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| 1 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 2 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 3 | ITO@TiO_(2)nanoarray:An efficient and robust nitrite reduction reaction electrocatalyst toward NH_(3)production under ambient conditions显示文摘Ambient electrochemical nitrite(NO_(2)^(-))reduction is viewed as an effective and sustainable approach for simul-taneously removing NO_(2)^(-)and producing ammonia(NH_(3)).However,the complex multi-electron transfer steps involved in the NO_(2)^(-)reduction reaction(NO_(2)^(-)RR)lead to sluggish kinetics and low product selectivity toward NH_(3),underscoring the need for NH_(3)synthesis electrocatalysts with high activity and durability.Herein,we report amorphous indium-tin oxide sputtered on a TiO_(2)nanobelt array on a Ti plate(ITO@TiO_(2)/TP)as a 3D NH_(3)-producing catalyst for the NO_(2)^(-).In 0.5 M LiClO_(4)with 0.1 M NO_(2)^(-),it shows greatly boosted NO_(2)^(-)RR activity toward NH_(3)production,with excellent selectivity,achieving a large NH_(3)yield of 411.3μmol h^(-1)cm^(-2)and a high Faradaic efficiency of 82.6%.It also shows high durability for continuous electrolysis.A Zn-NO_(2)^(-)battery with ITO@TiO_(2)/TP cathode offers an NH_(3)yield of 23.1μmol h^(-1)cm^(-2)and a peak power density of 1.22 m. | Shaoxiong Li Jie Liang Peipei Wei Qian Liu Lisi Xie Yonglan Luo Xuping Sun | 2022 | eScience2022，2，4： | 3 |
| 4 | Generation of Tripotent Neural Progenitor Cells from Rat Embryonic Stem Cells显示文摘老鼠是为药理学和生理的研究的一个珍贵模型。胚胎的茎(物件) 房间衬里的 Germline 能干的老鼠成功地被建立了,维持物件细胞的自我更新的、无差别的状态的分子的网络也好揭开。然而,很少对区别策略和这些真老鼠 pluripotent 干细胞怎么产生特定的房间类型的内在的机制被知道。这研究的目的是调查物件房间的神经区别能力。借助于一个修改过程基于 激活mitogen 的蛋白质 kinase ( MAPK )和肝糖 synthase kinase 的以前的出版物联合 3 ( GSK3 )禁止者(二个禁止者, 2i )与喂调节中等,我们成功地从物件房间获得了高质量的老鼠胚胎植物或动物身体(美国南北战争时南军士兵)然后区分了他们到 tripotent 神经祖先。这些物件导出房间的神经祖先房间(rNPCs ) 能够自我更新并且产生所有三个神经的系,包括的星形细胞, oligodendrocytes,和神经原。而且,这些导出房间的神经原染色了的物件为 -aminobutyric 酸(伽马氨基丁酸) 和酷氨酸 hydroxylase (TH ) 积极。在摘要,我们为区分物件房间到 tripotent 开发一个试验性的系统神经祖先,它可以为学习象 Parkinson 的疾病和老鼠神经系统的开发那样的许多 neurodegenerative 混乱的致病为药理学测试和一个珍贵平台提供一个强大的工具。 | Zhenkun Wang Chao Sheng Tianda Li Fei Teng Lisi Sang Fenglin Cao Ziwei Wang Wanwan Zhu Wei Li Xiaoyang Zhao Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，12： | 2 |
| 5 | Dynamic Shortest Path Monitoring in Spatial Networks显示文摘与即时交通信息的增加的可获得性,动态空间网络现在是弥漫的,路径在动态空间网络计划成为一个重要问题。在这盏灯,我们建议并且调查动态地在空间网络(DSPM 质问) 监视最短的路径的一个新奇问题。当一个旅行者瞄准到一个目的地时,到目的地的其最短的路径可以由于二个原因变化:1 ) 一些边的旅行费用被更新了并且 2 ) 旅行者从预告计划的路径背离。我们的目标是加速在动态空间网络计算的最短的路径,并且我们相信这研究可能在许多活动应用程序是有用的,例如线路计划和建议,汽车航行并且追踪,并且基于地点的服务一般来说。这个问题由于二个原因是挑战性的:1 ) 怎么维持并且再使用存在计算结果加速下列计算,并且 2 ) 怎么有效地修剪搜索空间。克服这些挑战, filter-and-refinement 范例被采用。我们维持一棵扩大树并且定义一双上面、更低的界限修剪搜索空间。一系列优化技术被开发加速最短的路径计算。发达方法的表演基于真实空间数据在广泛的实验被学习。 | Shuo Shang Lisi Chen Zhe-Wei Wei Dan-Huai Guo Ji-Rong Wen | 2016 | Journal of Computer Science & Technology2016，31，4： | 2 |
| 6 | Material basis for inhibition of dragon' s blood on capsaicin?induced TRPV 1 receptor currents in rat dorsal root ganglion neurons 显示文摘 | Wei Lisi Chen Su Huang Xianju | 2013 | European Journal of Pharmacology2013，702，1： | 1 |
| 7 | Research on the Equivalence Between Double Differential- mode Current Injection and Radiation Test Method显示文摘There are the application scope limits for single differential-mode current injection test method, so in order to carry out injection susceptibility test for two-pieces equipment interconnected with both ends of a cable simultaneously, a double differential-mode current in- jection test method (DDMCI) is proposed. The method adopted the equivalence source wave theorem and Baum-Liu-Tesche(BLT) equation as its theory foundation. The equivalent corresponding relation between injection voltage and radiation electric field intensity is derived, and the phase relation between the two injection voltage sources is confirmed. The results indicate that the amplitude and phase of the equivalent injection voltage source is closely related to the S parameter of directional coupling device, the transmission line length, and the source vector in BLT equation, but has nothing to do with the reflection coefficient between the two equipment pieces. Therefore, by choosing the right amplitude and phase of the double injection voltage sources, the DDMCI test is equivalent to the radiation test for two interconnected equipment of a system. | PAN Xiaodong WEI Guanghui FAN Lisi LU Xinfu YANG Zhe | 2013 | 高电压技术2013，39，8： | 1 |
| 8 | Assembly dynamics of East Asian subtropical evergreen broadleaved forests: New insights from the dominant Fagaceae trees显示文摘The dominant species of a biome can be regarded as its genuine indicator.Evergreen broadleaved forests(EBLFs) in subtropical East Asia harbor high levels of species biodiversity and endemism and are vital to regional carbon storage and cycling.However,the historical assembly of this unique biome is still controversial.Fagaceae is the most essential family in East Asian subtropical EBLFs and its dominant species are vital for the existence of this biome.Here,we used the dominant Fagaceae species to shed light on the dynamic process of East Asian subtropical EBLFs overtime.Our results indicate high precipitation in summer and low temperature in winter are the most influential climatic factors for the distribution of East Asian subtropical EBLFs.Modern East Asian subtropical EBLFs did not begin to appear until 23 Ma,subsequently experienced a longlasting development in the Miocene and markedly deteriorated at about 4 Ma,driven jointly by orogenesis and paleoclimate.We also document that there is a lag time between when one clade invaded the region and when its members become dominant species within the region.This study may improve our ability to predict and mitigate the threats to biodiversity of East Asian subtropical EBLFs and points to a new path for future studies involving multidisciplinary methods to explore the assembly of regional biomes. | Lisi Hai Xiao-Qian Li Jing-Bo Zhang Xiao-Guo Xiang Rui-Qi Li Florian Jabbour Rosa del COrtiz An-Ming Lu Zhi-Duan Chen Wei Wang | 2022 | Journal of Integrative Plant Biology2022，64，11： | 1 |
| 9 | A cobalt(Ⅱ)porphyrin with a tethered imidazole for efficient oxygen reduction and evolution electrocatalysis显示文摘Electrocatalytic oxygen reduction and evolution reactions are involved in new energy conversion and storage technologies,such as various fuel cells and metal-air batteries and also water splitting devices[1,2].However,both reactions are very slow in kinetics,and thus catalysts are required[3,4]. | Xialiang Li Ping Li Jindou Yang Lisi Xie Ni Wang Haitao Lei Chaochao Zhang Wei Zhang Yong-Min Lee Weiqiang Zhang Shunichi Fukuzumi Wonwoo Nam Rui Cao | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 10 | Simple Double Hetero[5]helicenes Realize Highly Efficient and Narrowband Circularly Polarized Organic Light-Emitting Diodes显示文摘Helicene-based emitters with unique inherent circularly polarized luminescence(CPL)are promising yet remain a formidable challenge for highly efficient circularly polarized organic light-emitting diodes(CP-OLEDs),ascribed to their tough synthesis,low emission efficiency,and easy racemization in the thermal deposition process.Herein,a pair of helicenebased enantiomers,namely(P)-helicene-BN and(M)-helicene-BN,were developed,which merge helical chirality and the B/N/S inserted polycyclic aromatic framework to concurrently feature CPL and narrow thermally activated delayed fluorescence(TADF)characteristics.Benefiting from the excellent thermal/photophysical/chiroptical properties,the narrowband green CP-OLEDs based on enantiomers achieved maximum external quantum efficiencies(EQE_(max))of up to 31.5%,and dissymmetry factor(|g_(EL)|)of 2.2×10^(−3).This work reveals the great potential of helicene-based emitters in CP-OLEDs. | Wei Yang Nengquan Li Jingsheng Miao Lisi Zhan Shaolong Gong Zhongyan Huang Chuluo Yang | 2022 | CCS Chemistry2022，4，11： | 1 |
| 11 | Frequency-time Domain Shielding Effectiveness of Materials and Their Strong Electromagnetic Field Test显示文摘To describe the shielding ability of materials accurately and comprehensively,the frequency-domain and time-domain shielding effectiveness(SE) of material is investigated.The relevance between them was analyzed based on the minimum phase method,and the time-domain SE can be derived from frequency-domain SE.The SE of an energy selective surface(ESS) made of a novel material is investigated,and the relationship between SE and radiation field intensity are analyzed.The results show that not only material,but also the intensity of radiation electric field shows influence on SE in its frequency; for some materials,the dependence of SE on radiation electric field intensity needs to be considered.Therefore,it is necessary to research on the SE of shielding material in high-intensity electromagnetic environment. | ZHANG Long WEI Guanghui FAN Lisi HU Xiaofeng ZHAO Yang ZHANG Yongqiang | 2013 | 高电压技术2013，39，10： | 1 |
| 12 | Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro显示文摘Haploid pluripotent stem cells,such as haploid embryonic stem cells(haESCs),facilitate the genetic study of recessive traits.In vitro,fish haESCs maintain haploidy in both undifferentiated and differentiated states,but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested.Here,wereport thatmousehaESCs can differentiate in vitro into haploid epiblast stem cells(haEpiSCs),which maintain an intact haploid genome,unlimited self-renewal potential,and durable pluripotency to differentiate into various tissues in vitro and in vivo.Mechanistically,the maintenance of self-renewal potential depends on the Activin/bFGF pathway.We further show that haEpiSCs can differentiate in vitro into haploid progenitor-like cells.When injected into the cytoplasm of an oocyte,androgenetic haEpiSC(ahaEpiSCs)can support embryonic development until midgestation(E12.5).Together,these resultsdemonstrate durable pluripotency inmousehaESCs andhaEpiSCs,aswell asthe valuable potential of using these haploid pluripotent stem cells in high-throughput genetic screening. | Ling Shuai Yukai Wang Mingzhu Dong Xuepeng Wang Lisi Sang Mei Wang Haifeng Wan Guanzheng Luo Tiantian Gu Yan Yuan Chunjing Feng Fei Teng Wei Li Xiuying Liu Tianda Li Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2015 | Journal of Molecular Cell Biology2015，7，4： | 1 |
| 13 | The development of an iridium(Ⅲ) complex functionalized G-quadruplex probe for the stability of G-quadruplex and lifetime image in cytoplasm显示文摘G-quadruplex(G4) is widely known as a non-classical secondary structure of nucleic acid. With the indepth study of G4, it is an urgent need for a phosphorescent probe with a high G4 binding ability to evaluate the level of G4 in the cytoplasm. Thus, this study designed and synthesized Ir-PDP where an Ir(Ⅲ)complex was used as a phosphorescent emitter. Meanwhile, two installed PDPs(pyridostatin derivatives)were used to improve the combination ability with G4 and reduced the cytotoxicity of the Ir(Ⅲ) complex.Compared with other nucleic acid secondary structures, Ir-PDP produced a higher phosphorescence lifetime after interacting with G4. Ir-PDP was distributed in the cytoplasm of living cells, and two-photon phosphorescence lifetime imaging can detect the binding events of the probe in the cytoplasm. The addition of G4 binder PDS significantly regulated cytoplasmic phosphorescence lifetime. The project explored a new sensing pathway to observe the binding manners of probes in the cytoplasm through the phosphorescence lifetime of probes. | Shaokang Jia Wenjin Wang Shanshan Qin Shengjie Xie Lisi Zhan Qi Wei Ziang Lu Xiaolu Zhou Cong Chen Kun Chen Shen Yan Caiping Tan Zongwan Mao Xiang Zhou | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 14 | NIR-Ⅱ-absorbing conjugated polymer-based theranostic agent for NIR-Ⅱfluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy显示文摘Despite tremendous advances in gas therapy,there are major concerns about the inevitable concentration of toxicity and the ability to perform real-time tracking of drug delivery.Second near-infrared(NIR-Ⅱ)window absorbing nanoplatforms hold great promise for precision medicine because of their excellent tissue penetration of light and non-invasive nature.In this study,we engineered an NIR-Ⅱlaser-activated theranostic agent(named CP-bF@PEG)that was composed of amphiphilic polymers(Pluronic F127,with polyethylene glycol,PEG,moieties)coated with an NIR-Ⅱ-absorbing conjugated polymer(PTTBBT,CP)and nitric oxide(NO)donor(benzofuroxan,bF),which served as an NIR-Ⅱphotothermal inducer and NO nanogenerator.Under deep tissue penetration of NIR-Ⅱlaser irradiation,CP-bF@PEG was found to possess fluorescence imaging ability to accurately identify tumor and excellent photothermal effect.Moreover,CP-bF@PEG could generate NO via glutathione activation in the tumor microenvironment in a controllable manner.This NIR-Ⅱ-absorbing polymer for high-contrast NIR-Ⅱfluorescence imaging-guided precision photothermal therapy achieved synergistic effects with NO therapy,as evidenced by pronounced tumor therapeutic efficacy and few side effects.This nanotheranostic agent is a highly promising candidate for high-contrast NIR-Ⅱimaging-guided precision photothermal therapy combined with gas therapy against cancer. | Jie Li Lisi Xie Wei Sang Wenxi Li Guohao Wang Hao Tian Zhan Zhang Jianhua Liu Quli Fan Yunlu Dai | 2022 | ChemPhysMater2022，1，1： | 0 |
| 15 | A'three musketeers'tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy显示文摘Interferon-γ(IFN-γ),secreted by activated T cells predominantly,plays a crucial performance in the tumoricidal immune response.Unfortunately,a high level of IFN-γseverely ignites the immunosuppressive response,especially by increasing the expression of immune checkpoint programmed death-ligand 1(PD-L1)and immunoregulatory enzyme indoleamine 2,3-dioxygenase 1(IDO-1).Herein,we have explored a versatile IFN-γ-nano-integrator(aPD-L1-SH@Ce6@NLG919-PEG,simplified as CNDP)to establish a positive anti-tumor feedback loop to amplify the IFN-γ-mediated tumoricidal effect.In this nanointegrator,photosensitizer chlorin e6(Ce6)mediates photodynamic therapy(PDT)to re-shape immunogenicity and activate the adaptive immune response,followed by the secretion of high-level IFN-γto struggle tumor cells.IDO-1 inhibitor(NLG919)afterwards mitigates the immunosuppressive behavior of IFN-γby neutralizing the function of IDO-1.To turn“waste”into wealth,anti-PD-L1(aPD-L1)antibodies are technically integrated into the nano-integrator to propel the precise attack of breast cancer through ascending PD-L1 blockade.Together,this“three musketeers”nano-integrator tumoricidal tactic may give a unique insight into the clinical anti-tumor therapy. | Wenxi Li Lisi Xie Yi Ju Zhan Zhang Bei Li Jie Li Wei Sang Guohao Wang Hao Tian Yunlu Dai | 2022 | Nano Research2022，15，4： | 0 |
| 16 | Tuning Electronic Structures of Covalent Co Porphyrin Polymers for Electrocatalytic CO_(2) Reduction in Aqueous Solutions显示文摘Improving the selectivity of the electrocatalytic CO_(2) reduction reaction(CO_(2)RR)over hydrogen evolution in aqueous solutions is required but challenging because the two reactions occur at close thermodynamic potentials and compete with each other.Herein,we report on the selective CO_(2)RR in aqueous solutions utilizing covalent Co porphyrin polymers with fine-tuned electronic structures. | Yabo Wang Xue-Peng Zhang Haitao Lei Kai Guo Gelun Xu Lisi Xie Xialiang Li Wei Zhang Ulf-Peter Apfel Rui Cao | 2022 | CCS Chemistry2022，4，9： | 0 |
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