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| 1 | High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression显示文摘Hyperglycemia-mediated reactive oxygen species(ROS)accumulation plays an important role in hyperglycemia-induced endothelial injury.Kelch-like ECH-associated protein 1(Keap1)/nuclear factor erythroid 2-related factor 2(Nrf2)/antioxidant response element(ARE)pathway inhibition participates in hyperglycemia-induced ROS accumulation.Our previous study indicated that SET8 overexpression inhibits high glucose-mediated ROS accumulation in human umbillical vein endothelial cells(HUVECs).In the present study,we hypothesize that SET8 may play a major role in high glucose-induced ROS accumulation via modulation of Keap1/Nrf2/ARE pathway.Our data indicated that high glucose mediated cell viability reduction,ROS accumulation,and Nrf2/ARE signal pathway inhibition via upregulation of Keap1 expression in HUVECs.Moreover,high glucose inhibited the expressions of SET8 and H4K20me1(a downstream target of SET8).SET8 overexpression improved high glucose-mediated Keap 1/Nrf2/ARE pathway inhibition and endothelial oxidation.Consistently,the effects of sh-SET8 were similar to that of high glucose treatment and were reversed by si-Keap1.A mechanistic study found that H4K20me1 was enriched at the Keap1 promoter region.SE T8 overexpression attenuated Keap1 promoter activity and its expression,while mutant SET8 R259G did not affect Keap1 promoter activity and expression.The results of this study demonstrated that SET8 negatively regulates Keap1 expression,thus participating in high glucose-mediated Nrf2/ARE signel pathway inhibition and oxidative injury in HUVECs. | Xiangyuan Chen Jie Qi Qichao Wu Hui Jiang Jing Wang Wankun Chen Anrong Mao Minmin Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 2 | Design of Liveness-enforcing Supervisors for Flexible Manufacturing Systems Using Petri nets显示文摘 | Li Zhiwu Hu Hesuan Wang Anrong | 2007 | IEEE Trans on Systems Man and Cybernetics Part C2007，37，4： | 1 |
| 3 | X-RAY TOPOGRAPHIC STUDY OF HYDROGEN DAMAGE IN Fe-3 wt-% Si ALLOY显示文摘The formation and aggravation of hydrogen damage in Fe-3 wt-% Si alloy during cathodiccharging Were studied by means of Lange transmission X-ray topography.Results showedthat hydrogen damage did not form in the specimens charged in 0.5 mol/L H2S04 so-lution without poison,and occurred with addition of 250 mg/L As2O3 even at very lowcharge current density.As charging at a certain current density,the size of the damagemay enlarge up to a limit yet no more by prolonged time.The damage size increasedwith increase of charging current density,but not so apparent at high current density.An external tensile stress could promote the formation of hydrogen damage obviously.It seems that for charging in H2SO4 solution containing poison,the drop of hydrogenpermeation curve against time prolongation is due to the formation of hydrogen damages. | WANG Yanbin WANG Anrong CHU Wuyang XIAO Jimei University of Science and Technology Beijing,Beijing,China associate professor,Department of Materials Physics,University of Science and Technology Beijing,Beijing 100083,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，8： | 0 |
| 4 | Correlation Between Serum C-Reactive Protein And Cystatin C In Patients With Acute Cerebral Infarction And Carotid Artery Stenosis显示文摘To investigate the correlation between serum C-reactive protein (CRP) and serum cystatin C (Cys-C) levels in patients with acute cerebral infarction and carotid artery stenosis. Methods: From January 2015 to December 2016 admitted to our hospital new acute cerebral infarction parallel neck vascular color Doppler ultrasound examination showed 121 cases of carotid stenosis as the case group;select the same period of hospitalized patients with non-cerebrovascular disease in 50 cases As a control group. Fasting venous blood was collected on the third day after onset of the disease and serum levels of CRP and Cys-C were measured and compared. Results: Serum levels of CRP and Cys-C in case group were significantly higher than those in control group (P <0.05). The correlation between serum CRP and Cys-C was found in any pairwise comparison (r = 0.4732). The level of CRP and Cys-C were closely related to the degree of carotid artery stenosis (P <0.05). Conclusion: The combined detection of serum CRP and Cys-C levels can be used to evaluate the degree of carotid artery stenosis in patients with acute cerebral infarction and provide a reference for the next carotid endarterectomy. | Tao Zhang Xiaowen Yang Hui Wang Jie Luo Anrong Li Yi Zhou Yusi Cheng | 2018 | Advanced Emergency Medicine2018，7，1： | 0 |
| 5 | Preparation and antibacterial properties of polycaprolactone/quaternized chitosan blends显示文摘This article is a preliminary study on antibacterial blends of polycaprolactone,chitosan and quaternized chitosan by melt processing.Blends were characterized,mechanical test and antibacterial evaluation against Escherichia coli and Staphylococcus aureus,were conducted.Results showed that the antibacterial potential of chitosan was limited in blends and polycaprolactone/chitosan did not show significant antibacterial effect compared with neat polycaprolactone(PCL).Inhibition rates of polycaprolactone/quaternized chitosan were 39.2%99.9%against Escherichia coli,while inhibition rate was 40.9%99.9%against Staphylococcus aureus.When quaternized chitosan(QCTS)content was up to 20%,blends exhibited 99.9%inhibition rates against both two types of bacteria. | Anrong Zeng Yangtao Wang Dajun Li Juedong Guo Qiaowen Chen | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 0 |
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