|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 2 | Dynamical decoupling of electron spins in phosphorus-doped silicon显示文摘Quantum coherence is an important enabling feature underpinning quantum computation. However, because of couplings with its noisy surrounding environment, qubits suffer from the decoherence effects. The dynamical decoupling (DD) technique uses pulse-induced qubit flips to effectively mitigate couplings between qubits and environment. Optimal DD eliminates dephasing up to a given order with the minimum number of pulses. In this paper, we first introduce our recent work on prolonging electron spin coherence in γ-irradiated malonic acid crystals and analyze different decoherence mechanisms in this solid system. Then we focus on electron spin relaxation properties in another system, phosphorous-doped silicon (Si:P) crystals. These properties have been investigated by pulse electron paramagnetic resonance (EPR). We also investigate the performance of the dynamical decoupling technique on this system. Using 8-pulse periodic DD, the coherence time can be extended to 296 μs compared with 112 μs with one-pulse control. | RONG Xing WANG Ya YANG JiaHui ZHU JinXian XU WanJie FENG PengBo WEN XuJie SU JiHu DU JiangFeng | 2011 | Chinese Science Bulletin2011，56，7： | 4 |
| 3 | Functions for patch test in finite element analysis of the Mindlin plate and the thin cylindrical shell显示文摘Current patch test for Mindlin plate element only satisfies the zero shear deformation condition.The patch test of non-zero constant shear for Mindlin plate problem cannot be performed.For shell element, the patch test does not even exist.Based on the theory of enhanced patch test proposed by Chen W J (2006),the authors proposed the enhanced patch test function for Mindlin plate and thin cylindrical shell elements.This enhanced patch test function can be used to assess the convergence of the Mindlin plate and cylindrical thin shell elements. | CHEN WanJi 1,2 ,WANG JinZhi 1,3 &ZHAO Jie 1 1State Key Laboratory for Structural Analysis of Industrial Equipment,Dalian University of Technology,Dalian 116023,China 2Institute for Structural Analysis of Aerocraft,Shenyang Institute of Aeronautical Engineering,Shenyang 110136,China 3 College of Science,Institute of Dalian Nationalities,Dalian 116022,China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 2 |
| 4 | Potential of geosynchronous SAR interferometric measurements in estimating three-dimensional surface displacements显示文摘The ability of differential interferometric synthetic aperture radar(DIn SAR) technology used for centimeter level deformation detection has been well-proved. Nevertheless, the applications of DIn SAR under the low Earth orbit(LEO) are limited to the line-of-sight(LOS) measurements, the limited observation area and the long revisited time. Geosynchronous SAR(GEO SAR), which runs in the height of 36000 km with the advantage of a short revisit time and a large observation area, is a potential approach to overcome the series problems in LEO SAR. This paper focuses on estimating three-dimensional(3D) displacements by using GEO SAR DIn SAR measurements acquired from multiple imaging geometries. Aiming to provide a normal solution for geologic hazard monitoring and relative geophysical application in the future, the errors induced by decorrelation noise, orbital ramp and ionospheric distortion are analyzed for the GEO SAR DIn SAR measurements. A series of experiments have been conducted to find the relationship between the 3D displacements and the DIn SAR observations which are provided with different noises and combinations of imaging geometries. The results reveal that 3D displacements can be expected from the combination of left-and right-looking GEO SAR DIn SAR measurements. In particular, the north-south solution can achieve centimeter and even millimeter level. | Wanji ZHENG Jun HU Wei ZHANG Changjiang YANG Zhiwei LI Jianjun ZHU | 2017 | Science China(Information Sciences)2017，60，6： | 2 |
| 5 | Review on the development of genotyping methods for assessing farm animal diversity显示文摘Advances in molecular biotechnology have introduced new generations of molecular markers for use in the genetic improvement of farm animals. Consequently, more accurate genetic information can be obtained to better understand existing animal genetic resources. This review gives a brief summary on the development of genetic markers including both the classical genetic markers and more advanced DNA-based molecular markers. This review will help us better understand the characteristics of different genetic markers and the genetic diversity of animal genetic resources. | Wanjie Yang Xiaolong Kang Qingfeng Yang Yao Lin Meiying Fang | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 2 |
| 6 | Mapping three-dimensional co-seismic surface deformations associated with the 2015 MW7.2 Murghab earthquake based on InSAR and characteristics of crustal strain显示文摘Three-dimensional(3 D) co-seismic surface deformations are of great importance to interpret the characteristics of coseismic deformations and to understand the geometries and dynamics of seismogenic faults. In this paper, we propose a method for mapping 3 D co-seismic deformations based on InSAR observations and crustal strain characteristics. In addition, the search strategy of correlation points is optimized by adaptive correlation distance, which greatly improves the applicability of the proposed method in restoring deformations in decorrelation areas. Results of the simulation experiment reveal that the proposed method is superior to conventional methods in both the accuracy and completeness. The proposed method is then applied to map the 3 D co-seismic surface deformations associated with the 2015 MW7.2 Murghab earthquake using ascending and descending ALOS-2 PALSAR-2 images. The results show that the seismogenic fault is the Sarez-Karakul fault(SKF), which is dominated by NE-SW strike slips with an almost vertical dip angle. The north section and the south segment near the epicentre have obvious subsidence along with a southwestward motion in the northwest wall, and the southeast wall has northeast movement and surface uplift trend along the fault zone. The strain field of the earthquake is also obtained by the proposed method. It is found that the crustal block of the seismic area is obviously affected by dilatation and shear forces, which is in good agreement with the movement character of the sinistral slip. | Jie GAN Jun HU Zhiwei LI Changjiang YANG Jihong LIU Qian SUN Wanji ZHENG | 2018 | Science China Earth Sciences2018，61，10： | 2 |
| 7 | Study on the viscoelastic behavior of SEEPS block copolymer based on a modified BSW model显示文摘Studies on the viscoelastic behavior of styrene- [ethylene-(ethylene-propylene)]-styrene block copolymer (SEEPS) were carried out, and some characteristic viscoelas-tic parameters were calculated. The longest relaxation time τmax was obtained through simulating the relaxation spec-trum on the basis of a modified Baumgaertel-Schausberger- Winter (mBSW) model. The results revealed that there exists a “second plateau” in the low frequency region of the master curves. The reason for this phenomenon is attributed to the entanglement of macromolecular chains. It is suggested that the hard blocks, polystyrene, act as entanglement points, resulting in a topology restraint to the movement of macro-molecular chains. Meanwhile, it is found that the horizontal shift factors (aT) vs temperature in the master curve could be fitted to the Williams-Landel-Ferry (WLF) equation and Ar-rhenius equation respectively and the flow activation energy (Ea) is 127.88 kJ/mol. In addition, the plateau modulus (GN0) and entanglement molecule weight (Me) were calculated. | WANG Wanjie ZHENG Qiang YU Qiuming | 2005 | Chinese Science Bulletin2005，50，19： | 2 |
| 8 | A size-dependent composite laminated skew plate model based on a new modified couple stress theory显示文摘In this study, a size-dependent composite laminated skew Mindlin plate model is proposed based on a new modified couple stress theory. This plate model can be viewed as a simplified couple stress theory in engineering mechanics. Governing equations and related boundary conditions are derived based on the principle of minimum potential energy. The Rayleigh–Ritz method is employed to obtain the numerical solutions of the center deflections of simply supported plates with different ply orientations. Numerical results show that the normalized center deflections obtained by the proposed model are always smaller than those obtained by the classical one, i.e. the present model can capture the scale effects of microstructures. Moreover, a phenomenon reveals that the ply orientation would make a significant influence on the magnitude of scale effects of composite laminated plates at micro scale. Additionally, the present model of thick skew plate can be degenerated to the model of Kirchhoff plate based on the modified couple stress theory by adopting the assumptions in Bernoulli–Euler beam and material isotropy. | Dan He Wanli Yang Wanji Chen | 2017 | Acta Mechanica Solida Sinica2017，30，1： | 2 |
| 9 | Enhanced patch test of finite element methods显示文摘Theoretically, the constant stress patch test is not rigorous. Also, either the patch test of non-zero constant shear for Mindlin plate problem or non-zero strain gradient curvature of the microstructures cannot be performed. To improve the theory of the patch test, in this paper, based on the variational principle with relaxed continuity requirement of nonconforming element for homogeneous differential equations, the author proposed the individual element condition for passing the patch test and the convergence condition of the element: besides passing the patch test, the element function should include the rigid body modes and constant strain modes and satisfy the weak continuity condition, and no extra zero energy modes occur. Moreover, the author further established a variational principle with relaxed continuity requirement of nonconforming element for inhomogene-ous differential equations, the enhanced patch test condition and the individual element condition. To assure the convergence of the element that should pass the enhanced patch test, the element function should include the rigid body modes and non-zero strain modes which satisfied the equilibrium equations, and no spurious zero energy modes occur and should satisfy new weak continuity condition. The theory of the enhanced patch test pro-posed in this paper can be applied to both homogeneous and inhomogeneous differential equations. Based on this theory, the patch test of the non-zero constant shear stress for Mindlin plate and the C0-1 patch test of the non-zero constant curvature for the couple stress/strain gradient theory were established. | CHEN Wanji | 2006 | Science China(Physics,Mechanics & Astronomy)2006，49，2： | 2 |
| 10 | High-resolution two-photon transcranial imaging of brain using direct wavefront sensing显示文摘Imaging of the brain in its native state at high spatial resolution poses major challenges to visualization techniques.Two-photon microscopy integrated with the thinned-skull or optical clearing skull technique provides a minimally invasive tool for in vivo imaging of the cortex of mice without activating immune response and inducing brain injury.However,the imaging contrast and spatial resolution are severely compromised by the optical heterogeneity of the skull,limiting the imaging depth to the superficial layer.In this work,an optimized configuration of an adaptive optics two-photon microscope system and an improved wavefront sensing algorithm are proposed for accurate correction for the aberrations induced by the skull window and brain tissue.Using this system,we achieved subcellular resolution transcranial imaging of layer 5 pyramidal neurons up to 700μm below pia in living mice.In addition,we investigated microglia–plaque interaction in living brain of Alzheimer’s disease and demonstrated high-precision laser dendrotomy and single-spine ablation. | CONGPING CHEN ZHONGYA QIN SICONG HE SHAOJUN LIU SHUN-FAT LAU WANJIE WU DAN ZHU NANCY Y.IP JIANAN Y.QU | 2021 | Photonics Research2021，9，6： | 2 |
| 11 | Measurement of length-scale and solution of cantilever beam in couple stress elasto-plasticity显示文摘Owing to the absence of proper analytical solutionof cantilever beams for couple stress/strain gradient elas-to-plastictheory, experimental studies of the cantilever beamin the micro-scale are not suitable for the determination ofmaterial length-scale. Based on the couple stress elasto-plas-ticity,an analytical solution of thin cantilever beams is firstlypresented, and the solution can be regarded as an extension ofthe elastic and rigid-plastic solutions of pure bending beam.A comparison with numerical results shows that the currentanalytical solution is reliable for the case of σ0(?)H(?)E,where σ0 is the initial yield strength, H is the hardeningmodulus and E is the elastic modulus. Fortunately, the abovementioned condition can be satisfied for many metal materials,and thus the solution can be used to determine the materiallength-scale of micro-structures in conjunction with theexperiment of cantilever beams in the micro-scale. | Bin Ji Wanji Chen Jie Zhao | 2009 | Acta Mechanica Sinica2009，25，3： | 2 |
| 12 | A modified couple stress model for bending analysis of composite laminated beams with first order shear deformation 显示文摘 | Chen Wanji Li Li Ma Xu | 2011 | Compos Struct2011，93，： | 1 |
| 13 | Optical elements with subwavelength stmctured surfaces显示文摘 | Toyota H Yu Wanji | 2004 | Proceedings of SPIE2004，5515，： | 1 |
| 14 | Refined non-conforming triangular elements for analysis of shell structures 显示文摘 | Wanji C Cheung Y K | 1999 | Inter J for Numer Methods in Eng1999，46，： | 1 |
| 15 | Refined 9-DOF triangular Mindlin plate elements显示文摘 | CHEN Wanji CHEUNG Y K | 2001 | Int J Numer Methods Eng2001，51，12： | 1 |
| 16 | Finite element formulations of strain gradient theory for mierostructures and the C^0-1 patch test显示文摘 | AI-KAH CHEN WANJI | 2004 | Int J Number Methods Eng2004，61，： | 1 |
| 17 | Studies on structure and phase behavior of multicomponent polymers through rheological test显示文摘 | Zuo Min Zheng Qiang Wang Wanjie | 2007 | Chin J Polym Sci2007，25，： | 1 |
| 18 | Geometrically nonlinear generalized hybrid element and refined element method for non-conforming modes显示文摘 | Zheng Shijie Chen Wanji | 1995 | Acta Mechanica Sinica1995，11，2： | 1 |
| 19 | Synthesis of polarization-selective optical components with multi-layer subwavelength structures显示文摘 | Kikuta H Konishi T | 2003 | Proceedings of SHE2003，5183，： | 1 |
| 20 | Discharge characteristics of cohesive fine coal from aerated hopper显示文摘 | Huang Wanjie Gong Xin | 2009 | Powder Technology2009，194，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员