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| 1 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 2 | Comparisons of dosimetric properties between GD-300 series of radiophotoluminescent glass detectors and GR-200 series of thermoluminescent detectors显示文摘In order to compare the dosimetric properties of two kinds of solid state detectors used for monitoring ex- ternal exposures,experiments were performed for the GD-300 series of radiophotoluminescent glass detectors (RPLGD)and the GR-200 series of thermoluminescent detectors(TLD).X-rays and ^(137)Cs and ^(60)Coγ-rays were used to irradiate the RPLGDs and TLDs,their dose linearity,uniformity/reproducibility of signal,fading effect and energy dependence were compared.Both kinds of the detectors have generally good dosimetric properties.The dose linearity and energy dependence of the GD-351 dosimeters and the TLDs are nearly the same,but the RPLGD is much better than the TLD in terms of the uniformity and fading effect. | ZHUO Weihai LIU Weiqi HUANG Gang ZHU Guoying MA Guocai | 2007 | Nuclear Science and Techniques2007，18，6： | 6 |
| 3 | Controllable Biosynthesis and Properties of Gold Nanoplates Using Yeast Extract显示文摘Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy. | Zhi Yang Zhaohui Li Xuxing Lu Fengjiao He Xingzhong Zhu Yujie Ma Rong He Feng Gao Weihai Ni Yasha Yi | 2017 | Nano-Micro Letters2017，9，1： | 2 |
| 4 | Discrete-Time Mean-Field Stochastic H_2/H_∞ Control显示文摘The finite horizon H_2/H_∞ control problem of mean-field type for discrete-time systems is considered in this paper. Firstly, the authors derive a mean-field stochastic bounded real lemma(SBRL). Secondly, a sufficient condition for the solvability of discrete-time mean-field stochastic linearquadratic(LQ) optimal control is presented. Thirdly, based on SBRL and LQ results, this paper establishes a sufficient condition for the existence of discrete-time stochastic H_2/H_∞ control of meanfield type via the solvability of coupled matrix-valued equations. | ZHANG Weihai MA Limin ZHANG Tianliang | 2017 | Journal of Systems Science & Complexity2017，30，4： | 1 |
| 5 | Vulnerability Testing of HTTP based on Vulnerability-testing Oriented Petri Net(VOPN)显示文摘Vulnerability-testing Oriented Petri Net(VOPN), a vulnerability testing model for communication protocol is brought forward rst, which is combined Petri Net system with protocol Syntax analysis.Then vulnerability testing of implementation of HTTP protocol based on VOPN is made and the process is analyzed to prove the feasibility of the model. | Li Weihai Ma Yan Huang Xiaohong | 2009 | China Communications2009，6，4： | 1 |
| 6 | Lightweight Si_(3)N_(4)@SiO_(2) ceramic foam for thermal insulation and electromagnetic wave transparency显示文摘Increasing porosity is one of the most direct ways to improve the thermal insulation and dielectric properties of materials.Until now,many wet methods for preparing Si_(3)N_(4) ceramic foams usually face the problems of complex rheology,long period,and expensive cost,and the reported pore sizes of Si_(3)N_(4) ceramic foams are typically micron-grade,resulting in a lack of competitiveness in thermal insulation and wave-transparent applications.In this paper,the Si_(3)N_(4)@SiO_(2) ceramic foams were prepared using an efficient dry-method,which combined three processes of low temperature chemical vapor deposition(LTCVD),template,and isostatic pressing.The method has the advantages of simple operation and short preparation period,and can realize near-net size molding and mass production.In addition,the evolution mechanisms of honeycomb microstructure and composition of Si_(3)N_(4)@SiO_(2) ceramic foam during sintering were studied by chemical reaction thermodynamics.The as-prepared Si_(3)N_(4)@SiO_(2) ceramic foam possesses low density(0.377 g·cm^(-3)),high compressive strength(7.5 MPa),low thermal conductivity(0.0808 W·m^(-1)·K^(-1)),and excellent dielectric properties(ε<1.32,tanδ<0.009)in the frequency range of 8-18 GHz,and its maximum working temperature in air can reach up to 1100℃.It will be recommended to be applied in the interlayer of Si_(3)N_(4) ceramic radome to improve its thermal insulation and electromagnetic wave transparency performances. | Zongwei Tong Xiangjie Yan Yuexiang Wang Kexun Li Weihai Ma | 2024 | Nano Research2024，17，5： | 0 |
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