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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Clinical measures of disease severity and outcome in psoriasis:a critical appraisal of their quality显示文摘 | ASHCROFT D M WAN PO A L WILLIAMS H C | 1999 | Br J Dermatol1999，141，2： | 1 |
| 3 | Improving the release characteristics of water-soluble drugs from hydrophilic sustained release matrices by in situ gas generation显示文摘 | Hashim H Li Wan Po A | 1987 | Int J Pharm1987，35，： | 1 |
| 4 | Delay-independent criteria for exponential stability generalized Cohen- Grossberg neural networks with discrete delay显示文摘 | Wan A H Qiao H Peng J G Wang M S | 2006 | Physics Letters A2006，353，： | 1 |
| 5 | Wheat stripe rust in China 显示文摘 | Wan A M Chen X M He Z H | 2007 | Australian Journal of Agricultural Research2007，58，6： | 1 |
| 6 | Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheu- matoid arthritis 显示文摘 | Wan B Nie H Liu A etal | 2006 | J Immunol2006，177，： | 1 |
| 7 | Influence of aging days and age at harvest on meat quality of Gannan Black yak显示文摘 | Wan H L Zhang L P Brown M A | 2011 | J Anim and Vet Adv2011，10，9： | 1 |
| 8 | Wheat stripe rust in China显示文摘 | Wan A M Chen X M He Z H | 2007 | Austrulian Journal of Agricultural Research2007，58，6： | 1 |
| 9 | An algorithm for dispatching a largepumped storage plant 显示文摘 | COHEN A I WAN S H | 1985 | IEEE Trans on Power Apparatus andSystems1985，104，8： | 1 |
| 10 | Wheat stripe rust in China显示文摘 | Wan A M Chen X M He Z H | | 0，，： | 1 |
| 11 | Brassinosteroids regulate grain filling in rice 显示文摘 | Wu C Y Trleu A Radhakrishnan P Kwok S F Harris S Zhang K Wang J L Wan J M Zhai H Q Takatsuto S Matsumoto S Fujioka S Feldmann K A Pennell R I | 2008 | Plant Cell2008，20，8： | 1 |
| 12 | Pioglitazone, a PPAR gamma ligand, suppresses NF kappaB activation through inhibition of IkappaB kinase activation in ceru- lean-treated AR42J cells 显示文摘 | Wan H Yuan Y Qian A | 2008 | Biomed Pharmacother2008，62，7： | 1 |
| 13 | Natural (^210Pb, ^7Be) and fallout (^137Cs,^239,240pu,^9OSr) radionuclides as geochemical tracers of sedimentation in Greifensee, Switzerland 显示文摘 | Wan G J Santsehi P H Sturm M Farrenkothen K Lueck A Werth W Schuler Ch | 1987 | Chem Geol1987，63，34： | 1 |
| 14 | Adolescent and adult soy intake and risk of breast cancer in Asian-Americans显示文摘 | Wu A H Wan P Hankin J | 2002 | Carcinogenesis2002，23，： | 1 |
| 15 | Generalized Vector Equilibrium Problems with Set-valued Mappings显示文摘 | Fu J Y and Wan A H | 2002 | Mathematical Methods of Operations Research2002，56，： | 1 |
| 16 | Industrial implementation issues of total site heat integration 显示文摘 | CHEW K H KLEMES J J WAN A S R | 2013 | Applied Thermal Engineering2013，61，1： | 1 |
| 17 | The behavior of suspended solid particles in rolling and sliding elastohydrody- namic contacts显示文摘 | Wan G T Y Spikes H A | 1988 | Stle Transactions1988，31，1： | 1 |
| 18 | Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability显示文摘 | Wu H Kuzmenko A Wan S | 2003 | J Clin Invest2003，111，10： | 1 |
| 19 | Wheat stripe rust in China 显示文摘 | Wan A M Chen X M He Z H | 2007 | Australian Journal of Agricultural Research2007，58，： | 1 |
| 20 | Characteristics of Triassic marine source rocks and prediction of favorable hydrocarbon generation area in Qiangtang basin,Tibet显示文摘 | Ding W Wan H Su A | 2011 | Energy Exploration & Exploitation2011，29，2： | 1 |
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