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您的检索式：作者名="Wanlong Lei"
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| 1 | Does diffusion tensor data reflect pathological changes in the spinal cord with chronic injury?显示文摘Magnetic resonance diffusion tensor imaging has been shown to quantitatively measure the early pathological changes in chronic cervical spondylotic myelopathy.In this study,a novel spongy polyurethane material was implanted in the rat C3–5epidural space to establish a rat model of chronic cervical spondylotic myelopathy.Diffusion tensor data were used to predict pathological changes.Results revealed that the fractional anisotropy value gradually decreased at 4,24,and 72 hours and1 week after injury in rat spinal cord,showing a time-dependent manner.Average diffusion coefficient increased at 72 hours and 1 week after implantation.Hematoxylin-eosin staining and Luxol-fast-blue staining exhibited that the number of neurons in the anterior horn of the spinal cord gray matter and the nerve fiber density of the white matter gradually reduced with prolonged compression time.Neuronal loss was most significant at 1 week after injury.Results verified that the fractional anisotropy value and average diffusion coefficient reflected the degree of pathological change in the site of compression in rat models at various time points after chronic spinal cord compression injury,which potentially has a reference value in the early diagnosis of chronic cervical spondylotic myelopathy. | Erjian Lin Houqing Long Guangsheng Li Wanlong Lei | 2013 | Neural Regeneration Research2013，8，36： | 2 |
| 2 | Part of decortication ameliorates dopamine depletion-induced striatal neuron lesions in rats显示文摘The degeneration of dopaminergic neurons can lead to the hyperexcitability of striatal neurons.The motor symptoms of Parkinson's disease(PD)are caused by striatal dopamine insufficiency.After degeneration of dopaminergic neurons,the reduction of corticostriatal glutamate can reestablish the balance of striatal neurons which leads to relieve the PD pathology process.However,the mechanisms that reduction of corticostriatal glutamate can relieve vulnerability of striatal neurons were unclear.With the Golgi staining and electron microscopic analysis,we found that reduction of corticostriatal glutamate that used to decorticate decrease in the total length of dendrites and the density of dendritic spines of the striatal neurons in 6-hydroxydopamine(6-OHDA)lesion-induced PD rat model.Moreover,we found that reduction of corticostriatal glutamate recovered mitochondrial membrane potential. | Zhu Yaofeng Zheng Xuefeng Wanlong Lei | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 3 | Morphological characteristics of the striatal neural pathway by biotinylated dextran amine tracing in rats显示文摘Using neural pathway tracing and immunohistochemical technique, the striato-direct pathway (BDA3 kDa injected into the rat lateral globus pallidus) and striato-indirect pathway (BDA3 kDa injected into the substantia nigra pars reticulata) neurons were specifically labeled, and then subjected to double-labeled immunohistochemistry for mu-OPIOID Receptor (specifically-labeled striatal patch compartment), D1, and D2, respectively. The experimental findings showed that there are no statistically significant differences in the soma diameter and the number of primary dendrites between the striato-direct (substantia nigra pars reticularis) and indirect (globus pallidum externum) neurons labeled retrograde by BDA3 kDa. In addition, these two kinds of projection neurons revealed no obvious coexistence. This evidence indicates that as a highly sensitive neural pathway tracer, BDA could yield reliably and exquisitely detailed labeling of target neurons and synaptic structures. The variance of the morphologic structures and the localization of neurons were not statistically significant between the striato-substantia nigra pars reticularis and the globus pallidum externum projection neurons. Mesencephalic and thalamic neurons correlated with striatal neurons in morphology. Especially the latter which make typical excitatory synaptic contacts with striato-direct and -indirect neurons. Thus, this evidence suggests that thalamic neurons may extensively excite striatal neurons. | Bingbing Liu Shuhua Mu Lisi Ouyang Yaxi Zhu Keyi Li Mali Zhan Zongwei Liu Yu Jia Wanlong Lei | 2011 | Neural Regeneration Research2011，6，25： | 0 |
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