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| 1 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 2 | Phototriggered targeting of nanocarriers for drug delivery显示文摘 | Yafei Li Yarning Zhang Weiping Wang | 2018 | Nano Research2018，11，10： | 4 |
| 3 | Characterization of Four Toll Related Genes During Development and Immune Responses in Anopheles gambiae显示文摘 | Xuelan Wang b Yarning Huang | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 4 | Preparation of polysulfone- Fe3O4 composite ultrafiltration membrane and its behavior in magnetic field显示文摘 | Pan Jian He Yahui Wang YarN Li Linlin | 2006 | J Membr Sci2006，284，： | 1 |
| 5 | Vohage-controlled three terminal GaAs negative differential resistance device using n ^+-i-p^+-i-n^+ structure 显示文摘 | Yarn K F Wang Y H Chang C Y | 1990 | IEEE Proceedings1990，137，3： | 1 |
| 6 | Reliable controller design for linear systems 显示文摘 | YARN Guanghong WANG Jianliang SOH Y C | 2001 | Automatic2001，37，5： | 1 |
| 7 | Transcrystallization behavior at the poly(lactic acid) / sisal fibre biocomposite interface显示文摘 | Wang Yarning Tong Beibei Hou Shujia | 2011 | Composites Part A:Applied Science and Manufacturing2011，42，1： | 1 |
| 8 | Corrosion evaluation of microarc oxidation coatings formed on 2024 aluminium alloy显示文摘 | Wen Lei Wang Yarning Zhou Yu | 2010 | Corrosion Science2010，52，： | 1 |
| 9 | Nonisothermal melt crystallization kinetics of poly(ethylene terephthalate)/clay nanocomposites 显示文摘 | Wang Yarning Shen Changyu Li H aimei | 2004 | Journal of Applied Polymer Science2004，91，1： | 1 |
| 10 | Photo-triggered nucleus targeting for cancer drug delivery显示文摘Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control.The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs.By incorporating a nucleus localization sequence in the system,drug nanoparticles could be delivered into nuclei upon visible light irradiation.The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability,which efficiently killed cancer cells.This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery. | Yafei Li Wen Lv Lang Wang Yarning Zhang Lipeng Yang Tianyi Wang Linyong Zhu Yufeng Wang Weiping Wang | 2021 | Nano Research2021，14，8： | 1 |
| 11 | Hand,foot,and mouth disease in China:patterns of spread and transmissibility显示文摘 | Wang Y Feng Z Yarn Y | | 0，，6： | 1 |
| 12 | 'An Anti-compressionWatermarking Scheme for Vector Map Based on ImprovedDouglas-Peucker Algorithm '显示文摘 | ZHANG Zuoli WANG Yarning | 2009 | First InternationalWorkshop on Education Technology and Computer Science2009，，2： | 1 |
| 13 | In-line monitoring of the thermal degradation of poly (L-Lactic acid) during melt extrusion by UV-vis spectroscopy 显示文摘 | Yarning Wang Bemd Steinhoff Christoph Brinkmann | 2008 | Polymer2008，49，： | 1 |
| 14 | Exposure to low intensity ultrasound increase aggrecan gene expression in a rat femur fracture mode 显示文摘 | Yarn KH Parvizi J Wang SJ | 1996 | ] Orthop Res1996，14，7： | 1 |
| 15 | Influences of Sintering Atmosphere on the Formation and Photocatalytic Property of BaFe2O4显示文摘 | Yarn Y Jiang Y S Wang Y W | 2007 | Materials Chemistry and Physies2007，，105： | 1 |
| 16 | Characterization of a GaAs current-controlled bipolar-unipolar transition negative differential resistance transistor显示文摘 | YARN K F WANG Y H CHANG C Y | 1990 | Appl Phys Lett1990，57，： | 1 |
| 17 | Mean Shift Tracking Algorithm Based on Multi-Feature Space and Grey Model 显示文摘 | WANG Yarning ZAHNG Jiaxin WU Lang | 2010 | Journal of Computational Information Systems2010，6，11： | 1 |
| 18 | Simdation study of temperature fidd and stress field of disc brake based on direct muplilag method 显示文摘 | Yarn Xun Wang Jixin | 2009 | Materials Sdenee Fort2009，628，8： | 1 |
| 19 | Transcrys- tallization Behavior at the Poly (Lactic Acid)/Sisal Fibre Bio- composite lnterface显示文摘 | Wang Yarning Tong Beibei Hou Shujia | 2011 | Composites PartA2011，42，1： | 1 |
| 20 | Microstruc-ture and corrosion resistance of modified 2024 Al alloyusing surface mechanical attrition treatment combinedwith microarc oxidation process 显示文摘 | WEN Lei WANG Yarning ZHOU Yu | 2011 | Corrosion Science2011，53，1： | 1 |
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