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| 1 | Dietary garcinol supplementation improves diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets显示文摘Background:The effects of dietary garcinol on diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets were investigated.Method:One hundred forty four weaned piglets(Duroc×Yorkshire×Landrace)from 16 pens(9 piglets per pen)were randomly divided into four treatment groups:controls(CON)or those supplemented with 200 mg/kg(LOW),400 mg/kg(MID),or 600 mg/kg(HIGH)diet garcinol.After 14-day trial,three piglets per pen were chosen to collect plasma,intestinal tissue and colonic digesta samples.Results:We demonstrated for the first time that garcinol promoted growth performance,as increased average daily feed intake(ADFI)and decreased feed/gain ratio(F/G);and reduced diarrhea incidence(P<0.05);and strengthened antioxidant capacity,as an increased antioxidative index(P<0.05).Additionally,garcinol ameliorated intestinal barrier dysfunction,as an increased villus height to crypt depth ratio,increased zonula occludens protein 1(ZO-1),occludin and claudin-1 expression in the jejunum and ileum(P<0.05),and decreased intestinal permeability(P<0.05);and reduced inflammation,as decreased cytokine interleukin(IL)-6,IL-10,IL-1βand tumor necrosis factor-α(TNF-α)levels in the mucosa of the jejunum and ileum,and NF-κB p65 translocation(P<0.05).Moreover,garcinol inhibited the growth of most harmful bacteria in the gut,especially Escherichia coli,and increased the growth of the beneficial bacteria Lactobacillus.Conclusion:This work provides a fundamental basis for the future development of garcinol-functional food use for improving diarrhea and intestinal barrier function in weaned piglets and for understanding the biological effects of garcinol and its potential as a functional feed additive. | Tongxin Wang Weilei Yao Juan Li Yafei Shao Qiongyu He Jun Xia Feiruo Huang | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 8 |
| 2 | Efficacy and prognostic factors of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘一个 CALLG2008 协议被中国尖锐成淋巴细胞的白血病合作的组为成年尖锐成淋巴细胞的白血病(所有) 开发。我们回顾地与费城染色体(Ph ) 分析了 153 个最新诊断的成年病人积极加在 2009 和 2015 之间的 CALLG2008 政体注册进 imatinib (400 mg/d ) 的所有。中部的年龄是 40 年(范围, 1868 年) ,与 81 (52.3%) 男性。全面 hematologic 完全的宽恕(CR ) 率在正式就职以后是 96.7% 。与 24.2 个月的中部的后续,估计的 3 年的全面幸存(OS ) 和没有事件的幸存(EFS ) 评价是 49.5%(95% 信心间隔(CI ) :38.5%59.5%) 并且 49.2%(95% CI:38.3%59.2%) 分别地。58 (36 与 haploidentical 施主) 病人们经历了 allogeneic 在第一 CR 的造血的干细胞移植(allo-HSCT ) 。在在在正式就职以后的 CR1 的病人之中, 3 年的 OS 和 EFS 比在 without allo-HSCT 组在 allo-HSCT 组显著地更好(73.2% , 95% CI:58.3%83.5% 对 22.2% , 95% CI:8.7%39.6% 并且 66.5% , 95% CI:50.7%78.2% 对 16.1% , 95% CI:5.1%32.7% ,分别地) 。Multivariate 分析显示出那 allo-HSCT,主要分子的反应的成就独立地与有利 OS 或 EFS 被联系。在 allo-HSCT 队,有趣地,施主类型(haploidentical 对匹配的施主) 没在 EFS 或 OS 上有重要影响。所有这些结果建议加 CALLG2008 的那 imatinib 是一个有效协议为 Ph 积极所有。Haploidentical 施主能也是一个合理其他的有用施主水池。 | Yinjun Lou Yafang Ma Chenyin Li Sansan Suo Hongyan Tong Wenbin Qian Wenyuan Mai Haitao Meng Wenjuan Yu Liping Mao Juyin Wei Weilei Xu Jie Jin | 2017 | Frontiers of Medicine2017，11，2： | 3 |
| 3 | Identification, through transcriptome analysis, of transcription factors that regulate anthocyanin biosynthesis in different parts of red-fleshed apple 'May' fruit显示文摘Anthocyanins, a class of flavonoid compounds that provide pigmentation to plant organs, are beneficial components of the human diet and there is an interest in understanding the regulation of their formation in crop plants. The apple cultivar ‘May’ represents an excellent model for the study of anthocyanin metabolism due to the spatial color pattern of its flesh, which transitions sequentially from red to white to red again,from the outside to the inside of the apple fruit. To screen the transcription factors involved in the anthocyanin pathway, transcriptomes from differently colored sections of ‘May’ fruits were analyzed by RNA sequencing. Kyoto Encyclopedia of Genes and Genomes(KEGG) database was used to analyse the gene expression data. The results suggested differentially expressed genes(DEGs) that are related to phytohormones are involved in regulating anthocyanin biosynthesis. K-means clustering analysis revealed 167 common DEGs between different sections of fruit with the same expression pattern as candidates for regulating anthocyanin synthesis. Further analysis showed that nine of the 167 DEGs were annotated as transcription factors and quantitative real time PCR(qRT-PCR) confirmed that their expression was obviously higher in red regions of the fruit, consistent with their roles as hub genes that regulate anthocyanin synthesis. This study provides valuable results for future studies of anthocyanin synthesis in apple fruit. | Hua Li Shiyao Duan Weilei Sun Sifan Wang Jie Zhang Tingting Song Ji Tian Yuncong Yao | 2022 | Horticultural Plant Journal2022，8，1： | 2 |
| 4 | T-cell vaccination leads to suppression of intrapancreatic Th17 cells through Stat3-mediated RORyt inhibition in autoimmune diabetes显示文摘有使失去活性的 autoreactive T 房间的免疫是改善的一条有效治疗学的途径自体免疫的疾病,当调整 autoreactive T 房间的内在的机制完全没被理解时。这研究测试了 T 房间种痘(TCV ) 禁止的假设在通过 Th17 房间的抑制的老鼠的自体免疫的糖尿病。结果显示出在类型 1 糖尿病(T1D ) 的减少的多糖症作为与控制相比由多重低剂量的 streptozotocin (MLD-STZ ) 导致了的那个 TCV 处理,保存了健康胰腺的小岛的数字并且增加了在小岛的胰岛素的生产。进一步的学习表明 TCV 显著地减少了在通过 mRNA 的显著抑制渗入淋巴细胞(IPL ) 的 intrapancreatic 的 -17 和 IL-23 retinoic 铺平的两 interleukin (IL ) 的生产酸相关的孤儿受体 γ t (RORγ t ) 并且信号变换器和抄写 3 的使活跃之物(Stat3 ) phosphorylation。导致 TCV 的 Th17 抑制的角色进一步在 sub-diabetogenic 老鼠与极化的 Th17 房间在采纳转移实验被验证,它类似于 anti-IL-17 抗体处理的效果。一起,我们的学习证明 intrapancreatic Th17 房间抑制和健康小岛保藏由 TCV 在 T1D 的处理起一个重要作用。 | Min Wang Liu Yang Xiaoyan Sheng Weilei Chen Haiqing Tang Hongguang Sheng Beili Xi Ying Qin Zang | 2011 | Cell Research2011，21，9： | 2 |
| 5 | Analysis of Male Sterility-Related Proteins of Young Panicle in Rice (Oryza sativa L.) by Two-Dimensional Electrophoresis显示文摘For searching out male sterility-related proteins (polypeptides) in rice (Oryza sativa L.), we examined the difference of panicle protein (polypeptides) between hybrid rice (Wujin2A/R168, Wujin5A/R988) and their parents (male-sterile line Wujin2A, Wujin5A, and restorer line R168, R988) at the formation stage of pollen mother cell by two-dimensional electrophoresis (2-DE). The results revealed that the 2-DE polypeptide maps were similar among these experimental materials. A small group of polypeptides were disappeared in 2-DE polypeptide maps of male-sterile line (Wujin2A, Wujin5A) by comparing to restorer line (R168, R988) and the first filial (F generation (Wujin2A/R168, Wujin5A/R988). The isoelectric points of these polypeptides were pI 5.8-6.5, molecular weight 42.7×103-66.2×103. | HUYao-jun WEILei LIUShu-nan YUJin-hong DINGYi | 2005 | Wuhan University Journal of Natural Sciences2005，10，3： | 1 |
| 6 | Effect of low temperature phase changes on the mechanical properties of alloys near composition Ti-Ni 显示文摘 | Buehler W J GiLfrich J V Weiley K C | 1963 | Journal of Applied Physics1963，34，5： | 1 |
| 7 | Sub‐National Institutional Contingencies, Network Positions, and IJV Partner Selection显示文摘 | Weilei (Stone) Shi Sunny Li Sun Mike W. Peng | 2012 | Journal of Management Studies2012，，7： | 1 |
| 8 | Bismuth film-modified gold electrodes for the determination of trace level of heavy metals in vegetables 显示文摘 | DU Xiaoyan GONG Weilei ZHANG Yuxue | 2007 | Sensor Lett2007，5，： | 1 |
| 9 | 显示文摘 | WangMingfu(-明福) WangChang′an(汪长安) WeiLei(尉磊)etal | 2009 | 稀有金属材料与工程2009，38，2： | 1 |
| 10 | Bismuth film-modified gold electrodes for the determination of trace level of heavy metals in vegetables 显示文摘 | DU XIAOYAN GONG WEILEI ZHANG YUXUE | 2007 | Sensor Lett2007，5，： | 1 |
| 11 | Research on orthogonal coagulated setting and coagulation-flotation test of tannery wastewater显示文摘 | Zhi XU Qingzhi FEI Weilei ZHONG | 2009 | Journal of Environmental Sciences2009，，： | 1 |
| 12 | Transesterification of soybean oil catalyzed by potassium loaded on alumina as a solid-base catalyst 显示文摘 | XIE Weilei PENG Hang CHEN Ligong | 2006 | Applied Catalysis A2006，300，1： | 1 |
| 13 | A calcium-selected channel from root-tip endomembrane of garder cress显示文摘 | Klusener B weilei E W | 1999 | Plant Physiol1999，，19： | 1 |
| 14 | Research on orthogonal coagulated setting and coagu- lation - flotation test of tannery wastewater 显示文摘 | Zhi X Qingzhi F Weilei Z | 2009 | J Environ Sci Suppl2009，，： | 1 |
| 15 | 显示文摘 | JIXiao-Li(吉晓莉) ZHENGCai-Hua(郑彩华) WEILei(魏磊) etal | | HuaxueYuShengwuGongcheng0，，： | 1 |
| 16 | L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver显示文摘The liver is the most essential organ for the metabolism of ammonia, in where most of ammonia is removed by urea and glutamine synthesis. Regulated by leucine, glutamate dehydrogenase(GDH) catalyzes the reversible inter-conversion of glutamate to ammonia. To determine the mechanism of leucine regulating GDH, pigs weighing 20 ± 1 kg were infused for 80 min with ammonium chloride or alanine in the presence or absence of leucine. Primary pig hepatocytes were incubated with or without leucine. In the in vivo experiments with either ammonium or alanine as the nitrogen source, addition of leucine significantly inhibited ureagenesis and promoted the production of glutamate and glutamine in the perfused pig liver(P < 0.05). Similarly, leucine stimulated GDH activity and inhibited sirtuin4(SIRT4)gene expression(P < 0.01). Leucine could also activate mammalian target of rapamycin complex 1(m TORC1) signaling(P < 0.05), as evidenced by the increased phosphorylation levels of ribosomal protein S6 kinase 1(S6 K1) and ribosomal protein S6(S6). Interestingly, the leucine-induced m TORC1 pathway activation suitably correlated with increased GDH activity and decreased expression of SIRT4.Similar results were observed in primary cultured hepatocytes. Notably, leucine exerted no significant change in GDH activity in SIRT4-deficient hepatocytes(P > 0.05), while m TORC1 signaling was activated.Leucine exerted no significant changes in both GDH activity and SIRT4 gene expression in rapamycin treated hepatocytes(P > 0.05). In conclusion, L-leucine increases GDH activity and stimulates glutamate synthesis from different nitrogen sources by regulating m TORC1/SIRT4 pathway in the liver of pigs. | Tongxin Wang Weilei Yao Qiongyu He Yafei Shao Ruilong Zheng Feiruo Huang | 2018 | Animal Nutrition2018，，3： | 1 |
| 17 | Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation显示文摘 | Wong KK Chang S Weilei SR | 2000 | Nat Genet2000，26，1： | 1 |
| 18 | Embelin alleviates weaned piglets intestinal inflammation and barrier dysfunction via PCAF/NF-κB signaling pathway in intestinal epithelial cells显示文摘Background:Intestinal barrier plays key roles in maintaining intestinal homeostasis.Inflammation damage can severely destroy the intestinal integrity of mammals.This study was conducted to investigate the protective effects of embelin and its molecular mechanisms on intestinal inflammation in a porcine model.One hundred sixty 21-day-old castrated weaned pigs(Duroc×Landrace×Yorkshire,average initial body weight was 7.05 d to four groups and fed with a basal diet o±0.28 kg,equal numbers of castrated males and females)were allotter a basal diet containing 200,400,or 600 mg embelin/kg for 28 d.The growth performance,intestinal inflammatory cytokines,morphology of jejunum and ileum,tight junctions in the intestinal mucosa of piglets were tested.IPEC-1 cells with overexpression of P300/CBP associating factor(PCAF)were treated with embelin,the activity of PCAF and acetylation of nuclear factor-κB(NF-κB)were analyzed to determine the effect of embelin on PCAF/NF-κB pathway in vitro.Results:The results showed that embelin decreased(P<0.05)serum D-lactate and diamine oxidase(DAO)levels,and enhanced the expression of ZO-1,occludin and claudin-1 protein in jejunum and ileum.Moreover,the expression levels of critical inflammation molecules(interleukin-1β,interleukin-6,tumor necrosis factor-α,and NF-κB)were downregulated(P<0.05)by embelin in jejunal and ileal mucosa.Meanwhile,the activity of PCAF were down-regulated(P<0.05)by embelin.Importantly,transfection of PCAF siRNAs to IPEC-1 cell decreased NF-κB activities;embelin treatment downregulated(P<0.05)the acetylation and activities of NF-κB by 31.7%-74.6%in IPEC-1 cells with overexpression of PCAF.Conclusions:These results suggested that embelin ameliorates intestinal inflammation in weaned pigs,which might be mediated by suppressing the PCAF/NF-κB signaling pathway. | Weilei Yao Tongxin Wang Lu Huang Zhengxi Bao Shu Wen Feiruo Huang | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 0 |
| 19 | Photonic generation of ASK microwave signals with SSB format显示文摘Optical beating is the usual approach to generation of microwave signals.However,the highest frequency achievable for microwave signals is limited by the bandwidths of optoelectronic devices.To maximize the microwave frequency with a limited bandwidth of a photodetector(PD)and relieve the bandwidth bottleneck,we propose to generate microwave signals with the single sideband(SSB)format by beating a continuous wave(CW)light with an optical SSB signal.By simply adjusting the frequency diference between the CW light and the carrier of the optical SSB signal,the frequency of the generated microwave SSB signal is changed correspondingly.In the experiment,amplitude shift keying(ASK)microwave signals with the SSB format are successfully generated with diferent carrier frequencies and coding bit rates,and the recovered coding information agrees well with the original pseudo random binary sequence(PRBS)of 2^(7)−1 bits.The proposed approach can signifcantly relieve the bandwidth restriction set by optoelectronic devices in high-speed microwave communication systems. | Weilei Gou Yuan Yu Xinliang Zhang | 2023 | Frontiers of Optoelectronics2023，16，3： | 0 |
| 20 | 岛上酒庄游记显示文摘经历了500多年的岁月历史,马德拉的葡萄酒从最风光时的上百家酒庄到如今的8家酒庄,酒庄数量虽然减少但是仅存的酒庄对质量要求的进步是不曾停歇的。如果经过此地,不论是深度葡萄酒爱好者或者游客,部应该考虑抽出2天时间参访这些努力传承历史的马德拉酒庄。 | Weiley Lu | 2015 | 中国葡萄酒2015，，5： | 0 |
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