|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018，26，4： | 58 |
| 2 | 瑞舒伐他汀对存在亚临床动脉粥样硬化的低危人群颈动脉内膜中层厚度进展的影响——METEOR试验显示文摘背景:动脉粥样硬化往往在机体出现症状之前就已有所进展。目前,我们尚不清楚Framingham风险评分(Framinghaln risk score,FRS)较低的轻中度亚临床动脉粥样硬化中年人群是否能从治疗中获益。
目的:评价为期2年的他汀类药物治疗能否减缓颈动脉内膜中层厚度(carotid intimamedia thickness,CIMT)继续增厚或使粥样斑块消退。
设计、地点及参试者:“瑞舒伐他汀对内膜中层厚度影响的测评研究(Measuring Effects on Intima-Media Thickness:an Evaluation of Rosuvastatin,METEOR)”是2002年8月至2006年5月在美国及欧洲61个基层医疗中心开展的一项随机、双盲、安慰剂对照研究,共纳入984名参试者,有的参试者仅以年龄(平均年龄,57岁)为冠心病的危险因素,有的参试者10年内FRS低于10%、CIMT重庞增厚(1.2~3.5mm)、LDL胆固醇水平有所升高(平均值,154mg/dL)。
干预:参试者服用40mg瑞舒伐他汀或安慰剂。
主要观测指标:12个颈动脉位点最大CIMT的变化率(经B超检测);颈总动脉位点、颈动脉窦位点及颈内动脉位点最大CIMT的变化,颈总动脉位点平均CIMT的变化。仅在瑞舒伐他汀组中评估CIMT的消退情况。
结果:瑞舒伐他汀组参试者LDL胆固醇平均(SD)水平由基线时的155(24.1)mg/dL降至78(27.5)mg/dL,平均降低49%(与安慰剂组相比P〈0.001)。瑞舒伐他汀组12个颈动脉位点最大CIMT的变化值为-0.0014(95%CI,-0.0041~0.0014)mm/y,安慰剂组12个颈动脉位点最大CIMT的变化值为Q0131(95%CI,Q0087~Q0174)mm/y(P〈0.001)。瑞舒伐他汀组颈总动脉位点最大CIMT的变化值为-0.0038(95%CI,-0.0064~-0.0013)mm/y(P〈0.001),颈动脉窦位点最大CIMT的变化值为-0.0040(95%CI,-0.0090~0.0010)mm/y(P〈0.001),颈内动脉位点最大CIMT的变化值为0.0039(95%CI,-0.0009~0.0088)mm/y(P=0.02)。瑞舒伐他汀组颈总动脉位点平均CIMT的变化值为0.0004(95%CI,-0.0011~0.0019)mm/y(P〈0.001)。P值均为与安慰剂组相比。总的来说,瑞舒伐他汀具有良好的耐受性,很少引发严重的心血管不良事件(在2年内有6名参试者[0.86%]出现8起不良事件[1.1%])。
结论:对于FRS低于10%的亚临床动脉粥样硬化中年人群而言,瑞舒伐他汀能够在2年内显著降低最大CIMT的进展速率,与安慰剂相比差异具有统计学显著性。但是,瑞舒伐他汀无法诱导病变消退。今后,我们仍需开展大型远期试验来明确上述研究结果的临床意义. | John R. Crouse Ⅲ Joel S. Raichlen Ward A. Riley Gregory W. Evans Mike K. Palmer Daniel H. O' Leary Diederick E. Grobbee Michiel L. Bots 李军(译) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 44 |
| 3 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 4 | Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori显示文摘AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections. RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric; borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment. | Rachel O'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira John Holton Christelle Basset | 2005 | World Journal of Gastroenterology2005，11，47： | 29 |
| 5 | Role of liver transplantation in the management of hepatoblastoma in the pediatric population显示文摘Hepatoblastoma(HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB(unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplantation is an excellent option. The etiology of HB is mostly obscure because of its extreme rarity although some inherited syndromes and very low birth weight have been associated with it. The prognosis for children with HB has significantly improved in the past three decades thanks to advancements in chemotherapy, surgical resection and postoperative care. In 2002 a surgical staging system called pretreatment extent of disease(PRETEXT) was designed to allow a universal, multidisciplinary approach to patients with HB. Between one-third to two-thirds of patients initially present with unresectable tumors or distant metastases, but up to 85% of these tumors become operable after neoadjuvant chemotherapy. Patients with PRETEXT categories 1, 2, and some 3 are referred for neoadjuvant chemotherapy followed by surgical resection with the goal of complete tumor removal. Classic treatments regimens include a combination of cisplatin, fluorouracil, and vincristine or cisplatin and doxorubicin. Liver transplantation is the only treatment option for unresectable HB. In 2010 the pediatric end-stage liver disease, a pediatric-specific scoring system that determines a patient's ranking on the liver transplant list, began to award additional 'exception' points for patients with HB. We analyzed the Standard Transplant Analysis and Research dataset to assess the impact of changes in exception point criteria for HB on outcomes after liver transplantation at Texas Children's Hospital in Houston, Texas. We found that patients who were listed for transplantation with current HB exception criteria experienced a shorter waitlist time but survival was similar between the two eras. | Saira Khaderi Jacfranz Guiteau Ronald T Cotton Christine O'Mahony Abbas Rana John A Goss | 2014 | World Journal of Transplantation2014，4，4： | 23 |
| 6 | Role of radiation therapy in gastric adenocarcinoma显示文摘在有在美国的胃的癌症的病人的结果仍然保持令人失望,与约 23% 的五年的全面幸存率。本地人地区性的控制追随者外科的给定的高率,一个强壮的基本原理为辅助放射治疗的使用存在。使随机化的审判与辅助放射疗法显示出优异本地控制并且与辅助 chemoradiation 改进全面幸存。在由一位富有经验的外科医生经历了 D2 淋巴节点解剖的病人的辅助 chemoradiation 的利益不被知道,并且除了辅助化疗的辅助放射治疗的利益继续定义。在 unresectable 疾病, chemoradiation 在病人的一个小数字允许长期的幸存并且提供有效减轻。大多数试用独自与化疗或放射治疗相比显示出一个好处到联合形式治疗。使用外科手术前, intra 起作用, 3D 保角,并且在胃的癌症的调制放射治疗进一步正在答应,但是要求的紧张学习。当前的文章在能的将切除的治疗考察放射治疗的角色,集中于在美国的当前的建议并且 unresectable 胃的癌。 | Lisa Hazard John O'Connor Courtney Scaife | 2006 | World Journal of Gastroenterology2006，12，10： | 15 |
| 7 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 8 | A review of feed efficiency in swine:biology and application显示文摘Feed efficiency represents the cumulative efficiency with which the pig utilizes dietary nutrients for maintenance,lean gain and lipid accretion.It is closely linked with energy metabolism,as the oxidation of carbon-containing components in the feed drive all metabolic processes.While much is known about nutrient utilization and tissue metabolism,blending these subjects into a discussion on feed efficiency has proven to be difficult.For example,while increasing dietary energy concentration will almost certainly increase feed efficiency,the correlation between dietary energy concentration and feed efficiency is surprisingly low.This is likely due to the plethora of non-dietary factors that impact feed efficiency,such as the environment and health as well as individual variation in maintenance requirements,body composition and body weight.Nonetheless,a deeper understanding of feed efficiency is critical at many levels.To individual farms,it impacts profitability.To the pork industry,it represents its competitive position against other protein sources.To food economists,it means less demand on global feed resources.There are environmental and other societal implications as well.Interestingly,feed efficiency is not always reported simply as a ratio of body weight gain to feed consumed.This review will explain why this arithmetic calculation,as simple as it initially seems,and as universally applied as it is in science and commerce,can often be misleading due to errors inherent in recording of both weight gain and feed intake.This review discusses the importance of feed efficiency,the manner in which it can be measured and reported,its basis in biology and approaches to its improvement.It concludes with a summary of findings and recommendations for future efforts. | John F.Patience Mariana C.Rossoni-Seräo Nestor A.Gutiérrez | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 10 |
| 9 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 10 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 11 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 12 | Do probiotics have a therapeutic role in gastroenterology?显示文摘Several hundred species of bacteria inhabit the gut, and affect its cell biology, morphology and homeostasis. Many bacteria are however potential pathogens, especially if the integrity of the epithelial barrier is physically or functionally breached. Conversely, the interaction between host and commensal microbes can confer important health benefits. This has led to commercial and public interest in ’probiotics’, live microbes principally taken as food supplements. Might probiotics also be used in disease therapy? Experimental evidence that probiotics modulate gut physiology, particularly barrier integrity and immunological function, underpins exciting new gastroenterological research. We discuss below the scienti?c basis for probiotic effects and present a critical perspective for their use in relation to gastrointestinal disease. | Jimmy K Limdi Catherine O’Neill John McLaughlin | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 13 | Endoscopic balloon catheter dilatation via retrograde or static technique is safe and effective for cricopharyngeal dysfunction显示文摘AIM To evaluate the safety and efficacy of upper esophageal sphincter(UES) dilatation for cricopharyngeal(CP) dysfunction. To determine if:(1) indication for dilatation; or(2) technique of dilatation correlated with symptom improvement.METHODS All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success. Dilatation technique was separated into static(stationary balloon distention) and retrograde(brusque pull-back of a fully distended balloon across the UES).RESULTS Four hundred and eighty-eight dilatations were reviewed. Thirty-one patients were identified who underwent UES dilatation. Median age was 63 years(range 27-81)and 55% of patients were male. Indications included dysphagia(28 patients), globus sensation with evidence of UES dysfunction(2 patients) and obstruction to echocardiography probe with cricopharyngeal(CP)bar(1 patient). There was evidence of concurrent oropharyngeal dysfunction in 16 patients(52%) and a small Zenker's diverticula(≤ 2 cm) in 7 patients(23%). Dilator size ranged from 15 mm to 20 mm. Of the 31 patients, 11 had dilatation of other esophageal segments concurrently with UES dilatation and 20 had UES dilatation alone.Follow-up was available for 24 patients for a median of 2.5 mo(interquartile range 1-10 mo), of whom 19 reported symptomatic improvement(79%). For patients undergoing UES dilatation alone, follow-up was available for 15 patients, 12 of whom reported improvement(80%).Nineteen patients underwent retrograde dilatation(84%response) while 5 patients had static dilatation(60%response); however, there was no significant difference in symptom improvement between the techniques(P = 0.5).Successful symptom resolution was also not significantly affected by dilator size, oropharyngeal dysfunction,Zenker's diverticulum, age or gender(P > 0.05). The only complication noted was uvular edema and a shallow ulcer after static dilatation in one patient, which resolved spontaneously and did not require hospital admission.CONCLUSION UES dilatation with a through-the-scope balloon by either static or retrograde technique is safe and effective for the treatment of dysphagia due to CP dysfunction. To our knowledge, this is the first study evaluating retrograde balloon dilatation of the UES. | Vinay Chandrasekhara Joyce Koh Lakshmi Lattimer Kerry B Dunbar William J Ravich John O Clarke | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 6 |
| 14 | China organ donation and transplantation update: the Hangzhou Resolution显示文摘The much-anticipated change in the practice of organ donation and transplantation in China is now underway and affirmed by an important Hangzhou Resolution promulgated at the 2013 China Transplant Congress.Support of the National Health and Family Planning Commission On October 29,2013,in a meeting of the National Health and Family Planning Commission (NHFPC)officials with Jie-Fu Huang,Head of National Organ Transplant Committee(OTC), Hai-Bo Wang,Director of China Organ Transplant Response System (COTRS) | Jie-Fu Huang Shu-Sen Zheng Yong-Feng Liu Hai-Bo Wang Jeremy Chapman Philip O'Connell Michael Millis John Fung Francis Delmonico | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 6 |
| 15 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)显示文摘 | René Adam Vincent Karam Valérie Delvart John O’Grady Darius Mirza Jurgen Klempnauer Denis Castaing Peter Neuhaus Neville Jamieson Mauro Salizzoni Stephen Pollard Jan Lerut Andreas Paul Juan Carlos Garcia-Valdecasas Fernando San Juan Rodríguez Andrew Burro | 2012 | Journal of Hepatology2012，，3： | 6 |
| 16 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 17 | Mechanical and cellular processes driving cervical myelopathy显示文摘Cervical myelopathy is a well-described clinical syndrome that may evolve from a combination of etiological mechanisms. It is traditionally classified by cervical spinal cord and/or nerve root compression which varies in severity and number of levels involved. The vast array of clinical manifestations of cervical myelopathy cannot fully be explained by the simple concept that a narrowed spinal canal causes compression of the cord, local tissue ischemia, injury and neurological impairment. Despite advances in surgical technology and treatment innovations, there are limited neuro-protective treatments for cervical myelopathy, which reflects an incomplete understanding of the pathophysiological processes involved in this disease. The aim of this review is to provide a comprehensive overview of the key pathophysiological processes at play in the development of cervical myelopathy. | Roisin T Dolan Joseph S Butler John M O'Byrne Ashley R Poynton | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 18 | Protective effect of pineapple ( Ananas cosmosus ) peel extract on alcohol–induced oxidative stress in brain tissues of male albino rats显示文摘 | Ochuko L Erukainure John A Ajiboye Rachael O Adejobi Oluwatoyin Y Okafor Sunday O Adenekan | 2011 | Asian Pacific Journal of Tropical Disease2011，，1： | 5 |
| 19 | Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia显示文摘AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter(UES) abnormality, and clinical and manometric profiles were compared.Correlation between UES abnormality and sub-type(i.e.,hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also evaluated.RESULTS: Among all 41 patients, 24(58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response compared to those with no UES abnormality(P = 0.017).CONCLUSION: The presence of UES abnormalities in patients with achalasia significantly predicted poorer treatment response as compared to those with normal UES function. | Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John O Clarke Ellen Stein Bani Chander Roland | 2014 | World Journal of Clinical Cases2014，2，9： | 5 |
| 20 | 提高母猪妊娠后期和哺乳期日粮能量浓度对其生产性能、仔猪活力和后代终生生长的影响(下)显示文摘人们对高产母猪的选育,导致每窝活产仔数显著增加,但是随之而来的仔猪活力和生长性能会因此降低。为了增强仔猪活力和提高生长性能,提高母猪哺乳期能量摄入越来越重要。研究旨在探索提高哺乳期母猪日粮能量(DE)浓度对母猪体重、背膘厚、乳成分及其后代仔猪活力和生长的影响。在妊娠108 d时将妊娠母猪(N=100;大白×长白)随机分配饲喂4种能量浓度日粮(消化能,DE,MJ/kg)直到再次配种:13.8(LL)、14.5(L)、15.2(H)、15.9(HH)。所有日粮均含有1.2%总赖氨酸。妊娠108 d和断奶(哺乳期第26天)时采集血样,哺乳期采集初乳(0 d)和常乳(14 d)。每天记录母猪哺乳期采食量。仔猪出生时记录每窝(总活)产仔数、仔猪初生重、宫内生长受限(IUGR)特征和肌张力。在出生时和出生后24 h记录仔猪鼓膜耳温(TEMP)。在后代猪第1、6、14、26、33、40、54、75和141日龄时称重。后代猪于断奶后(PW)饲喂标准谷物基础日粮。后代猪屠宰时(141日龄)记录胴体数据。HH母猪的哺乳期消化能摄入高于其他处理组(P<0.01)。初乳和常乳成分以及哺乳期采食量不受日粮处理影响。各处理组间的每窝产仔猪数和仔猪初生重相近。与其他处理组相比,LL母猪的后代表现出更多的IUGR特征(P<0.01),而HH母猪的后代表现出更好的肌张力(P<0.01)。与HH母猪的后代仔猪相比,LL母猪(P<0.01)和H母猪(P<0.01)的后代具有更高的24 h TEMP。H母猪断奶仔猪数高于L母猪(P<0.05)和HH母猪(P<0.01),而L母猪断奶仔猪窝重低于H母猪(P<0.05)和LL母猪(P<0.05)。断奶后仔猪生长不受日粮各处理影响。高DE日粮提高母猪能量摄入水平,但并不抑制食欲。饲喂HH日粮提高了仔猪出生时肌张力,而饲喂H日粮提高每窝断奶仔猪数。此次研究观察到仔猪活力的其他特征和断奶前窝生长性能结果互相矛盾。 | 何颖(编译) Rooney H B O’driscoll Keelin O’doherty John V | 2020 | 猪业科学2020，37，9： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员