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| 1 | Two-phase smooth particle hydrodynamics modeling of air-water interface in aerated flows显示文摘Abstracted/indexed in:Science Citation Index,Science Citation Index Expanded(SciSearch),Journal Citation Reports/Science Edition,SCOPUS,INSPEC,Zentralblatt Math,Chemical Abstracts Service(CAS),Google Scholar,CSA,Academic OneFile,Current Contents/Engineering,Computing and Technology,Earthquake Engineering Abstracts,EI-Compendex,Gale,OCLC,SCImago,Summon by ProQuest Supervised by Chinese Academy of | YANG HuiXia LI Ran LIN PengZhi WAN Hang FENG JingJie | 2017 | Science China(Technological Sciences)2017，60，3： | 0 |
| 2 | MiR-590-5p suppresses renal fibrosis via targeting YAP显示文摘Persistent activation of Y esassociated protein(YAP)is profoundly implicated in facilitating transformation of myofibroblasts.However,its roles in the pathogenesis of renal fibrosis remain largely unexplored.In the present study,an upregulation of YAP was detected by qRT-PCR,Western blotting,and immunohistochemistry both in the kidney tissues of folic acid(F A)-induced chronic kidney disease(CKD)mice,and in SV40MES 13 cells stimulated with TGF-β1.The microRNAs predicted to target YAP were explored by transfection of miR-590-5p mimics or inhibitors and analyzed by luciferase reporter assay.The reporter indicated that miR 590-5p directly targeted the YAP 3-untranslated region. | Wang Kaiyue Wan Pengzhi Zou Yu Li Xue Xing Jia Deng Siqi Zhai Xiaoyue | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 3 | Effect of extracellular matrix stiffness on the progression of renal fibrosis显示文摘Medical University,Shenyang 110122,China.The mechanical microenvironment of cells is recently reported to associate with the progression of renal fibrosis.However,the mechanism has not been fully elucidated.In the present study,based on the precision measurement of atom force microscope(AFM),hydrogel substrates of various stiffness were prepared to simulate the hardness of extracellular matrix(ECM)in normal and fibrotic kidney tissue.Renal mesangial cells were then cultured on the hydrogel matrix with different hardness. | Fu Yuanyuan Wan Pengzhi Wang Kaiyue Xing Jia Zou Yu Li Xue Chen Hongyu Zhai Xiaoyue | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 4 | Roxadustat(FG-4592)pretreatment attenuates folic acid induced kidney injury via mitophagy显示文摘.Hypoxia precondition plays a protective role in tissues injured by oxidative stress.Whether or not mitophagy is involved needs to be explored.In the present study,the acute kidney injury model was established by folic acid(FA)administration.Roxadustat(FG-4592),a stabilizer of hypoxia-inducible factor(HIF)was used 2 days before FA insult to mimic hypoxia precondition.First of all,the results showed a protective effect,in both renal function and morphology with FG-4592 pretreatment.In addition,BNIP3 and FUNDC1,two key players in.receptor-mediated mitophagy,were induced to express with upregulation of HIF-1alpha.Meanwhile the mitochondrial marker translocase of outer mitochondrial membrane 20(TOMM20)and mtDNA decreased,indicating a decline of mitochondrial quality.On the other hand,PGC-lalpha,the master regulator of mitochondrial biogenesis,was detected no statistical significance,which implied that the decline may attribute to more mitophagy rather than less biogenesis.That upregulation of LC3B and downregulation of p62/SQSTM1 further proved the presence of mitophagy. | Zou Yu Li Xue Wang Kaiyue Xing Jia Wan Pengzhi Cong Jing Fu Yuanyuan Song Kexin Deng Siqi Zhai Xiaoyue | 2021 | 解剖学杂志2021，44，S01： | 0 |
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