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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 3 | Magnetic properties of BaFe12-2xZnxZrxO19 particles显示文摘 | WEI F L FANG H C ONG C K | 2000 | J Appl Phys2000，87，： | 1 |
| 4 | Isolation, characterization and expression analysis of a leaf-specific phosphoenolpyruvate carboxylase gene in Oryza sativa 显示文摘 | LIN C F WEI C JIANG L Z | 2004 | DNASeq2004，15，26： | 1 |
| 5 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 6 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 7 | Real-time hand tracking using a mean shift embedded particle filter显示文摘 | Shan C F Tan T N Wei Y C | 2007 | Pattern Recognition2007，40，7： | 1 |
| 8 | Combination of hemofiltration and peritoneal dialysis in the treatment of severe acute panereatitis 显示文摘 | Yang C Guanghua F Wei Z | 2010 | Pancreas2010，59，1： | 1 |
| 9 | Preparation and mechanical properties of cotton stalk bast fibers reinforced polylactic acid biodegradable composites显示文摘 | WU Z WEI C Y TIAN Z F | | 0，，： | 1 |
| 10 | The prevalence of dementia in urban and rural areas of China显示文摘 | Jia J Wang F Wei C | 2014 | Alzheimer''s Dement2014，10，1： | 1 |
| 11 | Identification and characterization of the miRNA transcriptome of ovis aries 显示文摘 | Zhang S F Zhao F P Wei C H Sheng X H Ren H X Xu L Y l u J Liu J S Zhang L Du L X | 2013 | PLoS One2013，8，58： | 1 |
| 12 | DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis显示文摘 | Tan C Qiao F Wei P | 2016 | Mol Carcinog2016，55，4： | 1 |
| 13 | Electrocatalytic oxidation of nitric oxide at multi-walled carbon nanotubes modified electrode显示文摘 | Wu F H Zhao G C Wei X W | 2002 | Electrochem Commun2002，，4： | 1 |
| 14 | A sufficient condition for a planar graph to be class 1显示文摘 | WEI F W YONG Z C | 2007 | Theoretical Computer Sci2007，385，13： | 1 |
| 15 | Diamondoid hydrocarbons as a molecular proxy for thermal maturity and oil cracking: Geochemical models from hydrous pyrolysis显示文摘 | Wei Z B Moldowan J M Zhang S C Hill R Jarvie D M Wang H T Song F Q Fago F | 2007 | Org Geochem2007，38，2： | 1 |
| 16 | Support vector machines with simulated annealing algorithms in electricity load forecasting显示文摘 | Ping F P Wei C H | 2005 | Energy Conversion and Management2005，，46： | 1 |
| 17 | Differential expression of anthocyanin biosynthetic genes in relation to anthocyanin accumulation in the pericarp of Litchi Chinensis Sonn显示文摘 | Wei Y Z Hu F C Hu G B | 2011 | PLoS ONE2011，6，19： | 1 |
| 18 | Free-style free flaps显示文摘 | MARDINI S | | Plast Reconstr Sury0，114，4： | 1 |
| 19 | Studies on the Spectroscopic Behavior of Cryptotanshinone,Tanshinone ⅡA,and Tanshinone I显示文摘 | Li J F Wei Y X Xu Z C Dong C Shuang S M | 2004 | Spectrochimic Acta Part A2004，60，： | 1 |
| 20 | Carotenoid biosynthesis in cya-nobacteria:structural and evolutionary scenarios based on comparative ge-nomics显示文摘 | LIANG C W ZHAO F Q WEI W | 2006 | Int J Biol Sci2006，2，4： | 1 |
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