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| 1 | 自主神经系统与室性心律失常显示文摘自主神经系统(ANS)与心律失常的关系一直是电生理领域的热点问题之一。ANS通过其特殊的传导通路与作用机制调控心脏的电生理活动。ANS功能失衡不仅在特发性室性心律失常(VA)中起重要作用,而且在缺血性心脏病、心力衰竭、Brugada综合征、埋藏式心脏转复除颤器植入者以及在其他各种疾病背景下VA的发生中亦起重要作用。干预或调节ANS功能失衡的措施包括一般性措施如缓解心理压力、药物措施如β受体阻滞剂的应用,以及非药物措施如针对长QT间期综合征所采取的左侧交感星状神经节切除术等。 | 侯应龙 Sunny Po | 2009 | 中国心脏起搏与心电生理杂志2009，23，1： | 22 |
| 2 | 心脏自主神经系统在心房颤动发生和维持中的作用显示文摘心脏自主神经系统(ANS)包括外在ANS与内在ANS,均同时含有肾上腺素能与胆碱能神经纤维。刺激实验动物(犬)的颈部迷走交感干或位于心房表面的神经丛可使其心房有效不应期(ERP)缩短,ERP离散度增加,心房颤动(简称房颤)的诱发性增加;不论有无器质性心脏病,某些房颤患者在房颤发作前表现出ANS张力的显著变化。针对实验动物(犬)的去神经措施,可以不同程度地消除心脏ANS刺激所介导的心房ERP缩短及其离散度增加,并使房颤的诱发率降低;针对房颤患者直接或间接、单独或辅助的心房神经丛消融治疗,可使部分患者房颤治愈,或显著提高肺静脉电隔离或环肺静脉消融治疗房颤的成功率。上述现象则可能与位于肺静脉及心房、特别是左心房的心脏自主神经纤维通过多种机制参与了房颤的发生与维持有关。 | 侯应龙 Sunny Po | 2008 | 中国心脏起搏与心电生理杂志2008，22，3： | 21 |
| 3 | 心脏自主神经重构与心肌梗死后室性心律失常显示文摘心肌梗死后心脏不同区域出现不同程度的去迷走神经支配、去交感神经支配以及交感神经过度再生。这种心脏自主神经的不均一重构加重了心肌梗死后心肌的电生理异质性,导致了室性心律失常易感性增加。多种针对自主神经重构的治疗手段可以有效预防及治疗心肌梗死后患者的室性心律失常,具有较大的临床应用前景。 | 毛俊 刘兴鹏 Sunny PO | 2011 | 心血管病学进展2011，32，3： | 12 |
| 4 | 心脏神经丛消融在心房颤动治疗中的作用显示文摘 | 侯应龙 Benjamin Scherlag 周菁 Sunny Po | 2005 | 中国心脏起搏与心电生理杂志2005，19，6： | 11 |
| 5 | Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy显示文摘遇见 c 的 proto-oncogenes 和 RON 的产品属于受体酷氨酸 kinases 的一个亚科显著地作出贡献到 tumorigenic 前进。在主要肿瘤,改变了调整被房间移植和矩阵侵略描绘的侵略生长的 c-MET/RON 表达式 transduces 信号。这些病原的特征为在癌症治疗指向 c-MET/RON 提供基础。在最后十年,各种各样的途径被调查了压制 c-MET/RON-transduced oncogenesis。在开发的治疗学之中, monoclonal 抗体(mAbs ) 和小分子的禁止者(SMI ) 作为有希望的候选人出现了。这些治疗学的候选人的机制是为幸存的 c-MET/RON 信号上的肿瘤相关性的混乱。对 hepatocyte 生长因素(AMG102 ) 特定、遇见 c 的 mAbs (MetMAb ) 是人性化并且能堵住遇见 c 的发信号,在异种皮移植在肿瘤生长的 vitro 和抑制导致肿瘤房间增长的抑制当模特儿。mAb AMG102 抵销 hepatocyte 生长因素并且在 vivo 提高各种各样的 chemotherapeutics 的 cytotoxicity 到肿瘤。AMG102 当前在为有先进稳固的肿瘤的病人的阶段 II 临床的试用。IMC-41A40 和 Zt/f2 是 RON 特定的 mAbs 那下面调整 RON 表情并且禁止导致 ligand 的 phosphorylation。两 mAbs 在老鼠禁止肿瘤生长由冒号和胰腺的癌症细胞调停了。对特定的 SMI 遇见 c (ARQ107 和 PF-02341066 ) 在临床的试用的各种各样的阶段。治疗学的功效也与象化合物那样的双禁止者被观察了我,它对 c-MET/RON 特定。然而,一个潜在的问题是到这些禁止者的获得的抵抗的出现。清楚地, c-MET/RON 治疗学的开发为以后与癌症作斗争提供机会和挑战。 | Ming-Hai WANG Snehal S PADHYE Sunny GUIN Qi MA Yong-qing ZHOU | 2010 | Acta Pharmacologica Sinica2010，31，9： | 10 |
| 6 | Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/ reperfusion injury显示文摘目的: 进一步描绘膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的角色在早、迟了(第二扇窗户) ischemic preconditioning (欧洲电脑生产厂商)- 并且 postconditioning (停靠港) 调停了对 ischemia/reperfusion (I/R ) 的 cardioprotection 损害。 | Sunny Yang XIANG Linda L YE Li-lu Marie DUAN Li-hui LIU Zhi-dong GE John A AUCHAMPACH Garrett J GROSS Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 9 |
| 7 | 自主神经系统与心房颤动关系及心脏神经丛消融疗效再认识显示文摘①刺激迷走神经或心脏神经丛(GP)可引起心房或肺静脉不应期缩短并诱发心房颤动(简称房颤);消融GP可消除心房或肺静脉诱发房颤的能力;刺激犬GP或在犬GP内注射乙酰胆碱可诱发复杂碎裂心房电图(CFAE),消融犬或房颤病人GP或使用自主神经阻断剂可使CFAE消失或减弱,提示自主神经与房颤关系密切。②单独或附加消融GP治疗房颤的成功率约40%~90%。入选病例、消融方法、GP定位、去神经程度、成功标准、随访方案、术者经验等均可能是形成疗效差异的因素,但高频电刺激定位GP的敏感性欠高可能是一个重要的影响因素,故解剖定位GP可能会得到更多关注。③GP消融后神经组织是否再生尚无定论,但部分消融GP所致的不平衡神经重构可能是房颤再发的重要因素之一。 | 侯应龙 Sunny Po | 2010 | 中国心脏起搏与心电生理杂志2010，24，5： | 6 |
| 8 | 通过刺激自主神经结丛建立持续局灶性心房颤动动物模型显示文摘目的探讨一种通过刺激自主神经结丛来建立持续局灶性心房颤动(房颤)动物模型的新方法。方法共选取20只雄性杂交狗,随机分为乙酰胆碱(Acetylcholine)组(10只)和卡巴胆碱(Carbachol)组(10只)。用苯巴比妥钠麻醉,行右侧开胸及心包切开手术,暴露出右肺静脉与右心房之间的脂肪垫,将一注射针插入该脂肪垫中,以备注入乙酰胆碱或卡巴胆碱。将多电极导管(CordisWebster公司,美国)缝合在右上肺静脉、右心房、左心房上。分别在给药前后(乙酰胆碱组:10 mmol/L乙酰胆碱0.5 mL;卡巴胆碱组:10 mmol/L卡巴胆碱0.5 mL),于右心房处行程序期前刺激,来测定有效不应期及诱发房颤,刺激强度分别采用2倍、4倍、10倍及20倍起搏域值,如出现房颤,则记录房颤持续最长时间及房颤时心房电活动的平均周期。结果向右心房脂肪垫注射乙酰胆碱或卡巴胆碱后可明显缩短心房有效不应期,增加诱发房颤最大与最小偶联间期之差,延长房颤持续的时间,缩短房颤时心房电活动的平均周期。乙酰胆碱组,未注射乙酰胆碱时,在刺激强度为2倍、4倍、10倍及20倍起搏域值时,在右心房处所测心房有效不应期分别为(116.3±17.8)ms,(102.3±22.7)ms,(91.7±21.9)ms和(80.0±23.0)ms,注入乙酰胆碱后则分别缩短为(103.8±26.1)ms(P>0.05),(94.7±21.9)ms(P<0.05),(74.3±20.0)ms(P<0.01)和(65.5±17.8)ms(P<0.05)。未注射乙酰胆碱或卡巴胆碱时,所诱发房颤均为短阵性房颤,持续时间为(9.7±6.0)s(乙酰胆碱组)和(10.4±8.0)s(卡巴胆碱组),心房平均电活动周期为(122.0±9.0)ms(乙酰胆碱组)和(120.0±8.0)ms(卡巴胆碱组);注入乙酰胆碱后持续时间延长为(596.7±281.0)s(P<0.01),心房平均电活动周期缩短为(76.0±32.0)ms(P<0.05);注入卡巴胆碱后则诱发出频率极快、持续时间更长的房颤,持续时间延长为(2 364.0±1169.0)s(P<0.01),心房平均电活动周期缩短为(39.0±12.0)ms(P<0.01)。结论向狗右心房脂肪垫注射卡巴胆碱可成功建立持续性房颤的动物模型。 | 耿宁 孙英贤 Sunny Po BenjammineJ.Scherlag | 2006 | 中国介入心脏病学杂志2006，14，3： | 6 |
| 9 | Effects of mindfulness-based intervention programs on sleep among people with common mental disorders:A systematic review and meta-analysis显示文摘BACKGROUND Sleep problems are particularly prevalent in people with depression or anxiety disorder.Although mindfulness has been suggested as an important component in alleviating insomnia,no comprehensive review and meta-analysis has been conducted to evaluate the effects of different mindfulness-based intervention(MBI)programs on sleep among people with depression or anxiety disorder.AIM To compare the effects of different MBI programs on sleep among people with depression or anxiety disorder.METHODS Related publications in Embase,Medline,PubMed and PsycINFO databases were systematically searched from January 2010 to June 2020 for randomised controlled trials.Data were synthesized using a random-effects or a fixed-effects model to analyse the effects of various MBI programs on sleep problems among people with depression or anxiety disorder.The fixed-effects model was used when heterogeneity was negligible,and the random-effects model was used when heterogeneity was significant to calculate the standardised mean differences(SMDs)and 95%confidence intervals(CIs).RESULTS We identified 397 articles,of which 10 randomised controlled trials,involving a total of 541 participants,were included in the meta-analysis.Studies of internet mindfulness meditation intervention(IMMI),mindfulness meditation(MM),mindfulness-based cognitive therapy(MBCT),mindfulness-based stress reduction(MBSR)and mindfulness-based touch therapy(MBTT)met the inclusion criteria.The greatest effect sizes are reported in favour of MBTT,with SMDs of-1.138(95%CI:-1.937 to-0.340;P=0.005),followed by-1.003(95%CI:-1.645 to-0.360;P=0.002)for MBCT.SMDs of-0.618(95%CI:-0.980 to-0.257;P=0.001)and-0.551(95%CI:-0.842 to-0.260;P<0.0001)were reported for IMMI and MBSR in the pooling trials,respectively.Significant effects on sleep problem improvement are shown in all reviewed MBI programs,except MM,for which the effect size was shown to be nonsignificant.CONCLUSION All MBI programs(MBTT,MBCT,IMMI and MBSR),except MM,are effective options to improve sleep problems among people with depression or anxiety disorder. | Sunny Ho-Wan Chan Danielle Lui Hazel Chan Kelly Sum Ava Cheung Hayley Yip Chong Ho Yu | 2022 | World Journal of Psychiatry2022，12，4： | 5 |
| 10 | Transfusion-transmitted hepatitis E:What we know so far?显示文摘Hepatitis E virus(HEV)is a major cause of viral hepatitis globally.There is growing concern about transfusion-transmitted HEV(TT-HEV)as an emerging global health problem.HEV can potentially result in chronic infection in immunocompromised patients,leading to a higher risk of liver cirrhosis and even death.Between 0.0013%and 0.281%of asymptomatic blood donors around the world have HEV viremia,and 0.27%to 60.5%have anti-HEV immunoglobulin G.HEV is infectious even at very low blood concentrations of the virus.Immunosuppressed patients who develop persistent hepatitis E infection should have their immunosuppressant regimen reduced;ribavirin may be considered as treatment.Pegylated interferon can be considered in those who are refractory or intolerant to ribavirin.Sofosbuvir,a nucleotide analog,showed modest antiviral activity in some clinical studies but sustained viral response was not achieved.Therefore,rescue treatment remains an unmet need.The need for HEV screening of all blood donations remains controversial.Universal screening has been adopted in some countries after consideration of risk and resource availability.Various pathogen reduction methods have also been proposed to reduce the risk of TT-HEV.Future studies are needed to define the incidence of transmission through transfusion,their clinical features,outcomes and prognosis. | Carmen Ka Man Cheung Sunny Hei Wong Alvin Wing Hin Law Man Fai Law | 2022 | World Journal of Gastroenterology2022，28，1： | 5 |
| 11 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 12 | 磷掺杂类金刚石薄膜的制备与性能研究显示文摘应用等离子体浸没离子注入与沉积方法合成了磷掺杂的类金刚石(P doped diamond like carbon,P-aopea DLC)薄膜。结构分析表明磷以微米级岛状结构分散于DLC薄膜表层,P的掺杂增加了DLC薄膜的无序性,俄歇能谱证明岛型区域是由P、C、O三种元素形成的化合物,衰减全反射傅里叶红外光谱(ATR-FTIR)的分析结果显示存在P-O-P和P-P-C的非对称伸缩振动。掺杂表面表现出强烈的亲水性(水接触角为16.9°),体外血小板粘附实验结果显示,P掺杂DLC薄膜表面粘附的血小板少且变形小,表现出的血液相容性优于热解碳和未改性DLCo。P-doped DLC薄膜与水的界面张力为2.7 nJ/cm2,具有较理想的接近于血细胞的界面张力,因此与血液保持了较高的相容性。 | 王进 Sunny C.H.Kwok 陈俊英 杨萍 黄楠 P.K.Chu | 2005 | 真空科学与技术学报2005，25，2： | 5 |
| 13 | Alkali salts of heteropoly tungstates: Efficient catalysts for the synthesis of biodiesel from edible and non-edible oils显示文摘Alkali salts of tungsten based heteropoly acids with different central atom such as P, Si and Co were prepared and evaluated for transesterification of both edible and non-edible oils to their corresponding fatty acid methyl esters. The catalyst of sodium salt of tungstic acid with Co as central atom(Na5Co W12O40) showed optimum activity towards transesterification compared with other heteropoly tungstates.The catalysts activities were correlated with the observed physico-chemical characteristics derived from FT-infrared(FT-IR), X-ray diffraction(XRD), temperature-programmed desorption of ammonia(NH3-TPD) and carbon dioxide(CO2-TPD). The Na5 Co W12O40catalyst exhibiting high activity even at 65°C is due to the presence of strong acidic as well as basic sites. The disclosed catalyst is tolerable towards water and free fatty acids present in the oils. The influence of catalyst loading, reaction time and reaction temperature is studied to optimize the reaction parameters. | Rekha Sree Sunny Kuriakose | 2015 | Journal of Energy Chemistry2015，24，1： | 4 |
| 14 | Virtual colonoscopy-induced perforation in a patient with Crohn's disease显示文摘We report a case of sigmoid colon perforation in a patient with Crohn's disease undergoing computed-tomographic (CT) colonography. A 70-year-old patient with Crohn's disease with terminal ileitis and sigmoid stricture underwent CT colonography after incomplete conventional colonoscopy. During the procedure, the colon was inflated by air insufflation and the patient developed abdominal pain with radiological evidence of retroperitoneal and intraperitoneal free gas. Hartmann's operation was performed. This case highlights that CT colonography is not risk-free. The risk of perforation may be higher in patients with inflammatory bowel disease. | Sunny H Wong Vincent WS Wong Joseph JY Sung | 2007 | World Journal of Gastroenterology2007，13，6： | 3 |
| 15 | 复杂碎裂心房电图区、心房颤动巢、主频点与心脏神经丛:现象与本质?显示文摘目前对心房颤动(简称房颤)机制的基本认识有①局灶起源机制;②多子波折返机制;③主导折返环机制。以这些机制为指导的消融治疗房颤,存在消融时间长、并发症多,且成功率不高的缺点。因此,人们在不断地探索新的标测方法。由于各个研究中心所采取的标测方法和技术不同,出现以复杂碎裂心房电图区、房颤巢、主频点以及心脏神经丛为消融靶点的治疗方法。这些方法均取得了较好的疗效,又对房颤的机制有了更深入的认识。从所有方法标测的部位上看,似乎这些方法均有联系,均与心脏神经丛关联。如果能透过这些现象认识到房颤的本质,那么就有可能找到消融治疗房颤的简单方法。 | 侯应龙 Benjamin J.Scherlag 周菁 张媛 Sunny Po | 2006 | 中国心脏起搏与心电生理杂志2006，20，3： | 2 |
| 16 | Retrograde jejunogastric intussusception following Braun's jejunojejunostomy显示文摘Jejunogastric intussusception is a rare long term complication of Billroth Ⅱ gastrectomy. The case reported here is a 50 year old man with history of a Billroth Ⅱ gastrectomy and Braun's side-to-side jejunojejunal anastomosis who presented with hematemesis. On abdominal examination, there was a mass in the left iliac fossa. Computed tomography scan showed a retrograde jejunogastric intussusception across the gastrojejunostomy. On laparotomy, a retrograde intussusception of the distal jejunum through the jejunojejunal anastomosis and across the gastrojejunostomy with a gangrenous intussusceptum was found. The jejunojejunal anastomosis was taken down, the gangrenous segment was resected and bowel continuity was restored with two jejunojejunal anastomoses, proximal and distal to the gastrojejunostomy. The gastrojejunostomy was preserved. This case brings out an unusual type of retrograde gangrenous intussusception which occurred at two points of a previous anastomosis, i.e., jejunojejunostomy and gastrojejunostomy simultaneously, which could be managed with jejunal resection. | Raj Gopal Thirthar Palanivelu Elamurugan Sunny Hage Rajakannu Muthukumarassamy Vikram Kate | 2014 | World Journal of Clinical Cases2014，2，1： | 2 |
| 17 | Detection and quantification of enteroviruses in coastal seawaters from Bohai Bay,Tianjin,China显示文摘An 8-month survey was conducted to detect and quantify enteroviruses in Tianjin coastal seawaters of Bohai Bay to assess coastal water quality. Ten water samples were collected from Bohai Bay for the detection and quantification of enteroviruses by conventional reverse transcription polymerase chain reaction (RT-PCR) and SYBR Green real-time quantitative RT-PCR (qRT-PCR). Total viral nucleic acid was extracted from 500 mL of seawater samples concentrated by Centricon plus-70 centrifugal filter devices. The viral recovery rate was 29.1% based on viral seeding study. The centrifugal ultrafiltration method applied is effective for viral recovery from small volume of polluted water, which may have broader applications to monitoring human virus in aquatic environment. Our results indicated that there was a severe viral contamination in seawater of Bohai Bay. Enteroviruses were detected at concentrations ranging from 1.7×106 to 6.3×107 copies/L by qRT-PCR. Sequencing analyses identified that all of the twenty clones as poliovirus type 2. This is the first quantitative report of human viruses in coastal waters of a metropolitan city in China. This study emphasized the importance for the local and central governments to monitor and assess the water quality. | Minglu Zhang Huabing Zhao Jian Yang Sunny Jiang Baoli Cai | 2010 | Journal of Environmental Sciences2010，22，1： | 2 |
| 18 | The RAS-RAL axis in cancer: evidence for mutationspecific selectivity in non-small cell lung cancer显示文摘激活的地岬变化在人的肿瘤是普通的。这些变化经常是为到治疗和随后的差的预后的抵抗的标记。到目前为止,指向地岬下游地表明小径的 RAF-MEK-ERK 和 PI3K-AKT 是唯一的在怀有地岬变化的癌症病人的治疗答应途径。RAL GTPase,地岬的另一个下游的受动器,也为地岬异种癌症的治疗被看作一种治疗学的选择。RAL GTPase 家庭包括 RALA 和 RALB,它能在不同肿瘤模型有分叉或类似的功能。非小的房间肺癌症(NSCLC ) 上的最近的研究证明了不同地岬变化有选择地激活特定的受动器小径。这观察在另外的肿瘤组织类型要求更宽广的确认,但是如果真,将由根据地岬的类型指向特定的下游的地岬受动器提供一条新途径给地岬异种癌症病人的治疗变化。它也建议 RAL GTPase 抑制将是为怀有地岬 glycine 到半胱氨酸(G12C ) 或 glycien 到缬氨酸(G12V ) 的肿瘤的重要治疗策略变化,它通常在 NSCLC 和胰腺的癌症被发现。 | Sunny GUIN | 2015 | Acta Pharmacologica Sinica2015，36，3： | 2 |
| 19 | Outcome of nucleoplasty in patients with radicular pain due to lumbar intervertebral disc herniation显示文摘 | Sunny Ogbonnaya Chandrasekaran Kaliaperumal Abdulla Qassim Michael O′Sullivan | 2013 | Journal of Natural Science Biology and Medicine2013，，1： | 2 |
| 20 | A Study on the Effect of Low Calcium Ultra-fine Fly Ash as a Partial Sustainable Supplementary Material to Cement in Self-compacting Concrete显示文摘The aim and scope of the present study were to determine the efficacy of UFFA in evaluating the workability,static and dynamic stabilization properties,retention period,and slump loss of SCC systems in their fresh state,as well as their compressive strength at various ages.Microstructure(SEM and XRD)of blended SCC systems were studied.Also,the thermogravimetry behavior of blended SCC specimens were researched.According to the evaluated results,incorporating up to 20%UFFA into fresh concrete improved its performance due to its engineered fine particle size and spherical geometry,both of which contribute to the enhancement of characteristics.Blends of 25%and 30%of UFFA show effect on the water-binder ratio and chemical enhancer dosage,resulting in a loss of homogeneity in fresh SCC systems.The reduced particle size,increased amorphous content,and increased surface area all contribute to the pozzolanic reactivity of the early and later ages,resulting in denser packing and thus an increase in compressive strength.The experimental results indicate that UFFA enhances the properties of SCC in both its fresh and hardened states,which can be attributed to the particles’fineness and their relative effect on SCC. | Adapala Sunny Suprakash Karthiyaini S | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，2： | 2 |
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