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| 1 | Vitamin K2 suppresses rotenone-induced microglial activation in vitro显示文摘瞄准:增加的证据证明了象毒鱼藤素和 paraquat 那样的环境因素导致 neuroinflammation,它贡献 Parkinsons 疾病(PD ) 的致病。在这研究,我们调查了由 menaquinone-4 (MK-4 ) 位于压抑下面的分子的机制,在 vitro.Methods 的导致毒鱼藤素的 microglial 激活的维生素 K 2, 的一种子类型:一根 microglial 房间线(BV2 ) 暴露于毒鱼藤素(1 μ mol/L ) 与或没有 MK-4 处理。TNF-α 的层次;或 IL-1β在 100 μ BV2 房间的有教养的媒介的 L 用 ELISA 工具包被测量。与毒鱼藤素对待与或没有 MK4 的 BV2 房间受到 mitochondrial 膜潜力, ROS 生产, immunofluorescence 或 immunoblot 试金。neuroblastoma SH-SY5Y 房间与暴露于毒鱼藤素与或没有 MK-4 处理的 BV2 房间的调节媒介(厘米) 被对待,并且房间生存能力用 MTT assay.Results 被估计:在对待毒鱼藤素的 BV2 房间, MK-4 (0.5-20 μ mol/L ) dose-dependently 在 TNF-α 的房间,以及生产在 iNOS 和 COX-2 的表示压制了 upregulation;并且 IL-1β在有教养的媒介。MK-4 (5-20 μ mol/L ) NF-κ 的显著地禁止的导致毒鱼藤素的原子 translocation;在 BV2 房间的 B。MK-4 (5-20 μ mol/L ) 在 BV2 房间的显著地禁止的导致毒鱼藤素的 p38 激活, ROS 生产,和 caspase-1 激活。MK-4 (5-20 μ mol/L ) 也恢复了被毒鱼藤素损坏了的 mitochondrial 膜潜力。到从对待毒鱼藤素的 BV2 房间的厘米的暴露显著地减少了 SH-SY5Y 房间的生存能力。然而,当 BV2 房间与 MK-4 被共同对待时, SH-SY5Y 房间的这激活毒鱼藤素的调停 microglia 的死亡显著地被稀释(5-20 μ mol/L ).Conclusion:维生素 K 2 能直接由镇压在 vitro 压制 microglial BV2 房间的导致毒鱼藤素的激活 ROS 生产和 p38 激活。 | Yan-xia YU Yi-pei LI Feng GAO Qing-song HU Yah ZHANG Dong CHEN Guang-hui WANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 5 |
| 2 | A New Acylated Iridoid Glucoside from Avicennia marina显示文摘A new acylated iridoid glucoside, namely, 2′-O-(5-phenyl-2E, 4E-pentadienoyl)- mussaenosidic acid, was isolated from the aerial parts of the mangrove plant Avicennia marina. The structure of the new compound was established on the basis of various NMR spectroscopic analyses, including 2D NMR techniques (1H-1H COSY, HMQC, and HMBC) and HR-FAB-MS. This compound displayed moderate antioxidant activity. | Yah FENG Xiao Ming LI Xiao Juan DUAN Bin Gui WANG | 2006 | Chinese Chemical Letters2006，17，9： | 2 |
| 3 | Synthesis, characterization and ring-opening polymerization of a novel six-membered cyclic carbonate bearing pendent allyl ether group显示文摘 | He Feng Wang Yah Ping Zhuo Ren Xi | 2008 | Polymer2008，49，5： | 1 |
| 4 | Influence of Mg21Ga5Hg3 compound on electrochemical properties of Mg-5%Hg-5%Ga alloy显示文摘 | FENG Yah WANG Ri-chu PENG Chao-qun WANG Nai-guang | 2009 | Transactions of Nonferrous Metals Society of China2009，19，： | 1 |
| 5 | A discussion on im- proving hydration activity of steel slag by altering its miner- al compositions显示文摘 | Wang Qiang Yah Peiyu Feng Jianwen | 2011 | Journal of Hazardous Materials2011，186，23： | 1 |
| 6 | Activation of Mg-Hg anodes by Ga in NaC1 solution显示文摘 | FENG Yah WANG Ri-chu YU Kun PNEG Chao-qun ZHANG Jia-pei ZHANG Chun | 2009 | Journal of Alloys and Compounds2009，473，1： | 1 |
| 7 | A novel N- doped TO2 with high visible light photocatalytic activity 显示文摘 | Wang Yah Feng Caixia Jin Zhensheng | 2006 | Molecular Catalysis A : Chemlcal2006，260，： | 1 |
| 8 | Chromate passivation of hot dipped Zn25Al alloy coatings显示文摘 | LI Yah WANG Hong-ren HOU B-tong FENG Fa-lun WEI Xu-jun | 2001 | British Corrosion Journal2001，36，1： | 1 |
| 9 | Design of high-volume fly ash concrete for a massive foundation slab 显示文摘 | Wang Q Yah P Y Feng J G | 2013 | Magazine of Concrete Research2013，65，2： | 1 |
| 10 | The expression of NF-E2-related factor 2 in the rat brain after traumatic brain injury显示文摘 | Yah W Wang H D Feng X M | 2009 | J Trauma2009，66，5： | 1 |
| 11 | Synthesis of novel fullereneα-amino acid conjugates显示文摘有氨基的保护的伪 - 和伪 - carboxyl 组的丁氨二酸酸和 glutamic 酸被用来与代替 N 的 3,4-fullero pyrrolidine 的激活的氢氧根组一起反应。产品是 deprotected,负担得起二 monofullerene 伪 - 氨基酸, monofullerene 丁氨二酸酸(mFas ) 和 monofullerene glutamic 酸(mFgu ) 。然后 bifullerene glutamic 酸结合(bFguC ) 被与代替 N 的 3,4-fullero pyrrolidine 包含保护的氨基的组的 mFgu 的反应综合。 | Jing Zhang Yah Xia Wang Feng Kang Ying Ya Shao Zong Jie Li Xin Lin Yang | 2008 | Chinese Chemical Letters2008，19，10： | 1 |
| 12 | Clinical research on treatment of dysphagia with neck acupuncture显示文摘 | Wang Feng yah Sun Ping | 2007 | World J Acu-moxi2007，17，2： | 1 |
| 13 | Recon- structing Hyperspectral Images from Compressive Sensors via Exploiting Multiple Priors显示文摘 | JIA Ying-biao FENG Yah WANG Zhong-liang | 2015 | Spectroscopy Letters2015，48，1： | 1 |
| 14 | The mechanism of the sudden termination of carbon nanotube supergrowth 显示文摘 | Wang Xiaozhi Feng Yah Unalan H E | 2011 | Carbon2011，49，1： | 1 |
| 15 | Research progress of magnesium anodes and their applications in chemical power sources显示文摘 | WANG Nai-guang WANG Ri-chu PENG Chao-qun HU Chang-wang FENG Yah PENG Bing | 2014 | Transaction of Nonferrous Metals Society of China2014，24，8： | 1 |
| 16 | Imatinib plasma levels are correlated with clinical benefit in patients with unresectable/metastatic gastrointestinal stromal tumors显示文摘 | DEMETRI GD WANG Yah -feng WEHRLE E | 2009 | Journal of Clinical Oncology2009，27，19： | 1 |
| 17 | Hydroxyethyl starch,but not modified fluid gelatin,affects inflammatory response in a rat model of polymicrobial sepsis with capillary leakage显示文摘 | Feng X Yah W Wang Z | | 0，，03： | 1 |
| 18 | Seasonal variation of gaseous mercury exchange rate between air and water surface over Baihua reservoir,Guizhou,China显示文摘 | Feng X Yah H Wang S | 2004 | Atmospheric Environmetn2004，38，： | 1 |
| 19 | Synthesis of a New Asymmetrical Ether Diamine with Aromatic Structure and Related Polyimide显示文摘A new aromatic asymmetrical ether diamine, 1,4-bis(3’,4’’-diaminophenoxy)benzene 3 was synthesized in three steps, using hydroquinone as starting material. A new aromatic polyimide containing asymmetrical diaryl ether segments was prepared from the resulting diamine with 4,4’-oxydiphthalic anhydride (ODPA) via a conventional two-step thermal or chemical imidization method. The resulting polyimide exhibits high thermal resistance, excellent solubility, film-forming capability, high mechanical strength and modulus. | Yu SHAO Yah Feng LI Xiao Long WANG Shu Jiang ZHAN Xin ZHAO Tao MA | 2006 | Chinese Chemical Letters2006，17，5： | 1 |
| 20 | A discussion on improving hydration activity of steel slag by altering its mineral compositions显示文摘 | WANG Qinag YAH Peiyu FENG Jianwen | 2011 | Journal of Hazardous Materials2011，186，： | 1 |
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