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| 1 | Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence显示文摘Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant radiotherapy.Methods:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control group.Patients'outcome,adverse events,long-term recurrence and survival rates were investigated.Results:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin hepatectomy.Long-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC. | Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 2 | Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger显示文摘 | ChengkunWang JieShen ZhongzhengYang PingChen BinZhao WeiHu WenxianLan XiaotianTong HoumingWu GuohongLi ChunyangCao | 2011 | Cell Research2011，21，9： | 5 |
| 3 | A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro显示文摘AIM: To establish a high-throughput model for screening anti-tumor agents capable of promoting the polymeriza- tion of tubulin in vitro. METHODS: Tubulin was prepared in different purity for two screening steps. The first step was a high-throughput screening (HTS) for a set of 1500 samples using the GTP-containing tubulin and the end-reading method. The second step was performed on 119 hits from the first screening by a kinetic assay with GTP-lacking tubulin. RESULTS: The HTS for 1500 samples was accomplished in less than 3 h. From the screening, 108 samples were identified with >20 % promotion activity at 10 mg/L. Five of 108 were further confirmed by the kinetic assay using the purified tubulin subsequently. Three of the hit compounds were Epothilone A or its analogs, the other two compounds had new structures with a common pharmacophore for cytotoxic natural products that stabilize microtubules. In an MTT test, the five selected samples from the screening showed a minimal IC50 at0.28±0.06 nmol/Lto Helacells. CONCLUTION: The two-stepscreening methodis a high-throughtput, cost-effective, and efficient approach to identify microtubule-stabilizing agents. | WeiHU HuiDONG Yue-zhongLI Xi-taoHU Guan-junHAN Yin-boQU | 2004 | Acta Pharmacologica Sinica2004，25，6： | 4 |
| 4 | A first-principles study of the size-dependent electronic properties of SiC nanotubes显示文摘We investigate the structural and electronic properties of SiC nanotubes(NTs) with hexagonal cross sections by a first-principles calculation using plane-wave ultra-soft pseudo-potential technology based on the density-functional theory.Our results reveal that surface-layer C and Si atoms relax significantly upon decreasing the tube-wall thickness because of surface-size and quantum-size effects.We also find that all relaxed SiC NTs stay stably on the nanoscale because of an admixture of sp2 and sp3 hybridization between C and Si atoms and a strong covalent,and that the band gap tends to decrease with increasing tube-wall thickness.Our calculations further indicate that both C and Si atoms on the inner and outer surface of SiC NTs contribute to defect states at the top of the valence band and at the bottom of the conduction band.These results provide reference information for a thorough understanding of the properties of SiC nanostructures and also enable more precise monitoring and control of the growth of SiC nanostructures. | ZHANG WeiHu 1,2,3,ZHANG FuChun 3,ZHANG ZhiYong 4*,LU ShuYuan 5 & YANG YanNing 3 1 Xi’an Institute of Optics and Precision Mechanics,Chinese Academy of Sciences,Xi’an 710068,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 College of Physics and Electronic Information,Yan’an University,Yan’an 716000,China 4 College of Information Science and Technology,Northwest University,Xi’an 710127,China 5 Department of Telecommunications,Xi’an Institute of Posts and Telecommunications,Xi’an 710121,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，7： | 4 |
| 5 | Elastic and thermodynamic properties of TiC from first-principles calculations显示文摘Using the pseudopotential plane-wave method, we investigate the elastic constants and thermodynamic properties of the rocksalt structure Titanium Carbide (TiC). The obtained lattice parameters, bulk modulus and elastic constants are in very good agreement with the available experimental data and other theoretical results. The thermodynamic properties of the cubic TiC are predicted by using the quasi-harmonic Debye model. The normalized volume V/V 0 , bulk modulus B, thermal expansion , heat capacity C V , Grüneisen parameter and Debye temperature dependence on the pressure and temperature are obtained successfully. At low temperature and low pressure, thermal expansion coefficient increases rapidly with temperature. At high temperature and high pressure, the increasing trend becomes tender. At low temperatures, C V is proportional to T 3 , and C V tends to the Dulong-Petit limit at higher temperatures. | LI YanHong WANG WanFeng ZHU Bo XU Ming ZHU Jun HAO YanJun LI WeiHu LONG XiaoJiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，12： | 4 |
| 6 | Addition of rituximab is not associated with survival benefit compared with CHOP alone for patients with stage I diffuse large B-cell lymphoma显示文摘Background:The role of rituximab in combination with CHOP regimen in patients with stage I diffuse large B-cell lymphoma(DLBCL) remains to be defined.We aimed to compare CHOP plus rituximab(R-CHOP) with CHOP alone and determine the value of radiotherapy in these patients.Methods:Between 2003 and 2009,140 untreated patients with stage I DLBCL were retrospectively analyzed in this study.Results:Seventy-eight patients were treated in R-CHOP group and 62 in CHOP group.Ninety-one patients received additional radiotherapy at the end of chemotherapy.The different treatment groups were well-balanced with respect to baseline characteristics.Complete response(CR) rate was 77% both in R-CHOP and CHOP groups(P=0.945).After a median follow-up period of 56 months,patients received R-CHOP regimen had similar 5-year progression-free survival(PFS)(76%vs.85%;log-rank P=0.215)and 5-year overall survival(OS)(90%vs.96%;log-rank P=0.175) compared with those with CHOP alone.Patients with radiotherapy had significantly increased 5-year PFS compared with those who had chemotherapy alone(86%vs.71%;log-rank P=0.005).At multivariate analysis,patients who had CR(P=0.008) and received radiotherapy(P=0.003) were significantly associated with superior PFS.Conclusions:CHOP alone could be as effective as R-CHOP regimen and additional radiotherapy would be necessary for stage I or stage I non-bulky DLBCL patients. | Bo Jia Yuankai Shi Suyi Kang Sheng Yang Shaoxuan Hu Yexiong Li Mei Dong Weihu Wang Jianliang Yang Liqiang Zhou Peng Liu Shengyu Zhou Yan Qin Lin Gui Changgong Zhang Hua Lin Shanshan Chen Lin Wang Xiaohui He | 2015 | Chinese Journal of Cancer Research2015，27，5： | 2 |
| 7 | Management of extramedullary plasmacytoma: Role of radiotherapy and prognostic factor analysis in 55 patients显示文摘Objective: To investigate potential prognostic factors affecting patient outcomes and to evaluate the optimal methods and effects of radiotherapy(RT) in the management of extramedullary plasmacytoma(EMP).Methods: Data from 55 patients with EMP between November 1999 and August 2015 were collected. The median age was 51(range, 22–77) years. The median tumor size was 3.5(range, 1.0–15.0) cm. The median applied dose was 50.0(range, 30.0–70.0) Gy. Thirty-nine patients(70.9%) presented with disease in the head or neck region. Twelve patients received RT alone, 9 received surgery(S) alone, 3 received chemotherapy(CT) alone, and 3 patients did not receive any treatment. Combination therapies were applied in 28 patients.Results:The median follow-up duration was 56 months.The 5-year local recurrence-free survival(LRFS),multiple myeloma-free survival(MMFS),progression-free survival(PFS)and overall survival(OS)rates were 79.8%,78.6%,65.2% and 76.0%,respectively.Univariate analysis revealed that RT was a favourable factor for all examined endpoints.Furthermore,head and neck EMPs were associated with superior LRFS,MMFS and PFS.Tumor size<4 cm was associated with superior MMFS,PFS and OS;serum M protein negativity was associated with superior MMFS and PFS;age≥50 years and local recurrence were associated with poor MMFS.The dose≥45 Gy group exhibited superior 5-year LRFS,MMFS and PFS rates(94.7%,94.4%,90.0%,respectively),while the corresponding values for the dose<45 Gy group were 62.5%(P=0.008),53.3%(P=0.036)and 41.7%(P<0.001).Conclusions:Involved-site RT of at least 45 Gy should be considered for EMP.Furthermore,patients with head and neck EMP,tumor size<4 cm,age<50 years and serum M protein negativity had better outcomes. | Ge Wen Weihu Wang Yujing Zhang Shaoqing Niu Qiwen Li Yexiong Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 2 |
| 8 | Progression of inflammatory bowel disease in China显示文摘 | Yu FangWANG QinOUYANG Ren WeiHU | 2010 | Journal of Digestive Diseases2010，，2： | 2 |
| 9 | The pharmacology and clinical uses of naftopidil 显示文摘 | Weilin Q Weihu F Wenhang Q | 2001 | Chinese Journal of New Drugs2001，10，8： | 1 |
| 10 | Facile synthe- sis of water-soluble highly fluorescent grapheme quantum dots as a robust biological label for stern cells 显示文摘 | Mo Zhang Linling Bai Weihu Shang eta! | 2012 | J Master Chem2012，22，： | 1 |
| 11 | Printed triple‐band rectangular ring monopole antenna with symmetrical L‐strips for WLAN/WiMAX applications显示文摘 | XinLi WeiHu Ya FangWang Xiao WeiShi Xin TaoGu | 2012 | Microw Opt Technol Lett2012，，4： | 1 |
| 12 | First-principles study on electronic structures and optical properties of the single-walled (n, 0) ZnO nanotubes显示文摘Using the first-principles calculations, we studied the geometric structures, electronic structures and optical properties of the single-walled (n, 0) ZnO nanotubes (NTs). The calculated results show that all the bind energies of the single-walled (n,0) ZnO NTs are of negative values, which indicate that the ZnO NTs can exist stably as single-walled NTs. While the calculated results of electronic structure indicate that the single-walled (n,0) ZnO NTs are a type of direct wide band-gap semiconductor materials, the whole valence bands are spread and drift to low-energy direction with the increase of the NT diameter. The defect energy levels caused by quantum size and surface effects emerge on the top of the valence bands. Furthermore, the calculated results of optical properties reveal that the dielectric peaks have a blue shift and the edge of absorption band corresponds to ultraviolet band with the decrease of the NT diameter. The single-walled (n, 0) ZnO NTs can be applied to ultraviolet semiconductor systems. | DONG JunTang ZHANG FuChun ZHANG WeiHu ZHANG ZhiYong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，4： | 1 |
| 13 | TiO 2 nanotubes as drug nanoreservoirs for the regulation of mobility and differentiation of mesenchymal stem cells显示文摘 | Yan Hu Kaiyong Cai Zhong Luo Dawei Xu Daichao Xie Yuran Huang Weihu Yang Peng Liu | 2011 | Acta Biomaterialia2011，，1： | 1 |
| 14 | Synthesis and reactivity of hydroxy poly (ethylene oxide) propyl-b- polydimethylsiloxane b-propyl hydroxypoly(ethylene ox- ide)显示文摘 | LI Weihu ZHANG Xingyuan DAI Jiabing | 2009 | J Maeromol Sei Part A Pure Appl Chem2009，46，9： | 1 |
| 15 | Variable selection for partially linear models with randomly censored data显示文摘 | YANG Yiping XUE Liugen CHENG Weihu | 2010 | Communications in Statistics-Simulation and Computation2010，39，： | 1 |
| 16 | The application of fuzzy risk in researching food disasters 显示文摘 | Feng Lihua Hong Weihu Wan Zi | 2010 | Natural Hazards2010，53，3： | 1 |
| 17 | On Hydrologic Calculation Using Artificial Neural Networks显示文摘 | Feng Lihua Hong Weihu | 2008 | Applied Mathematics Letters2008，21，5： | 1 |
| 18 | Predictors of pathologic complete response in patients with residual flat mucosal lesions after neoadjuvant chemoradiotherapy for locally advanced rectal cancer显示文摘Objective:The accurate prediction of tumor response to neoadjuvant chemoradiotherapy(nCRT)remains challenging.Few studies have investigated pathologic complete response(ypCR)prediction in patients with residual flat mucosal lesions after treatment.This study aimed to identify variables for predicting ypCR in patients with residual flat mucosal lesions after nCRT for locally advanced rectal cancer(LARC).Methods:Data of patients with residual flat mucosal lesions after nCRT who underwent radical resection between 2009 and 2015 were retrospectively collected from the LARC database at Peking University Cancer Hospital.Univariate and multivariate analyses of the association between clinicopathological factors and ypCR were performed,and a nomogram was constructed by incorporating the significant predictors.Results:Of the 246 patients with residual flat mucosal lesions included in the final analysis,56(22.8%)had ypCR.Univariate and multivariate analyses showed that pretreatment cT stage(pre-cT)≤T2(P=0.016),magnetic resonance tumor regression grade(MR-TRG)1-3(P=0.001)and residual mucosal lesion depth=0 mm(P<0.001)were associated with a higher rate of ypCR.A nomogram was developed with a concordance index(C-index)of0.759 and the calibration curve showed that the nomogram model had good predictive consistency.The follow-up time ranged from 3.0 to 113.3 months,with a median follow-up time of 63.77 months.The multivariate Cox regression model showed that the four variables in the nomogram model were not risk factors for disease-free survival(DFS)or overall survival(OS).Conclusions:Completely flat mucosa,early cT stage and good MR-TRG were predictive factors for ypCR instead of DFS or OS in patients with LARC with residual flat mucosal lesions after nCRT.Endoscopic mucosal re-evaluation before surgery is important,as it may contribute to decision-making and facilitate nonoperative management or organ preservation. | Changlong Li Zhen Guan Yi Zhao Tingting Sun Zhongwu Li Weihu Wang Zhexuan Li Lin Wang Aiwen Wu | 2022 | Chinese Journal of Cancer Research2022，34，4： | 1 |
| 19 | An experiment of femtosecond laser absolute distance measurement by spectrally-resolved interferometry显示文摘 | Zhou Weihu Li Yao Ji Rongyi | 2012 | SHE2012，51，8： | 1 |
| 20 | Correlation of132-Adrenergic Receptor Gene Polymorphisins With Heart Failure显示文摘 | Hou Xumin Fan Weihu | 2004 | Chin J Circulation2004，19，2： | 1 |
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