5篇
您的检索式：作者名="Wanjia Chen"
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| 1 | Lipidomics reveals association of circulating lipids with body mass index and outcomes in IgA nephropathy patients显示文摘IgA nephropathy(IgAN)is a leading cause of chronic kidney disease(CKD),which are commonly accompanied by dyslipidemia.Obesity is also associated with dyslipidemia and risk of CKD,but the relation of the dyslipidemia patterns with obesity and disease progression in IgAN patients remains unknown.Traditional Chinese medicine(TCM)and the combined treatment with corticosteroids and TCM have been shown to be of benefit for IgAN patients,but predictive markers for guiding these treatments are lacking.Here,we quantified 545 lipid species in the plasma from 196 participants,including 140 IgAN patients and 56 healthy volunteers,and revealed an altered plasma lipidome in IgAN patients as compared to healthy participants.Association analysis showed that a subgroup of glycerides,particularly triacylglycerols(TGs)containing docosahexaenoic acid,were positively associated with high body mass index(BMI)in under-or normal-weight IgAN patients,while several free fatty acids and sphingomyelins were positively associated with high BMI in overweight or obese IgAN patients.Further,our study suggested that elevated levels of eight lipids,mainly TG species containing linolenic acid,were independent risk factors for IgAN progression and also reported the prospective association of circulating lipids with treatment outcomes in IgAN.Taken together,our findings may not only help to achieve precision medicine but also provide a knowledge base for dietary intervention in the treatment of IgAN. | Yueyi Deng Qingqing Wu Wanjia Chen Li Zhu Wangyi Liu Fangying Xia Liang Sun Xu Lin Rong Zeng | 2021 | Journal of Molecular Cell Biology2021，13，8： | 2 |
| 2 | A hybrid information security risk assess-ment procedure considering interdependences between controls 显示文摘 | Luo Chichun Chen Wanjia | 2012 | Expert Systems with Applications2012，39，24： | 1 |
| 3 | A hybrid information security risk assessment procedure considering interdependenees between controls 显示文摘 | LO Chichun CHEN Wanjia | 2012 | Expert Systems with Applications2012，39，2012： | 1 |
| 4 | A hybrid information se- curity risk assessment procedure considering interde-pendences between controls 显示文摘 | LO Chichun CHEN Wanjia | 2012 | Expert Systems with Applications2012，39，2012： | 1 |
| 5 | Effects of Driver Response Time Under Take‑Over Control Based on CAR‑ToC Model in Human–Machine Mixed Traffic Flow显示文摘The take-over control(ToC)of human–machine interaction is a hotspot.From automatic driving to manual driving,some factors affecting driver response time have not been considered in existing models,and little attention has been paid to its effects on mixed traffic flow.This study establishes a ToC model of response based on adaptive control of thought-rational cognitive architecture(CAR-ToC)to investigate the effects of driver response time on traffic flow.A quantification method of driver’s situation cognition uncertainty is also proposed.This method can directly describe the cognitive effect of drivers with different cognitive characteristics on vehicle cluster situations.The results show that when driver response time in ToC is 4.2 s,the traffic state is the best.The greater the response time is,the more obvious the stop-and-go waves exhibit.Besides,crashes happen when manual vehicles hit other types of vehicles in ToC.Effects of driver response time on traffic are illustrated and verified from various aspects.Experiments are designed to verify that road efficiency and safety are increased by using a dynamic take-over strategy.Further,internal causes of effects are revealed and suggestions are discussed for the safety and efficiency of autonomous vehicles. | Yucheng Zhao Haoran Geng Jun Liang Yafei Wang Long Chen Linhao Xu Wanjia Wang | 2023 | Automotive Innovation2023，6，1： | 0 |
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