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| 1 | Fracture mechanism of inversed trapezoidal shaped tunnel excavated in 45° inclined rock strata显示文摘In order to understand failure mechanisms of the tunnel excavated in the stratified rock masses in deep mine, the physical modeling experiment by using the large-scale model was carried out. The field case simulated in the experiment is a main connection tunnel located at depth of 1000 m in Qishan coal mine,Xuzhou mining district. Tunnel deformation was monitored by using strain gauges and a video camera simultaneously. Crack initiation and propagation process during the test were analyzed based on image analysis of the captured video photographs. At the same time, deformation process of the key monitoring points around the tunnel section is given by the monitored strain plots. Under the increasing external loads, crack initiation occurs firstly on the left wall of the tunnel, then on the immediate roof.Complete failure of the tunnel occurs as a result of the slippage of the rock layers along the interfaces. | He Manchao Peng Yanyan Zhao Shuaiyang Shi Haiyang Wang Ning Gong Weili | 2015 | International Journal of Mining Science and Technology2015，25，4： | 2 |
| 2 | Amorphous Catalysts for Electrochemical Water Splitting显示文摘Hydrogen production by water electrolysis is an important route for generating green hydrogen.However,the development of efficient and inexpensive electrocatalysts is crucial for future industrial applications.Amorphous catalysts possess a large specific surface area with abundant structural defects.In addition,their structures can be tuned to provide more efficient active sites,leading to superior water electrolysis activity compared with their crystalline counterparts.In this review,we summarize recent progress on amorphous electrocatalysts for water splitting,with a focus on the reaction mechanisms under both acidic and alkaline conditions,catalyst synthesis,and the application of these catalysts to the hydrogen and oxygen evolution reactions.Moreover,we highlight the current challenges and promising opportunities relating to amorphous catalysts for electrochemical water splitting. | Zhang Cong Wang Shuaiyang Rong Junfeng Mi Wanliang | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 3 | Plasma metabolomics identifies metabolic alterations associated with the growth and development of cat显示文摘Background:The purpose of our study was to study the composition and content of the feline plasma metabolome revealing the critical metabolites and metabolic pathways associated with age during growth and development.Methods:Blood samples were collected from juvenile and adult groups for blood routine tests and serum biochemistry tests.Non-targeted metabolomics analyses of plasma were also performed to investigate changes in metabolites and metabolic pathways.Results:In this study,we found that the red blood cell counts,liver function indexes(albumin and gamma-glutamyl transpeptidase),and the concentration of triglyceride and glucose changed significant with growth and development.The metabolomics results revealed that 1427 metabolites were identified in the plasma of young and adult cats.Most of these metabolites belong to major classes of lipids and lipid-like molecules.The most obvious age-related metabolites include reduced levels of chenodeoxycholate,taurocholate,cholate,and taurochenodeoxycholate but increased levels of L-cysteine and taurocyamine in the adult cat's serum.These metabolites are mainly involved in the primary bile acid biosynthesis pathway,the bile secretion pathway,and the taurine and hypotaurine metabolism pathway.Conclusion:This study revealed many age-related metabolite alterations in the feline plasma.These age-varying metabolites,especially in the bile acid biosynthesis and secretion metabolism pathways,indicate that the regulation of these pathways is involved in the growth and development of cats.This study promotes our understanding of the mechanism of feline growth and provides new insights into nutrition and medicine for cats of different ages. | Shuaiyang Liu Yun Chen Xiaoming Wang Shuang Wang Lan Bai Xu Cheng Juan Wan Yufeng Hu Yi Ding Xin Zhang Mingxing Ding Hongliang Li Manli Hu | 2023 | Animal Models and Experimental Medicine2023，6，4： | 0 |
| 4 | A Design of 2-Stage Voltage Ramp-Up SRAM Physical Unclonable Function显示文摘Silicon physical unclonable function(PUF)implemented by static random access memory(SRAM)exists inherent demerit of unstable cells due to noise of environment and circuits,which significantly restricts its reproducibility.In this paper,a 16T SRAM cell with reset-delay circuit and a 2-stage voltage ramp up is fabricated and reported.Compared to conventional SRAM structure,each PUF cell adds a pair of pull-up PMOS(P-channel metal oxide semiconductor)and pull-down NMOS(N-channel metal oxide semiconductor)controlled by reset and delayed-reset signals respectively,resulting in two positive feedback stages with different amplification coefficients when the voltage is ramped up.PUF array consists of 4064 cells,322 dummy cells and a group of 8 series-connected inverters with an area of 304μm×650μm to match the digital post-processing module.PUF test chip was fabricated in HHGrace 110 nm platform with total area 1140×1140μm^(2).The average HDintra(intra-chip Hamming distance,also bit error rate,BER)and HDinter(inter-chip Hamming distance)values of the 50 PUF chips in SOP16 package measured at normal point(1.5 V/25℃)were 1.92%and 49.85%,respectively. | Minte SONG Nan LIU Shuaiyang ZHOU Zhengguang WANG Zhanqiang RU Peng DING Wei HUANG Helun SONG | 2024 | Chinese Journal of Electronics2024，33，2： | 0 |
| 5 | Chinese herbal compound Jinsiwei(金思维)improves synaptic plasticity in mice with sporadic Alzheimer’s disease induced by streptozotocin显示文摘OBJECTIVE:To investigate the efficacy of Jinsiwei(a patented Chinese herbal compound)on learning and memory impairment,the number of synapses and synaptic plasticity-related structural and functional protein expression in mice with sporadic Alzheimer’s disease(SAD)induced by streptozotocin.METHODS:Seventy-five C57/BL6J male mice were intracerebroventricularly injected with streptozotocin to establish the animal model of SAD.Mice were randomly divided into the model group(MG),donepezil group(DG),and the Jinsiwei high,medium,and low-dose groups(JH,JM,JL).Another fifteen C57/BL6J male mice were injected with artificial cerebrospinal fluid as the control group(CG).The intervention groups were intragastrically administrated with corresponding medicine,while the CG and MG were given 0.5%carboxymethyl cellulose by gavage.After 3 months,the Morris Water Maze test and step-down passive avoidance test were used to assess the learning and memory ability of mice.Synapses in hippocampal CA1 were observed by transmission electron microscope.Immunohistochemistry and western blotting were used to assess the distribution and expression levels of synaptic plasticity-related structural and functional proteins involving drebrin,cofilin,synapsin(syn),and N-methyl D-aspartate receptor subtype 2B(NR2B).RESULTS:The Morris Water Maze results showed that the escape latency in the Jinsiwei intervention groups was significantly shorter than that of the MG.Results of the step-down passive-avoidance test showed that the error times in the Jinsiwei intervention groups were significantly reduced compared with the MG.Transmission electron microscope results showed that the number of synapses in hippocampal CA1 was obviously increased in the Jinsiwei intervention groups compared with the MG.Immunohistochemical and western blotting results revealed that the positive cells and expression levels of drebrin,syn,and NR2B were significantly decreased in the MG and meanwhile cofilin significantly increased,while these changes were reversed after the Jinsiwei treatment.CONCLUSIONS:Jinsiwei can alleviate learning and memory impairments in a mouse model of SAD,increase the number of synapses and enhance synaptic plasticity via rescuing the expression of drebrin,syn,and NR2B and inhibiting cofilin expression. | TIAN Meijing HE Yannan ZHENG Mingcui QIN Gaofeng GONG Zhuoyan HUANG Shuaiyang WANG Pengwen | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 6 | Effect of intermittent joint distribution on the mechanical and acoustic behavior of rock masses显示文摘The mechanical characteristics and acoustic behavior of rock masses are greatly influenced by stochastic joints.In this study,numerical models of rock masses incorporating intermittent joints with different numbers and dip angles were produced using the finite element method(FEM)with the intrinsic cohesive zone model(ICZM).Then,the uniaxial compressive and wave propagation simulations were performed.The results indicate that the joint number and dip angle can affect the mechanical and acoustic properties of the models.The uniaxial compressive strength(UCS)and wave velocity of rock masses decrease monotonically as the joint number increases.However,the wave velocity grows monotonically as the joint dip angle increases.When the joint dip angle is 45°–60°,the UCS of the rock mass is lower than that of other dip angles.The wave velocity parallel to the joints is greater than that perpendicular to the joints.When the dip angle of joints remains unchanged,the UCS and wave velocity are positively related.When the joint dip angle increases,the variation amplitude of the UCS regarding the wave velocity increases.To reveal the effect of the joint distribution on the velocity,a theoretical model was also proposed.According to the theoretical wave velocity,the change in wave velocity of models with various joint numbers and dip angles was consistent with the simulation results.Furthermore,a theoretical indicator(i.e.fabric tensor)was adopted to analyze the variation of the wave velocity and UCS. | Shuaiyang Fu Haibo Li Liwang Liu Di Wu Ben Wang | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，4： | 0 |
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