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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 3 | Re–Os Dating of Bitumen from Paleo–Oil Reservoir in the Qinglong Antimony Deposit, Guizhou Province, China and Its Geological Significance显示文摘Abundant organic inclusions are present in the Qinglong antimony deposit. However, the source rocks of these organic matters have not been reliably identified. Recently, a paleo–oil reservoir was found in the Qinglong antimony deposit. In view of similar components of gaseous hydrocarbon, we propose that the organic matters observed in inclusions in Qinglong antimony deposit would come from this paleo–oil reservoir. We used the Re–Os dating method to determine the age of the bitumen from this paleo–oil reservoir, and obtained an isochron age of 254.3±2.8 Ma. The age indicates that the oilgeneration from source rock occurred in the early Late Permian, earlier than the Sb mineralization age(~148±8.5 Ma) in the Qinglong antimony deposit area. After oil generation from Devonian source rock, first and secondary migration, the crude oil have probably entered into the fractures and pores of volcanic rocks and limestone and formed a paleo–oil reservoir in the western wing of Dachang anticline. As burial process deepened, the crude oil has turned into natural gas, migrates into the core of Dachang anticline and formed a paleo–gas reservoir. The hydrocarbons(including CH_4) in the reservoirs can serve as reducing agent to provide the sulfur required for Sb mineralization through thermal chemical reduction of sulfates. Therefore, the formation of oil–gas in the area is a prerequisite for the Sb mineralization in the Qinglong antimony deposit. | WANG Pengpeng HU Yuzhao LIU Lu JIANG Xiaojun LI Chao Chad Joseph Bartholomew ZHANG Guiquan | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 6 |
| 4 | Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats显示文摘Bisphenol A (BPA), an estrogenic chemical, has been shown to reduce sperm count; however, the underlyingmechanisms remain unknown. Herein, we show that oral administration of BPA (2 μg/kg) for consecutive 14 daysin adult rats (BPA rats) significantly reduced the sperm count and the number of germ cells compared to controls.The serum levels of testosterone and follicle-stimulating hormone (FSH), as well as the level of GnRH mRNA inBPA rats were lower than those of control rats. Testosterone treatment could partially rescue the reduction of germcells in BPA rats. Notably, the number of apoptotic germ cells was significantly increased in BPA rats, which wasinsensitive to testosterone. Furthermore, the levels of Fas, FasL and caspase-3 mRNA in the testicle of BPA ratswere increased in comparison with controls. These results indicate that exposure to a low dose of BPA impairsspermatogenesis through decreasing reproductive hormones and activating the Fas/FasL signaling pathway. | Pengpeng Jin Xiaoli Wang Fei Chang Yinyang Bai Yingchun Li Rong Zhou Ling Chen | 2013 | The Journal of Biomedical Research2013，27，2： | 5 |
| 5 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 6 | Time-Variant Reliability-Based Multi-Objective Fuzzy Design Optimization for Anti-Roll Torsion Bar of EMU显示文摘Although various types of anti-roll torsion bars have been developed to inhibit excessive roll angle of the electric multiple unit(EMU)car body,it is critical to ensure the reliability of structural design due to the complexity of the problems involving time and uncertainties.To address this issue,amulti-objective fuzzy design optimization model is constructed considering time-variant stiffness and strength reliability constraints for the anti-roll torsion bar.A hybrid optimization strategy combining the design of experiment(DoE)sampling and non-linear programming by quadratic lagrangian(NLPQL)is presented to deal with the design optimization model.To characterize the effect of time on the structural performance of the torsion bar,the continuous-time model combined with Ito lemma is proposed to establish the time-variant stiffness and strength reliability constraints.Fuzzy mathematics is employed to conduct uncertainty quantification for the design parameters of the torsion bar.A physical programming approach is used to improve the designer’s preference and to make the optimization results more consistent with engineering practices.Moreover,the effectiveness of the proposed method has been validated by comparing with current methods in a practical engineering case. | Pengpeng Zhi Zhonglai Wang Bingzhi Chen Ziqiang Sheng | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 5 |
| 7 | Controllable synthesis of highly crystallized mesoporous TiO2/WO3 heterojunctions for acetone gas sensing显示文摘Mesoporous semiconducting metal oxides(SMOs)heterojunctions are appealing sensors for gas detecting.However,due to the different hydrolysis and condensation mechanism of every metal precursor and the contradiction between high crystallinity and high surface area,the synthesis of mesoporous SMOs heterojunctions with highly o rdered mesostructures,highly crystallized frameworks,and high surface area remains a huge challenge.In this work,we develop a novel'acid-base pair'adjusted solvent evaporation induced self-assembly(EISA)strategy to prepare highly crystallized ordered mesoporous TiO2/WO3(OM-TiO2/WO3)heterojunctions.The WCl6 and titanium isopropoxide(TIPO)are used as the precursors,respectively,which function as the'acid-base pair',enabling the coassembly with the structure directing agent(PEO-b-PS)into highly ordered meso structures.In addition,PEO-b-PS can be converted to rigid carbon which can protect the meso structures from collapse during the crystallization process.The resultant OM-TiO2/WO3 heterojunctions possess primitive cubic mesostructures,large pore size(~21.1 nm),highly crystalline frameworks and surface area(~98 m2/g).As a sensor for acetone,the obtained OM-TiO2/WO3 show excellent re sponse/recovery perfo rmance(3 s/5 s),good linear dependence,repeatability,selectivity,and long-term stability(35 days). | Changyao Wang Yuhui Li Pengpeng Qiu Linlin Duan Wei Bi Yan Chen Dingyi Guo Yupu Liu Wei Luo Yonghui Deng | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 8 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 9 | Integration of nanoscale light emitters:an efficient ultraviolet and blue random lasing from NaYF_4:Yb/Tm hexagonal nanocrystals显示文摘Near infrared light-controlled release of payloads from ultraviolet-sensitive(UV-sensitive) polymer hydrogels or nanocarriers is one of the most promising strategies for biotherapy. Here, we propose the concept of light activation of NaYF_4:20%Yb, 2%Tm nanocrystals(NCs). NaYF_4:20%Yb, 2%Tm NCs are synthesized by a solvothermal method. Effective upconversion luminescence from NaYF_4:20%Yb, 2%Tm NCs excited by a continuous wave(CW) 980 nm laser is obtained. The NaYF_4:20%Yb, 2%Tm NCs are then used as a laser gain medium and sandwiched between Al and quartz reflectors to form laser microcavities. UV and blue upconverted random lasing is obtained from the laser microcavities. Hence, we verify explicitly that the NaYF_4:Yb, Tm NCs support UV and blue upconversion random lasing via a 980 nm nanosecond laser excitation. Our work provides what we believe is a new concept for precision and localized cancer therapy by external light excitation. | YA-PEI PENG WEI LU PENGPENG REN YIQUN NI YUNFENG WANG LONG ZHANG YU-JIA ZENG WENFEI ZHANG SHUANGCHEN RUAN | 2018 | Photonics Research2018，6，10： | 4 |
| 10 | Dynamics of unstable continental subduction:Insights from numerical modeling显示文摘Numerical experiments are used in this study to systematically investigate the effects of convergence rate,crustal rheological strength,and lithospheric thermal structure on the dynamics of continental collision.The study focuses on the types,conditions and processes of unstable continental subduction.Modelling results suggest that the development of unstable continental subduction can be promoted by conditions that tend to decrease rheological strength of the lithosphere,such as low crustal rheological strength,'hot'thermal structure of the lithosphere,or low convergence rate.Unstable subduction mode can be further categorized into three types:(1)multi-stage slab breakoff,(2)continuously'flowing'of fluid-like slab into the upper mantle,and(3)large-scale detachment of the thickened orogenic root.These three types of unstable continental subduction are respectively associated with(1)a low convergence rate,(2)'hot'thermal structure of the lithosphere with a high convergence rate,and(3)moderate-high crustal rheological strength with a low convergence rate.It is also revealed that the evolution of crustal melting is dominated by the deformation pattern of continental collision,which is mainly controlled by crustal rheological strength.The modelling results have important implications for understanding of continental subduction mode selection under specific geodynamic conditions. | HUANGFU PengPeng WANG YueJun FAN WeiMing LI ZhongHai ZHOU YongZhi | 2017 | Science China Earth Sciences2017，60，2： | 3 |
| 11 | A Phase Shift Demodulation Technique: Verification and Application in Fluorescence Phase Based Oxygen Sensors显示文摘基于能够测量 0.03 阶段度的减法,在正弦曲线之间的限制表明的一种阶段移动解调技术在这份报纸被介绍。一个自我获得模块和实际 subtracter 扮演阶段移动解调系统的内核部分。在不同阶段的电的信号被用来验证系统的性能。另外,新设计光来源,激光纤维微分来源(LFDS ) ,能够产生微型阶段被用来进一步验证系统可靠性。在电的信号的 0.99997 的 R 平方和在 LFDS 的 0.99877 的 R 平方被完成,并且 0.03 度测量限制在实验被认识到。而且,阶段移动解调系统被用于荧光阶段认识到基础的基于的氧传感器工作。试验性的结果揭示那一次好重复并且更好,比 0.02% 氧集中测量,精确性被认识到。另外,阶段移动解调系统能对另外的应用程序容易综合。 | Chuanwu JIA Jun CHANG Fupeng WANG Hao JIANG Cunguang ZHU Pengpeng WANG | 2016 | Photonic Sensors2016，6，2： | 3 |
| 12 | Rationally tailoring interface characteristics of ZnO/amorphous carbon/graphene for heat-conduction microwave absorbers显示文摘With the increasingly severe electromagnetic interference issue and the huge heat dissipation demand caused by the miniaturized and integrated electronic devices,exploring the heat-conduction microwave absorption(MA)materials is highly desired and remains a great challenge.Herein,we reported the fabrication of ZnO/amorphous carbon(ZnO/AC)hybrid films covered on the surface of graphene(ZnO/AC/Graphene)to simultaneously apply as the MA and thermal management materials.The ZnO/AC coatings synthesized with the auxiliary of an atomic layer deposition(ALD)method are highly uniform and controllable,which can significantly improve the MA performance and thermal conduction properties of graphene.The reflection loss(RL)of−55.4 dB and the effective absorption bandwidth of 5.3 GHz were achieved with thickness of 2.0 mm for ZnO/AC/Graphene at a low loading content(3 wt.%).The minimum RL of−57.9 dB can be obtained in the ZnO/AC/Graphene composites at a low frequency(7.8 GHz).Moreover,the absorption frequency can be regulated by changing the ZnO/AC which can be readily implemented by adjusting the ALD cycles of ZnO.The thermal conductivity of ZnO/AC/Graphene is up to 257.8 mW·m^(−1)·K^(−1),increased by 53.2%compared with natural rubber.The enhancement mechanisms of microwave loss and heat conduction are systematically studied in detail.This work not only develops an excellent candidate,but also provides a novel strategy to design functional materials for heat-conduction MA application. | Maofan Zhou Xuefei Xu Gengping Wan Pengpeng Mou Shengjie Teng Guizhen Wang | 2022 | Nano Research2022，15，10： | 3 |
| 13 | A Four-Element Sensor Array Consisting of Asymmetric Distributed-Feedback Fiber Lasers显示文摘在根据他们的斜坡效率登上顺序安排四不对称的分布式反馈的纤维激光(DFB-FL ) 形成的一个传感器数组系统被建议。产量平坦能有效地用不对称的 DFB-FLs 的申请被改进。尽管它获得了最小的泵力量,最后元素几乎与其它一起有一样的产量。相对紧张噪音(RIN ) 和传感器数组的松驰摆动频率也被分析。某个 DFB-FL 的松驰摆动频率与它在数组的相对位置相关,这被发现。并且某个 DFB-FL 的 RIN 被另外的元素总是在数组影响,它不大概他们的安排是依赖的。 | Pengpeng WANG Jun CHANG Cunguang ZHU Boning SUN Guangping LV Sasa ZHANG Yanjie ZHAO Zhihui SUN Xiaolei ZHANG Gangding PENG | 2014 | Photonic Sensors2014，4，2： | 2 |
| 14 | Ordered mesoporous carbon-silica frameworks confined magnetic mesoporous TiO_(2) as an efficient catalyst under acoustic cavitation energy显示文摘Herein,we report a biphase stratification strategy that enables the encapsulation of magnetic mesoporous TiO_(2) inside an ordered mesoporous C/SiO_(2) framework.The obtained composites exhibit high surface areas(up to 600 m^(2) g^(-1)),large perpendicular pore sizes(up to 9 nm)and a strong magnetic response(~10.0 emu g^(-1)),presenting significantly enhanced degradation activities toward pentachlorophenol(PCP)and bisphenol-A(BPA)under acoustic cavitation energy.The remarkable performance is ascribed to the synergistic effect from the unique structural modulation:1)The large ordered mesopores favors the mass transfer,2)The mesoporous C/SiO_(2) frameworks promote the adsorption of organic pollutants and enrich them close to the TiO_(2) surface and 3)The special spatial arrangement of different components facilitates the generation of cavitation bubbles,leading to the increase in the overall hydroxyl-radical-production rate.Moreover,owing to the effective confinement,the as-prepared materials possess an excellent stability and durability.More importantly,the catalysts can easily be recovered by a magnet and show an excellent reusability.It is believed that these results could provide an important insight for the development of an efficient,stable and facile recoverable catalyst for the acoustic chemical process. | Pengpeng Qiu Tao Zhao Jeehyeong Khim Wan Jiang Lianjun Wang Wei Luo | 2020 | Journal of Materiomics2020，6，1： | 2 |
| 15 | Hepatitis B virus-associated follicular lymphoma presents T-cell inflamed phenotype and response to lenalidomide显示文摘Dear Editor,Follicular lymphoma(FL)represents the most common subtype of indolent non-Hodgkin's lymphoma(NHL)with distinct pathological,cytogenetic,and molecular features,accounting for 9.7%of NHLs in China[1].FL maintains a differentiation stage similar to germinal center(GC)B cells and is divided into grades 1,2,3A,and 3B[2].Up to 90%of FLs harbor the t(14;18)(q32;q21)/BCL2 apoptosis regula-tor(BCL2)-immunoglobulin heavy locus(IGH)transloca-tion and epigenetic modifier mutations,particularly lysine methyltransferase 2D(KMT2D)and CREB-binding pro-tein(CREBBP)[2]. | Nan Wang Wei Qin Zhong Zheng Ming Zhao Jie Xiong Hai Fang Rui Sun Yichao Wang Chen Li Lei DongXiaojian Sun Li Wang Pengpeng Xu Shu Cheng Haimin Xu Fan Zhang Weili Zhao | 2022 | Cancer Communications2022，42，2： | 2 |
| 16 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 17 | CRISPR-Cas adaptive immune systems in Sulfolobales:genetic studies and molecular mechanisms显示文摘CRISPR-Cas systems provide the small RNA-based adaptive immunity to defend against invasive genetic elements in archaea and bacteria.Organisms of Sulfolobales,an order of thermophilic acidophiles belonging to the Crenarchaeotal Phylum,usually contain both type I and typeⅢCRISPR-Cas systems.Two species,Saccharolobus solfataricus and Sulfolobus islandicus,have been important models for CRISPR study in archaea,and knowledge obtained from these studies has greatly expanded our understanding of molecular mechanisms of antiviral defense in all three steps:adaptation,expression and crRNA processing,and interference.Four subtypes of CRISPR-Cas systems are common in these organisms,including I-A,I-D,Ⅲ-B,andⅢ-D.These cas genes form functional modules,e.g.,all genes required for adaptation and for interference in the I-A immune system are clustered together to form aCas and i Cas modules.Genetic assays have been developed to study mechanisms of adaptation and interference by different CRISPR-Cas systems in these model archaea,and these methodologies are useful in demonstration of the protospacer-adjacent motif(PAM)-dependent DNA interference by I-A interference modules and multiple interference activities byⅢ-B Cmr systems.Ribonucleoprotein effector complexes have been isolated for SulfolobalesⅢ-B andⅢ-D systems,and their biochemical characterization has greatly enriched the knowledge of molecular mechanisms of these novel antiviral immune responses. | Zhenxiao Yu Suping Jiang Yuan Wang Xuhui Tian Pengpeng Zhao Jianan Xu Mingxia Feng Qunxin She | 2021 | Science China(Life Sciences)2021，64，5： | 2 |
| 18 | Analysis and Improvement of SNR in FBG Sensing System显示文摘到噪音比率(SNR ) 的信号的改进有重要意思到察觉到系统的纤维布拉格栅栏(FBG ) 。噪音以及察觉到系统的 FBG 的信号变细的来源被分析。光回来损失(ORL ) 引起的光噪音是在系统的噪音的主要来源,这被发现,并且 coupler 是信号的变细的主要来源。在光纤的元素的 ORL 的原因(例如跳线开关电报,接头和纤维结束) 被介绍。另外,优化纤维的建议光察觉到网络被介绍以便改进 SNR。压制噪音的方法由 FBG 的纤维结束接口引起了,用匹配索引的液体包括,把以在这份报纸提及的方法的纤维辫子弄弯并且劈开是 8 湩敧 ? 楷桴的纤维接口的观点角度吗? | Delong KONG Jun CHANG Peijun GONG Yongning LIU Boning SUN Xiangzhi LIU Pengpeng WANG Zongliang WANG Weijie WANG Yan ZHANG | 2012 | Photonic Sensors2012，2，2： | 2 |
| 19 | Effective inhibition of infectious bursal disease virus replication by recombinant avian adeno-associated virus-delivered microRNAs 显示文摘 | Sun H C Wang U J Shen Pengpeng | 2009 | Journal of General Virology2009，90，： | 1 |
| 20 | Spermatogenesis following syngeneictesticular transplantation in Balb/c mice 显示文摘 | Ma Pengpeng Ge Yehua Wang Shali | 2004 | Reproduction2004，128，： | 1 |
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