5篇
您的检索式：作者名="Wang Naijing"
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| 1 | Emergence of trend trading and its effects in minority game显示文摘 | Liu Xinghua Liang Xiaobei Wang Naijing | 2006 | Physca A2006，369，： | 1 |
| 2 | Feature weighted na?ve Bayes algorithm for information retrieval of enterprise systems显示文摘 | Li Wang Ping Ji Jing Qi Siqing Shan Zhuming Bi Weiguo Deng Naijing Zhang | 2014 | Enterprise Information Systems2014，，1： | 1 |
| 3 | Emergence of Trend Trading and Its Effects In Minority Game显示文摘 | Liu Xinghua Xiaobei Liang Naijing Wang | 2006 | Physica A2006，，： | 1 |
| 4 | High-Affinity Decoy PD-1 Mutant Screened from an Epitope-Specific Cell Library显示文摘Immunotherapy with anti-programmed cell death protein-1(PD-1)/programmed cell death ligand-1(PDL1)monoclonal antibodies has become routine in the treatment of many kinds of human cancers,such as lung cancer,intestinal cancer,and melanoma.The PD-1/PD-L1 pathway inhibits T cell activation in the micro-environment,making it an attractive target against cancer.Wild-type(WT)PD-1 ectodomain has been shown to have difficulty blocking PD-1/PD-L1 mixture formation due to its low affinity.The present work uses three-dimensional(3D)crystal complex structures to analyze the interaction by which PD-1 binds to PD-L1 or PD-L2.It also reports on a theoretical study of the binding mode between PD-1 and its clinical antibody Opdivo.Based on the theoretical binding analysis of PD-1 and its ligands(i.e.,PD-L1 and PD-L2)or antibody(Opdivo),a small-content,epitope-oriented mammalian cell library was established for PD-1.After three rounds of cell sorting,the decoy PD-1 mutant 463,which presented a higher affinity than WT PD-1 to the PD-L1(the affinity has increased by almost three orders of magnitude)was screened out.It exhibited an inhibitory effect against PD-1 to prevent it from forming mixtures with PD-L1,which was similar to the effect of the commercial anti-PD-L1 antibody atezolizumab(ATE).The median effective concentration(EC50)value of the decoy mutant was 0.031 μg·mL^(-1) in comparison with 0.063 μg·mL^(-1) for ATE;both values were much lower than that of WT PD-1,at 2.571 μg·mL^(-1).The 463 decoy mutant reversed the inhibitory function of PD-1 in T cell activation;furthermore,10 mg·kg^(-1) of 463 inhibited about 75%of tumor growth in vivo in a MC38 transgenic xenograft mice model,which was similar to the activity of ATE.More interestingly,an even lower dose of 463(2 mg·kg^(-1))showed a better effect than 10 mg·kg^(-1) of WT PD-1.This work offers the decoy 463 with an improved curative effect,which holds potential to become a good option against PD-1/PD-L1-related cancers. | Hao Liu Chunxia Qiao Naijing Hu Zhihong Wang Jing Wang Jiannan Feng Beifen Shen Yuanfang Ma Longlong Luo | 2021 | Engineering2021，7，11： | 0 |
| 5 | Potential Distribution of Seagrass Meadows Based on the MaxEnt Model in Chinese Coastal Waters显示文摘Seagrass meadows are generally diverse in China and have become important ecosystem with essential functions.However,the seagrass distribution across the seawaters of China has not been evaluated,and the magnitude and direction of changes in seagrass meadows remain unclear.This study aimed to provide a nationwide seagrass distribution map and explore the dynamic changes in seagrass population under global climate change.Simulation studies were performed using the modeling software MaxEnt with 58961 occurrence records and 27 marine environmental variables to predict the potential distribution of seagrasses and calculate the area.Seven environmental variables were excluded from the modeling processes based on a correlation analysis to ensure predicted suitability.The predicted area was 790.09 km^(2),which is much larger than the known seagrass distribution in China(87.65 km^(2)).By 2100,the suitable habitat of seagrass will shift northwest and increase to 923.62 km2.Models of the sum of the individual family under-pre-dicted the national distribution of seagrasses and consistently showed a downward trend in the future.Out of all environmental vari-ables,physical parameters(e.g.,depth,land distance,and sea surface temperature)contributed the most in predicting seagrass distri-butions,and nutrients(e.g.,nitrate,phosphate)ranked among the key influential predictors for habitat suitability in our study area.This study is the first effort to fill a gap in understanding the distribution of seagrasses in China.Further studies using modeling and biological/ecological approaches are warranted. | WANG Ming WANG Yong LIU Guangliang CHEN Yuhu YU Naijing | 2022 | Journal of Ocean University of China2022，21，5： | 0 |
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