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| 1 | Leukotriene D4 induces brain edema and enhances CysLT2 receptor- mediated aquaporin 4 expression显示文摘 | Wang Meng - Ling Yuan Yu - Mei Huang Xiao - Jia Fang San - Hua Zhang Wei-Ping Lu Yu-Bi Ding Qian Wei Er-Qing | 2006 | 中国药理通讯2006，23，4： | 14 |
| 2 | Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China显示文摘Objective To investigate a potential relationship between Solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients,respectively).Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment.An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study.Δ value of homeostasis model assessment of beta cell function (HOMA-B)and Δ value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149 and 0.0246,respectively) after rosiglitazone treatment.However,no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.Conclusion The SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai,China. | JIANG Feng LI Qing HU Cheng ZHANG Rong WANG Cong Rong YU Wei Hui LU Jing Yi TANG Shan Shan BAO Yu Qian XIANG Kun San JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 8 |
| 3 | Two new saponins from Anemarrhena asphodeloides Bge.显示文摘Two new saponins 3-O-β-D-glucopyranosyl (1→2)-β-D-mannopyranosyl sarsasapogenin, named timosaponin A IV(1) and (5β, 25S)-26-O-β-D-glucopyranosyl-furost-20(22)-en-3,26-diol-3-O-β-D-glucopyranosyl (1→4) glucopyranosyl (1→2)-β-D-galacopyranoside, named timosaponin B IV(2), were isolated by silica gel column chromatography and preparative HPLC from Anemarrhena asphodeloides Bge. Their structures were elucidated by chemical characters and spectroscopic analysis. | Ying Peng Yu Jing Zhang Zhi Qiang Ma Wei San Pan Yu Qing Sun Shao Jiang Song | 2007 | Chinese Chemical Letters2007，18，2： | 7 |
| 4 | Activation of the Ig la I promoter by the transcription factor Ets-1 triggers Ig lal-Cal germline transcription in epithelial cancer cells显示文摘 | Zhi Duan Hui Zheng San Xu Yiqun Jiang Haidan Liu Ming Li Duosha Hu Wei Li Ann M. Bode Zigang Dong Ya Cao | 2014 | Cellular & Molecular Immunology2014，11，2： | 3 |
| 5 | A novel linear microprobe array for the fabrication of neural microelectrodes显示文摘A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from silicon.The LMPA leverages the properties of conventional microwire with additional features of naturally formed regular spacing.With the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the LMPA.The fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo test.The SNR of the spikes recorded was 6. | ZHAO Shan Shan PEI Wei Hua ZHAO Hui WANG Yi Jun CHEN San Yuan CHEN Yuan Fang ZHANG He GUO Dong Mei GUI Qiang CHEN Hong Da | 2015 | Science China(Technological Sciences)2015，58，2： | 3 |
| 6 | Ophthalmology simulation for undergraduate and postgraduate clinical education显示文摘This is a review education paper on the current ophthalmology simulators utilized worldwide for undergraduate and postgraduate training. At present,various simulators such as the EYE Exam Simulator(Kyoto Kagaku Co. Ltd., Kyoto, Japan), Eyesi direct ophthalmoscope simulator(VRmagic, Gmb H, Mannheim,Germany), Eyesi indirect ophthalmoscope simulator(VRmagic, Gmb H, Mannheim, Germany) and Eyesi cataract simulators(VRmagic, Gmb H, Mannheim,Germany). These simulators are thought to be able to reduce the initial learning curve for the ophthalmology training but further research will need to be conducted to assess the effectiveness of the simulation-assisted ophthalmology training. Future research will be of great value to assess the medical students and residents' responses and performance regarding the usefulness of the individual eye simulator. | Daniel Shu Wei Ting Shaun Sebastian Khung Peng Sim Christine Wen Leng Yau Mohamad Rosman Ai Tee Aw Ian Yew San Yeo | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 3 |
| 7 | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance显示文摘Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in OSCC.Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib response.Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations.Consistently, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in mice.Conclusions: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies. | Nur Syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 8 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 3 |
| 9 | A review of the thermal stability of metastable austenite in steels:Martensite formation显示文摘Metastable austenite plays a critical role in achieving improved combinations of high strength and high ductility/toughness in the design of advanced high-strength steels(AHSS). The thermal stability of metastable austenite determines the transformation characteristics of AHSS and thus primarily determines the microstructure evolution during complex processes, e.g., the quenching and partitioning process, to achieve the desirable microstructure. This study provides a review of the thermal stability of austenite and its influence on martensitic transformation from both experimental and theoretical modeling perspectives. From the experimental perspective, factors affecting the thermal stability are analyzed,the relative sensitivities are compared, and their corresponding mechanisms are discussed. From the theoretical modeling perspective, the most representative kinetic models that describe athermal and isothermal martensitic transformation are reviewed. The advantages, shortcomings, and applicability of each model are discussed. The systematic review of both experimental and theoretical aspects reveals critical factors in tailoring the stability of metastable austenite and, therefore, provides guidance for the design of advanced steels. | Yong Li David San Martín Jinliang Wang Chenchong Wang Wei Xu | 2021 | Journal of Materials Science & Technology2021，，32： | 3 |
| 10 | Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury显示文摘 | Zhang Lei Zhang Wei - Ping Chen Ke - Da Qian Xiao - Dong Fang San - Hua Wei Er - Qing | 2006 | 中国药理通讯2006，23，4： | 3 |
| 11 | Association between Vitamin D Levels and the Risk of Metabolic Syndrome in a Rural Chinese Population显示文摘Metabolic syndrome(MS)is a cluster of metabolic abnormalities that include obesity,dyslipidemia,hyperglycemia,and high blood pressure(BP)[1].Previous studies have shown that the prevalence of MS is increasing in both developing and developed countries[2].Currently,about a quarter of the adult population worldwide have MS,which has become a serious global public health problem. | SUN Hua Lei LONG Shao Rong FU San Xian CHEN Gai Yun WANG Ya Juan LIANG Rui WANG Su Fan ZHANG Li Ke ZHOU Li Wei LU Quan Jun LI Wen Jie | 2021 | Biomedical and Environmental Sciences2021，34，4： | 2 |
| 12 | Regional brain structural abnormality in ischemic stroke patients:a voxel-based morphometry study显示文摘Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly.In the current study,we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants,and analyzing the data using voxel-based morphometry.Compared with healthy participants,patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract.In contrast,gray matter density in the right cerebellum,left precentral gyrus,right middle frontal gyrus,and left middle temporal gyrus was less in ischemic stroke patients.The changes of gray matter density in the middle frontal gyrus were negatively associated with the clinical rating scales of the Fugl-Meyer Motor Assessment(r=–0.609,P=0.047) and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale(r=–0.737,P=0.010).Our findings can objectively identify the functional abnormality in some brain regions of ischemic stroke patients. | Ping Wu Yu-mei Zhou Fang Zeng Zheng-jie Li Lu Luo Yong-xin Li Wei Fan Li-hua Qiu Wei Qin Lin Chen Lin Bai Juan Nie San Zhang Yan Xiong Yu Bai Can-xin Yin Fan-rong Liang | 2016 | Neural Regeneration Research2016，11，9： | 2 |
| 13 | RBF neural network based on q-Gaussian function in function approximation显示文摘提高光线的基础功能(RBF ) 的归纳性能神经网络,一个 RBF 神经网络基于一个 q-Gaussian 函数被建议。q-Gaussian 功能被选择为 RBF 神经网络的光线的基础功能,并且一个粒子群优化算法被采用选择网络的参数。非广泛的 entropic 索引 q 被编码为粒子并且在人口的进化过程适应地调整了。函数近似的模拟结果显示一个 RBF 神经网络基于 q-Gaussian 功能完成最好的归纳性能。 | Wei ZHAO Ye SAN | 2011 | Frontiers of Computer Science2011，5，4： | 2 |
| 14 | Comparative study of MCe_(0.75)Zr_(0.25)O_(y)(M=Cu,Mn,Fe)catalysts for selective reduction of NO by CO:Activity and reaction pathways显示文摘Basic oxygen furnace steelmaking leads to the production of CO-rich off-gas.When CO and NO are combined in off-gas,selective catalytic reduction by CO(CO-SCR)effectively achieves the synergistic removal of both pollutants.In this paper,CuCe_(0.75)Zr_(0.25)O_(y),MnCe_(0.75)Zr_(0.25)O_(y),and FeCe_(0.75)Zr_(0.25)O_(y) catalysts are prepared and evaluated for their CO-SCR activity,and the results show that the reaction system needs to be anaerobic;thus,the CO-SCR reaction can be dominant.The T_(90) values of CuCe_(0.75)Zr_(0.25)O_(y) and FeCe_(0.75)Zr_(0.25)O_(y) are 200℃ and 223℃,respectively.The activities of these two catalysts are higher than that of MnCe_(0.75)Zr_(0.25)O_(y)(T_(90)=375℃).Linear nitrate and bridged bidentate nitrate are the main intermediate species involved in NO conversion on the catalyst surface,and bidentate CO_(3)^(2-)��coordination is the main intermediate species involved in CO conversion on the catalyst surface.CuCe_(0.75)Zr_(0.25)O_(y) has high lattice oxygen mobility and is more likely to react with NO and CO.In the presence of oxygen,most CO is oxidized by O_(2),which increases continuously to 100%,100%,and 98%for CuCe_(0.75)Zr_(0.25)O_(y),FeCe_(0.75)Zr_(0.25)O_(y),and MnCe_(0.75)Zr_(0.25)O_(y),respectively;additionally,CO is oxidized by O_(2),and the CO-SCR reaction cannot be carried out. | Junyao He Running Kang Xiaolin Wei Junqin Huang Feng Bin Kwun Nam Hui Kwan San Hui Dongyin Wu | 2021 | Carbon Resources Conversion2021，4，1： | 2 |
| 15 | Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19显示文摘Objective The coronavirus disease 2019(COVID-19) pandemic continues to present a major challenge to public health. Vaccine development requires an understanding of the kinetics of neutralizing antibody(NAb) responses to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods In total, 605 serum samples from 125 COVID-19 patients(from January 1 to March 14, 2020)varying in age, sex, severity of symptoms, and presence of underlying diseases were collected, and antibody titers were measured using a micro-neutralization assay with wild-type SARS-CoV-2.Results NAbs were detectable approximately 10 days post-onset(dpo) of symptoms and peaked at approximately 20 dpo. The NAb levels were slightly higher in young males and severe cases, while no significant difference was observed for the other classifications. In follow-up cases, the NAb titer had increased or stabilized in 18 cases, whereas it had decreased in 26 cases, and in one case NAbs were undetectable at the end of our observation. Although a decreasing trend in NAb titer was observed in many cases, the NAb level was generally still protective.Conclusion We demonstrated that NAb levels vary among all categories of COVID-19 patients. Longterm studies are needed to determine the longevity and protective efficiency of NAbs induced by SARS-CoV-2. | LI Ling Hua TU Hong Wei LIANG Dan WEN Chun Yan LI An An LIN Wei Yin HU Ke Qi HONG Wen Shan LI Yue Ping SU Juan ZHAO San Tao LI Wei YUAN Run Yu ZHOU Ping Ping HU Feng Yu TANG Xiao Ping KE Chang Wen KE Bi Xia CAI Wei Ping | 2021 | Biomedical and Environmental Sciences2021，34，12： | 1 |
| 16 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 1 |
| 17 | Optimized tool path generation for fast tool servo diamond turning of micro-structured surfaces显示文摘 | De Ping Yu Sze Wei Gan Yoke San Wong Geok Soon Hong Mustafizur Rahman Jin Yao | 2012 | The International Journal of Advanced Manufacturing Technology2012，，9： | 1 |
| 18 | The effect of powder size on induction behaviour and binder distribution during high shear melt agglomeration of calcium carbonate 显示文摘 | Wei - Da Tu Shu - San Hsiau Andy Ingram | 2008 | Powder Technology2008，，184： | 1 |
| 19 | A line- based,memory efficient and programmable architecture for 2D DWT using lifting scheme 显示文摘 | Chang Wei Hsin Lee Yew San Peng Wen Shiaw | 2001 | Circuits and Systems2001，4，： | 1 |
| 20 | Studies on controlled release effervescent osmotic pump tablets from Traditional Chinese Medicine Compound Recipe 显示文摘 | Xiao dong Li Wei san Pan Shu fang Nie | 2004 | Controlled Release2004，96，： | 1 |
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