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| 1 | Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus显示文摘Diabetes mellitus(DM) is the third most common noninfectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of microand macroangiopathies. Metabolic disorders caused by insulin deficiency in diabetes significantly impede the functioning of a homeostasis system, which change the physical, biochemical, morphological, and functional properties of blood cells. As a result, the oxygen-transport function of red blood cells(RBCs), rheological properties of the blood, and functions of immunocompetent cells as well as the process of apoptosis are primarily affected. Modern pharmacotherapy focuses on the search for new preparations that aim to decrease blood glucose levels. Undesirable side effects and adverse reactions caused by synthetic medicines led to the search and investigation of new preparations of natural origin. Medicinal mushrooms play an important role among such new preparations. They are a source of a large number of high-and lowmolecular compounds with pronounced biological effects. Our investigations show pronounced hypoglycemic and anti-anemic action of submerged cultivated mycelium powder of medicinal mushrooms Agaricus brasiliensis(A. brasiliensis) and Ganoderma lucidum(G. lucidum) on streptozotocin-induced DM in rats. Also, we showed that mycelium powders have membrane protective properties as evidenced by the redistribution of RBC populations towards the growth of full functional cell numbers. Normalization of parameters of leukocyte formula and suppression of apoptosis of white blood cells in diabeticrats treated with A. brasiliensis and G. lucidum mycelia indicates pronounced positive effects of these strains of mushrooms. Thus, the use of medicinal mushrooms for treatment of DM and in prevention development of its secondary complications might be a new effective approach of this disease's cure. This article is aimed at summarizing and analyzing the literature data and basic achievements concerning DM type 1 treatment using medicinal mushrooms and showing the results obtained in our research. | Taras Vitak Borys Yurkiv Solomon Wasser Eviatar Nevo Natalia Sybirna | 2017 | World Journal of Diabetes2017，8，5： | 6 |
| 2 | Polo-like kinase 1,a new therapeutic target in hepatocellular carcinoma显示文摘AIM:To investigate the role of polo-like kinase 1 (PLK1) as a therapeutic target for hepatocellular carcinoma (HCC).METHODS:PLK1 gene expression was evaluated in HCC tissue and HCC cell lines.Gene knockdown with short-interfering RNA (siRNA) was used to study PLK1 gene and protein expression using real-time reverse transcription polymerase chain reaction (RT-PCR) and Western blotting,and cell proliferation using 3-(4,5-dim ethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2(4-sulf ophenyl)-2H-tetrazolium (MTS) and bromodeoxyuridine (BrdU) assays.Apoptosis was evaluated using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay,and caspase-inhibition assay.Huh-7 cells were transplanted into nude mice and co-cultured with PLK1 siRNA or control siRNA,and tumor progression was compared with controls.RESULTS:RT-PCR showed that PLK1 was overexpressed 12-fold in tumor samples compared with controls,and also was overexpressed in Huh-7 cells.siRNA against PLK1 showed a reduction in PLK1 gene and protein expression of up to 96% in Huh-7 cells,and a reduction in cell proliferation by 68% and 92% in MTS and BrdU cell proliferation assays,respectively.There was a 3-fold increase in apoptosis events,and TUNEL staining and caspase-3 assays suggested that this was caspase-independent.The pan-caspase inhibitor Z-VAD-FMK was unable to rescue the apoptotic cells.Immnofluorescence co-localized endonuclease-G to fragmented chromosomes,implicating it in apoptosis.Huh-7 cells transplanted subcutaneously into nude mice showed tumor regression in siPLK1-treated mice,but not in controls.CONCLUSION:Knockdown of PLK1 overexpression in HCC was shown to be a potential therapeutic target,leading to apoptosis through the endonuclease-G pathway. | Wei Chuen Mok Shanthi Wasser Theresa Tan Seng Gee Lim | 2012 | World Journal of Gastroenterology2012，18，27： | 4 |
| 3 | Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation显示文摘 | Hans F.A. Vasen Martin Wasser Anneke van Mil Rob A. Tollenaar Marja Konstantinovski Nelleke A. Gruis Wilma Bergman Frederik J. Hes Daniel W. Hommes G. Johan A. Offerhaus Hans Morreau Bert A. Bonsing Wouter H. de Vos tot Nederveen Cappel | 2011 | Gastroenterology2011，，3： | 3 |
| 4 | Medicinal mushroom modulators of molecular targets as cancer therapeutics显示文摘 | Ben-Zion Zaidman Majed Yassin Jamal Mahajna Solomon P. Wasser | | Applied Microbiology and Biotechnology0，，： | 2 |
| 5 | Survival of Filamentous Fungi in Hypersaline Dead Sea Water显示文摘 | Kis-Papo T Oren A Wasser S P | 2003 | Microbial Ecology2003，45，2： | 1 |
| 6 | Medicinal mushrooms as a sourre erf antitumor and immu-nomodulating polysaccharides 显示文摘 | Wasser S P | 2002 | Appl Microbiol HotechnoK2002，60，： | 1 |
| 7 | Therapeutic effect of substances occurring in higher basidiomycetes mushrooms, a modern perspective 显示文摘 | Wasser S P Weis A L | 1999 | Crit Rev Immunol1999，19，1： | 1 |
| 8 | Inhibitory Effect of ethyl acetate extract of the shaggy inc cap medicinal mush- room,coprinus comatus(higher basidiomycetes) fruit bodies on cell growth of human ovarian cancer显示文摘 | Rouhana-Toubi A Wasser SP Agbarya A | 2013 | Int J Med Mushrooms2013，15，5： | 1 |
| 9 | Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides 显示文摘 | WASSER SP | 2002 | Appl Microbiol Biotechnol2002，60，： | 1 |
| 10 | Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides 显示文摘 | Wasser S P | 2002 | Appl Microbiol Biotechnol2002，60，： | 1 |
| 11 | Medicinal mushroons as a source of antitumor and immunomodulating polysaccharides显示文摘 | Wasser SP | 2002 | Appl Microbiol Biotechnol2002，60，3： | 1 |
| 12 | Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides 显示文摘 | Wasser SP | 2002 | Appl Microbiol Biotechnol2002，60，3： | 1 |
| 13 | Medicinal mus hrooms as a source of antitumor and immunomodulating polysaccharides显示文摘 | Wasser SP | | 0，，03： | 1 |
| 14 | Excreted steroids in primate feces over the menstrual cycle and pregnancy显示文摘 | Wasser S K Risler L Steiner R A | 1988 | Biology of Reproduction1988，39，4： | 1 |
| 15 | Casey at the Bat: A hybrid genre of two worlds 显示文摘 | Bresler L Wasser J D Hertzog N B | 1997 | Research in Drama Education1997，2，： | 1 |
| 16 | Therapeutic effect of substances occurring in higher Basidiomycetes mushrooms: a modem perspective显示文摘 | Wasser SP Weis AL | 1999 | Crit Rev Immunol1999，19，1： | 1 |
| 17 | Non-invasive measurement of thyroid hormone in feces of a diverse array of avian and mammalian species显示文摘 | Wasser S K Azkarate J C Booth R K | 2010 | General and Comparative Endocrinology2010，168，1： | 1 |
| 18 | The design of optimum multi-factorial experiments 显示文摘 | PLACKETT R L WASSER S P | 1946 | Biometrika1946，33，： | 1 |
| 19 | Therapeutic effects of substances occuring in higher Basidiomycetes mushrooms: a modern perspective显示文摘 | Wasser SP Weis AL | 1999 | Crit Rev Immunol1999，19，1： | 1 |
| 20 | Variability of Splanchnic Blood Flow Measurements Using MR VelocityMapping under Fasting and Post-prandial Conditions-comparison with Echo-Doppler显示文摘 | Lycklarna Nijeholt GJ Burggraaf K Wasser MN | 1997 | J Hepatol1997，26，2： | 1 |
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