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| 1 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 2 | ^(99m)Tc-labeled HAb18 McAb Fab fragment for radioimmunoimaging in nude mice bearing human hepatocellular carcinoma显示文摘99mTclabeledHAb18McAbFabfragmentforradioimmunoimaginginnudemicebearinghumanhepatocelularcarcinomaQIUKai1,2,WANGBoChen1,CHE... | Qiu K Wang BC Chen ZN Fang P Liu CG Wan WX Liu YF | 1998 | World Journal of Gastroenterology1998，4，2： | 8 |
| 3 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 4 | Mixed-layer water oscillations in tropical Pacific for ENSO cycle显示文摘The main modes of interannal variabilities of thermocline and sea surface wind stress in the tropical Pacific and their interactions are investigated,which show the following results.(1) The thermocline anomalies in the tropical Pacific have a zonal dipole pattern with 160°W as its axis and a meridional seesaw pattern with 6-8°N as its transverse axis.The meridional oscillation has a phase lag of about 90° to the zonal oscillation,both oscillations get together to form the El Ni?o/La Ni?a cycle,which be-haves as a mixed layer water oscillates anticlockwise within the tropical Pacific basin between equator and 12°N.(2) There are two main patterns of wind stress anomalies in the tropical Pacific,of which the first component caused by trade wind anomaly is characterized by the zonal wind stress anomalies and its corresponding divergences field in the equatorial Pacific,and the abnormal cross-equatorial flow wind stress and its corresponding divergence field,which has a sign opposite to that of the equatorial region,in the off-equator of the tropical North Pacific,and the second component represents the wind stress anomalies and corresponding divergences caused by the ITCZ anomaly.(3) The trade winds anomaly plays a decisive role in the strength and phase transition of the ENSO cycle,which results in the sea level tilting,provides an initial potential energy to the mixed layer water oscillation,and causes the opposite thermocline displacement between the west side and east side of the equator and also between the equator and 12°N of the North Pacific basin,therefore determines the amplitude and route for ENSO cycle.The ITCZ anomaly has some effects on the phase transition.(4) The thermal anomaly of the tropical western Pacific causes the wind stress anomaly and extends eastward along the equator accompanied with the mixed layer water oscillation in the equatorial Pacific,which causes the trade winds anomaly and produces the anomalous wind stress and the corresponding divergence in favor to conduce the oscillation,which in turn intensifies the oscillation.The coupled system of ocean-atmo-sphere interactions and the inertia gravity of the mixed layer water oscillation provide together a phase-switching mechanism and interannual memory for the ENSO cycle.In conclusion,the ENSO cycle essentially is an inertial oscillation of the mixed layer water induced by both the trade winds anomaly and the coupled ocean-atmosphere interaction in the tropical Pacific basin between the equator and 12°N.When the force produced by the coupled ocean-atmosphere interaction is larger than or equal to the resistance caused by the mixed layer water oscillation,the oscillation will be stronger or maintain as it is,while when the force is less than the resistance,the oscillation will be weaker,even break. | ZHAO YongPing1,CHEN YongLi1,WANG Fan1 & WU AiMing2 1 Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China 2 Department of Earth & Ocean Sciences,University of British Columbia,Vancouver,BC,V6T 1Z4,Canada | 2007 | Science China Earth Sciences2007，50，12： | 7 |
| 5 | Construction of energy transfer model of C-phycocyanin and allophycocyanin from Spirulina platensis显示文摘PHYCOBILIPROTEINS. which include phycoerythrin, phycocyanin, phycoerythroeyanin and allophycocyanin, are intensively coloured, highly fluorescent, water soluble chromoproteins. They are composed of at least two dissimilar polypeptides, α and β subunits, in a molar ratio of 1:1. The subunits possess linear tetrapyrrole prosthetic groups covalently linked to the primary structure via cysteine thioether linkages. In blue-green and red algae, phycobiliproteins occur in a supramolecular structure, the phycobilisome, located on the surface of thylakoid to | Wang, GC Zhou, BC Zeng, CK | 1997 | Chinese Science Bulletin1997，42，1： | 6 |
| 6 | 透析前后血压水平与全因死亡风险的关系:一项剂量-效应关系的荟萃分析显示文摘血液透析人群的血压管理是一个巨大挑战。该研究旨在通过剂量-效应关系的荟萃分析,评估血液透析人群中透析前后血压水平与全因死亡风险之间关联的定量特征和潜在阈值。研究人员搜索了2017年3月18日之前发表的、关于透析前后血压水平与全因死亡率风险关联的所有前瞻性队列研究资料,共纳入来自8项研究的229688例普通血液透析患者。 | 刘莉 叶鹏 Han YC Tu Y Zhou LT Pan MM Wang B Liu H Tang RN Liu BC | 2018 | 中华高血压杂志2018，26，11： | 2 |
| 7 | A conjecture on k-factor-critical and 3-γ-critical graphs显示文摘For a graph G =(V,E),a subset VS is a dominating set if every vertex in V is either in S or is adjacent to a vertex in S.The domination number γ(G) of G is the minimum order of a dominating set in G.A graph G is said to be domination vertex critical,if γ(G-v) < γ(G) for any vertex v in G.A graph G is domination edge critical,if γ(G ∪ e) < γ(G) for any edge e ∈/E(G).We call a graph G k-γ-vertex-critical(resp.k-γ-edge-critical) if it is domination vertex critical(resp.domination edge critical) and γ(G) = k.Ananchuen and Plummer posed the conjecture:Let G be a k-connected graph with the minimum degree at least k+1,where k 2 and k≡|V|(mod 2).If G is 3-γ-edge-critical and claw-free,then G is k-factor-critical.In this paper we present a proof to this conjecture,and we also discuss the properties such as connectivity and bicriticality in 3-γ-vertex-critical claw-free graph. | WANG Tao1&YU QingLin2 1Institute of Applied Mathematics,College of Mathematics and Information Science,Henan University,Kaifeng 475001,China 2Department of Mathematics and Statistics,Thompson Rivers University,Kamloops,BC V2C5N3,Canada | 2010 | Science China Mathematics2010，53，5： | 2 |
| 8 | The threatening of advanced Aden carcinoma expressing MDR1gene with high doseof CF and 52FU显示文摘 | Guo J Wang BC DIJ S | 1997 | J Cling Oncol1997，2，3： | 1 |
| 9 | An indirect boundary element method for three-dimensional explosion bubble显示文摘 | Wang C Khoo BC | 2004 | Journal of Comput Phys2004，194，： | 1 |
| 10 | Analysis of the efficacy and prognosis of limb-salvage surgery for osteosarcoma around the knee显示文摘 | Tan PX Yong BC Wang J | 2012 | Eur J Surg Oncol2012，38，12： | 1 |
| 11 | Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis显示文摘 | Wang G Kwan BC Lai FM | | 0，，1： | 1 |
| 12 | Doppler Ultrasoundguided Percutaneous Nephrolithotomy:A Prospective Randomized Study显示文摘 | Tzeng BC Wang CJ Huang SW | 2011 | Urology2011，78，3： | 1 |
| 13 | A novel chemokine receptor for SDF 1 and I-TAC involved in cell survival, cell adhesion, and tumor development显示文摘 | Burns JM Summers BC Wang Y | 2006 | J Ea''p Med2006，203，22： | 1 |
| 14 | Resequencing microarray probe design for typing genetically diverse viruses:human rhinoviruses and enteroviruses显示文摘 | Wang Z Malanoski AP Lin BC | | 0，，01： | 1 |
| 15 | A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival,cell adhesion,and tumor development显示文摘 | Bums JM Summers BC Wang Y | 2006 | J Exp Med2006，203，9： | 1 |
| 16 | Single-component versus multi-component dietary goals for the metabolic syndrome : a randomized trial 显示文摘 | Ma Y Olendzki BC Wang J | 2015 | Ann Intern Med2015，162，4： | 1 |
| 17 | Failure to confirm HIV infec- tion in two end - stage HIV/AIDS patients using a popular commer- cial line immunoassay 显示文摘 | Tang JW Wang BC Lam E | 2008 | J Med Virol2008，80，9： | 1 |
| 18 | Capsule Structural Heterogeneity and Antigenic Variation in Crypto- coccus neoformans 显示文摘 | McFadden DC Fries BC Wang F | 2007 | Eukaryotic Cell2007，6，8： | 1 |
| 19 | The cadherin- catenin complex is expressed alternately with the adeno- matous polyposis coli protein during rat incisor ameloge- nesis显示文摘 | Sorkin BC Wang MY Dobeck JM | 2000 | J Histochem Cytochem2000，48，3： | 1 |
| 20 | A novel chemokine receptor for SDF-1 and I-TAC involved in cell sunrival,eell adllesion,and tumor development显示文摘 | Burns JM Summers BC Wang Y et d | 2006 | J Exp Med2006，203，9： | 1 |
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