|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 3 | Preparation and characterization of gelatin gel with a gradient structure 显示文摘 | Wang Y L Cheng G X Yao K D | 2000 | Polymer Int2000，49，12： | 1 |
| 4 | Paleocene-Eocene record of ophiolite obduction and initial India-Asia collision,south central Tibet显示文摘 | DING L PAUL K WAN X | 2005 | Tectonics2005，24，： | 1 |
| 5 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 6 | The evolution of equatorial trough of ionospheric F-region ionization 显示文摘 | LIU L B WAN W X | 2001 | Terr Atmos Ocean Sci2001，12，3： | 1 |
| 7 | Hierarchical map building based UKF-SLAM approach for AUV 显示文摘 | Shao G Wan L Shen X D | 2013 | Applied Me-chanics and Materials2013，437，： | 1 |
| 8 | Absorption Rate into a MDEA Aqueous Solution Blended with Piperazine under a High CO_2 Partial Pressure显示文摘 | Zhang X Wan H L Weng W Z Yi X D | | 0，，1： | 1 |
| 9 | Effect of acicular ferrite formation on grain refinement in the coarse-grained region of heataffected zone 显示文摘 | Wan X L Wei R Wu K M | 2010 | Mater Charact2010，61，7： | 1 |
| 10 | Influence of Mg content on quench sensitivity of AI-Zn-Mg-Cu aluminum alloys 显示文摘 | DENG Y L WAN L ZHANG Y Y ZHANG X M | 2011 | Journal of Alloys and Compounds2011，509，13： | 1 |
| 11 | 查看详情显示文摘 | Qian X F Wan Y Wen Y L Jia N Q Li H X Zhao D Y | | 0，，： | 1 |
| 12 | miR-320 enhances the sensitivity of human colon cancer cells to chemoradio- therapy in vitro by targeting FOXMI显示文摘 | Wan L Y Deng J Xiang X J | 2015 | Biochem Bio- phys Res Commun2015，457，2： | 1 |
| 13 | Molecular characterization of the bla(KPC-2) gene in clinical isolates of carbapenem- resistant Klebsiella pneumoniae from the pediatric wards of a Chinese hospital显示文摘 | Liu Y Li X Y Wan L G | 2012 | Can JMicrobiol2012，58，： | 1 |
| 14 | Retrieval of geophysical parameters from moderate resolution imaging spectroradiometer thermal infrared data: evalution of a twostep physical algorithm显示文摘 | MA X L WAN Z M MOELLER C C | 2000 | Applied Optics2000，39，： | 1 |
| 15 | Hydrogen diffusivity in boron-doped polycrystalline Ni3Al 显示文摘 | WAN X J ZHU J H JING K L | 1994 | Scripta Metallurgica et Materialia1994，31，： | 1 |
| 16 | Simultaneous retrieval of atmospheric profiles, land-surface temperature, and surface emissivity from moderate resolution imaging spectroradiometer thermal infrared data: extension of a two-step physical algorithm显示文摘 | MA X L WAN Z M MOELLER C C | 2002 | Applied Optics2002，41，： | 1 |
| 17 | Effect of exponential decay in hydraulic conductivity with depth on regional groundwater flow 显示文摘 | Jiang X W Wan L Wang X S | 2009 | Geophysical Research Letters2009，36，24： | 1 |
| 18 | A study on the curing and viscoelastic characteristics of melamine-urea-formaldehyde resin in the presence of aluminium silicate nanoclays显示文摘 | CAI X L RIEDL B WAN H | 2010 | Composites(Part A):Applied Science and Manufacturing2010，41，5： | 1 |
| 19 | Effects of urbanization on e-cosystem service values in a mineral resource - based city显示文摘 | Wan L Ye X Lee J | 2015 | Habitat International2015，，： | 1 |
| 20 | A new analytical solution of topography-driven flow in a drainage basin with depth-dependent anisotropy of permeability 显示文摘 | Wang X S Jiang X W Wan L | 2011 | Water Resources Research2011，47，09： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员