的气体。无需采样、反应速度快、多组分多通道的特点为DOAS系统有更广阔的应用奠定了基础。 | SVANTE Wallin 黄兆开 范海华 | 2011 | 环境工程技术学报2011，1，1： | 13 |
| 5 | Venous thromboembolism in the emergency department:A survey of current best practice awareness in physicians and nurses in China显示文摘BACKGROUND: For emergency department(ED) patients, risk assessment, prophylaxis, early diagnosis and appropriate treatment of venous thromboembolism(VTE) are essential for preventing morbidity and mortality. This study aimes to investigate knowledge amongst emergency medical staff in the management of VTE. METHODS: We designed a questionnaire based on multiple scales. The questionnaire was distributed to the medical and nursing clinical staff in the large urban ED of a medical center in Northern China. Data was described with percentages and the Kruskal-Wallis test was used to compare ranked data between different groups. The statistical analysis was done using the SPSS 22.0 software.RESULTS: In this survey, 180 questionnaires were distributed and 174 valid responses(response rate of 96.67%) were collected and analyzed. In scores of VTE knowledge, no signifi cant differences were found with respect to job(doctor vs. nurse), the number of years working in clinical medicine, education level, and current position, previous hospital experience and nurses' current work location within the ED. However, in pair wise comparison, we found participants who worked in ED for more than 5 years(n=83) scored signifi cantly higher on the questionnaire than those under 5 years(n=91)(95.75 vs. 79.97, P=0.039). There was a signifi cant difference in some questions based on gender, age, job, and nurse work location, number of working years, education level, and different ED working lifetime.CONCLUSION: Our survey has shown defi ciencies among ED medical staff in knowledge and awareness of the management of VTE. We recommend several changes be considered, such as the introduction of an interdisciplinary workshop for medical staff; the introduction of a standardized VTE protocol; a mandatory study module on VTE for new physicians and nurses; the introduction of a mandatory reporting system for adverse events(including VTE). | Wen-hua Zhou Jian-qiang He Shi-gong Guo Joseph Walline Xiao-ying Liu Li-yuan Tian Hua-dong Zhu Xue-zhong Yu Yi Li | 2019 | World Journal of Emergency Medicine2019，10，1： | 8 |
| 6 | Hemodynamic characteristics in preeclampsia women during cesarean delivery after spinal anesthesia with ropivacaine显示文摘BACKGROUND Very few studies have been published on the hemodynamic changes associated with spinal anesthesia induced with ropivacaine during cesarean deliveries in preeclamptic women.AIM To record and analyze hemodynamic data in women with preeclampsia undergoing cesarean delivery after spinal anesthesia induced with ropivacaine.METHODS Ten eligible women with preeclampsia were enrolled in this prospective observational study.Spinal anesthesia was performed with 2.4 mL of 0.5%ropivacaine.Hemodynamic changes were then analyzed at multiple time points.The hemodynamic responses to vasopressor interventions and uterotonic agents,as well as maternal and neonatal outcomes were also recorded.RESULTS Stable hemodynamic trends were observed in this study.Cardiac output(CO)and stroke volume increased mildly during surgery.In contrast,mean arterial pressure and systemic vascular resistance showed a moderate decrease from induction until the end of surgery.Central venous pressure dramatically increased after delivery.Oxytocin administration was associated with the most significant hemodynamic fluctuations during surgery,namely,an increase in CO and heart rate.Phenylephrine intervention was only required in three patients,and caused an increase in mean arterial pressure and systemic vascular resistance along with a decrease in heart rate,stroke volume,and CO.No maternal and neonatal complications were observed during this study,except transient episodes of hypotension.CONCLUSION Spinal anesthesia for caesarian delivery with ropivacaine in women with preeclampsia is linked to modest hemodynamic changes of no clinical significance in this study.Careful cardiovascular monitoring is still recommended,particularly after the delivery of the fetus or the use of oxytocin. | Na Zhao Jin Xu Xiao-Guang Li Joseph Harold Walline Yi-Chong Li Lin Wang Guo-Sheng Zhao Ming-Jun Xu | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 7 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 8 | 系统性红斑狼疮患者急诊就诊的主诉症状显示文摘目的总结急诊就诊的系统性红斑狼疮(systemic lupus erythematosus,SLE)患者的主诉症状及特点。方法采用回顾性分析的方法对本院急诊科2009年9月至2013年1月留观的200例SLE患者主诉症状数目、常见症状分布、初治患者主诉症状分布、发热的病因等方面情况进行统计分析。结果 SLE患者急诊就诊时主诉症状以两种症状为多见(47.5%,95/200),发热是最常见症状(58%,116/200);中枢神经系统(38.5%,20/52)、呼吸系统(23.1%,12/52)和消化系统(19.2%,10/52)受累易伴发热;初治SLE患者发热病因多为狼疮活动(78.8%,26/33),非初治SLE患者发热病因多为继发感染(69.9%,58/83);感染性发热患者最常见的感染部位为肺部(81.5%,53/65)。结论急诊就诊的SLE患者主诉症状有一定的特点,了解其规律可最大程度避免误诊和漏诊。 | 韩红 于学忠 李毅 徐盛勇 须晋 Joseph Walline | 2013 | 协和医学杂志2013，4，3： | 2 |
| 9 | Does Ligation of the Intersphincteric Fistula Tract Raise the Bar in Fistula Surgery?显示文摘 | Ulrik G. Wallin Anders F. Mellgren Robert D. Madoff Stanley M. Goldberg | 2012 | Diseases of the Colon & Rectum2012，，11： | 2 |
| 10 | Polymorphisms in sulfotransferase 1A1 and glutathione 5-transferase P1 genes in relation to colorectal cancer risk and patients' survival显示文摘AIM: To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.METHODS: We examined the genotypes of 125colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR-restriction fragment length polymorphism (RFLP).RESULTS: SULT1A1*2/*2 genotype (OR=2.49,95%CI=1.48-4.19, P=0.0002) and *2 allele (OR=1.56, 95%CI = 1.16-2.10, P = 0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender,age, Dukes'stage, growth pattern, and differentiation (P=0.03).CONCLUSION: Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients. | Xiao-Feng Sun Ahmad Ahmadi Gunnar Arbman Asa Wallin Daniel Asklid Hong Zhang | 2005 | World Journal of Gastroenterology2005，11，43： | 2 |
| 11 | National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards显示文摘 | Vladimir Hachinski Costantino Iadecola Ron C. Petersen Monique M. Breteler David L. Nyenhuis Sandra E. Black William J. Powers Charles DeCarli Jose G. Merino Raj N. Kalaria Harry V. Vinters David M. Holtzman Gary A. Rosenberg Anders Wallin Martin Dichgans | 2006 | Stroke2006，，9： | 2 |
| 12 | A survey of ventilation strategies during cardiopulmonary resuscitation显示文摘BACKGROUND:Many controversies still exist regarding ventilator parameters during cardiopulmonary resuscitation(CPR).This study aimed to investigate the CPR ventilation strategies currently being used among physicians in Chinese tertiary hospitals.METHODS:A survey was conducted among the cardiac arrest team physicians of 500 tertiary hospitals in China in August,2018.Surveyed data included physician and hospital information,and preferred ventilation strategy during CPR.RESULTS:A total of 438(88%)hospitals completed the survey,including hospitals from all 31 Chinese mainland provinces.About 41.1%of respondents chose delayed or no ventilation during CPR,with delayed ventilations all starting within 12 minutes.Of all the respondents who provided ventilation,83.0%chose to strictly follow the 30:2 strategy,while 17.0%chose ventilations concurrently with uninterrupted compressions.Only 38.3%respondents chose to intubate after initiating CPR,while 61.7%chose to intubate immediately when resuscitation began.During bagvalve-mask ventilation,only 51.4%of respondents delivered a frequency of 10 breaths per minute.In terms of ventilator settings,the majority of respondents chose volume control(VC)mode(75.2%),tidal volume of 6–7 mL/kg(72.1%),PEEP of 0–5 cmH2O(69.9%),and an FiO2 of 100%(66.9%).However,62.0%of respondents had mistriggers after setting the ventilator,and 51.8%had high pressure alarms.CONCLUSION:There is a great amount of variability in CPR ventilation strategies among cardiac arrest team physicians in Chinese tertiary hospitals.Guidelines are needed with specific recommendations on ventilation during CPR. | Ye-cheng Liu Yan-meng Qi Hui Zhang Joseph Walline Hua-dong Zhu | 2019 | World Journal of Emergency Medicine2019，10，4： | 2 |
| 13 | Subeortieal ischaemie vascular dementia 显示文摘 | Roman GC Erkinjuntti T Wallin A | 2002 | Lancet Neurol2002，1，： | 1 |
| 14 | Cell-specific localization of nitric oxide synthases(NOS)in the rat ovary during follicular development,ovulation and luteal formation显示文摘 | Mikuni M Wallin A | 1996 | Hum Reprod 1996(12)1996，11，12： | 1 |
| 15 | Plant regeneation from trawberry (Fragaria ×ananssa) mesophyll protoplasts显示文摘 | Nyman M Wallin A | 1998 | Plant Physiol1998，133，： | 1 |
| 16 | Decreased cerehrospinal fluid acetylchollnesterase in patients with subcortical ischemlc vascular dementia 显示文摘 | Wallin A Sjogren M Blennow K | 2003 | Dement Geriatr Cogn Disord2003，16，4： | 1 |
| 17 | The abundance of arthroP0ds along two field margins with different types of vegetation compos- ition: an experimental study显示文摘 | Lagerlof J Wallin H | 1993 | Agriculture Ecosys- tems & Environment1993，43，： | 1 |
| 18 | Sevoflurane: A new inhala- tional anesthetic agent显示文摘 | Wallin RF Regan BM Napoli MD | 2005 | Anesth Analg2005，54，6： | 1 |
| 19 | Corneal reshaping and myopia progression显示文摘 | Walline JJ Jones LA Sinnott LT | | 0，，： | 1 |
| 20 | Subcortical ischaemic vascular dementia显示文摘 | Romtin GC Erkinjuutti T Wallin A | 2002 | Lancet Neurol2002，1，7： | 1 |
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